IL278366A - - Google Patents

Info

Publication number
IL278366A
IL278366A IL27836620A IL27836620A IL278366A IL 278366 A IL278366 A IL 278366A IL 27836620 A IL27836620 A IL 27836620A IL 27836620 A IL27836620 A IL 27836620A IL 278366 A IL278366 A IL 278366A
Authority
IL
Israel
Application number
IL27836620A
Other languages
English (en)
Other versions
IL278366B2 (en
IL278366B1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of IL278366A publication Critical patent/IL278366A/en
Publication of IL278366B1 publication Critical patent/IL278366B1/en
Publication of IL278366B2 publication Critical patent/IL278366B2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL278366A 2018-04-29 2019-04-29 BCL-2 inhibitors IL278366B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018085217 2018-04-29
CN2018107134 2018-09-21
PCT/CN2019/085001 WO2019210828A1 (en) 2018-04-29 2019-04-29 Bcl-2 INHIBITORS

Publications (3)

Publication Number Publication Date
IL278366A true IL278366A (https=) 2020-12-31
IL278366B1 IL278366B1 (en) 2025-05-01
IL278366B2 IL278366B2 (en) 2025-09-01

Family

ID=68386968

Family Applications (1)

Application Number Title Priority Date Filing Date
IL278366A IL278366B2 (en) 2018-04-29 2019-04-29 BCL-2 inhibitors

Country Status (22)

Country Link
US (3) US11420968B2 (https=)
EP (2) EP3788042B1 (https=)
JP (4) JP2021521138A (https=)
KR (1) KR102738032B1 (https=)
CN (3) CN117683029A (https=)
AU (1) AU2019264475C1 (https=)
BR (1) BR112020022092A2 (https=)
CA (1) CA3098348A1 (https=)
DK (1) DK3788042T3 (https=)
ES (1) ES3018793T3 (https=)
FI (1) FI3788042T3 (https=)
HR (1) HRP20250392T1 (https=)
HU (1) HUE071493T2 (https=)
IL (1) IL278366B2 (https=)
LT (1) LT3788042T (https=)
MX (2) MX2020011495A (https=)
PL (1) PL3788042T3 (https=)
PT (1) PT3788042T (https=)
SG (1) SG11202009933WA (https=)
SI (1) SI3788042T1 (https=)
TW (1) TWI855062B (https=)
WO (1) WO2019210828A1 (https=)

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HUE060310T2 (hu) 2017-04-18 2023-02-28 Shanghai Fochon Pharmaceutical Co Ltd Apoptosis-indukáló szerek
EP3737681A4 (en) 2018-01-10 2022-01-12 Recurium IP Holdings, LLC BENZAMIDE COMPOUNDS
SI3788042T1 (sl) * 2018-04-29 2025-06-30 Beigene Switzerland Gmbh Zaviralci BCL-2
WO2020140005A2 (en) 2018-12-29 2020-07-02 Newave Pharmaceutical Inc. Bcl-2 inhibitors
WO2021083135A1 (en) * 2019-10-28 2021-05-06 Beigene, Ltd. Bcl-2 INHIBITORS
WO2021110102A1 (en) * 2019-12-02 2021-06-10 Beigene, Ltd. Methods of cancer treatment using bcl-2 inhibitor
KR20220100992A (ko) 2019-12-06 2022-07-18 록쏘 온콜로지, 인코포레이티드 브루톤 티로신 키나제 억제제의 투여
WO2021133817A1 (en) 2019-12-27 2021-07-01 Guangzhou Lupeng Pharmaceutical Company Ltd. 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases
JP7839962B2 (ja) * 2020-04-15 2026-04-03 ビーワン メディシンズ ワン ゲーエムベーハー Bcl-2阻害剤
EP4146649A4 (en) * 2020-05-08 2024-09-11 Fochon Biosciences, Ltd. COMPOUNDS AS BCL-2 INHIBITORS
CN114478520B (zh) * 2020-10-28 2025-01-10 杭州和正医药有限公司 Bcl-2蛋白凋亡诱导剂及应用
CN117642157A (zh) * 2021-03-19 2024-03-01 伊尔治疗学股份有限公司 具有((3-硝基苯基)磺酰基)乙酰胺作为bcl-2抑制剂的化合物
CN117616023A (zh) * 2021-04-13 2024-02-27 爱新医药科技(香港)有限公司 Bcl-2或bcl-2/bcl-xl调节剂及其用途
EP4351542A4 (en) * 2021-06-02 2025-04-09 BeiGene Switzerland GmbH Method for treating B-cell malignancy with BCL-2 inhibitor
CN115490708B (zh) * 2021-06-18 2025-01-24 苏州亚盛药业有限公司 磺酰胺类大环衍生物及其制备方法和用途
CA3230314A1 (en) * 2021-08-31 2023-03-09 Beigene Switzerland Gmbh Solid forms of bcl-2 inhibitors, method of preparation, and use thereof
WO2023078398A1 (en) * 2021-11-05 2023-05-11 Fochon Pharmaceuticals, Ltd. Compounds as bcl-2 inhibitors
US20250122191A1 (en) * 2021-11-20 2025-04-17 Fochon Biosciences, Ltd Compounds as bcl-2 inhibitors
EP4442685A4 (en) * 2021-12-06 2025-11-19 Hangzhou Healzen Therapeutics Co Ltd BCL-2 PROTEIN ANTI-APOPTOTIC INHIBITOR: PHARMACEUTICAL COMPOSITION AND USES
TW202400163A (zh) 2022-05-12 2024-01-01 英屬開曼群島商百濟神州有限公司 使用bcl-2抑制劑治療髓性惡性腫瘤之方法
CN119365456A (zh) * 2022-06-01 2025-01-24 重庆复创医药研究有限公司 作为bcl-2抑制剂的化合物
CN119584963A (zh) * 2022-07-21 2025-03-07 百济神州(苏州)生物科技有限公司 使用bcl-2抑制剂治疗多发性骨髓瘤的方法
WO2024140690A1 (en) * 2022-12-27 2024-07-04 Beigene (Suzhou) Co., Ltd. Intermediates of sonrotoclax and the method of preparing the same
AU2023416871A1 (en) * 2022-12-27 2025-08-14 Beone Medicines I Gmbh Salts and solid forms of sonrotoclax intermediate
WO2024140678A1 (en) * 2022-12-27 2024-07-04 Beigene (Suzhou) Co., Ltd. A ketal protected intermediate for sonrotoclax and preparation method thereof
WO2026002056A1 (en) 2024-06-26 2026-01-02 Beone Pharmaceutical (Suzhou) Co., Ltd. A pharmaceutical formulation comprising solid dispersion of sonrotoclax and a process of preparation thereof
WO2026019442A1 (en) * 2024-07-14 2026-01-22 Eil Therapeutics, Inc. Compounds having (3-nitrophenyl)acetamide as bcl-2 inhibitors

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JP2015503518A (ja) 2011-12-23 2015-02-02 ノバルティス アーゲー Bcl2と結合相手の相互作用を阻害するための化合物
BR112014015442A8 (pt) 2011-12-23 2017-07-04 Novartis Ag compostos e composições para inibir a interação de bcl2 com parceiros de ligação
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CN106565706B (zh) 2016-10-27 2018-05-01 广东东阳光药业有限公司 一种磺酰胺衍生物及其在药学中的应用
CN106749233B (zh) * 2016-11-24 2020-04-21 中山大学 一类磺酰胺衍生物及其应用
EP3565815B1 (en) 2017-01-07 2024-03-13 Fochon Pharmaceuticals, Ltd. Compounds as bcl-2-selective apoptosis-inducing agents
HUE060310T2 (hu) 2017-04-18 2023-02-28 Shanghai Fochon Pharmaceutical Co Ltd Apoptosis-indukáló szerek
AU2018322059C1 (en) 2017-08-23 2024-09-12 Guangzhou Lupeng Pharmaceutical Company Ltd. BCL-2 inhibitors
SI3788042T1 (sl) 2018-04-29 2025-06-30 Beigene Switzerland Gmbh Zaviralci BCL-2
WO2020140005A2 (en) 2018-12-29 2020-07-02 Newave Pharmaceutical Inc. Bcl-2 inhibitors
WO2021083135A1 (en) 2019-10-28 2021-05-06 Beigene, Ltd. Bcl-2 INHIBITORS
WO2021110102A1 (en) 2019-12-02 2021-06-10 Beigene, Ltd. Methods of cancer treatment using bcl-2 inhibitor

Also Published As

Publication number Publication date
CA3098348A1 (en) 2019-11-07
HRP20250392T1 (hr) 2025-05-23
CN112437772A (zh) 2021-03-02
FI3788042T3 (fi) 2025-04-07
HUE071493T2 (hu) 2025-09-28
IL278366B2 (en) 2025-09-01
US20220402915A1 (en) 2022-12-22
TW202043217A (zh) 2020-12-01
MX2020011495A (es) 2021-01-15
JP2021521138A (ja) 2021-08-26
CN112437772B (zh) 2023-11-21
TWI855062B (zh) 2024-09-11
SG11202009933WA (en) 2020-11-27
AU2019264475B2 (en) 2024-09-26
CN117430601A (zh) 2024-01-23
EP3788042B1 (en) 2025-02-12
DK3788042T3 (en) 2025-04-07
EP3788042A4 (en) 2022-01-26
PT3788042T (pt) 2025-04-15
JP2025119001A (ja) 2025-08-13
EP4545515A1 (en) 2025-04-30
PL3788042T3 (pl) 2025-06-02
US11420968B2 (en) 2022-08-23
AU2019264475C1 (en) 2025-01-30
WO2019210828A1 (en) 2019-11-07
BR112020022092A2 (pt) 2021-02-02
ES3018793T3 (en) 2025-05-19
IL278366B1 (en) 2025-05-01
SI3788042T1 (sl) 2025-06-30
MX2023001689A (es) 2023-02-22
JP7540113B1 (ja) 2024-08-26
EP3788042A1 (en) 2021-03-10
JP2024119916A (ja) 2024-09-03
KR20210005677A (ko) 2021-01-14
CN117683029A (zh) 2024-03-12
JP2024161475A (ja) 2024-11-19
US20240376104A1 (en) 2024-11-14
AU2019264475A1 (en) 2020-11-12
US12077536B2 (en) 2024-09-03
LT3788042T (lt) 2025-03-25
KR102738032B1 (ko) 2024-12-05
JP7688210B2 (ja) 2025-06-03
US20210269433A1 (en) 2021-09-02

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