JP2021513360A5 - - Google Patents
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- Publication number
- JP2021513360A5 JP2021513360A5 JP2020558681A JP2020558681A JP2021513360A5 JP 2021513360 A5 JP2021513360 A5 JP 2021513360A5 JP 2020558681 A JP2020558681 A JP 2020558681A JP 2020558681 A JP2020558681 A JP 2020558681A JP 2021513360 A5 JP2021513360 A5 JP 2021513360A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- amino acids
- region
- sequence identity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 24
- 150000001413 amino acids Chemical class 0.000 claims 24
- 239000003446 ligand Substances 0.000 claims 23
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims 4
- 208000002780 macular degeneration Diseases 0.000 claims 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 208000034038 Pathologic Neovascularization Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 230000003074 vasoproliferative effect Effects 0.000 claims 2
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000008069 Geographic Atrophy Diseases 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010038926 Retinopathy hypertensive Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 201000001948 hypertensive retinopathy Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 208000004644 retinal vein occlusion Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17199552 | 2017-11-01 | ||
| EP17199552.5 | 2017-11-01 | ||
| PCT/EP2018/079949 WO2019086580A1 (en) | 2017-11-01 | 2018-11-01 | Antibodies against mfap4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021513360A JP2021513360A (ja) | 2021-05-27 |
| JP2021513360A5 true JP2021513360A5 (enExample) | 2021-12-09 |
| JP7382343B2 JP7382343B2 (ja) | 2023-11-16 |
Family
ID=60201899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020558681A Active JP7382343B2 (ja) | 2017-11-01 | 2018-11-01 | Ｍｆａｐ４に対する抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11993649B2 (enExample) |
| EP (1) | EP3704147A1 (enExample) |
| JP (1) | JP7382343B2 (enExample) |
| CN (1) | CN111315771B (enExample) |
| AU (1) | AU2018359635B2 (enExample) |
| CA (1) | CA3118361A1 (enExample) |
| WO (1) | WO2019086580A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3213181A1 (en) | 2021-04-12 | 2022-10-20 | Grith Lykke Sorensen | Mfap4 and treatment of fibrosis |
| WO2025242098A1 (zh) * | 2024-05-21 | 2025-11-27 | 康诺亚生物医药科技（成都）有限公司 | 针对ceacam5的抗体偶联药物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110059097A1 (en) | 2008-02-22 | 2011-03-10 | University Health Network | MFAP4 as a Marker For Regulatory Cells and Anti-Cancer Cells |
| JP5872805B2 (ja) | 2011-07-07 | 2016-03-01 | 花王株式会社 | Ｍｆａｐ−４産生促進剤 |
| CA2898239A1 (en) * | 2013-01-23 | 2014-07-31 | Syddansk Universitet | Mfap4 binding antibodies blocking the interaction between mfap4 and integrin receptors |
| WO2016008498A1 (en) | 2014-07-17 | 2016-01-21 | Syddansk Universitet | Mfap4 binding antibody blocking the interaction between mfap4 and integrin receptors |
| CN106771201A (zh) * | 2016-12-05 | 2017-05-31 | 江西惠肽生物科技有限公司 | 用于肝纤维化诊断试剂盒及其检测方法 |
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2018
- 2018-11-01 AU AU2018359635A patent/AU2018359635B2/en active Active
- 2018-11-01 JP JP2020558681A patent/JP7382343B2/ja active Active
- 2018-11-01 WO PCT/EP2018/079949 patent/WO2019086580A1/en not_active Ceased
- 2018-11-01 EP EP18800872.6A patent/EP3704147A1/en active Pending
- 2018-11-01 US US16/760,490 patent/US11993649B2/en active Active
- 2018-11-01 CN CN201880070581.2A patent/CN111315771B/zh active Active
- 2018-11-01 CA CA3118361A patent/CA3118361A1/en active Pending