JP2021511359A5 - - Google Patents
Info
- Publication number
- JP2021511359A5 JP2021511359A5 JP2020540750A JP2020540750A JP2021511359A5 JP 2021511359 A5 JP2021511359 A5 JP 2021511359A5 JP 2020540750 A JP2020540750 A JP 2020540750A JP 2020540750 A JP2020540750 A JP 2020540750A JP 2021511359 A5 JP2021511359 A5 JP 2021511359A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- cycloalkyl
- heterocycloalkyl
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023045583A JP7596427B2 (ja) | 2018-01-26 | 2023-03-22 | キナーゼ依存的障害を処置するための化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862622629P | 2018-01-26 | 2018-01-26 | |
| US201862622626P | 2018-01-26 | 2018-01-26 | |
| US62/622,626 | 2018-01-26 | ||
| US62/622,629 | 2018-01-26 | ||
| PCT/US2019/015289 WO2019148036A1 (en) | 2018-01-26 | 2019-01-25 | Compounds for the treatment of kinase-dependent disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023045583A Division JP7596427B2 (ja) | 2018-01-26 | 2023-03-22 | キナーゼ依存的障害を処置するための化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021511359A JP2021511359A (ja) | 2021-05-06 |
| JP2021511359A5 true JP2021511359A5 (enExample) | 2022-02-24 |
| JP7307733B2 JP7307733B2 (ja) | 2023-07-12 |
Family
ID=65409542
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020540750A Active JP7307733B2 (ja) | 2018-01-26 | 2019-01-25 | キナーゼ依存的障害を処置するための化合物 |
| JP2023045583A Active JP7596427B2 (ja) | 2018-01-26 | 2023-03-22 | キナーゼ依存的障害を処置するための化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023045583A Active JP7596427B2 (ja) | 2018-01-26 | 2023-03-22 | キナーゼ依存的障害を処置するための化合物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11708367B2 (enExample) |
| EP (2) | EP3743068B1 (enExample) |
| JP (2) | JP7307733B2 (enExample) |
| KR (1) | KR102759973B1 (enExample) |
| CN (1) | CN112312909B (enExample) |
| AU (1) | AU2019212719B2 (enExample) |
| CA (1) | CA3088127A1 (enExample) |
| CL (1) | CL2020001930A1 (enExample) |
| CO (1) | CO2020010467A2 (enExample) |
| CR (2) | CR20250117A (enExample) |
| IL (2) | IL302626B2 (enExample) |
| MA (1) | MA51672A (enExample) |
| MX (2) | MX2020007759A (enExample) |
| PE (1) | PE20210044A1 (enExample) |
| PH (1) | PH12020551059A1 (enExample) |
| SA (1) | SA520412488B1 (enExample) |
| SG (1) | SG11202006945PA (enExample) |
| UA (1) | UA128348C2 (enExample) |
| WO (1) | WO2019148036A1 (enExample) |
| ZA (1) | ZA202004065B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202006945PA (en) * | 2018-01-26 | 2020-08-28 | Exelixis Inc | Compounds for the treatment of kinase-dependent disorders |
| AU2019212800B2 (en) | 2018-01-26 | 2024-05-23 | Exelixis, Inc. | Compounds for the treatment of kinase-dependent disorders |
| HRP20251184T1 (hr) * | 2018-01-26 | 2025-12-05 | Exelixis, Inc. | Spojevi za liječenje poremećaja ovisnih o kinazi |
| CN112457308B (zh) | 2019-09-09 | 2024-01-02 | 上海长森药业有限公司 | 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用 |
| CN115244041A (zh) * | 2020-03-10 | 2022-10-25 | 南京明德新药研发有限公司 | 乙烯基取代吡啶类化合物 |
| GB202004960D0 (en) * | 2020-04-03 | 2020-05-20 | Kinsenus Ltd | Inhibitor compounds |
| FI4143169T3 (fi) | 2020-04-30 | 2026-06-08 | Exelixis Inc | Kinaasi-inhibiittorin valmistusmenetelmät |
| TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
| CN117164527B (zh) * | 2022-05-25 | 2026-02-17 | 大连理工大学 | 一种钒催化杂环芳香腈水解制备杂环芳香酰胺的方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| ATE446955T1 (de) | 1995-03-30 | 2009-11-15 | Pfizer Prod Inc | Chinazolinone derivate |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| CN100503580C (zh) | 1996-04-12 | 2009-06-24 | 沃尼尔·朗伯公司 | 酪氨酸激酶的不可逆抑制剂 |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| WO2005009387A2 (en) | 2003-07-23 | 2005-02-03 | X-Ceptor Therapeutics Inc. | Azepine derivatives as pharmaceutical agents |
| EP2210607B1 (en) | 2003-09-26 | 2011-08-17 | Exelixis Inc. | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer |
| WO2006113546A2 (en) | 2005-04-15 | 2006-10-26 | Neogenix Oncology, Inc. | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers |
| EP3530736A3 (en) | 2005-05-09 | 2019-11-06 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| US7723330B2 (en) | 2006-03-07 | 2010-05-25 | Array Biopharma Inc. | Heterobicyclic pyrazole compounds and methods of use |
| AU2009303602B2 (en) | 2008-10-14 | 2012-06-14 | Sunshine Lake Pharma Co., Ltd. | Compounds and methods of use |
| EP2213686A1 (en) | 2009-01-28 | 2010-08-04 | Externautics S.p.A. | Tumor markers and methods of use thereof |
| EP2214019A1 (en) | 2009-01-28 | 2010-08-04 | Externautics S.p.A. | Tumor markers and methods of use thereof |
| UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
| US8921058B2 (en) | 2009-10-26 | 2014-12-30 | Externautics Spa | Prostate tumor markers and methods of use thereof |
| US20130017546A1 (en) | 2009-10-26 | 2013-01-17 | Externautics S.P.A. | Breast Tumor Markers and Methods of Use Thereof |
| WO2011051278A1 (en) | 2009-10-26 | 2011-05-05 | Externautics S.P.A. | Lung tumor markers and methods of use thereof |
| WO2011051276A1 (en) | 2009-10-26 | 2011-05-05 | Externautics S.P.A. | Colon and rectal tumor markers and methods of use thereof |
| US10288617B2 (en) | 2009-10-26 | 2019-05-14 | Externautics Spa | Ovary tumor markers and methods of use thereof |
| EP2383578A1 (en) | 2010-04-30 | 2011-11-02 | Externautics S.p.A. | Tumor marker and methods of use thereof |
| SG187064A1 (en) | 2010-07-14 | 2013-02-28 | Zhejiang Beta Pharma Inc | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS |
| US8664244B2 (en) | 2010-09-12 | 2014-03-04 | Advenchen Pharmaceuticals, LLC | Compounds as c-Met kinase inhibitors |
| CN102093421B (zh) | 2011-01-28 | 2014-07-02 | 北京康辰药业有限公司 | 一种含磷取代基的喹啉类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
| CN102408411B (zh) | 2011-09-19 | 2014-10-22 | 北京康辰药业股份有限公司 | 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
| BR112015007672A2 (pt) | 2012-10-04 | 2017-08-08 | Dana Farber Cancer Inst Inc | anticorpos anti-pd-l1 monoclonais humanos e métodos de uso |
| RS61400B1 (sr) | 2013-05-02 | 2021-02-26 | Anaptysbio Inc | Antitela usmerena protiv programirane smrti-1 (pd-1) |
| US10359428B2 (en) | 2013-06-14 | 2019-07-23 | Externautics S.P.A. | Tumor marker, monoclonal antibodies and methods of use thereof |
| EA201690912A1 (ru) | 2013-11-05 | 2016-10-31 | Когнейт Биосервисис, Инк. | Комбинации ингибиторов контрольных точек и терапевтических средств для лечения рака |
| JP6696908B2 (ja) | 2014-04-25 | 2020-05-20 | エグゼリクシス， インコーポレイテッド | 肺腺癌の治療方法 |
| CN104817497B (zh) | 2015-03-20 | 2017-03-08 | 南京众睿缘生物科技有限公司 | 一种炔代喹啉衍生物及其制备方法和用途 |
| CN106279147A (zh) * | 2015-05-21 | 2017-01-04 | 中国科学院上海药物研究所 | 一种吡啶并氮杂环化合物及其制备方法和用途 |
| US20180009758A1 (en) | 2015-06-29 | 2018-01-11 | Ontogenesis, Llc | Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use |
| CN105797123A (zh) | 2016-05-18 | 2016-07-27 | 王超 | 一种治疗不孕不育的中药组合物 |
| CN106400155A (zh) | 2016-08-31 | 2017-02-15 | 飞佛特种纺织品（宁波）有限公司 | 一种防老化阳光面料 |
| CN110437145A (zh) | 2016-09-13 | 2019-11-12 | 上海翔锦生物科技有限公司 | 酪氨酸激酶抑制剂及其应用 |
| SG11202005719UA (en) | 2017-12-20 | 2020-07-29 | Angex Pharmaceutical Inc | Carbamate and urea compounds as multikinase inhibitors |
| SG11202006945PA (en) * | 2018-01-26 | 2020-08-28 | Exelixis Inc | Compounds for the treatment of kinase-dependent disorders |
-
2019
- 2019-01-25 SG SG11202006945PA patent/SG11202006945PA/en unknown
- 2019-01-25 UA UAA202005478A patent/UA128348C2/uk unknown
- 2019-01-25 PE PE2020001120A patent/PE20210044A1/es unknown
- 2019-01-25 WO PCT/US2019/015289 patent/WO2019148036A1/en not_active Ceased
- 2019-01-25 CR CR20250117A patent/CR20250117A/es unknown
- 2019-01-25 MX MX2020007759A patent/MX2020007759A/es unknown
- 2019-01-25 CN CN201980021547.0A patent/CN112312909B/zh active Active
- 2019-01-25 KR KR1020207024577A patent/KR102759973B1/ko active Active
- 2019-01-25 JP JP2020540750A patent/JP7307733B2/ja active Active
- 2019-01-25 US US16/964,228 patent/US11708367B2/en active Active
- 2019-01-25 IL IL302626A patent/IL302626B2/en unknown
- 2019-01-25 IL IL276028A patent/IL276028B2/en unknown
- 2019-01-25 CR CR20200355A patent/CR20200355A/es unknown
- 2019-01-25 EP EP19704968.7A patent/EP3743068B1/en active Active
- 2019-01-25 CA CA3088127A patent/CA3088127A1/en active Pending
- 2019-01-25 EP EP26173753.0A patent/EP4789723A2/en active Pending
- 2019-01-25 AU AU2019212719A patent/AU2019212719B2/en active Active
- 2019-01-25 MA MA051672A patent/MA51672A/fr unknown
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2020
- 2020-07-03 ZA ZA2020/04065A patent/ZA202004065B/en unknown
- 2020-07-09 PH PH12020551059A patent/PH12020551059A1/en unknown
- 2020-07-22 MX MX2022014351A patent/MX2022014351A/es unknown
- 2020-07-23 CL CL2020001930A patent/CL2020001930A1/es unknown
- 2020-07-23 SA SA520412488A patent/SA520412488B1/ar unknown
- 2020-08-25 CO CONC2020/0010467A patent/CO2020010467A2/es unknown
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2023
- 2023-03-22 JP JP2023045583A patent/JP7596427B2/ja active Active
- 2023-06-13 US US18/334,113 patent/US12195475B2/en active Active