JP2021505598A5 - - Google Patents
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- Publication number
- JP2021505598A5 JP2021505598A5 JP2020530969A JP2020530969A JP2021505598A5 JP 2021505598 A5 JP2021505598 A5 JP 2021505598A5 JP 2020530969 A JP2020530969 A JP 2020530969A JP 2020530969 A JP2020530969 A JP 2020530969A JP 2021505598 A5 JP2021505598 A5 JP 2021505598A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methyl
- dihydro
- pyridine
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **N(CC1)CCC1(C1)OCC1NCC(COc1cccc(S(N(*)*)(=O)=O)c1)O Chemical compound **N(CC1)CCC1(C1)OCC1NCC(COc1cccc(S(N(*)*)(=O)=O)c1)O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762595133P | 2017-12-06 | 2017-12-06 | |
| US62/595,133 | 2017-12-06 | ||
| PCT/US2018/064316 WO2019113359A1 (en) | 2017-12-06 | 2018-12-06 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021505598A JP2021505598A (ja) | 2021-02-18 |
| JP2021505598A5 true JP2021505598A5 (enExample) | 2022-01-11 |
| JP7357617B2 JP7357617B2 (ja) | 2023-10-06 |
Family
ID=64744985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530969A Active JP7357617B2 (ja) | 2017-12-06 | 2018-12-06 | 心不全およびそれに関連する障害の治療または予防に有用なβ－３アドレナリン受容体のモジュレーター |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11339172B2 (enExample) |
| EP (1) | EP3720858B1 (enExample) |
| JP (1) | JP7357617B2 (enExample) |
| CN (1) | CN111699189B (enExample) |
| AR (1) | AR114156A1 (enExample) |
| ES (1) | ES2953576T3 (enExample) |
| MA (1) | MA51015A (enExample) |
| TW (1) | TWI822713B (enExample) |
| WO (1) | WO2019113359A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA44037B1 (fr) | 2016-06-06 | 2020-03-31 | Arena Pharm Inc | Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci |
| PT3448859T (pt) | 2017-03-20 | 2019-10-25 | Forma Therapeutics Inc | Composições de pirrolopirrole como ativadores de piruvato quinase (pkr). |
| JP7357617B2 (ja) * | 2017-12-06 | 2023-10-06 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 心不全およびそれに関連する障害の治療または予防に有用なβ－３アドレナリン受容体のモジュレーター |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| US12053458B2 (en) | 2018-09-19 | 2024-08-06 | Novo Nordisk Health Care Ag | Treating sickle cell disease with a pyruvate kinase R activating compound |
| CN114615977B (zh) | 2019-09-19 | 2025-01-14 | 诺沃挪第克健康护理股份公司 | 丙酮酸激酶r(pkr)活化组合物 |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| JP2023024954A (ja) | 2021-08-09 | 2023-02-21 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ベータ－３アドレナリン作動性受容体に関連する障害の処置または予防に有用なベータ－３アドレナリン作動性受容体のモジュレーター |
| US20240358689A1 (en) | 2021-08-26 | 2024-10-31 | Arena Pharmaceuticals, Inc. | Modulators Of The Beta-3 Adrenergic Receptor Useful For The Treatment Or Prevention Of Renal Cystic Disease and Cardiorenal Syndrome |
| JP2024536333A (ja) | 2021-10-06 | 2024-10-04 | アリーナ ファーマシューティカルズ， インコーポレイテッド | それに関連する障害の処置または予防に有用なベータ－３アドレナリン作動性受容体のモジュレーター |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
| FR2755439B1 (fr) * | 1996-11-05 | 1998-12-24 | Virbac Sa | Derives aryloxypropanolamines, leur procede de preparation et leurs applications |
| JP4782342B2 (ja) * | 1999-12-17 | 2011-09-28 | サノフィ−アベンティス | フェノキシプロパノールアミン類、それらの製造方法およびそれらを含む医薬組成物 |
| CN1469876A (zh) * | 2000-10-20 | 2004-01-21 | �Ʒ� | α-芳基乙醇胺及其用作β-3肾上腺素能受体激动剂的用途 |
| EP1833480A2 (en) * | 2004-11-30 | 2007-09-19 | Artesian Therapeutics, Inc. | Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase |
| WO2016060564A1 (en) * | 2014-10-14 | 2016-04-21 | Brains Online Holding B.V. Et All | Body sculpting |
| MA44037B1 (fr) * | 2016-06-06 | 2020-03-31 | Arena Pharm Inc | Modulateurs du récepteur adrénergique bêta 3 utile dans le traitement ou la prévention de troubles associés à ceux-ci |
| JP7357617B2 (ja) * | 2017-12-06 | 2023-10-06 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 心不全およびそれに関連する障害の治療または予防に有用なβ－３アドレナリン受容体のモジュレーター |
-
2018
- 2018-12-06 JP JP2020530969A patent/JP7357617B2/ja active Active
- 2018-12-06 EP EP18822236.8A patent/EP3720858B1/en active Active
- 2018-12-06 MA MA051015A patent/MA51015A/fr unknown
- 2018-12-06 CN CN201880088219.8A patent/CN111699189B/zh active Active
- 2018-12-06 WO PCT/US2018/064316 patent/WO2019113359A1/en not_active Ceased
- 2018-12-06 US US16/769,507 patent/US11339172B2/en active Active
- 2018-12-06 AR ARP180103577A patent/AR114156A1/es unknown
- 2018-12-06 ES ES18822236T patent/ES2953576T3/es active Active
- 2018-12-06 TW TW107143855A patent/TWI822713B/zh active
-
2022
- 2022-04-22 US US17/726,807 patent/US11987588B2/en active Active
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