JP2021516046A - 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用 - Google Patents

新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用 Download PDF

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JP2021516046A
JP2021516046A JP2020545160A JP2020545160A JP2021516046A JP 2021516046 A JP2021516046 A JP 2021516046A JP 2020545160 A JP2020545160 A JP 2020545160A JP 2020545160 A JP2020545160 A JP 2020545160A JP 2021516046 A JP2021516046 A JP 2021516046A
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capsid
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aav
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JP2021516046A5 (https=
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ウイルソン，ジェームス・エム
テペ，エイプリル
ターナー，ケビン
シムス，ジョシュア・ジョイナー
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ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア
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Priority to JP2024005924A priority patent/JP2024041967A/ja
Priority to JP2025188265A priority patent/JP2026027394A/ja
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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JP2020545160A 2018-02-27 2019-02-27 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用 Pending JP2021516046A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2023131761A JP2023159235A (ja) 2018-02-27 2023-08-14 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用
JP2024005924A JP2024041967A (ja) 2018-02-27 2024-01-18 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用
JP2025188265A JP2026027394A (ja) 2018-02-27 2025-11-07 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862635964P 2018-02-27 2018-02-27
US62/635,964 2018-02-27
US201862677471P 2018-05-29 2018-05-29
US201862667585P 2018-05-29 2018-05-29
US62/667,585 2018-05-29
US62/677,471 2018-05-29
US201862703670P 2018-07-26 2018-07-26
US62/703,670 2018-07-26
US201862722382P 2018-08-24 2018-08-24
US62/722,382 2018-08-24
PCT/US2019/019804 WO2019168961A1 (en) 2018-02-27 2019-02-27 Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor

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JP2023131761A Division JP2023159235A (ja) 2018-02-27 2023-08-14 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用
JP2024005924A Division JP2024041967A (ja) 2018-02-27 2024-01-18 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用

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JP2021516046A true JP2021516046A (ja) 2021-07-01
JP2021516046A5 JP2021516046A5 (https=) 2022-02-18

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JP2020545160A Pending JP2021516046A (ja) 2018-02-27 2019-02-27 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用
JP2023131761A Pending JP2023159235A (ja) 2018-02-27 2023-08-14 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用
JP2024005924A Pending JP2024041967A (ja) 2018-02-27 2024-01-18 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用
JP2025188265A Pending JP2026027394A (ja) 2018-02-27 2025-11-07 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用

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JP2023131761A Pending JP2023159235A (ja) 2018-02-27 2023-08-14 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用
JP2024005924A Pending JP2024041967A (ja) 2018-02-27 2024-01-18 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用
JP2025188265A Pending JP2026027394A (ja) 2018-02-27 2025-11-07 新規アデノ随伴ウイルス（ａａｖ）ベクター、低減されたカプシド脱アミド化を有するａａｖベクター、およびその使用

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US (1) US20200407750A1 (https=)
EP (1) EP3758724A4 (https=)
JP (4) JP2021516046A (https=)
KR (1) KR20210010434A (https=)
CN (2) CN119842635A (https=)
AU (1) AU2019227726B2 (https=)
BR (1) BR112020017348A2 (https=)
CA (1) CA3091806A1 (https=)
CL (2) CL2020002200A1 (https=)
IL (1) IL276859B2 (https=)
MX (1) MX2020008933A (https=)
SG (1) SG11202008182TA (https=)
WO (1) WO2019168961A1 (https=)

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EP4048681A4 (en) * 2019-10-21 2024-03-20 The Trustees of The University of Pennsylvania AAV3B VARIANTS WITH IMPROVED PRODUCTION YIELD AND LIVER TROPISM
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AU2019227726A1 (en) 2020-09-10
EP3758724A4 (en) 2022-07-06
JP2026027394A (ja) 2026-02-18
MX2020008933A (es) 2021-01-15
CN112352050A (zh) 2021-02-09
CA3091806A1 (en) 2019-09-06
SG11202008182TA (en) 2020-09-29
CL2020002200A1 (es) 2021-01-29
EP3758724A1 (en) 2021-01-06
KR20210010434A (ko) 2021-01-27
IL276859B1 (en) 2025-08-01
CN119842635A (zh) 2025-04-18
IL276859A (en) 2020-10-29
CL2022003757A1 (es) 2023-05-19
AU2019227726B2 (en) 2025-09-04
WO2019168961A1 (en) 2019-09-06
JP2024041967A (ja) 2024-03-27
US20200407750A1 (en) 2020-12-31
IL276859B2 (en) 2025-12-01
JP2023159235A (ja) 2023-10-31
BR112020017348A2 (pt) 2020-12-29

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