KR102739782B1 - 생물학적으로 관련된 직교 사이토카인/수용체 쌍 - Google Patents

생물학적으로 관련된 직교 사이토카인/수용체 쌍 Download PDF

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KR102739782B1
KR102739782B1 KR1020187010150A KR20187010150A KR102739782B1 KR 102739782 B1 KR102739782 B1 KR 102739782B1 KR 1020187010150 A KR1020187010150 A KR 1020187010150A KR 20187010150 A KR20187010150 A KR 20187010150A KR 102739782 B1 KR102739782 B1 KR 102739782B1
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cells
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cytokine
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KR20180049080A (ko
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케난 크리스토퍼 가르시아
조나단 소콜로스키
데이비드 베이커
크리스 킹
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더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티
유니버시티 오브 워싱톤
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Application filed by 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티, 유니버시티 오브 워싱톤 filed Critical 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티
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KR1020187010150A 2015-09-11 2016-09-07 생물학적으로 관련된 직교 사이토카인/수용체 쌍 Active KR102739782B1 (ko)

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Application Number Priority Date Filing Date Title
KR1020247040181A KR20250004916A (ko) 2015-09-11 2016-09-07 생물학적으로 관련된 직교 사이토카인/수용체 쌍

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562217364P 2015-09-11 2015-09-11
US62/217,364 2015-09-11
US201662375089P 2016-08-15 2016-08-15
US62/375,089 2016-08-15
PCT/US2016/050511 WO2017044464A1 (en) 2015-09-11 2016-09-07 Biologically relevant orthogonal cytokine/receptor pairs

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KR1020247040181A Division KR20250004916A (ko) 2015-09-11 2016-09-07 생물학적으로 관련된 직교 사이토카인/수용체 쌍

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KR20180049080A KR20180049080A (ko) 2018-05-10
KR102739782B1 true KR102739782B1 (ko) 2024-12-09

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KR1020187010150A Active KR102739782B1 (ko) 2015-09-11 2016-09-07 생물학적으로 관련된 직교 사이토카인/수용체 쌍
KR1020247040181A Pending KR20250004916A (ko) 2015-09-11 2016-09-07 생물학적으로 관련된 직교 사이토카인/수용체 쌍
KR1020207028947A Pending KR20210062591A (ko) 2015-09-11 2019-03-08 생물학적으로 관련된 직교 사이토카인/수용체 쌍

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KR1020207028947A Pending KR20210062591A (ko) 2015-09-11 2019-03-08 생물학적으로 관련된 직교 사이토카인/수용체 쌍

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US (7) US10869887B2 (https=)
EP (2) EP3347056A4 (https=)
JP (5) JP7299021B2 (https=)
KR (3) KR102739782B1 (https=)
CN (4) CN117659160A (https=)
AR (1) AR114687A1 (https=)
AU (3) AU2016318621A1 (https=)
BR (1) BR112020018293A2 (https=)
CA (2) CA2998393A1 (https=)
HK (1) HK1258138A1 (https=)
IL (2) IL313413A (https=)
MX (1) MX2020009330A (https=)
PH (1) PH12020551417A1 (https=)
RU (1) RU2020133171A (https=)
SG (1) SG11202008780SA (https=)
TW (1) TW202017576A (https=)
WO (2) WO2017044464A1 (https=)
ZA (1) ZA202006168B (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117659160A (zh) 2015-09-11 2024-03-08 小利兰·斯坦福大学托管委员会 生物相关正交细胞因子/受体对
EP3596108A4 (en) 2017-03-15 2020-12-23 Pandion Operations, Inc. TARGETED IMMUNOTOLERANCE
US10676516B2 (en) 2017-05-24 2020-06-09 Pandion Therapeutics, Inc. Targeted immunotolerance
KR102777151B1 (ko) 2017-11-21 2025-03-05 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 인터루킨-2의 부분 효능제
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
CA3123392A1 (en) * 2018-12-19 2020-06-25 Iovance Biotherapeutics, Inc. Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
WO2020187848A1 (en) * 2019-03-18 2020-09-24 Biontech Cell & Gene Therapies Gmbh Lnterleukin-2 receptor (il2r) and interleukin-2 (il2) variants for specific activation of immune effector cells
BR112021023345A2 (pt) 2019-05-20 2022-02-01 Pandion Operations Inc Imunotolerância com alvo em madcam
PH12022550326A1 (en) * 2019-08-13 2023-03-13 Amgen Inc Interleukin-2 muteins for the expansion of t-regulatory cells
WO2021050752A1 (en) * 2019-09-11 2021-03-18 The Board Of Trustees Of The Leland Stanford Junior University Chimeric orthogonal receptor proteins and methods of use
EP4041760A4 (en) * 2019-10-08 2023-10-11 Zymeworks BC Inc. Modified extracellular domain of granulocyte colony-stimulating factor receptor (g-csfr) and cytokines binding same
CN121517534A (zh) 2019-12-13 2026-02-13 辛德凯因股份有限公司 Il-2直向同源物及其使用方法
WO2021127487A2 (en) 2019-12-20 2021-06-24 Regeneron Pharmaceuticals, Inc. Novel il2 agonists and methods of use thereof
US11633488B2 (en) 2020-01-10 2023-04-25 Bright Peak Therapeutics Ag Modified IL-2 polypeptides and uses thereof
AU2021208559A1 (en) * 2020-01-14 2022-07-07 Synthekine, Inc. CD122 with altered ICD STAT signaling
KR20220141299A (ko) * 2020-01-14 2022-10-19 신테카인, 인크. Il2 오르토로그 및 사용 방법
WO2021146436A2 (en) 2020-01-14 2021-07-22 Synthekine, Inc. Biased il2 muteins methods and compositions
EP4107187A4 (en) 2020-02-21 2024-07-03 Pandion Operations, Inc. TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR
CA3169095A1 (en) * 2020-03-05 2021-09-10 Kenan Christopher GARCIA Designed il-2 variants
US20230159892A1 (en) * 2020-04-06 2023-05-25 Synthekine, Inc. Engineered immune cells
CA3179414A1 (en) * 2020-04-06 2021-10-14 Synthekine, Inc. Human immune cells genomically modified to express orthogonal receptors
WO2022050401A2 (en) * 2020-09-01 2022-03-10 Takeda Pharmaceutical Company Limited Interleukin-2 muteins and uses thereof
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
JP2023549293A (ja) * 2020-10-26 2023-11-22 ネプチューン バイオサイエンシズ エルエルシー 直交il-21受容体/サイトカイン系
WO2022192346A1 (en) * 2021-03-09 2022-09-15 The Trustees Of The University Of Pennsylvania Selective stimulation of t cells in solid tumors using oncolytic viral delivery of orthogonal il-2
WO2022212918A1 (en) * 2021-04-02 2022-10-06 The Board Of Trustees Of The Leland Stanford Junior University Bispecific molecules and related compositions and methods
AU2022254143A1 (en) * 2021-04-07 2023-11-23 Provincial Health Services Authority Modified granulocyte colony-stimulating factor (g-csf) and chimeric cytokine receptors binding same
AU2022306974A1 (en) 2021-07-09 2024-01-04 Bright Peak Therapeutics Ag Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases
US20250288666A1 (en) * 2021-07-14 2025-09-18 Synthekine, Inc. Methods and compositions for use in cell therapy of neoplastic disease
AU2022348588A1 (en) 2021-09-17 2024-04-04 Parker Institute For Cancer Immunotherapy Switch receptors using il-9 signaling domains
EP4504247A1 (en) * 2022-04-04 2025-02-12 Gammadelta Therapeutics Ltd Novel gene armoring
EP4293040A1 (en) 2022-06-19 2023-12-20 ETH Zurich Cell line for engineering cytokine receptors
EP4724504A1 (en) * 2023-06-07 2026-04-15 FBD Biologics Limited Engineered il-7 variants and methods of use thereof
WO2025245495A1 (en) * 2024-05-24 2025-11-27 Cz Biohub Sf, Llc Selective sensitization of cancer cells to elimination by cytotoxic lymphocytes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047178A1 (en) 1998-03-20 1999-09-23 Genzyme Corporation Novel complementing receptor-ligand pairs and adoptive immunotherapy using same
US20060199250A1 (en) 2005-03-04 2006-09-07 Huimin Zhao Method for generating a mutant protein which efficiently binds a target molecule
US20140255360A1 (en) 2013-03-10 2014-09-11 Bellicum Pharmaceuticals, Inc. Modified caspase polypeptides and uses thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902502A (en) * 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US6955807B1 (en) * 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists
US7666400B2 (en) 2005-04-06 2010-02-23 Ibc Pharmaceuticals, Inc. PEGylation by the dock and lock (DNL) technique
EP2213743A1 (en) * 2000-04-12 2010-08-04 Human Genome Sciences, Inc. Albumin fusion proteins
DK1454138T3 (da) * 2001-12-04 2012-02-13 Merck Patent Gmbh Immunocytokiner med moduleret selektivitet
US20060234205A1 (en) * 2004-03-05 2006-10-19 Chiron Corporation In vitro test system for predicting patient tolerability of therapeutic agents
AU2007271398B2 (en) 2006-07-06 2013-06-20 Merck Patent Gmbh Compositions and methods for enhancing the efficacy of IL-2 mediated immune responses
JP5703020B2 (ja) 2007-08-24 2015-04-15 ノボ ノルディスク ヘルス ケア アーゲー タンパク質を選択的に修飾するための組成物と方法
EP2560994B1 (en) * 2010-04-08 2016-10-12 JN Biosciences LLC Antibodies to cd122
US10391126B2 (en) * 2011-11-18 2019-08-27 Board Of Regents, The University Of Texas System CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
BR122020002986A8 (pt) * 2012-08-20 2023-04-18 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Método e composições para imunoterapia celular
EP2968450A4 (en) 2013-03-15 2016-10-26 Angelica Therapeutics Inc MODIFIED TOXINS
FI2997141T3 (fi) 2013-05-13 2022-12-15 CD19-spesifinen kimeerinen antigeenireseptori ja sen käyttöjä
AU2015301936B2 (en) 2014-08-11 2019-03-07 Delinia, Inc. Modified IL-2 variants that selectively activate regulatory T cells for the treatment of autoimmune diseases
CR20170510A (es) * 2015-04-10 2018-02-26 Amgen Inc Muteínas de interuquina 2 para la expansión de células t regulatorias
CN117659160A (zh) * 2015-09-11 2024-03-08 小利兰·斯坦福大学托管委员会 生物相关正交细胞因子/受体对
JP7422480B2 (ja) * 2016-05-04 2024-01-26 アムジエン・インコーポレーテツド 制御性t細胞の増殖のためのインターロイキン-2変異タンパク質
CN107746831B (zh) 2017-11-07 2019-04-23 南京北恒生物科技有限公司 具有化疗药物抗性的通用型cart/tcrt细胞及其构建方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047178A1 (en) 1998-03-20 1999-09-23 Genzyme Corporation Novel complementing receptor-ligand pairs and adoptive immunotherapy using same
JP2002506980A (ja) * 1998-03-20 2002-03-05 ジェンザイム・コーポレーション 新規の相補的レセプター−リガンド対およびそれを使用する養子免疫療法
US20060199250A1 (en) 2005-03-04 2006-09-07 Huimin Zhao Method for generating a mutant protein which efficiently binds a target molecule
US20140255360A1 (en) 2013-03-10 2014-09-11 Bellicum Pharmaceuticals, Inc. Modified caspase polypeptides and uses thereof

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