JP2021514955A5 - - Google Patents
Info
- Publication number
- JP2021514955A5 JP2021514955A5 JP2020544425A JP2020544425A JP2021514955A5 JP 2021514955 A5 JP2021514955 A5 JP 2021514955A5 JP 2020544425 A JP2020544425 A JP 2020544425A JP 2020544425 A JP2020544425 A JP 2020544425A JP 2021514955 A5 JP2021514955 A5 JP 2021514955A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- nr1c
- nr1r2
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862634632P | 2018-02-23 | 2018-02-23 | |
| US62/634,632 | 2018-02-23 | ||
| PCT/US2019/019162 WO2019165216A1 (en) | 2018-02-23 | 2019-02-22 | Small molecules that block proteasome-associated ubiquitin receptor rpn13 function and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021514955A JP2021514955A (ja) | 2021-06-17 |
| JP2021514955A5 true JP2021514955A5 (enExample) | 2023-08-21 |
| JP7389749B2 JP7389749B2 (ja) | 2023-11-30 |
Family
ID=65724533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020544425A Active JP7389749B2 (ja) | 2018-02-23 | 2019-02-22 | プロテアソーム関連ユビキチン受容体ｒｐｎ１３機能を阻止する低分子およびその使用法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11702402B2 (enExample) |
| EP (1) | EP3755377A1 (enExample) |
| JP (1) | JP7389749B2 (enExample) |
| AU (1) | AU2019224089B2 (enExample) |
| CA (1) | CA3090414A1 (enExample) |
| WO (1) | WO2019165216A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3103185A1 (en) | 2018-06-13 | 2019-12-19 | Amphista Therapeutics Ltd | Bifunctional molecules for targeting rpn11 |
| AU2021264869B2 (en) * | 2020-04-29 | 2025-09-11 | Onegene Biotechnology Inc. | Novel protein conjugate, and use thereof for preventing or treating nonalcoholic steatohepatitis, obesity and diabetes |
| EP4323340A2 (en) | 2021-04-13 | 2024-02-21 | President and Fellows of Harvard College | E3 ligase binders and uses thereof |
| CN115260212B (zh) * | 2022-08-01 | 2023-05-23 | 桂林医学院 | 3,5-双(亚苄基)-4-哌啶酮衍生物及其制备方法和应用 |
| US20250137057A1 (en) * | 2023-10-26 | 2025-05-01 | The Chinese University Of Hong Kong | Adrm1/rpn13 spliced variant in the prognosis and treatment of hepatocellular carcinoma |
| WO2025207482A1 (en) * | 2024-03-25 | 2025-10-02 | Augusta University Research Institute, Inc. | Diarylpiperidone hybrid conjugates and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2994135B1 (en) * | 2013-05-08 | 2021-10-06 | The Johns Hopkins University | Novel bis-benzylidine piperidinone proteasome inhibitor with anticancer activity |
| EP4649963A3 (en) * | 2014-04-14 | 2026-05-13 | Arvinas Operations, Inc. | Imide-based modulators of proteolysis and associated methods of use |
-
2019
- 2019-02-22 US US16/969,458 patent/US11702402B2/en active Active
- 2019-02-22 CA CA3090414A patent/CA3090414A1/en active Pending
- 2019-02-22 WO PCT/US2019/019162 patent/WO2019165216A1/en not_active Ceased
- 2019-02-22 EP EP19710214.8A patent/EP3755377A1/en active Pending
- 2019-02-22 JP JP2020544425A patent/JP7389749B2/ja active Active
- 2019-02-22 AU AU2019224089A patent/AU2019224089B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021514958A5 (enExample) | ||
| JP2022533398A5 (enExample) | ||
| RU2497807C2 (ru) | Карбазольные соединения и терапевтические применения соединений | |
| JP2009536620A5 (enExample) | ||
| RU2339637C1 (ru) | Блокаторы гистаминного рецептора для фармацевтических композиций, обладающих противоаллергическим и аутоиммунным действием | |
| JP2018507238A5 (enExample) | ||
| RU2495044C2 (ru) | Ингибиторы активности протеинтирозинкиназы | |
| FI3848027T3 (fi) | Oktahydrofuusioituja atsadekaliiniglukokortikoidireseptorin modulaattoreita | |
| JP2016518437A5 (enExample) | ||
| RU2495873C2 (ru) | Новое урациловое соединение или его соль, обладающие ингибирующей активностью относительно дезоксиуридинтрифосфатазы человека | |
| JP2015531773A5 (enExample) | ||
| JP2015534574A5 (enExample) | ||
| RU2017120274A (ru) | Гетероарильные соединения в качестве ингибиторов irak и их применения | |
| JP2011046700A5 (enExample) | ||
| CY1108792T1 (el) | Παραγωγα διοξανιου-2-αλκυλκαρβαμικου, η παρασκευη τους και η εφαρμογη τους στην θεραπευτικη αγωγη | |
| RU2015123499A (ru) | Соединения замещенной триазолбороновой кислоты | |
| RU2015118145A (ru) | Замещенные бензольные соединения | |
| CA2608099A1 (en) | Dipyridyl-dihydropyrazolones and their use | |
| RU2012123154A (ru) | Способы лечения синдрома фибромиалгии | |
| JP2012511588A5 (enExample) | ||
| RU2019142472A (ru) | Глюкуронидные пролекарства ингибиторов янус-киназы | |
| JP2023520330A5 (enExample) | ||
| JP2018502141A5 (enExample) | ||
| JP2017502092A5 (enExample) | ||
| JP2018522861A5 (enExample) |