JP2021521138A5 - - Google Patents
Info
- Publication number
- JP2021521138A5 JP2021521138A5 JP2020555218A JP2020555218A JP2021521138A5 JP 2021521138 A5 JP2021521138 A5 JP 2021521138A5 JP 2020555218 A JP2020555218 A JP 2020555218A JP 2020555218 A JP2020555218 A JP 2020555218A JP 2021521138 A5 JP2021521138 A5 JP 2021521138A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- tetrahydro
- oxy
- sulfonyl
- pyrrolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024094048A JP7540113B1 (ja) | 2018-04-29 | 2024-06-11 | Ｂｃｌ－２阻害剤 |
| JP2024135320A JP7688210B2 (ja) | 2018-04-29 | 2024-08-14 | Ｂｃｌ－２阻害剤 |
| JP2025085498A JP2025119001A (ja) | 2018-04-29 | 2025-05-22 | Ｂｃｌ－２阻害剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2018/085217 | 2018-04-29 | ||
| CN2018085217 | 2018-04-29 | ||
| CNPCT/CN2018/107134 | 2018-09-21 | ||
| CN2018107134 | 2018-09-21 | ||
| PCT/CN2019/085001 WO2019210828A1 (en) | 2018-04-29 | 2019-04-29 | Bcl-2 INHIBITORS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094048A Division JP7540113B1 (ja) | 2018-04-29 | 2024-06-11 | Ｂｃｌ－２阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021521138A JP2021521138A (ja) | 2021-08-26 |
| JP2021521138A5 true JP2021521138A5 (enExample) | 2022-04-22 |
Family
ID=68386968
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555218A Withdrawn JP2021521138A (ja) | 2018-04-29 | 2019-04-29 | Ｂｃｌ−２阻害剤 |
| JP2024094048A Active JP7540113B1 (ja) | 2018-04-29 | 2024-06-11 | Ｂｃｌ－２阻害剤 |
| JP2024135320A Active JP7688210B2 (ja) | 2018-04-29 | 2024-08-14 | Ｂｃｌ－２阻害剤 |
| JP2025085498A Pending JP2025119001A (ja) | 2018-04-29 | 2025-05-22 | Ｂｃｌ－２阻害剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024094048A Active JP7540113B1 (ja) | 2018-04-29 | 2024-06-11 | Ｂｃｌ－２阻害剤 |
| JP2024135320A Active JP7688210B2 (ja) | 2018-04-29 | 2024-08-14 | Ｂｃｌ－２阻害剤 |
| JP2025085498A Pending JP2025119001A (ja) | 2018-04-29 | 2025-05-22 | Ｂｃｌ－２阻害剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US11420968B2 (enExample) |
| EP (2) | EP4545515A1 (enExample) |
| JP (4) | JP2021521138A (enExample) |
| KR (1) | KR102738032B1 (enExample) |
| CN (3) | CN112437772B (enExample) |
| AU (1) | AU2019264475C1 (enExample) |
| BR (1) | BR112020022092A2 (enExample) |
| CA (1) | CA3098348A1 (enExample) |
| DK (1) | DK3788042T3 (enExample) |
| ES (1) | ES3018793T3 (enExample) |
| FI (1) | FI3788042T3 (enExample) |
| HR (1) | HRP20250392T1 (enExample) |
| HU (1) | HUE071493T2 (enExample) |
| IL (1) | IL278366B2 (enExample) |
| LT (1) | LT3788042T (enExample) |
| MX (2) | MX2020011495A (enExample) |
| PL (1) | PL3788042T3 (enExample) |
| PT (1) | PT3788042T (enExample) |
| SG (1) | SG11202009933WA (enExample) |
| SI (1) | SI3788042T1 (enExample) |
| TW (1) | TWI855062B (enExample) |
| WO (1) | WO2019210828A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| EP3612531B1 (en) | 2017-04-18 | 2022-08-24 | Shanghai Fochon Pharmaceutical Co., Ltd. | Apoptosis-inducing agents |
| KR20200108301A (ko) | 2018-01-10 | 2020-09-17 | 리커리엄 아이피 홀딩스, 엘엘씨 | 벤즈아미드 화합물 |
| SG11202009933WA (en) * | 2018-04-29 | 2020-11-27 | Beigene Ltd | Bcl-2 INHIBITORS |
| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| WO2021083135A1 (en) * | 2019-10-28 | 2021-05-06 | Beigene, Ltd. | Bcl-2 INHIBITORS |
| WO2021110102A1 (en) * | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
| JP7142173B2 (ja) | 2019-12-06 | 2022-09-26 | ロクソ オンコロジー， インコーポレイテッド | ブルトン型チロシンキナーゼ阻害剤の投薬 |
| WO2021133817A1 (en) | 2019-12-27 | 2021-07-01 | Guangzhou Lupeng Pharmaceutical Company Ltd. | 1h-pyrrolo[2,3-b]pyridine derivatives as bcl-2 inhibitors for the treatment of neoplastic and autoimmune diseases |
| IL296582A (en) * | 2020-04-15 | 2022-11-01 | Beigene Ltd | bcl-2 inhibitor |
| US20230159527A1 (en) * | 2020-05-08 | 2023-05-25 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
| CN114478520B (zh) * | 2020-10-28 | 2025-01-10 | 杭州和正医药有限公司 | Bcl-2蛋白凋亡诱导剂及应用 |
| MX2023011000A (es) * | 2021-03-19 | 2023-09-28 | Eil Therapeutics Inc | Compuestos que contienen ((3-nitrofenilo)sulfonilo)acetamida como inhibidores bcl-2. |
| WO2022218311A1 (en) * | 2021-04-13 | 2022-10-20 | Appicine Therapeutics (Hk) Limited | Modulators of bcl-2 or bcl-2/bcl-xl and uses thereof |
| EP4351542A4 (en) * | 2021-06-02 | 2025-04-09 | BeiGene Switzerland GmbH | Method for treating B-cell malignancy with BCL-2 inhibitor |
| CN115490708B (zh) * | 2021-06-18 | 2025-01-24 | 苏州亚盛药业有限公司 | 磺酰胺类大环衍生物及其制备方法和用途 |
| EP4396180A4 (en) * | 2021-08-31 | 2025-07-09 | Beigene Ltd | SOLID FORMS OF BCL-2 INHIBITORS, PROCESS FOR THEIR PREPARATION AND USE THEREOF |
| WO2023078398A1 (en) * | 2021-11-05 | 2023-05-11 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
| US20250122191A1 (en) * | 2021-11-20 | 2025-04-17 | Fochon Biosciences, Ltd | Compounds as bcl-2 inhibitors |
| CA3238433A1 (en) * | 2021-12-06 | 2023-06-15 | Xingguo LIU | Anti-apoptotic protein bcl-2 inhibitor, pharmaceutical composition and uses thereof |
| TW202400163A (zh) | 2022-05-12 | 2024-01-01 | 英屬開曼群島商百濟神州有限公司 | 使用ｂｃｌ－２抑制劑治療髓性惡性腫瘤之方法 |
| WO2023231777A1 (en) * | 2022-06-01 | 2023-12-07 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
| JP2025525609A (ja) * | 2022-07-21 | 2025-08-05 | ベイジーン スイッツァランド ゲーエムベーハー | Ｂｃｌ－２阻害剤を使用する多発性骨髄腫の治療方法 |
| AU2023417649A1 (en) * | 2022-12-27 | 2025-08-14 | Beone Medicines I Gmbh | Intermediates of sonrotoclax and the method of preparing the same |
| KR20250127311A (ko) * | 2022-12-27 | 2025-08-26 | 비원 메디슨즈 아이 게엠베하 | 손로토클락스를 위한 케탈 보호된 중간체 및 이의 제조 방법 |
| IL321700A (en) * | 2022-12-27 | 2025-08-01 | Beone Medicines I Gmbh | Salts and solid forms of sonrotoclax intermediate |
| WO2026002056A1 (en) | 2024-06-26 | 2026-01-02 | Beone Pharmaceutical (Suzhou) Co., Ltd. | A pharmaceutical formulation comprising solid dispersion of sonrotoclax and a process of preparation thereof |
| WO2026019442A1 (en) * | 2024-07-14 | 2026-01-22 | Eil Therapeutics, Inc. | Compounds having (3-nitrophenyl)acetamide as bcl-2 inhibitors |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR031130A1 (es) * | 2000-09-20 | 2003-09-10 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| US20020055631A1 (en) | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
| WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
| AU2005277223C1 (en) | 2004-08-20 | 2009-05-21 | The Regents Of The University Of Michigan | Small molecule inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof |
| PL1888550T3 (pl) | 2005-05-12 | 2014-12-31 | Abbvie Bahamas Ltd | Promotory apoptozy |
| MX2007014783A (es) | 2005-05-24 | 2008-02-19 | Abbott Lab | Activadores de apoptosis. |
| JP5277168B2 (ja) | 2006-09-05 | 2013-08-28 | アボット・ラボラトリーズ | 血小板過剰を治療するｂｃｌインヒビター |
| WO2009036051A1 (en) | 2007-09-10 | 2009-03-19 | Curis, Inc. | Bcl-2 inhibitors containing a zinc binding moiety |
| US8501992B2 (en) | 2008-06-09 | 2013-08-06 | Bristol-Myers Squibb Company | Hydroxyphenyl sulfonamides as antiapoptotic bcl inhibitors |
| US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
| UA108193C2 (uk) | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| DK2376480T3 (en) | 2008-12-05 | 2016-09-12 | Abbvie Inc | Sulfonamide derivatives AS BCL-2-selective apoptosis inducing agents for the treatment of cancer and immune diseases |
| US8759520B2 (en) | 2008-12-08 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Compounds for treating cancer |
| CA2747835A1 (en) | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2010083442A1 (en) | 2009-01-19 | 2010-07-22 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) * | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2010138588A2 (en) | 2009-05-26 | 2010-12-02 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| CA2772989A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Sulfonamides as inhibitors of bcl-2 family proteins for the treatment of cancer |
| RU2015141713A (ru) | 2010-03-25 | 2018-12-28 | Эббви Инк. | Средства, индуцирующие апоптоз, для лечения рака, иммунных и аутоиммунных заболеваний |
| TWI520960B (zh) | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑 |
| TWI535712B (zh) | 2010-08-06 | 2016-06-01 | 阿斯特捷利康公司 | 化合物 |
| CA3152557A1 (en) | 2010-10-29 | 2012-05-03 | Abbvie Inc. | Solid dispersions containing an apoptosis-inducing agent |
| IT1403156B1 (it) | 2010-12-01 | 2013-10-04 | Università Degli Studi Di Torino | Inibitori di fosfatidilinositol 3-chinasi, relative composizioni ed usi. |
| EP2668180B1 (en) | 2011-01-25 | 2018-08-01 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors for use in the treatment of cancer |
| JP2014521595A (ja) | 2011-05-25 | 2014-08-28 | ブリストル−マイヤーズ スクイブ カンパニー | 抗アポトーシスＢｃｌ阻害剤として有用な置換スルホンアミド |
| US8946445B2 (en) | 2011-10-12 | 2015-02-03 | Nanjing Allgen Pharma Co., Ltd. | Heterocyclic molecules as apoptosis inducers |
| WO2013096051A1 (en) | 2011-12-23 | 2013-06-27 | Novartis Ag | Compounds for inhibiting the interaction of bcl2 with binding partners |
| EP2794592A1 (en) | 2011-12-23 | 2014-10-29 | Novartis AG | Compounds for inhibiting the interaction of bcl2 with binding partners |
| US9126980B2 (en) | 2011-12-23 | 2015-09-08 | Novartis Ag | Compounds for inhibiting the interaction of BCL2 with binding partners |
| EP2794591A1 (en) | 2011-12-23 | 2014-10-29 | Novartis AG | Compounds for inhibiting the interaction of bcl2 with binding partners |
| BR112014015308A8 (pt) | 2011-12-23 | 2017-06-13 | Novartis Ag | compostos para inibição da interação de bcl2 com contrapartes de ligação |
| WO2013185202A1 (en) | 2012-06-14 | 2013-12-19 | Beta Pharma Canada Inc | Apoptosis inducers |
| EP3689886A1 (en) | 2013-01-16 | 2020-08-05 | The Regents of The University of Michigan | Bcl-2/bcl-xl inhibitors and their use in the treatment of cancer |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2017132474A1 (en) | 2016-01-30 | 2017-08-03 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| EP3481397A1 (en) | 2016-07-06 | 2019-05-15 | Concert Pharmaceuticals Inc. | Deuterated venetoclax |
| US10829488B2 (en) | 2016-08-05 | 2020-11-10 | The Regents Of The University Of Michigan | N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors |
| WO2018041248A1 (zh) | 2016-09-01 | 2018-03-08 | 北京赛林泰医药技术有限公司 | Bcl-2选择性抑制剂及其制备和用途 |
| CN106565706B (zh) | 2016-10-27 | 2018-05-01 | 广东东阳光药业有限公司 | 一种磺酰胺衍生物及其在药学中的应用 |
| CN106749233B (zh) * | 2016-11-24 | 2020-04-21 | 中山大学 | 一类磺酰胺衍生物及其应用 |
| EP3565815B1 (en) | 2017-01-07 | 2024-03-13 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
| EP3612531B1 (en) | 2017-04-18 | 2022-08-24 | Shanghai Fochon Pharmaceutical Co., Ltd. | Apoptosis-inducing agents |
| CN111511748B (zh) | 2017-08-23 | 2023-05-02 | 广州麓鹏制药有限公司 | Bcl-2抑制剂 |
| SG11202009933WA (en) * | 2018-04-29 | 2020-11-27 | Beigene Ltd | Bcl-2 INHIBITORS |
| WO2020140005A2 (en) | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
| WO2021083135A1 (en) | 2019-10-28 | 2021-05-06 | Beigene, Ltd. | Bcl-2 INHIBITORS |
| WO2021110102A1 (en) | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
-
2019
- 2019-04-29 SG SG11202009933WA patent/SG11202009933WA/en unknown
- 2019-04-29 JP JP2020555218A patent/JP2021521138A/ja not_active Withdrawn
- 2019-04-29 FI FIEP19797052.8T patent/FI3788042T3/fi active
- 2019-04-29 DK DK19797052.8T patent/DK3788042T3/da active
- 2019-04-29 KR KR1020207033817A patent/KR102738032B1/ko active Active
- 2019-04-29 BR BR112020022092-2A patent/BR112020022092A2/pt unknown
- 2019-04-29 SI SI201930922T patent/SI3788042T1/sl unknown
- 2019-04-29 CN CN201980029015.1A patent/CN112437772B/zh active Active
- 2019-04-29 PT PT197970528T patent/PT3788042T/pt unknown
- 2019-04-29 CN CN202311486964.7A patent/CN117683029A/zh active Pending
- 2019-04-29 HR HRP20250392TT patent/HRP20250392T1/hr unknown
- 2019-04-29 ES ES19797052T patent/ES3018793T3/es active Active
- 2019-04-29 CN CN202311185016.XA patent/CN117430601A/zh active Pending
- 2019-04-29 EP EP25150254.8A patent/EP4545515A1/en active Pending
- 2019-04-29 HU HUE19797052A patent/HUE071493T2/hu unknown
- 2019-04-29 AU AU2019264475A patent/AU2019264475C1/en active Active
- 2019-04-29 LT LTEPPCT/CN2019/085001T patent/LT3788042T/lt unknown
- 2019-04-29 WO PCT/CN2019/085001 patent/WO2019210828A1/en not_active Ceased
- 2019-04-29 PL PL19797052.8T patent/PL3788042T3/pl unknown
- 2019-04-29 CA CA3098348A patent/CA3098348A1/en active Pending
- 2019-04-29 MX MX2020011495A patent/MX2020011495A/es unknown
- 2019-04-29 US US17/050,581 patent/US11420968B2/en active Active
- 2019-04-29 EP EP19797052.8A patent/EP3788042B1/en active Active
- 2019-04-29 IL IL278366A patent/IL278366B2/en unknown
-
2020
- 2020-04-28 TW TW109114185A patent/TWI855062B/zh active
- 2020-10-29 MX MX2023001689A patent/MX2023001689A/es unknown
-
2022
- 2022-05-23 US US17/750,821 patent/US12077536B2/en active Active
-
2024
- 2024-06-11 JP JP2024094048A patent/JP7540113B1/ja active Active
- 2024-06-17 US US18/745,423 patent/US20240376104A1/en active Pending
- 2024-08-14 JP JP2024135320A patent/JP7688210B2/ja active Active
-
2025
- 2025-05-22 JP JP2025085498A patent/JP2025119001A/ja active Pending
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