|
US2512572A
(en)
|
|
1950-06-20 |
|
Substituted pteridines and method |
|
US3989703A
(en)
|
1974-03-22 |
1976-11-02 |
Institutul Oncologic |
Process of preparing N[p-{[(2,4-diamino-6-pteridyl)-methyl]N10 -methylamino}-benzoyl]-glutamic acid
|
|
US4106488A
(en)
|
1974-08-20 |
1978-08-15 |
Robert Thomas Gordon |
Cancer treatment method
|
|
US3892801A
(en)
|
1974-09-11 |
1975-07-01 |
American Cyanamid Co |
Method for preparing alkali salts of p-methylaminobenzoylglutamic acid
|
|
US4079056A
(en)
|
1975-03-31 |
1978-03-14 |
The United States Of America As Represented By The Department Of Health, Education And Welfare |
Method of making pteridine compounds
|
|
US4057548A
(en)
|
1975-11-11 |
1977-11-08 |
Jacek Wiecko |
Process for preparing methotrexate or an N-substituted derivative thereof and/or a di (lower) alkyl ester thereof and precursor therefor
|
|
US4067867A
(en)
|
1976-03-30 |
1978-01-10 |
Jacek Wiecko |
Process for preparing pyrazine precursor of methotrexate or an N-substituted derivative thereof and/or a di(lower)alkyl ester thereof
|
|
US4080325A
(en)
|
1976-11-17 |
1978-03-21 |
The United States Of America As Represented By The Department Of Health, Education And Welfare |
Synthesis of methotrexate
|
|
CH630380A5
(de)
|
1977-08-12 |
1982-06-15 |
Lonza Ag |
Verfahren zur herstellung von l-methotrexat.
|
|
US4136101A
(en)
|
1978-02-03 |
1979-01-23 |
American Cyanamid Company |
Process for preparing dialkyl (p-aminobenzoyl) glutamates
|
|
US4306064A
(en)
|
1980-03-25 |
1981-12-15 |
Ellard James A |
Synthesis of 2,4-diamino-6-hydroxymethylpteridine
|
|
US4421913A
(en)
|
1980-04-23 |
1983-12-20 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Separation of triphenylphosphine oxide from methotrexate ester and purification of said ester
|
|
US4374987A
(en)
|
1980-08-14 |
1983-02-22 |
American Cyanamid Company |
Process for the preparation of high purity methotrexate and derivatives thereof
|
|
US4558690A
(en)
|
1982-01-26 |
1985-12-17 |
University Of Scranton |
Method of administration of chemotherapy to tumors
|
|
US4662359A
(en)
|
1983-08-12 |
1987-05-05 |
Robert T. Gordon |
Use of magnetic susceptibility probes in the treatment of cancer
|
|
FR2564319A1
(fr)
|
1984-05-21 |
1985-11-22 |
Inst Nat Sante Rech Med |
Nouvelles compositions de liposomes dotees d'une action specifique vis-a-vis de la proliferation de cellules donnees
|
|
US4584375A
(en)
|
1984-08-21 |
1986-04-22 |
Rensselaer Polytechnic Institute |
Fluorine-containing antifolates incapable of polyglutamate formation
|
|
FR2590255B1
(fr)
|
1985-11-19 |
1987-12-24 |
Rhone Poulenc Sante |
Procede de preparation de derives de la pteridine
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
EP0492316A1
(en)
|
1990-12-14 |
1992-07-01 |
Takeda Chemical Industries, Ltd. |
Condensed heterocyclic oligoglutamate derivatives, their production and pharmaceutical compositions containing them
|
|
JP3202999B2
(ja)
|
1991-01-31 |
2001-08-27 |
協和醗酵工業株式会社 |
肝移行性リポソーム製剤
|
|
US5646253A
(en)
|
1994-03-08 |
1997-07-08 |
Memorial Sloan-Kettering Cancer Center |
Recombinant human anti-LK26 antibodies
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US6569432B1
(en)
|
1995-02-24 |
2003-05-27 |
Sloan-Kettering Institute For Cancer Research |
Prostate-specific membrane antigen and uses thereof
|
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
|
CN1122456C
(zh)
|
1996-01-31 |
2003-10-01 |
南亚拉巴马医学科学基金会 |
含有天然的还原叶酸盐异构体的食品和维生素制品
|
|
US20020168761A1
(en)
*
|
2000-01-24 |
2002-11-14 |
Gour Barbara J. |
Peptidomimetic modulators of cell adhesion
|
|
US20030073640A1
(en)
|
1997-07-23 |
2003-04-17 |
Ribozyme Pharmaceuticals, Inc. |
Novel compositions for the delivery of negatively charged molecules
|
|
US5912251A
(en)
|
1998-01-17 |
1999-06-15 |
Nair; Madhavan G. |
Metabolically inert anti-inflammatory and anti-tumor antifolates
|
|
US20050031679A1
(en)
|
1998-03-27 |
2005-02-10 |
Clemens Unger |
Method for producing liposomal formulations of active ingredients
|
|
AU5283099A
(en)
|
1998-07-09 |
2000-02-01 |
Rhodia Chimie |
Water-soluble or water-dispersible grafted copolymers
|
|
WO2001005405A1
(en)
|
1999-07-16 |
2001-01-25 |
The General Hospital Corporation |
Folylpolyglutamyl synthetase gene transfer to enhance antifolate drug sensitivity
|
|
CN1095472C
(zh)
|
2000-04-17 |
2002-12-04 |
上海复康医药科技发展有限公司 |
叶酸－多聚糖复合物，其制备方法和以该复合物为活性成分的药物组合物
|
|
AU7526901A
(en)
|
2000-06-09 |
2001-12-24 |
Gilead Sciences Inc |
Liposomal benzoquinazoline thymidylate synthase inhibitor formulations
|
|
EP1313508B1
(en)
|
2000-06-30 |
2007-04-18 |
Eli Lilly And Company |
Combination containing an antifolate and methylmalonic acid lowering agent
|
|
US20040175756A1
(en)
|
2001-04-26 |
2004-09-09 |
Avidia Research Institute |
Methods for using combinatorial libraries of monomer domains
|
|
US20050053973A1
(en)
|
2001-04-26 |
2005-03-10 |
Avidia Research Institute |
Novel proteins with targeted binding
|
|
US20050048512A1
(en)
|
2001-04-26 |
2005-03-03 |
Avidia Research Institute |
Combinatorial libraries of monomer domains
|
|
US20050163832A1
(en)
*
|
2002-02-13 |
2005-07-28 |
Vladimir Torchilin |
Intracellular delivery of therapeutic agents
|
|
CH696628A5
(de)
|
2002-02-26 |
2007-08-31 |
Eprova Ag |
Verwendung von Folaten zur Herstellung einer Zubereitung geeignet zur Vorbeugung und Behandlung von Entzündungen und entzündungsassoziierter Krankheiten, im Speziellen zur Beeinflussung der
|
|
US7563590B2
(en)
|
2002-08-30 |
2009-07-21 |
Cypress Bioscience Inc. |
Methods of quantifying methotrexate metabolites
|
|
DK1587907T3
(da)
|
2003-01-07 |
2011-04-04 |
Dyax Corp |
Kunitz-domænebibliotek
|
|
US6921667B2
(en)
|
2003-03-07 |
2005-07-26 |
Prometheus Laboratories, Inc. |
Methods for direct detection of individual methotrexate metabolites
|
|
US20040265368A1
(en)
|
2003-04-02 |
2004-12-30 |
Lawrence Mayer |
Combination compositions of camptothecins and fluoropyrimidines
|
|
NZ548195A
(en)
|
2004-01-14 |
2011-01-28 |
Gilead Sciences Inc |
Lipid-based dispersions useful for drug delivery
|
|
CA2556027C
(en)
|
2004-02-12 |
2015-11-24 |
Morphotek, Inc. |
Monoclonal antibodies that specifically block biological activity of a tumor antigen
|
|
US7612071B2
(en)
|
2004-03-12 |
2009-11-03 |
Syntrix Biosystems, Inc. |
Compositions and methods employing aminopterin
|
|
WO2005103250A1
(ja)
|
2004-04-26 |
2005-11-03 |
Takami Matsuyama |
葉酸リセプターベータ（FR-β）に対する単クローン抗体を含有する治療薬
|
|
CA2928387A1
(en)
*
|
2004-05-03 |
2005-11-17 |
Merrimack Pharmaceuticals, Inc. |
Drug delivery liposomes containing anionic polyols or anionic sugars
|
|
US7695908B2
(en)
|
2004-06-15 |
2010-04-13 |
Prometheus Laboratories Inc. |
Methods for predicting methotrexate polyglutamate levels using pharmacogenetics
|
|
US20060008844A1
(en)
|
2004-06-17 |
2006-01-12 |
Avidia Research Institute |
c-Met kinase binding proteins
|
|
EP1791544A4
(en)
|
2004-09-08 |
2007-09-12 |
Chelsea Therapeutics Inc |
CHINAZOLINE DERIVATIVES AS METABOLIC INERT ANTIFOLATE
|
|
WO2006035876A1
(ja)
|
2004-09-29 |
2006-04-06 |
Kowa Co., Ltd. |
関節リウマチの予防及び／又は治療薬
|
|
US8126089B2
(en)
|
2004-09-30 |
2012-02-28 |
Alcatel Lucent |
Method and apparatus for providing frame synchronization in a digital communication system that supports multiple modulation formats
|
|
US20100266709A1
(en)
|
2004-12-16 |
2010-10-21 |
Hicks Terry Lee |
Compositions and Methods for Treating Burns
|
|
WO2006074416A1
(en)
|
2005-01-07 |
2006-07-13 |
Health Research Inc. |
5-amino-4-imidazolecarboxamide riboside and its nucleobase as potentiators of antifolate transport and metabolism
|
|
JP5042863B2
(ja)
|
2005-02-14 |
2012-10-03 |
サーナ・セラピューティクス・インコーポレイテッド |
生物学的に活性な分子をデリバリーするための脂質ナノ粒子系組成物および方法
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
JP2006248978A
(ja)
|
2005-03-10 |
2006-09-21 |
Mebiopharm Co Ltd |
新規なリポソーム製剤
|
|
CA2619992A1
(en)
|
2005-08-24 |
2007-03-01 |
Protherics Medicines Development Limited |
Cleavage of antifolate compounds
|
|
US20090155345A1
(en)
|
2005-12-08 |
2009-06-18 |
Ben Gurion University Of The Negev Research And Development Authority |
Methods for affecting liposome composition ultrasound irradiation
|
|
WO2007098089A2
(en)
|
2006-02-17 |
2007-08-30 |
Novacea, Inc. |
Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
|
|
US9265746B2
(en)
|
2006-05-31 |
2016-02-23 |
Merck & Cie |
Method for cell-specific targeting
|
|
WO2008030818A2
(en)
|
2006-09-05 |
2008-03-13 |
Mebiopharm Co., Ltd. |
Novel liposome compositions
|
|
EP1900752A1
(en)
|
2006-09-15 |
2008-03-19 |
DOMPE' pha.r.ma s.p.a. |
Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma
|
|
KR101195366B1
(ko)
|
2006-12-29 |
2012-11-21 |
트라콘 파마수티칼즈, 인코포레이티드 |
암치료에서의 항엽산제 조합물
|
|
RU2423114C2
(ru)
|
2006-12-29 |
2011-07-10 |
Тракон Фармасьютикалз, Инк. |
Комбинации антифолатного агента в лечении рака
|
|
BRPI0806632A2
(pt)
|
2007-01-19 |
2011-09-06 |
Chelsea Therapeutics Inc |
composto, composição farmacêutica, método para o tratamento de uma condição selecionada a partir do grupo constituìdo de proliferação celular anormal, inflamação, asma e artrite
|
|
US20100015218A1
(en)
|
2007-02-16 |
2010-01-21 |
Vasant Jadhav |
Compositions and methods for potentiated activity of biologically active molecules
|
|
CN101977620B
(zh)
|
2008-03-18 |
2014-05-07 |
英国技术集团国际有限公司 |
用于治疗类风湿性关节炎或急性骨髓性白血病的环戊二烯并[g]喹唑啉衍生物
|
|
GB0811360D0
(en)
|
2008-06-20 |
2008-07-30 |
Imp Innovations Ltd |
Methods
|
|
US20110224447A1
(en)
|
2008-08-18 |
2011-09-15 |
Bowman Keith A |
Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids
|
|
WO2010080724A1
(en)
|
2009-01-12 |
2010-07-15 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
|
WO2010141711A1
(en)
|
2009-06-03 |
2010-12-09 |
Ex-Tek, Llc |
Skin treatment compositions
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
ES2613498T3
(es)
|
2009-07-01 |
2017-05-24 |
Protiva Biotherapeutics Inc. |
Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos
|
|
TW201118098A
(en)
|
2009-08-13 |
2011-06-01 |
Reddy S Lab Liimited Dr |
Processes for preparing pemetrexed
|
|
EP2467357B1
(en)
|
2009-08-20 |
2016-03-30 |
Sirna Therapeutics, Inc. |
Novel cationic lipids with various head groups for oligonucleotide delivery
|
|
US20120253032A1
(en)
|
2009-10-08 |
2012-10-04 |
Merck Sharp & Dohme Corporation |
Novel cationic lipids with short lipid chains for oligonucleotide delivery
|
|
US20130116419A1
(en)
|
2010-01-22 |
2013-05-09 |
Daniel Zewge |
Post-synthetic chemical modification of rna at the 2'-position of the ribose ring via "click" chemistry
|
|
CN103037900B
(zh)
|
2010-02-24 |
2016-04-06 |
伊缪诺金公司 |
叶酸受体1抗体与免疫缀合物以及其用途
|
|
JP5686886B2
(ja)
|
2010-03-19 |
2015-03-18 |
マサチューセッツ インスチテュート オブ テクノロジーＭａｓｓａｃｈｕｓｅｔｔｓ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｔｅｃｈｎｏｌｏｇｙ |
脂質小胞組成物及び使用方法
|
|
US9770414B2
(en)
|
2010-05-13 |
2017-09-26 |
Pacira Pharmaceuticals, Inc. |
Sustained release formulation of methotrexate as a disease-modifying antirheumatic drug (DMARD) and an anti-cancer agent
|
|
EP2394640A1
(en)
|
2010-05-21 |
2011-12-14 |
MediGene AG |
Improved liposomal formulations of lipophilic compounds
|
|
US8802863B2
(en)
|
2010-05-24 |
2014-08-12 |
Sirna Therapeutics, Inc. |
Amino alcohol cationic lipids for oligonucleotide delivery
|
|
CA2800693A1
(en)
|
2010-05-28 |
2011-12-01 |
Purdue Research Foundation |
Delivery of therapeutic agents to inflamed tissues using folate-targeted agents
|
|
US8748667B2
(en)
|
2010-06-04 |
2014-06-10 |
Sirna Therapeutics, Inc. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
CA2801523C
(en)
|
2010-07-30 |
2021-08-03 |
Curevac Gmbh |
Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation
|
|
WO2012033987A2
(en)
|
2010-09-09 |
2012-03-15 |
Purdue Research Foundation |
Anti-human folate receptor beta antibodies and methods of use
|
|
WO2012037068A1
(en)
|
2010-09-13 |
2012-03-22 |
De Novo Diagnostics, Inc. |
Methods for monitoring methotrexate therapy
|
|
ES2888231T3
(es)
|
2010-09-20 |
2022-01-03 |
Sirna Therapeutics Inc |
Lípidos catiónicos de bajo peso molecular para el suministro de oligonucleótidos
|
|
EP2621480B1
(en)
|
2010-09-30 |
2018-08-15 |
Sirna Therapeutics, Inc. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
JP2013545727A
(ja)
|
2010-10-21 |
2013-12-26 |
メルク・シャープ・アンド・ドーム・コーポレーション |
オリゴヌクレオチド送達用の新規低分子量カチオン性脂質
|
|
EP2635265B1
(en)
|
2010-11-05 |
2018-04-04 |
Sirna Therapeutics, Inc. |
Novel low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery
|
|
AU2011323124C1
(en)
|
2010-11-05 |
2016-09-22 |
Eisai Inc. |
Folate receptor alpha as a diagnostic and prognostic marker for folate receptor alpha-expressing cancers
|
|
WO2012078708A1
(en)
|
2010-12-07 |
2012-06-14 |
Chelsea Therapeutics, Inc. |
Combination comprising methotrexate and an antifolate compound
|
|
US20140086939A1
(en)
|
2011-02-28 |
2014-03-27 |
Michael Karin |
Compositions and methods for detecting and treating cancer
|
|
PL226015B1
(pl)
|
2011-03-03 |
2017-06-30 |
Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną |
Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
|
|
WO2012121682A2
(en)
|
2011-03-10 |
2012-09-13 |
National Science And Technology Development Agency |
Anti-folate antimalarials with dual-binding modes and their preparation
|
|
US8673914B2
(en)
*
|
2011-03-28 |
2014-03-18 |
St. John's University |
Use of phosphodiesterase inhibitors for treating multidrug resistance
|
|
EP2508894A1
(en)
*
|
2011-04-05 |
2012-10-10 |
Receptomon LLC |
Method for monitoring gene expression of translation and Integral/Secretory protein synthesis by magnetic resonance spectroscopy (MRS)
|
|
EP3354644A1
(en)
|
2011-06-08 |
2018-08-01 |
Translate Bio, Inc. |
Cleavable lipids
|
|
US8183227B1
(en)
|
2011-07-07 |
2012-05-22 |
Chemo S. A. France |
Compositions, kits and methods for nutrition supplementation
|
|
PT2731591T
(pt)
|
2011-07-13 |
2020-09-18 |
Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd |
Lipossomas que coencapsulam um bisfosfonato e um agente anfipático
|
|
PL2731972T3
(pl)
|
2011-07-15 |
2018-06-29 |
Eisai R&D Management Co., Ltd. |
Przeciwciała skierowane przeciwko receptorowi folianowemu alfa i ich zastosowania
|
|
EP2591770B1
(en)
|
2011-11-14 |
2016-03-16 |
Silenseed Ltd |
Compositions for siRNA delivery and methods of manufacturing and using same
|
|
US20150239956A1
(en)
|
2012-06-27 |
2015-08-27 |
Asahi Kasei Medical Co., Ltd. |
High-affinity antibody and method for manufacturing the same
|
|
WO2014016740A2
(en)
|
2012-07-23 |
2014-01-30 |
Fresenius Kabi Oncology Ltd. |
Improved process for the preparation of pralatrexate
|
|
WO2014046630A1
(en)
|
2012-09-19 |
2014-03-27 |
Keskin, Dilek |
Tumor targeted liposomal drug delivery system
|
|
US20140120157A1
(en)
|
2012-09-19 |
2014-05-01 |
Georgetown University |
Targeted liposomes
|
|
JP6224619B2
(ja)
|
2012-12-07 |
2017-11-01 |
協和発酵キリン株式会社 |
抗ｆｏｌｒ１抗体
|
|
CN103040748B
(zh)
|
2012-12-18 |
2014-07-02 |
海南圣欣医药科技有限公司 |
一种培美曲塞二钠脂质体注射剂
|
|
CA2911499A1
(en)
|
2013-05-14 |
2014-11-20 |
Immunogen, Inc. |
Anti-folr1 immunoconjugate dosing regimens
|
|
MX386433B
(es)
*
|
2014-08-14 |
2025-03-18 |
L E A F Holdings Group Llc |
Fármaco de afinidad encapsulado en liposoma.
|
|
RS61907B1
(sr)
|
2015-04-06 |
2021-06-30 |
Subdomain Llc |
Polipeptidi koji sadrže de novo vezujući domen i njihova primena
|
|
JOP20170004B1
(ar)
|
2016-01-15 |
2022-09-15 |
Lilly Co Eli |
الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
|
|
CN109069666B
(zh)
|
2016-04-29 |
2023-04-04 |
纪念斯隆凯特琳癌症中心 |
使靶向颗粒穿透、分布和响应于恶性脑肿瘤中的组合物和方法
|
|
WO2018031968A1
(en)
|
2016-08-12 |
2018-02-15 |
L.E.A.F. Holdings Group Llc |
Alpha and gamma-d polyglutamated antifolates and uses thereof
|
|
WO2018031979A1
(en)
*
|
2016-08-12 |
2018-02-15 |
L.E.A.F. Holdings Group Llc |
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