JP2021516222A - 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法 - Google Patents

副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法 Download PDF

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JP2021516222A
JP2021516222A JP2020542898A JP2020542898A JP2021516222A JP 2021516222 A JP2021516222 A JP 2021516222A JP 2020542898 A JP2020542898 A JP 2020542898A JP 2020542898 A JP2020542898 A JP 2020542898A JP 2021516222 A JP2021516222 A JP 2021516222A
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JP2021516222A5 (enExample
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トーマス ジェイ． ガーデラ
トーマス ジェイ． ガーデラ
アショク カトリ
アショク カトリ
寛 野田
寛 野田
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ザ ジェネラル ホスピタル コーポレイション
ザ ジェネラル ホスピタル コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2020542898A 2018-03-16 2019-03-15 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法 Pending JP2021516222A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862644316P 2018-03-16 2018-03-16
US62/644,316 2018-03-16
PCT/US2019/022439 WO2019178462A1 (en) 2018-03-16 2019-03-15 Parathyroid hormone polypeptide conjugates and methods of their use

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JP2021516222A true JP2021516222A (ja) 2021-07-01
JP2021516222A5 JP2021516222A5 (enExample) 2022-03-23

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US (1) US11975050B2 (enExample)
EP (1) EP3765061A4 (enExample)
JP (1) JP2021516222A (enExample)
WO (1) WO2019178462A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022024058A2 (pt) * 2020-05-26 2022-12-20 Univ Indiana Res & Tech Corp Análogos de pth para o tratamento de hipoparatireoidismo
EP4593867A2 (en) 2022-09-30 2025-08-06 Extend Biosciences, Inc. Long-acting parathyroid hormone
WO2025250793A1 (en) * 2024-05-29 2025-12-04 The General Hospital Corporation Parathyroid hormone polypeptide conjugates and methods of their use
WO2026067798A1 (zh) * 2024-09-30 2026-04-02 长春金赛药业有限责任公司 Pth复合物及其应用

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JP2007505840A (ja) * 2003-09-19 2007-03-15 ノボ　ノルディスク　アクティーゼルスカブ 新規ｇｌｐ−１誘導体
JP2007528836A (ja) * 2003-03-19 2007-10-18 ザ ジェネラル ホスピタル コーポレーション α−ヘリックス安定化剤を用いる高次構造的に制約された副甲状腺ホルモン
WO2010053548A2 (en) * 2008-11-04 2010-05-14 Anchor Therapeutics, Inc. Pthr1 receptor compounds
US20120083448A1 (en) * 2009-03-27 2012-04-05 Van Andel Research Institute Parathyroid Hormone Peptides And Parathyroid Hormone-Related Protein Peptides And Methods Of Use
JP2013526864A (ja) * 2010-05-13 2013-06-27 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン類似体およびその使用
WO2017148883A1 (en) * 2016-03-01 2017-09-08 Ascendis Pharma Bone Diseases A/S Pth prodrugs
WO2017173372A1 (en) * 2016-04-01 2017-10-05 The General Hospital Corporation Parathyroid hormone receptor 1 antagonist and inverse agonist polypeptides and methods of their use

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US7150974B1 (en) 1991-04-05 2006-12-19 The General Hospital Corporation Parathyroid hormone receptor binding method
US7132260B2 (en) 1991-04-05 2006-11-07 The General Hospital Corporation DNA encoding parathyroid hormone receptor
US5261686A (en) 1992-04-06 1993-11-16 Buckler Clive E Semi-recumbent
AU3819497A (en) 1996-07-31 1998-02-20 General Hospital Corporation, The Novel parathyroid hormone-related peptide analogs
US6183974B1 (en) 1997-07-31 2001-02-06 The General Hospital Corporation Screening assays for G protein coupled receptor agonists and antagonists
WO2000023594A1 (en) 1998-10-22 2000-04-27 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
ATE384743T1 (de) 1998-11-25 2008-02-15 Gen Hospital Corp Aminoterminal modifizierte parathyroidhormon (pth) analoge
JP4486258B2 (ja) 1998-11-25 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション ヒト副甲状腺ホルモンの改変、調製および使用
WO2000032771A1 (en) 1998-11-30 2000-06-08 The General Hospital Corporation Pth1r and pth3r receptors, methods and uses thereof
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US11975050B2 (en) 2024-05-07
EP3765061A4 (en) 2022-01-26
WO2019178462A1 (en) 2019-09-19
EP3765061A1 (en) 2021-01-20
US20200405820A1 (en) 2020-12-31

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