JP2021519312A5 - - Google Patents
Info
- Publication number
- JP2021519312A5 JP2021519312A5 JP2020551973A JP2020551973A JP2021519312A5 JP 2021519312 A5 JP2021519312 A5 JP 2021519312A5 JP 2020551973 A JP2020551973 A JP 2020551973A JP 2020551973 A JP2020551973 A JP 2020551973A JP 2021519312 A5 JP2021519312 A5 JP 2021519312A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- optionally substituted
- nhc
- group
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862649451P | 2018-03-28 | 2018-03-28 | |
| US62/649,451 | 2018-03-28 | ||
| PCT/US2019/023457 WO2019190885A1 (en) | 2018-03-28 | 2019-03-21 | Calpain modulators and therapeutic uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021519312A JP2021519312A (ja) | 2021-08-10 |
| JP2021519312A5 true JP2021519312A5 (cg-RX-API-DMAC7.html) | 2022-03-03 |
Family
ID=68060735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020551973A Pending JP2021519312A (ja) | 2018-03-28 | 2019-03-21 | カルパインモジュレーター及びその治療的使用 |
Country Status (20)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| WO2018064119A1 (en) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| CA3093749A1 (en) * | 2018-03-28 | 2019-10-03 | Blade Therapeutics, Inc. | Method of treating fibrotic disease |
| BR112020026744A2 (pt) * | 2018-06-28 | 2021-03-30 | Blade Therapeutics, Inc. | Métodos para tratar fibrose hepática com o uso de inibidores de calpaína |
| PH12022553378A1 (en) | 2020-06-10 | 2024-03-25 | Univ Leuven Kath | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
| AU2022306289A1 (en) | 2021-07-09 | 2024-01-18 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| EP0650368A1 (en) * | 1992-06-24 | 1995-05-03 | Cortex Pharmaceuticals, Inc. | Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity |
| DE19642591A1 (de) * | 1996-10-15 | 1998-04-16 | Basf Ag | Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| HK1039110A1 (zh) * | 1999-03-15 | 2002-04-12 | Axys Pharmaceuticals, Inc. | 以新颖的合成物及组分作为蛋白酶抑制剂 |
| WO2005000793A1 (ja) * | 2003-06-26 | 2005-01-06 | Taisho Pharmaceutical Co., Ltd. | ２位置換シクロアルキルカルボン酸誘導体 |
| EP1493739A1 (fr) * | 2003-07-03 | 2005-01-05 | Warner-Lambert Company LLC | Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR064693A1 (es) * | 2006-12-29 | 2009-04-22 | Abbott Gmbh & Co Kg | Compuestos carboxamidas y su utilizacion en la elaboracion de un medicamento para el tratamiento de enfermedades asociadas a alta actividad de calpaina. |
| US9051304B2 (en) * | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| JP2017517475A (ja) * | 2014-02-19 | 2017-06-29 | エーテーハー チューリヒ | 化合物ライブラリーの製造方法 |
| KR102519948B1 (ko) * | 2016-06-29 | 2023-04-11 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 암 치료용 화합물 및 조성물 |
| WO2018064119A1 (en) * | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| CA3093749A1 (en) * | 2018-03-28 | 2019-10-03 | Blade Therapeutics, Inc. | Method of treating fibrotic disease |
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2019
- 2019-03-21 RU RU2020130022A patent/RU2020130022A/ru unknown
- 2019-03-21 JP JP2020551973A patent/JP2021519312A/ja active Pending
- 2019-03-21 PE PE2020001468A patent/PE20212111A1/es unknown
- 2019-03-21 KR KR1020207029538A patent/KR20200139702A/ko not_active Ceased
- 2019-03-21 EP EP19777469.8A patent/EP3774737A4/en not_active Withdrawn
- 2019-03-21 CA CA3095164A patent/CA3095164A1/en active Pending
- 2019-03-21 CN CN201980035887.9A patent/CN112204014A/zh active Pending
- 2019-03-21 US US17/041,596 patent/US20210009564A1/en not_active Abandoned
- 2019-03-21 MX MX2020010033A patent/MX2020010033A/es unknown
- 2019-03-21 BR BR112020019560-0A patent/BR112020019560A2/pt not_active Application Discontinuation
- 2019-03-21 WO PCT/US2019/023457 patent/WO2019190885A1/en not_active Ceased
- 2019-03-21 AU AU2019242387A patent/AU2019242387A1/en not_active Abandoned
- 2019-03-21 SG SG11202008750XA patent/SG11202008750XA/en unknown
- 2019-03-28 TW TW108111017A patent/TW202003472A/zh unknown
- 2019-03-28 AR ARP190100806A patent/AR115303A1/es not_active Application Discontinuation
-
2020
- 2020-09-23 IL IL277548A patent/IL277548A/en unknown
- 2020-09-25 CL CL2020002496A patent/CL2020002496A1/es unknown
- 2020-09-25 PH PH12020551555A patent/PH12020551555A1/en unknown
- 2020-09-30 CO CONC2020/0012359A patent/CO2020012359A2/es unknown
- 2020-10-26 EC ECSENADI202068210A patent/ECSP20068210A/es unknown