JP2021514349A - 光散乱減少物質を含む肌の光学特性改善用の組成物 - Google Patents
光散乱減少物質を含む肌の光学特性改善用の組成物 Download PDFInfo
- Publication number
- JP2021514349A JP2021514349A JP2020542991A JP2020542991A JP2021514349A JP 2021514349 A JP2021514349 A JP 2021514349A JP 2020542991 A JP2020542991 A JP 2020542991A JP 2020542991 A JP2020542991 A JP 2020542991A JP 2021514349 A JP2021514349 A JP 2021514349A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- composition
- improving
- light scattering
- optical properties
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000149 argon plasma sintering Methods 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 230000003287 optical effect Effects 0.000 title claims abstract description 33
- 239000003638 chemical reducing agent Substances 0.000 title claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000002537 cosmetic Substances 0.000 claims abstract description 21
- 239000000126 substance Substances 0.000 claims abstract description 21
- 230000000694 effects Effects 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 17
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 17
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 17
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 17
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 17
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 17
- 239000000600 sorbitol Substances 0.000 claims description 17
- 235000010356 sorbitol Nutrition 0.000 claims description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 239000006210 lotion Substances 0.000 claims description 15
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 12
- 230000001603 reducing effect Effects 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 10
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 claims description 10
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 9
- 230000006872 improvement Effects 0.000 claims description 9
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 8
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 8
- 239000002552 dosage form Substances 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 8
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims description 7
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 7
- 229960004203 carnitine Drugs 0.000 claims description 7
- 239000000499 gel Substances 0.000 claims description 6
- 239000001103 potassium chloride Substances 0.000 claims description 6
- 235000011164 potassium chloride Nutrition 0.000 claims description 6
- 210000002966 serum Anatomy 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 5
- 239000004386 Erythritol Substances 0.000 claims description 5
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 5
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 5
- 229960003237 betaine Drugs 0.000 claims description 5
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 5
- 235000019414 erythritol Nutrition 0.000 claims description 5
- 229940009714 erythritol Drugs 0.000 claims description 5
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
- 229960002920 sorbitol Drugs 0.000 claims description 5
- 229940074410 trehalose Drugs 0.000 claims description 5
- 239000000811 xylitol Substances 0.000 claims description 5
- 235000010447 xylitol Nutrition 0.000 claims description 5
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 5
- 229960002675 xylitol Drugs 0.000 claims description 5
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 claims description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 235000019270 ammonium chloride Nutrition 0.000 claims description 4
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 4
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 4
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 4
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 4
- -1 pack Substances 0.000 claims description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 4
- 239000004323 potassium nitrate Substances 0.000 claims description 4
- 235000010333 potassium nitrate Nutrition 0.000 claims description 4
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 4
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 4
- 235000011151 potassium sulphates Nutrition 0.000 claims description 4
- 239000000344 soap Substances 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 239000004317 sodium nitrate Substances 0.000 claims description 4
- 235000010344 sodium nitrate Nutrition 0.000 claims description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 4
- 235000011152 sodium sulphate Nutrition 0.000 claims description 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 3
- 210000003298 dental enamel Anatomy 0.000 claims description 3
- 210000004709 eyebrow Anatomy 0.000 claims description 3
- 239000006260 foam Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 235000016709 nutrition Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000000686 essence Substances 0.000 claims description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 2
- 235000011181 potassium carbonates Nutrition 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 235000002639 sodium chloride Nutrition 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 abstract description 78
- 239000000470 constituent Substances 0.000 abstract description 8
- 210000002510 keratinocyte Anatomy 0.000 abstract description 8
- 239000012466 permeate Substances 0.000 abstract description 6
- 230000036548 skin texture Effects 0.000 abstract description 6
- 238000002425 crystallisation Methods 0.000 abstract description 5
- 230000008025 crystallization Effects 0.000 abstract description 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 36
- 230000009467 reduction Effects 0.000 description 21
- 239000004202 carbamide Substances 0.000 description 18
- 102000011782 Keratins Human genes 0.000 description 17
- 108010076876 Keratins Proteins 0.000 description 17
- 238000000034 method Methods 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
- 210000000736 corneocyte Anatomy 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 8
- 210000000434 stratum corneum Anatomy 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 6
- 229920002674 hyaluronan Polymers 0.000 description 6
- 229960003160 hyaluronic acid Drugs 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 5
- 108010087806 Carnosine Proteins 0.000 description 5
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 5
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 5
- 229940044199 carnosine Drugs 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 239000012752 auxiliary agent Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 239000001099 ammonium carbonate Substances 0.000 description 3
- 235000012501 ammonium carbonate Nutrition 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000012459 cleaning agent Substances 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000003746 surface roughness Effects 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000004902 Softening Agent Substances 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000004299 exfoliation Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 229960005150 glycerol Drugs 0.000 description 2
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 238000001000 micrograph Methods 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- 230000021148 sequestering of metal ion Effects 0.000 description 2
- 239000001540 sodium lactate Substances 0.000 description 2
- 235000011088 sodium lactate Nutrition 0.000 description 2
- 229940005581 sodium lactate Drugs 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940113120 dipropylene glycol Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000003701 histiocyte Anatomy 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
被験者の角質を角質テープ(D−Squame sampling disk,22mm diameter,CuDermTM)を用いて採取した後、100μLの水(対照群)とウレアを各々塗布してから3〜4時間後、水洗して乾燥して光散乱効果を確認した。
本発明の光散乱減少物質、プロパンジオール、エリスリトール、キシリトール、ソルビトール、トレハロース、ジプロピレングリコール、ベタイン、カルニチン、カルノシン及びセリンを10重量%含む組成物に対して、上述の実施例1と同様の方法で光散乱減少効果を確認した。
本発明の光散乱物質であるオリゴヒアルロン酸の光散乱減少効果を確認するために、相異なる分子量を有するヒアルロン酸と比較実験した。
本発明の光散乱物質であるトレハロースと、プロパンジオールと、ソルビトールとの混合割合による光散乱減少効果を実験した。
本発明の肌キメの改善を確認するために角質テープを用いて被験者の角質を採取した後、200μLの水(対照群1)及び実験群11(下記の表を参照)を塗布してから4時間後、水洗して乾燥した。肌キメの改善は、3次元レーザー顕微鏡(Keyence VK−X200)を用いて表面厚さ(surface thickness)及び表面粗さ(surface roughness)を測定した。実験結果を下記の表3及び図6に示した。
本発明の肌の透明度改善を確認するために、被験者10人を対象にして対照群2及び実験群12、13(下記の表を参照)を塗布してから3時間後、ボディソープで洗浄した後、塗布前とは変わった肌の透明度を、皮膚透明度測定器(Translucency Meter,TLS850)を用いて評価した。
Claims (9)
- キシリトール、エリスリトール、ソルビトール、トレハロース、プロパンジオール、ジプロピレングリコール、ベタイン、オリゴヒアルロン酸、硝酸ナトリウム、塩化ナトリウム、硫酸ナトリウム、炭酸ナトリウム、硝酸カリウム、塩化カリウム、硫酸カリウム、炭酸カリウム、硝酸アンモニウム、塩化アンモニウム、硫酸アンモニウム、炭酸アンモニウム、硝酸マグネシウム、塩化マグネシウム、硫酸マグネシウム、セリン、カルニチン及びカルノシンからなる群より選択されたいずれか一つ以上の光散乱減少物質を有効成分として含む、肌の光学特性改善用の組成物。
- 前記光散乱減少物質が、組成物総重量に対して0.01〜40重量%で含まれることを特徴とする、請求項1に記載の肌の光学特性改善用の組成物。
- 前記オリゴヒアルロン酸は、分子量が300〜100,000Daであることを特徴とする、請求項1に記載の肌の光学特性改善用の組成物。
- 前記光散乱減少物質は、ソルビトールと、トレハロースと、プロパンジオールとの混合物を含むことを特徴とする、請求項1に記載の肌の光学特性改善用の組成物。
- 前記ソルビトールと、トレハロースと、プロパンジオールとの混合物は、ソルビトールと、トレハロースと、プロパンジオールとが、1:0.01〜20:0.01〜20の重量比で含まれることを特徴とする、請求項4に記載の肌の光学特性改善用の組成物。
- 前記光散乱減少物質は、肌の透明度、肌トーンまたは肌のキメの改善効果を奏することを特徴とする、請求項1に記載の肌の光学特性改善用の組成物。
- 前記肌の光学特性改善用の組成物は、化粧料組成物または皮膚外用剤であることを特徴とする、請求項1に記載の肌の光学特性改善用の組成物。
- 前記化粧料組成物は、柔軟化粧水、収れん化粧水、栄養化粧水、ローション、エッセンス、アイクリーム、アイエッセンス、オイルセラム、セラム、クレンジングクリーム、クレンジングフォーム、クレンジングウォーター、パック、ゲル、ボディソープ、ボディローション、ボディオイル、ボディエッセンス、メイクアッププライマー、ファンデーション、メイクアップベース、パウダーファンデーション、パクト、パウダー、リップスティック、リップグロス、リップライナー、マスカラ、アイブロウ、アイシャドウ及びネイルエナメルからなる群より選択された剤形に剤形化したことを特徴とする、請求項7に記載の肌の光学特性改善用の組成物。
- 前記皮膚外用剤は、クリーム、ゲル、軟膏、液体、パウダー、噴霧剤及びパッチからなる群より選択された剤形に剤形化したことを特徴とする、請求項7に記載の肌の光学特性改善用の組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022136806A JP2022173215A (ja) | 2018-02-08 | 2022-08-30 | 光散乱減少物質を含む肌の光学特性改善用の組成物 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2018-0015933 | 2018-02-08 | ||
KR20180015933 | 2018-02-08 | ||
KR1020180067069A KR102015903B1 (ko) | 2018-02-08 | 2018-06-11 | 광산란 감소 물질을 포함하는 피부 광산란 감소용 조성물 |
KR10-2018-0067069 | 2018-06-11 | ||
PCT/KR2018/012667 WO2019156311A1 (ko) | 2018-02-08 | 2018-10-24 | 광산란 감소 물질을 포함하는 피부 광특성 개선용 조성물 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022136806A Division JP2022173215A (ja) | 2018-02-08 | 2022-08-30 | 光散乱減少物質を含む肌の光学特性改善用の組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2021514349A true JP2021514349A (ja) | 2021-06-10 |
Family
ID=67774865
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020542991A Pending JP2021514349A (ja) | 2018-02-08 | 2018-10-24 | 光散乱減少物質を含む肌の光学特性改善用の組成物 |
JP2022136806A Pending JP2022173215A (ja) | 2018-02-08 | 2022-08-30 | 光散乱減少物質を含む肌の光学特性改善用の組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022136806A Pending JP2022173215A (ja) | 2018-02-08 | 2022-08-30 | 光散乱減少物質を含む肌の光学特性改善用の組成物 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20210000730A1 (ja) |
JP (2) | JP2021514349A (ja) |
KR (3) | KR102015903B1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116669694A (zh) * | 2021-02-02 | 2023-08-29 | 株式会社Lg生活健康 | 化妆料组合物 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10279466A (ja) * | 1997-04-07 | 1998-10-20 | Kose Corp | 外用剤 |
JP2000327553A (ja) * | 1999-05-19 | 2000-11-28 | Kose Corp | 皮膚外用剤 |
KR20060067296A (ko) * | 2004-12-14 | 2006-06-20 | 주식회사 태평양 | 자일리톨 및 베타-1,3-글루칸을 함유한 피부보습용 화장료조성물 |
JP2016141663A (ja) * | 2015-02-04 | 2016-08-08 | 株式会社サンシャインコーポレーション | 美容パック材 |
JP2017511346A (ja) * | 2014-04-23 | 2017-04-20 | ザ プロクター アンド ギャンブル カンパニー | 皮膚を水和させるための美容組成物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4854194B2 (ja) * | 2004-07-05 | 2012-01-18 | 株式会社ファンケル | ラメラ構造再生剤及び皮膚外用剤 |
KR20110060800A (ko) * | 2009-11-30 | 2011-06-08 | (주)아모레퍼시픽 | 세포 외 기질을 모사한 피부 세포 재생용 화장료 조성물 |
KR101181266B1 (ko) | 2010-04-06 | 2012-09-10 | 덕산하이메탈(주) | 카바졸유도체를 포함하는 비스다이아릴아민화합물 및 이를 이용한 유기전기소자, 그 단말 |
-
2018
- 2018-06-11 KR KR1020180067069A patent/KR102015903B1/ko active Application Filing
- 2018-10-24 JP JP2020542991A patent/JP2021514349A/ja active Pending
- 2018-10-24 US US16/968,826 patent/US20210000730A1/en not_active Abandoned
-
2019
- 2019-08-20 KR KR1020190101994A patent/KR102353161B1/ko active IP Right Grant
-
2022
- 2022-01-13 KR KR1020220005549A patent/KR102509436B1/ko active IP Right Grant
- 2022-08-30 JP JP2022136806A patent/JP2022173215A/ja active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10279466A (ja) * | 1997-04-07 | 1998-10-20 | Kose Corp | 外用剤 |
JP2000327553A (ja) * | 1999-05-19 | 2000-11-28 | Kose Corp | 皮膚外用剤 |
KR20060067296A (ko) * | 2004-12-14 | 2006-06-20 | 주식회사 태평양 | 자일리톨 및 베타-1,3-글루칸을 함유한 피부보습용 화장료조성물 |
JP2017511346A (ja) * | 2014-04-23 | 2017-04-20 | ザ プロクター アンド ギャンブル カンパニー | 皮膚を水和させるための美容組成物 |
JP2016141663A (ja) * | 2015-02-04 | 2016-08-08 | 株式会社サンシャインコーポレーション | 美容パック材 |
Non-Patent Citations (5)
Title |
---|
"Clarins, Brightening Aqua Treatment Lotion", MINTEL GNPD [ONLINE], JPN6021047844, May 2017 (2017-05-01), ISSN: 0004831117 * |
"Shiseido, Hydro-Clarifying Lotion", MINTEL GNPD [ONLINE], JPN6021047842, July 2017 (2017-07-01), ISSN: 0004831116 * |
"新製品ニュース、資生堂 ザ・スキンケア エッセンシャルティンティッドモイスチャーライザー", FRAGRANCE JOURNAL, JPN6021047841, April 2002 (2002-04-01), pages 102, ISSN: 0004831115 * |
LIOPO ANTON, ET AL.: "Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imagin", JOURNAL OF BIOMEDICAL OPTICS, vol. 21, no. 8, JPN6022030843, August 2016 (2016-08-01), pages 081208 - 1, ISSN: 0004831118 * |
ZHU DAN, ET AL.: "Recent progress in tissue optical clearing", LASER PHOTONICS REV., vol. 7, no. 5, JPN6022030845, 2013, pages 732 - 757, XP055217356, ISSN: 0004831119, DOI: 10.1002/lpor.201200056 * |
Also Published As
Publication number | Publication date |
---|---|
KR20220011773A (ko) | 2022-01-28 |
JP2022173215A (ja) | 2022-11-18 |
KR102353161B1 (ko) | 2022-01-19 |
KR20190096262A (ko) | 2019-08-19 |
KR102015903B1 (ko) | 2019-08-28 |
KR102509436B1 (ko) | 2023-03-14 |
US20210000730A1 (en) | 2021-01-07 |
KR20190100141A (ko) | 2019-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4767914B2 (ja) | 皮膚をひきしめる効果のある化粧組成物 | |
JP5691053B2 (ja) | 化粧用組成物における新規な天然物質の使用 | |
EP1759688A1 (fr) | Procédé cosmétique de soin des peaux grasses et kit associé | |
WO2014058066A1 (ja) | 美容方法 | |
JP2011509256A (ja) | 色を向上させるナノ粒子含有化粧品組成物 | |
KR102509436B1 (ko) | 광산란 감소 물질을 포함하는 피부 광특성 개선용 조성물 | |
TWI229605B (en) | Cosmetic method | |
JP2009234945A (ja) | h−EGF含有スフィンゴミエリンリポソームおよびこれを配合した化粧料及び医薬品 | |
ITRM20100540A1 (it) | "uso di un preparato basato su micro-patch di caffeina e polisaccaridi di betaglucano in trattamenti antirughe" | |
CN109562051A (zh) | 护肤品及其用途 | |
WO2020183108A1 (fr) | Nouvelle utilisation cosmetique de spheres poreuses d'oxyde metallique | |
KR102203167B1 (ko) | 라멜라 액정상에 봉입된 하이드롤라이즈드 해면파우더 또는 해면파우더를 함유하여 빠른 피부 재생능과 피부 및 두피 개선능이 있는 화장료 조성물 | |
FR3062302A1 (fr) | Nouvelle composition cosmetique comprenant de la nacre ou un extrait de nacre | |
FR3125967A1 (fr) | Utilisations cosmétiques contre la lumière bleue de microsphères poreuses d’oxyde métallique | |
WO2019156311A1 (ko) | 광산란 감소 물질을 포함하는 피부 광특성 개선용 조성물 | |
KR20200135807A (ko) | 미용적 국소 적용을 위한 건조 필름의 용도 | |
FR2895253A1 (fr) | Utilisation d'un agoniste du neuropeptide y pour repulper et/ou colorer naturellement les levres | |
WO2024034159A1 (ja) | 化粧料及び美容方法 | |
KR102204345B1 (ko) | 광산란 감소 물질을 포함하는 광특성 개선용 조성물 | |
JP2553474B2 (ja) | 皮膚化粧料 | |
JP2002291722A (ja) | 口唇の老化度の判定方法および口唇用組成物 | |
WO2021163915A1 (zh) | 含接近饱和、饱和、或超饱和活性成分的温和洁净组合物及其制备方法 | |
RU2304961C2 (ru) | Способ подготовки кожи перед нанесением декоративной косметики на время длительного сна | |
CN113499277A (zh) | 一种抗衰组合物及其制备方法与应用 | |
Mavon | The wetting properties of human skin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20201009 |
|
A80 | Written request to apply exceptions to lack of novelty of invention |
Free format text: JAPANESE INTERMEDIATE CODE: A80 Effective date: 20201028 Free format text: JAPANESE INTERMEDIATE CODE: A801 Effective date: 20201026 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20211008 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20211206 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220307 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20220725 |