JP2021510818A5 - - Google Patents
Info
- Publication number
- JP2021510818A5 JP2021510818A5 JP2020538841A JP2020538841A JP2021510818A5 JP 2021510818 A5 JP2021510818 A5 JP 2021510818A5 JP 2020538841 A JP2020538841 A JP 2020538841A JP 2020538841 A JP2020538841 A JP 2020538841A JP 2021510818 A5 JP2021510818 A5 JP 2021510818A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- mmol
- compound according
- disease
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023143506A JP7692963B2 (ja) | 2018-01-11 | 2023-09-05 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862616253P | 2018-01-11 | 2018-01-11 | |
| US62/616,253 | 2018-01-11 | ||
| PCT/US2019/013193 WO2019140188A1 (en) | 2018-01-11 | 2019-01-11 | Inhibitors of dihydroceramide desaturase for treating disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023143506A Division JP7692963B2 (ja) | 2018-01-11 | 2023-09-05 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021510818A JP2021510818A (ja) | 2021-04-30 |
| JP2021510818A5 true JP2021510818A5 (enExample) | 2022-01-19 |
| JP7346425B2 JP7346425B2 (ja) | 2023-09-19 |
Family
ID=67219929
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020538841A Active JP7346425B2 (ja) | 2018-01-11 | 2019-01-11 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
| JP2023143506A Active JP7692963B2 (ja) | 2018-01-11 | 2023-09-05 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023143506A Active JP7692963B2 (ja) | 2018-01-11 | 2023-09-05 | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11597715B2 (enExample) |
| EP (1) | EP3737361A4 (enExample) |
| JP (2) | JP7346425B2 (enExample) |
| KR (1) | KR20250057925A (enExample) |
| CN (1) | CN111787916B (enExample) |
| AU (1) | AU2019207887B2 (enExample) |
| CA (1) | CA3087729A1 (enExample) |
| WO (1) | WO2019140188A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3529245A4 (en) | 2016-10-24 | 2020-12-23 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES OF THE LATEST |
| WO2018112077A1 (en) * | 2016-12-13 | 2018-06-21 | Centaurus Therapeutics | Inhibitors of dihydroceramide desaturase for treating disease |
| MA47212A (fr) | 2017-01-06 | 2019-11-13 | Yumanity Therapeutics Inc | Méthodes de traitement de troubles neurologiques |
| WO2019084157A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES THEREOF |
| EP3737361A4 (en) * | 2018-01-11 | 2021-08-25 | Centaurus Therapeutics | INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR THE TREATMENT OF DISEASES |
| ES3043183T3 (en) | 2018-03-23 | 2025-11-25 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
| MA54829A (fr) | 2019-01-24 | 2021-12-01 | Yumanity Therapeutics Inc | Composés et leurs utilisations |
| WO2020168294A1 (en) | 2019-02-15 | 2020-08-20 | Lysosomal And Rare Disorders Research And Treatment Center, Llc | Methods and compositions for treating lysosomal storage disorders: ambroxol as treatment agent for mucopolysaccharidoses iii (sanfilippo syndrome) |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
| EP4251140A4 (en) * | 2020-11-25 | 2024-11-27 | Lysosomal and Rare Disorders Research and Treatment Center, Inc. | CASPASE PATHWAY INHIBITION AS A TREATMENT FOR LYSOSOMAL STORAGE DISORDERS |
| JP2024528021A (ja) * | 2021-07-29 | 2024-07-26 | 上海齊魯制藥研究中心有限公司 | 新規なｐａｒｐ７阻害剤及びその使用 |
| CN117897380A (zh) * | 2021-08-17 | 2024-04-16 | 益方生物科技(上海)股份有限公司 | 哒嗪酮或吡啶酮化合物、其制备方法和用途 |
| CN120136787A (zh) * | 2023-12-13 | 2025-06-13 | 青岛清原化合物有限公司 | 一种吡唑取代的芳基硫化物类化合物及其应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62249945A (ja) | 1986-04-23 | 1987-10-30 | Fuji Photo Film Co Ltd | ハイドロキノン・モノエステル類の合成方法 |
| EP0968200A1 (en) | 1997-02-24 | 2000-01-05 | ZymoGenetics, Inc. | Calcitonin mimetics |
| FR2770131A1 (fr) | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| CO5150173A1 (es) | 1998-12-10 | 2002-04-29 | Novartis Ag | Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv |
| US6894063B2 (en) | 2000-09-14 | 2005-05-17 | Schering Corporation | Substituted urea neuropeptide Y Y5 Receptor antagonists |
| ES2170030B1 (es) * | 2000-12-19 | 2003-11-16 | Consejo Superior Investigacion | Inhibidores de la dihidroceramida desaturasa. |
| AU2002355286B2 (en) | 2001-07-26 | 2005-10-13 | Schering Corporation | Substituted urea neuropeptide Y Y5 receptor antagonists |
| BRPI0410657A (pt) | 2003-06-12 | 2006-06-20 | Novo Nordisk As | composto, composição farmacêutica, uso de um composto, método para tratar um distúrbio de um paciente, e, processo para a preparação de um composto |
| JP2006527212A (ja) | 2003-06-12 | 2006-11-30 | ノボ ノルディスク アクティーゼルスカブ | ホルモン感受性リパーゼの阻害剤として使用するための、置換ピペラジンカルバメート |
| US7129235B2 (en) | 2003-07-11 | 2006-10-31 | Abbott Laboratories | Amides useful for treating pain |
| JP2007501805A (ja) | 2003-08-08 | 2007-02-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピリジルピペラジニルウレア |
| US7491720B2 (en) | 2004-10-29 | 2009-02-17 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives having Aurora A selective inhibitory action |
| TW200633990A (en) | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
| EP1817025A2 (en) | 2004-11-23 | 2007-08-15 | PTC Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control |
| WO2006074025A1 (en) | 2004-12-30 | 2006-07-13 | Janssen Pharmaceutica N.V. | Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase |
| MX2007010076A (es) * | 2005-02-17 | 2007-10-16 | Astellas Pharma Inc | Derivado de heterociclico-1-carboxilato que contiene nitrogeno no aromatico de piridilo. |
| US7790726B2 (en) | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
| WO2007149865A2 (en) | 2006-06-19 | 2007-12-27 | University Of Utah Research Foundation | Methods and compositions related to inhibition of ceramide synthesis |
| JPWO2008023720A1 (ja) | 2006-08-23 | 2010-01-14 | アステラス製薬株式会社 | ウレア化合物又はその塩 |
| KR20110065417A (ko) * | 2008-01-03 | 2011-06-15 | 욱크하르트 리미티드 | 파라세타몰 및 이부프로펜을 포함하는 경구 약제학적 현탁액 |
| WO2010023512A1 (en) | 2008-08-28 | 2010-03-04 | Matrix Laboratories Ltd. | Novel vanilloid receptor modulators, process for their preparation and pharmaceutical compositions containing them |
| FR2939135B1 (fr) | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| CA2750835C (en) | 2009-01-28 | 2018-09-04 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds and methods for using the same |
| JP2010195688A (ja) | 2009-02-23 | 2010-09-09 | Shionogi & Co Ltd | Ｎｐｙｙ５受容体拮抗作用を有するアミド及びウレア誘導体 |
| US20130029978A1 (en) | 2009-12-25 | 2013-01-31 | Mochida Pharmaceutical Co., Ltd. | Novel aryl urea derivative |
| CN103172635B (zh) * | 2011-12-21 | 2016-04-27 | 上海医药工业研究院 | 哌嗪或哌啶类化合物、其盐、中间体、制备方法及应用 |
| WO2015038704A1 (en) * | 2013-09-11 | 2015-03-19 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Compositions for preparing cardiomyocytes |
| EP3478678A1 (en) | 2016-06-30 | 2019-05-08 | Basilea Pharmaceutica International AG | Mitochondrial inhibitors for the treatment of proliferation disorders |
| WO2018112077A1 (en) * | 2016-12-13 | 2018-06-21 | Centaurus Therapeutics | Inhibitors of dihydroceramide desaturase for treating disease |
| EP3737361A4 (en) * | 2018-01-11 | 2021-08-25 | Centaurus Therapeutics | INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR THE TREATMENT OF DISEASES |
-
2019
- 2019-01-11 EP EP19738156.9A patent/EP3737361A4/en active Pending
- 2019-01-11 CN CN201980015846.3A patent/CN111787916B/zh active Active
- 2019-01-11 KR KR1020257012348A patent/KR20250057925A/ko active Pending
- 2019-01-11 CA CA3087729A patent/CA3087729A1/en active Pending
- 2019-01-11 AU AU2019207887A patent/AU2019207887B2/en active Active
- 2019-01-11 WO PCT/US2019/013193 patent/WO2019140188A1/en not_active Ceased
- 2019-01-11 US US16/959,807 patent/US11597715B2/en active Active
- 2019-01-11 JP JP2020538841A patent/JP7346425B2/ja active Active
-
2023
- 2023-02-06 US US18/106,305 patent/US12247019B2/en active Active
- 2023-09-05 JP JP2023143506A patent/JP7692963B2/ja active Active
-
2025
- 2025-01-24 US US19/036,846 patent/US20260070884A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7692963B2 (ja) | 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤 | |
| US11771684B2 (en) | Inhibitors of dihydroceramide desaturase for treating disease | |
| US7834004B2 (en) | Sulfonyl-substituted bicyclic compounds as modulators of PPAR | |
| CN108727363B (zh) | 一种新型细胞周期蛋白依赖性激酶cdk9抑制剂 | |
| JP7802655B2 (ja) | 疾患の処置のための受容体相互作用プロテインキナーゼｉの阻害剤 | |
| EP3157917A1 (en) | Compounds, compositions and methods of increasing cftr activity | |
| BR112021000395A2 (pt) | Compostos imunomoduladores diméricos contra mecanismos baseados em cereblon | |
| CN120794975A (zh) | 作为cdk8/19抑制剂的新型杂环化合物 | |
| AU2015272560A1 (en) | Novel anticancer agent | |
| TW201100400A (en) | Piperazine compound capable of inhibiting prostaglandin d synthase | |
| EP3578549A1 (en) | Heterocyclic compound | |
| EP4499148A1 (en) | Cyclin-dependent kinase 9 (cdk9) degraders and methods of using thereof | |
| GB2467561A (en) | Dual calpain-ROS inhibitors | |
| TW201910312A (zh) | 環狀胺衍生物及其醫藥用途 | |
| KR102798144B1 (ko) | 질병 치료를 위한 디하이드로세라마이드 불포화화효소의 저해제 | |
| JP2025526814A (ja) | 化合物、それを含む医薬組成物及びその用途 | |
| WO2023030170A1 (zh) | 基于nampt靶蛋白的蛋白降解化合物及其应用 | |
| CN117120443A (zh) | 作为腺苷A2a受体拮抗剂的化合物及包含其的药物组合物 | |
| WO2025171225A1 (en) | Compositions and methods for inducing ferroptosis | |
| HK1236029A1 (en) | Naphthofuran derivatives for use as anticancer agents | |
| HK1236029B (en) | Naphthofuran derivatives for use as anticancer agents |