JP2021516996A5 - - Google Patents
Info
- Publication number
- JP2021516996A5 JP2021516996A5 JP2020571337A JP2020571337A JP2021516996A5 JP 2021516996 A5 JP2021516996 A5 JP 2021516996A5 JP 2020571337 A JP2020571337 A JP 2020571337A JP 2020571337 A JP2020571337 A JP 2020571337A JP 2021516996 A5 JP2021516996 A5 JP 2021516996A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- polypeptide
- cells
- amino acid
- polypeptide according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023204147A JP2024037778A (ja) | 2015-09-11 | 2023-12-01 | 生物学的に関連する直交サイトカイン/受容体対 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562217364P | 2015-09-11 | 2015-09-11 | |
| US201662375089P | 2016-08-15 | 2016-08-15 | |
| US15/916,689 US10869887B2 (en) | 2015-09-11 | 2018-03-09 | Biologically relevant orthogonal cytokine/receptor pairs |
| US15/916,689 | 2018-03-09 | ||
| PCT/US2019/021451 WO2019173773A1 (en) | 2015-09-11 | 2019-03-08 | Biologically relevant orthogonal cytokine/receptor pairs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023204147A Division JP2024037778A (ja) | 2015-09-11 | 2023-12-01 | 生物学的に関連する直交サイトカイン/受容体対 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021516996A JP2021516996A (ja) | 2021-07-15 |
| JP2021516996A5 true JP2021516996A5 (https=) | 2022-03-16 |
| JP7846963B2 JP7846963B2 (ja) | 2026-04-16 |
Family
ID=58240003
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513275A Active JP7299021B2 (ja) | 2015-09-11 | 2016-09-07 | 生体関連の直交性サイトカイン/受容体ペア |
| JP2020571337A Active JP7846963B2 (ja) | 2015-09-11 | 2019-03-08 | 生物学的に関連する直交サイトカイン/受容体対 |
| JP2021180486A Active JP7495385B2 (ja) | 2015-09-11 | 2021-11-04 | 生体関連の直交性サイトカイン/受容体ペア |
| JP2023204147A Pending JP2024037778A (ja) | 2015-09-11 | 2023-12-01 | 生物学的に関連する直交サイトカイン/受容体対 |
| JP2024013400A Pending JP2024054175A (ja) | 2015-09-11 | 2024-01-31 | 生体関連の直交性サイトカイン/受容体ペア |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513275A Active JP7299021B2 (ja) | 2015-09-11 | 2016-09-07 | 生体関連の直交性サイトカイン/受容体ペア |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021180486A Active JP7495385B2 (ja) | 2015-09-11 | 2021-11-04 | 生体関連の直交性サイトカイン/受容体ペア |
| JP2023204147A Pending JP2024037778A (ja) | 2015-09-11 | 2023-12-01 | 生物学的に関連する直交サイトカイン/受容体対 |
| JP2024013400A Pending JP2024054175A (ja) | 2015-09-11 | 2024-01-31 | 生体関連の直交性サイトカイン/受容体ペア |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US10869887B2 (https=) |
| EP (2) | EP3347056A4 (https=) |
| JP (5) | JP7299021B2 (https=) |
| KR (3) | KR102739782B1 (https=) |
| CN (4) | CN117659160A (https=) |
| AR (1) | AR114687A1 (https=) |
| AU (3) | AU2016318621A1 (https=) |
| BR (1) | BR112020018293A2 (https=) |
| CA (2) | CA2998393A1 (https=) |
| HK (1) | HK1258138A1 (https=) |
| IL (2) | IL313413A (https=) |
| MX (1) | MX2020009330A (https=) |
| PH (1) | PH12020551417A1 (https=) |
| RU (1) | RU2020133171A (https=) |
| SG (1) | SG11202008780SA (https=) |
| TW (1) | TW202017576A (https=) |
| WO (2) | WO2017044464A1 (https=) |
| ZA (1) | ZA202006168B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117659160A (zh) | 2015-09-11 | 2024-03-08 | 小利兰·斯坦福大学托管委员会 | 生物相关正交细胞因子/受体对 |
| EP3596108A4 (en) | 2017-03-15 | 2020-12-23 | Pandion Operations, Inc. | TARGETED IMMUNOTOLERANCE |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| KR102777151B1 (ko) | 2017-11-21 | 2025-03-05 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인터루킨-2의 부분 효능제 |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| CA3123392A1 (en) * | 2018-12-19 | 2020-06-25 | Iovance Biotherapeutics, Inc. | Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof |
| WO2020187848A1 (en) * | 2019-03-18 | 2020-09-24 | Biontech Cell & Gene Therapies Gmbh | Lnterleukin-2 receptor (il2r) and interleukin-2 (il2) variants for specific activation of immune effector cells |
| BR112021023345A2 (pt) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Imunotolerância com alvo em madcam |
| PH12022550326A1 (en) * | 2019-08-13 | 2023-03-13 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
| WO2021050752A1 (en) * | 2019-09-11 | 2021-03-18 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric orthogonal receptor proteins and methods of use |
| EP4041760A4 (en) * | 2019-10-08 | 2023-10-11 | Zymeworks BC Inc. | Modified extracellular domain of granulocyte colony-stimulating factor receptor (g-csfr) and cytokines binding same |
| CN121517534A (zh) | 2019-12-13 | 2026-02-13 | 辛德凯因股份有限公司 | Il-2直向同源物及其使用方法 |
| WO2021127487A2 (en) | 2019-12-20 | 2021-06-24 | Regeneron Pharmaceuticals, Inc. | Novel il2 agonists and methods of use thereof |
| US11633488B2 (en) | 2020-01-10 | 2023-04-25 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
| AU2021208559A1 (en) * | 2020-01-14 | 2022-07-07 | Synthekine, Inc. | CD122 with altered ICD STAT signaling |
| KR20220141299A (ko) * | 2020-01-14 | 2022-10-19 | 신테카인, 인크. | Il2 오르토로그 및 사용 방법 |
| WO2021146436A2 (en) | 2020-01-14 | 2021-07-22 | Synthekine, Inc. | Biased il2 muteins methods and compositions |
| EP4107187A4 (en) | 2020-02-21 | 2024-07-03 | Pandion Operations, Inc. | TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR |
| CA3169095A1 (en) * | 2020-03-05 | 2021-09-10 | Kenan Christopher GARCIA | Designed il-2 variants |
| US20230159892A1 (en) * | 2020-04-06 | 2023-05-25 | Synthekine, Inc. | Engineered immune cells |
| CA3179414A1 (en) * | 2020-04-06 | 2021-10-14 | Synthekine, Inc. | Human immune cells genomically modified to express orthogonal receptors |
| WO2022050401A2 (en) * | 2020-09-01 | 2022-03-10 | Takeda Pharmaceutical Company Limited | Interleukin-2 muteins and uses thereof |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
| JP2023549293A (ja) * | 2020-10-26 | 2023-11-22 | ネプチューン バイオサイエンシズ エルエルシー | 直交il-21受容体/サイトカイン系 |
| WO2022192346A1 (en) * | 2021-03-09 | 2022-09-15 | The Trustees Of The University Of Pennsylvania | Selective stimulation of t cells in solid tumors using oncolytic viral delivery of orthogonal il-2 |
| WO2022212918A1 (en) * | 2021-04-02 | 2022-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Bispecific molecules and related compositions and methods |
| AU2022254143A1 (en) * | 2021-04-07 | 2023-11-23 | Provincial Health Services Authority | Modified granulocyte colony-stimulating factor (g-csf) and chimeric cytokine receptors binding same |
| AU2022306974A1 (en) | 2021-07-09 | 2024-01-04 | Bright Peak Therapeutics Ag | Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases |
| US20250288666A1 (en) * | 2021-07-14 | 2025-09-18 | Synthekine, Inc. | Methods and compositions for use in cell therapy of neoplastic disease |
| AU2022348588A1 (en) | 2021-09-17 | 2024-04-04 | Parker Institute For Cancer Immunotherapy | Switch receptors using il-9 signaling domains |
| EP4504247A1 (en) * | 2022-04-04 | 2025-02-12 | Gammadelta Therapeutics Ltd | Novel gene armoring |
| EP4293040A1 (en) | 2022-06-19 | 2023-12-20 | ETH Zurich | Cell line for engineering cytokine receptors |
| EP4724504A1 (en) * | 2023-06-07 | 2026-04-15 | FBD Biologics Limited | Engineered il-7 variants and methods of use thereof |
| WO2025245495A1 (en) * | 2024-05-24 | 2025-11-27 | Cz Biohub Sf, Llc | Selective sensitization of cancer cells to elimination by cytotoxic lymphocytes |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902502A (en) * | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| EP1069917A4 (en) * | 1998-03-20 | 2005-02-09 | Genzyme Corp | NEW COMPLEMENTARY PAIRS OF RECEPTORS / LIGANDS AND ADOPTIVE IMMUNOTHERAPY USING THE SAME |
| US6955807B1 (en) * | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
| US7666400B2 (en) | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
| EP2213743A1 (en) * | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| DK1454138T3 (da) * | 2001-12-04 | 2012-02-13 | Merck Patent Gmbh | Immunocytokiner med moduleret selektivitet |
| US20060234205A1 (en) * | 2004-03-05 | 2006-10-19 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| US20060199250A1 (en) * | 2005-03-04 | 2006-09-07 | Huimin Zhao | Method for generating a mutant protein which efficiently binds a target molecule |
| AU2007271398B2 (en) | 2006-07-06 | 2013-06-20 | Merck Patent Gmbh | Compositions and methods for enhancing the efficacy of IL-2 mediated immune responses |
| JP5703020B2 (ja) | 2007-08-24 | 2015-04-15 | ノボ ノルディスク ヘルス ケア アーゲー | タンパク質を選択的に修飾するための組成物と方法 |
| EP2560994B1 (en) * | 2010-04-08 | 2016-10-12 | JN Biosciences LLC | Antibodies to cd122 |
| US10391126B2 (en) * | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| BR122020002986A8 (pt) * | 2012-08-20 | 2023-04-18 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Método e composições para imunoterapia celular |
| US9434935B2 (en) * | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
| EP2968450A4 (en) | 2013-03-15 | 2016-10-26 | Angelica Therapeutics Inc | MODIFIED TOXINS |
| FI2997141T3 (fi) | 2013-05-13 | 2022-12-15 | CD19-spesifinen kimeerinen antigeenireseptori ja sen käyttöjä | |
| AU2015301936B2 (en) | 2014-08-11 | 2019-03-07 | Delinia, Inc. | Modified IL-2 variants that selectively activate regulatory T cells for the treatment of autoimmune diseases |
| CR20170510A (es) * | 2015-04-10 | 2018-02-26 | Amgen Inc | Muteínas de interuquina 2 para la expansión de células t regulatorias |
| CN117659160A (zh) * | 2015-09-11 | 2024-03-08 | 小利兰·斯坦福大学托管委员会 | 生物相关正交细胞因子/受体对 |
| JP7422480B2 (ja) * | 2016-05-04 | 2024-01-26 | アムジエン・インコーポレーテツド | 制御性t細胞の増殖のためのインターロイキン-2変異タンパク質 |
| CN107746831B (zh) | 2017-11-07 | 2019-04-23 | 南京北恒生物科技有限公司 | 具有化疗药物抗性的通用型cart/tcrt细胞及其构建方法 |
-
2016
- 2016-09-07 CN CN202311460072.XA patent/CN117659160A/zh active Pending
- 2016-09-07 AU AU2016318621A patent/AU2016318621A1/en not_active Abandoned
- 2016-09-07 KR KR1020187010150A patent/KR102739782B1/ko active Active
- 2016-09-07 CA CA2998393A patent/CA2998393A1/en active Pending
- 2016-09-07 EP EP16844963.5A patent/EP3347056A4/en active Pending
- 2016-09-07 HK HK19100492.2A patent/HK1258138A1/zh unknown
- 2016-09-07 CN CN201680065667.7A patent/CN108430518A/zh active Pending
- 2016-09-07 JP JP2018513275A patent/JP7299021B2/ja active Active
- 2016-09-07 WO PCT/US2016/050511 patent/WO2017044464A1/en not_active Ceased
- 2016-09-07 KR KR1020247040181A patent/KR20250004916A/ko active Pending
-
2018
- 2018-03-09 US US15/916,689 patent/US10869887B2/en active Active
-
2019
- 2019-02-28 US US16/289,274 patent/US11439664B2/en active Active
- 2019-03-08 RU RU2020133171A patent/RU2020133171A/ru unknown
- 2019-03-08 US US16/977,385 patent/US20210060068A1/en not_active Abandoned
- 2019-03-08 CA CA3093472A patent/CA3093472A1/en active Pending
- 2019-03-08 AU AU2019231997A patent/AU2019231997B2/en active Active
- 2019-03-08 BR BR112020018293-1A patent/BR112020018293A2/pt active Search and Examination
- 2019-03-08 IL IL313413A patent/IL313413A/en unknown
- 2019-03-08 WO PCT/US2019/021451 patent/WO2019173773A1/en not_active Ceased
- 2019-03-08 KR KR1020207028947A patent/KR20210062591A/ko active Pending
- 2019-03-08 MX MX2020009330A patent/MX2020009330A/es unknown
- 2019-03-08 IL IL277118A patent/IL277118B2/en unknown
- 2019-03-08 EP EP19764492.5A patent/EP3761997A4/en active Pending
- 2019-03-08 SG SG11202008780SA patent/SG11202008780SA/en unknown
- 2019-03-08 CN CN202510224041.7A patent/CN120209111A/zh active Pending
- 2019-03-08 JP JP2020571337A patent/JP7846963B2/ja active Active
- 2019-03-08 CN CN201980031023.XA patent/CN112272560B/zh active Active
- 2019-03-11 AR ARP190100597A patent/AR114687A1/es unknown
- 2019-03-11 TW TW108108068A patent/TW202017576A/zh unknown
-
2020
- 2020-09-09 PH PH12020551417A patent/PH12020551417A1/en unknown
- 2020-10-05 ZA ZA2020/06168A patent/ZA202006168B/en unknown
- 2020-11-19 US US16/953,000 patent/US12005079B2/en active Active
-
2021
- 2021-11-04 JP JP2021180486A patent/JP7495385B2/ja active Active
-
2022
- 2022-07-26 US US17/815,092 patent/US20220354893A1/en not_active Abandoned
-
2023
- 2023-06-15 AU AU2023203727A patent/AU2023203727B2/en active Active
- 2023-12-01 JP JP2023204147A patent/JP2024037778A/ja active Pending
-
2024
- 2024-01-31 JP JP2024013400A patent/JP2024054175A/ja active Pending
- 2024-07-30 US US18/789,470 patent/US20240374645A1/en active Pending
-
2025
- 2025-08-12 US US19/298,037 patent/US20260108586A1/en active Pending
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