JP2021505683A5 - - Google Patents
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- Publication number
- JP2021505683A5 JP2021505683A5 JP2020550593A JP2020550593A JP2021505683A5 JP 2021505683 A5 JP2021505683 A5 JP 2021505683A5 JP 2020550593 A JP2020550593 A JP 2020550593A JP 2020550593 A JP2020550593 A JP 2020550593A JP 2021505683 A5 JP2021505683 A5 JP 2021505683A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- ellagolix
- solvent
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DCBMRVNOKRIPHR-UHFFFAOYSA-N CC(C(C(SC(N1)=O)=O)=C1O)=N Chemical compound CC(C(C(SC(N1)=O)=O)=C1O)=N DCBMRVNOKRIPHR-UHFFFAOYSA-N 0.000 description 1
- BTGXKSQIUUCGTQ-UHFFFAOYSA-N CC(C(C(SC(N1)=O)=O)=C1O)=O Chemical compound CC(C(C(SC(N1)=O)=O)=C1O)=O BTGXKSQIUUCGTQ-UHFFFAOYSA-N 0.000 description 1
- YUCGIKTVAIPINQ-UHFFFAOYSA-N Cc(c(C(F)(F)F)ccc1)c1F Chemical compound Cc(c(C(F)(F)F)ccc1)c1F YUCGIKTVAIPINQ-UHFFFAOYSA-N 0.000 description 1
- FCYVKQRWNQRCFE-UHFFFAOYSA-N NCc1c(C(F)(F)F)cccc1F Chemical compound NCc1c(C(F)(F)F)cccc1F FCYVKQRWNQRCFE-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711263255.7A CN109867631A (zh) | 2017-12-05 | 2017-12-05 | 一种含有6-甲基尿嘧啶结构化合物的制备方法 |
| CN201711263255.7 | 2017-12-05 | ||
| CN201810042494.8A CN110128355A (zh) | 2018-01-17 | 2018-01-17 | 一种含有6-甲基尿嘧啶结构化合物的制备方法 |
| CN201810042494.8 | 2018-01-17 | ||
| CN201811104129.1 | 2018-08-14 | ||
| CN201810941650.4 | 2018-08-17 | ||
| CN201810941650.4A CN110835302A (zh) | 2018-08-17 | 2018-08-17 | 一种恶拉戈利及其钠盐的中间体及其制备方法 |
| CN201811104129.1A CN110938037A (zh) | 2018-09-21 | 2018-09-21 | 一种依拉戈利钠盐药物中间体的制备方法 |
| PCT/US2018/063682 WO2019112968A1 (en) | 2017-12-05 | 2018-12-03 | Processes to produce elagolix |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021505683A JP2021505683A (ja) | 2021-02-18 |
| JP2021505683A5 true JP2021505683A5 (https=) | 2022-01-11 |
| JP7200261B2 JP7200261B2 (ja) | 2023-01-06 |
Family
ID=66751637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020550593A Active JP7200261B2 (ja) | 2017-12-05 | 2018-12-03 | エラゴリクスを作製するプロセス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11377426B2 (https=) |
| EP (1) | EP3720845A4 (https=) |
| JP (1) | JP7200261B2 (https=) |
| TW (2) | TWI693208B (https=) |
| WO (1) | WO2019112968A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7200261B2 (ja) | 2017-12-05 | 2023-01-06 | スージョウ ポンシュー ファーマテック カンパニー リミテッド | エラゴリクスを作製するプロセス |
| BR112021000973A2 (pt) * | 2018-07-23 | 2021-04-20 | Abbvie Inc. | composições e processos de sódio de elagolix |
| ES2802815B2 (es) | 2019-07-12 | 2022-03-14 | Moehs Iberica Sl | Sal clorhidrato de 3-[2(r)-amino-2-feniletil]-5-(2-fluoro-3-metoxifenil)-1-[2-fluoro-6-(trifluorometil)bencil]-6-metil-1h-pirimidin-2,4(1h,3h)-diona (i) en forma solida, procedimiento para su preparacion y uso de la misma en la sintesis de elagolix |
| TWI755055B (zh) * | 2019-09-18 | 2022-02-11 | 台灣神隆股份有限公司 | 用於製備惡拉戈利鈉及其中間體的方法 |
| CN116283797B (zh) * | 2022-12-30 | 2024-11-29 | 浙江车头制药股份有限公司 | 一种噁拉戈利钠的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998004509A1 (en) | 1996-07-30 | 1998-02-05 | Nippon Soda Co., Ltd. | 2,3-dihalogeno-6-trifluoromethylbenzene derivatives and processes for the preparation thereof |
| US6949574B2 (en) | 2002-02-08 | 2005-09-27 | Bristol-Myers Squibb Company | (Oxime)carbamoyl fatty acid amide hydrolase inhibitors |
| AU2004257639B2 (en) * | 2003-07-07 | 2011-01-06 | Neurocrine Biosciences, Inc. | Pyrimidine-2, 4-dione derivatives as gonadotropin-releasing hormone receptor antagonists |
| GB0711521D0 (en) | 2007-06-14 | 2007-07-25 | Glaxo Group Ltd | Novel compounds |
| US8765948B2 (en) | 2007-11-07 | 2014-07-01 | Neurocrine Biosciences, Inc. | Processes for the preparation of uracil derivatives |
| US20120059179A1 (en) | 2009-04-03 | 2012-03-08 | The Scripps Research Insitiute | Palladium-catalyzed ortho-fluorination |
| AU2016229268B2 (en) | 2015-03-06 | 2020-09-10 | Pharmakea, Inc. | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof |
| JP7200261B2 (ja) | 2017-12-05 | 2023-01-06 | スージョウ ポンシュー ファーマテック カンパニー リミテッド | エラゴリクスを作製するプロセス |
-
2018
- 2018-12-03 JP JP2020550593A patent/JP7200261B2/ja active Active
- 2018-12-03 US US16/770,035 patent/US11377426B2/en active Active
- 2018-12-03 WO PCT/US2018/063682 patent/WO2019112968A1/en not_active Ceased
- 2018-12-03 EP EP18885965.6A patent/EP3720845A4/en not_active Withdrawn
- 2018-12-04 TW TW107143337A patent/TWI693208B/zh not_active IP Right Cessation
- 2018-12-04 TW TW109111870A patent/TW202030177A/zh unknown
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