JP2021501887A - 体液分析用カートリッジおよびシステム - Google Patents
体液分析用カートリッジおよびシステム Download PDFInfo
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Abstract
Description
本発明は、国防脅威削減局により授与された契約番号HDTRA1−17−C−0011および米国陸軍医学研究取得活動により授与された許可番号W81XWH−17−1−0694に基づく政府支援によりなされた。米国政府は、本発明において特定の権利を有する。
本出願は2017年11月2日に出願された米国仮特許出願第62/580,496号、2017年11月5日に出願された米国仮特許出願第62/581,728号、および2018年7月5日に出願された米国仮特許出願第62/694,083号の優先権の利益を主張し、これらの内容は、その全体が参照により本明細書に組み込まれる。
本発明はそのいくつかの実施形態では医療装置に関し、限定するものではないが、より詳細には、体液、限定するものではないが、血液等のサンプルを分析するためのカートリッジおよびシステムに関する。
本明細書中に提示されるタンパク質名は、例として与えられていることが理解される。多くの代替名、エイリアス、修飾、アイソフォームおよびバリエーションは、当業者に明らかである。従って、全ての代替的なタンパク質名、エイリアス、修飾アイソフォームおよびバリエーションを包含することが意図される。
Claims (73)
- 体液を分析するためのカートリッジ装置であって、
アッセイを実施するための複数のウェルを有する第1の部材と、
前記第1の部材に接続され、少なくとも1つの使い捨てピペットチップを保持するためのコンパートメントを有する第2の部材と、
を備えるカートリッジ装置。 - 前記第2の部材は、前記第1の部材にヒンジ接続される、請求項1に記載の装置。
- 前記第2の部材は、前記第1の部材に摺動可能に接続される、請求項1に記載の装置。
- 前記第2の部材の前記コンパートメントは、前記少なくとも1つの使い捨てピペットチップを概ね直立した向きに保持するように配向される、請求項1に記載の装置。
- 前記第2の部材の前記コンパートメントは、前記少なくとも1つの使い捨てピペットチップを概ね直立した向きに保持するように配向される、請求項2から3のいずれか一項に記載の装置。
- 体液を分析するためのキットであって、
アッセイを実施するための複数のウェルを有する第1の部材と、
前記第1の部材に接続可能であり、少なくとも1つの使い捨てピペットチップを保持するためのコンパートメントを有する第2の部材と、
を備えるキット。 - 前記ウェルを覆う開放可能または穿孔可能なカバー構造をさらに備える、請求項1に記載の装置。
- 前記ウェルを覆う開放可能または穿孔可能なカバー構造をさらに備える、請求項2から6のいずれか一項に記載の装置またはキット。
- 廃棄物収集チャンバをさらに備える、請求項1に記載の装置。
- 廃棄物収集チャンバをさらに備える、請求項2から7のいずれか一項に記載の装置またはキット。
- 前記廃棄物収集チャンバは、吸湿材を備える、請求項9に記載の装置またはキット。
- 前記廃棄物収集チャンバは、吸湿材を備える、請求項10に記載の装置またはキット。
- 前記廃棄物収集チャンバは、吸湿材を備える、請求項9に記載の装置。
- 前記廃棄物収集チャンバは、吸湿材を備える、請求項10に記載の装置またはキット。
- 前記廃棄物収集チャンバは、蓋によって覆われる、請求項9に記載の装置。
- 前記廃棄物収集チャンバは、蓋によって覆われる、請求項11に記載の装置またはキット。
- 前記廃棄物収集チャンバは、一方向弁によってロックされる、請求項9に記載の装置またはキット。
- 前記廃棄物収集チャンバは、一方向弁によってロックされる、請求項10から16のいずれか一項に記載の装置またはキット。
- 前記廃棄物収集チャンバは、方向付け構造を使用して液体のこぼれを防止する、請求項9に記載の装置。
- 前記廃棄物収集チャンバは、方向付け構造を使用して液体のこぼれを防止する、請求項10から18のいずれか一項に記載の装置またはキット。
- 前記廃棄物収集チャンバは、穿孔可能な障壁によって覆われる、請求項9に記載の装置。
- 前記廃棄物収集チャンバが、穿孔可能な障壁によって覆われる、請求項10から20のいずれか一項に記載の装置またはキット。
- 前記廃棄物収集チャンバは、前記第2の部材に接続されるか、または前記第2の部材の延長部である蓋によって覆われ、前記第2の部材が概ね直立した向きでヒンジ止めされたときに露出される、請求項9に記載の装置。
- 前記廃棄物収集チャンバは、前記第2の部材に接続されるか、または前記第2の部材の延長部である蓋によって覆われ、前記第2の部材が概ね直立した向きでヒンジ止めされたときに露出される、請求項10から22のいずれか一項に記載の装置またはキット。
- 前記廃棄物収集チャンバは、複数の部分チャンバに分割される、請求項9に記載の装置。
- 前記廃棄物収集チャンバは、複数の部分チャンバに分割される、請求項10から24のいずれか一項に記載の装置またはキット。
- 前記廃棄物収集チャンバは、2つ以上の入口点を備える、請求項9に記載の装置。
- 前記廃棄物収集チャンバは、2つ以上の入口点を備える、請求項10から26のいずれか一項に記載の装置またはキット。
- 前記廃棄物収集チャンバは、前記ウェルの下まで延在する、請求項9に記載の装置。
- 前記廃棄物収集チャンバは、前記ウェルの下まで延在する、請求項10から28のいずれか一項に記載の装置またはキット。
- 前記第2の部材は、それぞれが1つのピペットチップを保持するように構成された複数の区画に仕切られている、請求項1に記載の装置。
- 前記第2の部材は、それぞれが1つのピペットチップを保持するように構成された複数の区画に仕切られている、請求項2から30のいずれか一項に記載の装置またはキット。
- 前記区画の数が少なくとも前記アッセイの数に等しい、請求項31に記載の装置。
- 前記複数のウェルは、固体磁性キャリアに固定化された第1の抗体を含む少なくとも1つのウェルと、標識物質で標識された第2の抗体を含む少なくとも1つのウェルとを備え、前記抗体が、体液中の標的物質に特異的に結合するように選択される、請求項1に記載の装置。
- 前記複数のウェルは、固体磁性キャリアに固定化された第1の抗体を含む少なくとも1つのウェルと、標識物質で標識された第2の抗体を含む少なくとも1つのウェルと、を備え、前記抗体が、体液中の標的物質に特異的に結合するように選択される、請求項2から33のいずれか一項に記載の装置またはキット。
- 前記標識物質が酵素であり、前記抗体および前記酵素が、サンドイッチELISA試験によって前記標的物質を検出するために選択される、請求項34に記載の装置。
- 前記標識物質が酵素であり、前記抗体および前記酵素が、サンドイッチELISA試験によって前記標的物質を検出するために選択される、請求項35に記載の装置またはキット。
- 前記抗体は、TRAILタンパク質、CRPタンパク質およびIP−10タンパク質からなる群から選択されるタンパク質に特異的に結合するように選択される、請求項34および36のいずれか一項に記載の装置またはキット。
- 前記抗体は、PCT、IL−6、BNP、トロポニン、トロポニンI、トロポニンT、高感受性トロポニン、高感受性CRP、IL1RA、CKB、RSAD2、MX1、TREM−1、PTHおよびユビキチンC末端ヒドロラーゼ−L1(UCH−L1)からなる群より選択されるタンパク質に特異的に結合するように選択される、請求項34および36のいずれか一項に記載の装置またはキット。
- 前記コンパートメント内に前記少なくとも1つの使い捨てピペットチップをさらに備える、請求項1に記載の装置。
- 前記コンパートメント内に前記少なくとも1つの使い捨てピペットチップをさらに備える、請求項2から39のいずれか一項に記載の装置またはキット。
- 前記少なくとも1つの使い捨てピペットチップ抗体が、前記使い捨てピペットチップ内の固体磁性キャリアに固定化されている、請求項40に記載の装置。
- 前記少なくとも1つの使い捨てピペットチップ抗体が、前記使い捨てピペットチップ内の固体磁性キャリアに固定化されている、請求項41に記載の装置またはキット。
- 前記第1の部材または第2の部材が、前記体液を収容する容器を受け入れ、かつ、ぴったりと保持するように構成された凹部を備える、請求項1に記載の装置。
- 前記第1の部材または第2の部材が、前記体液を収容する容器を受け入れ、かつ、ぴったりと保持するように構成された凹部を備える、請求項2から40のいずれか一項に記載の装置またはキット。
- 体液を分析するためのカートリッジ装置であって、カートリッジは、
それぞれがテーパ状の底部を有する第1の複数のウェルと、
それぞれが非テーパ状の底部を有する第2の複数のウェルと、
を備え、前記第1の複数のウェルおよび前記第2の複数のウェルは両方ともモノリシック構造で形成される、カートリッジ装置。 - 前記第1の複数のウェルのうちの少なくとも1つのウェルは、試薬を含む、請求項46に記載のカートリッジ装置。
- 前記第2の複数のウェルのうちの少なくとも1つのウェルは、体液を収容するためにマーキングされる、請求項46に記載のカートリッジ装置。
- 体液を分析するためのキットであって、請求項44および47のいずれか一項に記載の装置と前記容器とを別個のパッケージで備える、キット。
- 前記容器が、約5μlから約500μlの体積を有する、請求項49に記載のキット。
- 前記容器が、約5μlから約500μlの体積を有する、請求項49に記載のキット。
- 前記容器を平坦な底部に取り付けることができる、請求項49および50のいずれか一項に記載のキット。
- 前記容器が蓋を備える、請求項49および50のいずれか一項に記載のキット。
- 前記蓋が折り畳み可能である、請求項53に記載のキット。
- 前記蓋が穿孔可能である、請求項53および54のいずれか一項に記載のキット。
- 前記蓋が前記容器を密封する、請求項53から55のいずれか一項に記載のキット。
- 前記容器が可視光に対して透明である、請求項49から55のいずれか一項に記載のキット。
- 前記容器の内壁が、抗凝固剤で少なくとも部分的にコーティングされる、請求項49から57のいずれか一項に記載のキット。
- 体液を分析するためのシステムであって、
請求項1に記載のカートリッジ装置を受け入れるように適合されたカートリッジホルダと、
分析チャンバを有し、前記分析チャンバ内に封入されたときに体液を分析するように構成された内部分析器システムと、
ピペットを搬送するロボットアームシステムと、
前記ピペットが少なくともチップコンパートメントを訪れ、前記コンパートメントからチップを拾い上げ、カートリッジ装置、前記分析チャンバおよび前記コンパートメントを訪れ、前記ピペットのチップを前記コンパートメント内に解放して戻すように前記カートリッジ装置と前記ピペットとの間の相対運動を確立するように前記ロボットアームシステムを制御するように構成されたコントローラと、
を備えるシステム。 - 体液を分析するためのシステムであって、
請求項2から44のいずれか一項に記載のカートリッジ装置またはキットを受け入れるように適合されたカートリッジホルダと、
分析チャンバを有し、前記分析チャンバ内に封入されたときに体液を分析するように構成された内部分析器システムと、ピペットを搬送するロボットアームシステムと、
前記ピペットが少なくともチップコンパートメントを訪れ、前記コンパートメントからチップを拾い上げ、カートリッジ装置、前記分析チャンバおよび前記コンパートメントを訪れ、前記ピペットのチップを前記コンパートメント内に解放して戻すように前記カートリッジ装置と前記ピペットとの間の相対運動を確立するように前記ロボットアームシステムを制御するように構成されたコントローラと、
を備えるシステム。 - 前記受け入れに応答して前記第2の部材を自動的にヒンジ止めするためのレバーシステムをさらに備える、請求項59に記載のシステム。
- 前記受け入れに応答して前記第2の部材を自動的にヒンジ止めするためのレバーシステムをさらに備える、請求項60に記載のシステム。
- 体液を分析するためのシステムであって、
アッセイを実施するための複数のウェルを有する第1のカートリッジ部材を受け入れるように適合された第1のカートリッジホルダと、
少なくとも1つの使い捨てピペットチップを保持するためのコンパートメントを有する第2のカートリッジ部材を受け入れるように適合された第2のカートリッジホルダと、
分析チャンバを有し、前記分析チャンバ内に封入されたときに体液を分析するように構成された内部分析器システムと、
ピペットを搬送するロボットアームシステムと、
前記ピペットが少なくとも前記チップのコンパートメントを訪れ、前記コンパートメントからチップを拾い上げ、前記ウェルおよび前記分析チャンバを訪れ、前記ピペットのチップを前記コンパートメントに解放して戻すように、前記カートリッジ部材と前記ピペットとの間の相対運動を確立するように前記ロボットアームシステムを制御するように構成されたコントローラと、
を備えるシステム。 - 前記カートリッジ装置は、前記ウェルを覆う穿孔可能なフィルムを備え、前記コントローラは、前記カートリッジ装置を訪れている間に前記フィルムを穿孔するように前記ロボットアームシステムを制御するように構成される、請求項59から63のいずれか一項に記載のシステム。
- 前記カートリッジ装置は、廃棄物収集チャンバを備え、前記コントローラは、前記廃棄物収集チャンバを訪れるように前記ロボットアームシステムを制御するように構成される、請求項59および64のいずれか一項に記載のシステム。
- 前記第2の部材は、複数の区画に分割され、前記コントローラは前記ロボットアームシステムを制御して、異なるピペットチップを拾い上げ、異なる区画に解放するように構成される、請求項59から65のいずれか一項に記載のシステム。
- 前記第1の部材は、前記体液を収容する容器を受け入れ、かつ、ぴったりと保持するように構成された凹部を備え、前記コントローラは、前記容器を訪れるように前記ロボットアームシステムを制御するように構成される、請求項59から66のいずれか一項に記載のシステム。
- 前記複数のウェルは、固体磁性キャリアに固定化された第1の抗体を含む少なくとも1つのウェルと、標識物質で標識された第2の抗体を含む少なくとも1つのウェルと、を備え、前記抗体は、体液中の標的物質に特異的に結合するように選択され、前記コントローラは、前記ピペットが、体液、前記固定化された第1の抗体、および前記標識された第2の抗体を前記チップ内に吸引するように前記相対運動を確立するように構成され、前記システムは、前記固体磁性キャリアを分離し、それによって前記標的物質も前記チップ内の他の構成要素から分離するように構成された磁気システムを備える、請求項59から67のいずれか一項に記載のシステム。
- 加熱システムをさらに備える、請求項59から68のいずれか一項に記載のシステム。
- 前記加熱システムは、前記カートリッジ装置の前記受け入れに応答して前記カートリッジ装置と自動的に接続するように構成されたステージを備える、請求項69に記載のシステム。
- 前記分析チャンバは、暗チャンバであり、前記分析器システムは、前記ピペットチップが前記暗チャンバ内にあるときに前記ピペットチップからの化学発光信号を検出するように構成された光学分析器である、請求項59から70のいずれか一項に記載のシステム。
- 前記暗チャンバの内壁が、反射性コーティングによって少なくとも部分的にコーティングされている、請求項71に記載のシステム。
- 体液を分析する方法であって、
体液を含むピペットチップと前記チップ内の前記抗体および前記体液の反応中に化学発光信号を生成する酵素および基質に結合された抗体とを提供することと、
前記ピペットチップから前記化学発光信号を検出するために光学分析器を動作させることと、
を備える方法。
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US62/694,083 | 2018-07-05 | ||
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Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018129056A1 (en) | 2017-01-04 | 2018-07-12 | The Research Foundation For The State University Of New York | Biomarker detection device |
CN111432726A (zh) | 2017-11-02 | 2020-07-17 | 米密德诊断学有限公司 | 用于分析体液的卡盒及系统 |
USD888267S1 (en) | 2018-04-24 | 2020-06-23 | Memed Diagnostics Ltd. | Diagnostic instrument |
US11459604B2 (en) * | 2018-07-12 | 2022-10-04 | Luminex Corporation | Systems and methods for performing variable sample preparation and analysis processes |
USD951482S1 (en) | 2018-09-02 | 2022-05-10 | Memed Diagnostics Ltd. | Cartridge device |
USD888269S1 (en) | 2018-09-02 | 2020-06-23 | Memed Diagnostics Ltd. | Capillary blood collector device |
USD944410S1 (en) * | 2020-05-11 | 2022-02-22 | Maxcyte, Inc. | Electroporation processing assembly |
USD943760S1 (en) * | 2020-05-11 | 2022-02-15 | Maxcyte, Inc. | Electroporation processing assembly |
CA3195299A1 (en) * | 2020-11-23 | 2022-05-27 | Martina MEDKOVA | Modified elisa with hemoglobin correction apparatus and methods thereof |
USD979093S1 (en) | 2022-05-05 | 2023-02-21 | Singular Genomics Systems, Inc. | Reagent cartridge |
USD981591S1 (en) | 2022-05-05 | 2023-03-21 | Singular Genomics Systems, Inc. | Sample cartridge |
USD970036S1 (en) | 2022-05-05 | 2022-11-15 | Singular Genomics Systems, Inc. | Reagent cartridge |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004531725A (ja) * | 2001-05-09 | 2004-10-14 | アクシス−シールド エイエスエイ | アッセイシステム |
JP2007178328A (ja) * | 2005-12-28 | 2007-07-12 | Shimadzu Corp | 反応容器キット及び反応容器処理装置 |
WO2011040504A1 (ja) * | 2009-09-30 | 2011-04-07 | 凸版印刷株式会社 | 核酸分析装置 |
JP2014528577A (ja) * | 2011-09-30 | 2014-10-27 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | ユニット化された試薬ストリップ |
JP2014211437A (ja) * | 2013-04-05 | 2014-11-13 | 協和メデックス株式会社 | 試薬ボトル用キャップおよび試薬容器 |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD282208S (en) | 1983-02-07 | 1986-01-14 | Data Packaging Corporation | Pipetter tip cartridge |
US4576185A (en) | 1983-12-05 | 1986-03-18 | Terumo Medical Corporation | Collection device for capillary blood |
US5681743A (en) * | 1995-07-20 | 1997-10-28 | Becton Dickinson And Company | Plate assembly useful for microbiological laboratory procedures |
US5568881A (en) * | 1995-07-31 | 1996-10-29 | Chi; Wen Y. | Pipette tip dispenser |
EP1340982B1 (en) * | 1997-11-14 | 2009-10-21 | Gen-Probe Incorporated | Assay work station |
WO2001011374A2 (en) | 1999-08-06 | 2001-02-15 | Thermo Biostar, Inc. | An automated point of care detection system including complete sample processing capabilities |
USD438633S1 (en) | 1999-12-21 | 2001-03-06 | Compucyte Corporation | Reagent cartridge for treating a sample |
DE60124705T2 (de) | 2000-04-28 | 2007-09-13 | Mitsubishi Kagaku Iatron, Inc. | Automatische messpatrone und dazu gehoerendes messverfahren |
US7157047B2 (en) | 2001-02-09 | 2007-01-02 | Pss Bio Instruments, Inc. | Device for containing, reacting and measuring, and method of containing, reacting and measuring |
TW558699B (en) | 2002-08-28 | 2003-10-21 | Au Optronics Corp | Driving circuit and method for light emitting device |
CA2772050C (en) * | 2002-12-26 | 2016-09-06 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same |
CN1849515B (zh) | 2003-07-17 | 2013-09-04 | 三菱化学美迪恩斯株式会社 | 用于自动测定的检测盒和使用该检测盒的测定装置 |
DE10361167A1 (de) * | 2003-12-22 | 2005-07-28 | Brand Gmbh + Co Kg | Verpackungsbox für Laborgegenstände |
US8211386B2 (en) | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
JP4548359B2 (ja) | 2006-02-20 | 2010-09-22 | 株式会社島津製作所 | 反応キット処理装置 |
KR101245218B1 (ko) | 2006-06-22 | 2013-03-19 | 엘지디스플레이 주식회사 | 유기발광다이오드 표시소자 |
KR100837335B1 (ko) | 2006-12-13 | 2008-06-12 | 재단법인서울대학교산학협력재단 | 평판 표시 장치의 화소 회로 |
EP2197584A4 (en) * | 2007-09-19 | 2011-08-03 | Sorenson Bioscience Inc | HOLDER FOR PIPETTE BITS AND ASSOCIATED METHODS |
NZ584963A (en) | 2007-10-02 | 2012-11-30 | Theranos Inc | Modular Point-of-care devices as addressible assay units with tips of assay units having interior to immobilize reagents by capillary action |
CA127470S (en) | 2008-08-21 | 2010-06-21 | Dna Genotek Inc | Sample collector |
WO2010065307A1 (en) * | 2008-12-02 | 2010-06-10 | Bayer Healthcare Llc | Sealed analyte sensor container systems and storage methods |
USD638953S1 (en) | 2009-05-12 | 2011-05-31 | Invitrogen Dynal As | Laboratory apparatus |
JP5690724B2 (ja) | 2009-06-04 | 2015-03-25 | ユニバーサル・バイオ・リサーチ株式会社 | 検体検査装置およびその方法 |
USD639975S1 (en) | 2009-12-18 | 2011-06-14 | Abbott Point Of Care, Inc. | Cartridge for sample analysis |
USD669169S1 (en) | 2009-12-23 | 2012-10-16 | Whole Life Designs, Inc. | Cup |
US20130183769A1 (en) * | 2010-09-17 | 2013-07-18 | Universal Bio Research Co., Ltd. | Cartridge and automatic analysis device |
USD649658S1 (en) | 2011-02-08 | 2011-11-29 | CSP Technolgies, Inc. | Vial |
SG193283A1 (en) | 2011-03-03 | 2013-10-30 | Life Technologies Corp | Sampling probes, systems, apparatuses, and methods |
CN103562720B (zh) | 2011-03-28 | 2016-08-17 | 美迪恩斯生命科技株式会社 | 全血检样的免疫测定方法和测定试剂盒 |
USD686311S1 (en) | 2011-05-10 | 2013-07-16 | Fujifilm Corporation | Cartridge for immunochromatographic test device |
CN102768826B (zh) | 2011-07-27 | 2015-08-12 | 京东方科技集团股份有限公司 | 一种扫描背光方法及装置 |
WO2013043203A2 (en) * | 2011-09-25 | 2013-03-28 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US20130116597A1 (en) * | 2011-11-04 | 2013-05-09 | Phenomenex, Inc. | Method and apparatus for acquiring blood for testing |
GB201119521D0 (en) | 2011-11-11 | 2011-12-21 | Axis Shield Asa | Assay cartridge |
USD682441S1 (en) | 2011-12-30 | 2013-05-14 | Samsung Electronics Co., Ltd. | Blood test machine |
TWD154473S (zh) | 2012-02-21 | 2013-07-01 | 尼普洛股份有限公司 | 血液迴路用連接器 |
USD694422S1 (en) | 2012-05-15 | 2013-11-26 | Wellstat Diagnostics, Llc | Diagnostic instrument and sample cassette combination |
US20150250456A1 (en) | 2012-06-27 | 2015-09-10 | Argeron Medikal Arastirma Sanayi Ve Ticaret Anonim Sirketi | Urine collecting and analyzing apparatus |
US9446406B2 (en) | 2012-06-29 | 2016-09-20 | Biocontrol Systems, Inc. | Sample collection and bioluminescent analysis system |
USD704348S1 (en) | 2013-02-08 | 2014-05-06 | Sysmex Corporation | Automatic analyzer |
BR112015023079B1 (pt) * | 2013-03-15 | 2020-12-29 | Cepheid | aparelho |
CN109738224B (zh) * | 2013-06-21 | 2021-07-16 | 伯乐生命医学产品有限公司 | 具有流体收集管的微流体系统 |
WO2015134053A1 (en) | 2014-03-04 | 2015-09-11 | Streck, Inc. | Improved sample tube with transparent tip having particular utility for nucleic acid amplification |
US10118177B2 (en) | 2014-06-02 | 2018-11-06 | Seahorse Bioscience | Single column microplate system and carrier for analysis of biological samples |
US20160051415A1 (en) | 2014-08-22 | 2016-02-25 | TCI Gene, Inc. | Dna collection kit and dna collecting method using the same |
JP2016133331A (ja) | 2015-01-16 | 2016-07-25 | ソニー株式会社 | 電気的測定用カートリッジ、生体試料用電気的測定装置及び生体試料用電気的測定方法 |
USD777940S1 (en) | 2015-02-19 | 2017-01-31 | Thermo Fisher Scientific Oy | Sample vessel |
USD830548S1 (en) | 2015-03-17 | 2018-10-09 | Intersurgical Ag | Accessory for medical care apparatus |
USD772086S1 (en) | 2015-04-27 | 2016-11-22 | IntegenX, Inc. | Housing for biochemical analysis apparatus |
USD774205S1 (en) | 2015-12-24 | 2016-12-13 | Beckman Coulter, Inc. | Diagnostic device |
USD785811S1 (en) | 2016-02-12 | 2017-05-02 | Illumina, Inc. | Sample preparation cartridge |
JP1583615S (ja) | 2016-04-15 | 2017-08-14 | ||
JP1571527S (ja) | 2016-08-15 | 2017-03-13 | ||
USD843009S1 (en) | 2016-10-14 | 2019-03-12 | Illumina, Inc. | Sample preparation cartridge |
USD821601S1 (en) | 2016-10-26 | 2018-06-26 | Shenzhen Edan Messer Diagnostics Co., Limited | Diagnostic medical device |
USD827859S1 (en) | 2017-06-02 | 2018-09-04 | Life Technologies Corporation | Electrophoresis and imaging system |
CN111432726A (zh) | 2017-11-02 | 2020-07-17 | 米密德诊断学有限公司 | 用于分析体液的卡盒及系统 |
CN107978280A (zh) | 2017-12-12 | 2018-05-01 | 北京京东方光电科技有限公司 | 一种背光模组驱动方法、装置、显示装置及背光模组 |
CN108227287B (zh) | 2018-01-26 | 2019-12-17 | 京东方科技集团股份有限公司 | 显示装置、虚拟现实显示设备及其控制方法 |
JP6694486B2 (ja) * | 2018-03-29 | 2020-05-13 | バイオティクス, インコーポレイテッド | 剛性を高められたピペットチップトレイ |
CN108694914B (zh) | 2018-07-30 | 2022-12-02 | 京东方科技集团股份有限公司 | 背光源驱动方法及其装置、可读存储介质和背光源 |
CN109192150B (zh) | 2018-11-01 | 2021-08-24 | 京东方科技集团股份有限公司 | 背光模组驱动方法及驱动结构、显示装置 |
TWI689913B (zh) | 2018-12-25 | 2020-04-01 | 友達光電股份有限公司 | 顯示裝置 |
CN109686320B (zh) | 2019-01-24 | 2020-05-15 | 厦门天马微电子有限公司 | 背光模组及其驱动方法、显示装置 |
CN109785800B (zh) | 2019-03-05 | 2020-12-22 | 北京大学深圳研究生院 | 一种微显示像素电路 |
CN111028767B (zh) | 2019-12-06 | 2021-03-16 | 深圳市华星光电半导体显示技术有限公司 | 像素电路及驱动方法 |
US11850596B2 (en) * | 2020-01-07 | 2023-12-26 | Integra Biosciences Ag | Pipette tip rack system |
CN111354319A (zh) | 2020-04-26 | 2020-06-30 | 福州京东方光电科技有限公司 | 一种显示模组及显示装置 |
CN111580304B (zh) | 2020-05-06 | 2021-09-24 | Tcl华星光电技术有限公司 | 背光模组、显示面板及电子装置 |
CN112331151A (zh) | 2020-11-09 | 2021-02-05 | Tcl华星光电技术有限公司 | 发光基板及显示装置 |
-
2018
- 2018-09-02 CN CN201880078086.6A patent/CN111432726A/zh active Pending
- 2018-09-02 JP JP2020524089A patent/JP7403447B2/ja active Active
- 2018-09-02 CA CA3079954A patent/CA3079954A1/en active Pending
- 2018-09-02 WO PCT/IL2018/050972 patent/WO2019087176A1/en active Application Filing
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- 2020-04-30 IL IL274377A patent/IL274377A/en unknown
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004531725A (ja) * | 2001-05-09 | 2004-10-14 | アクシス−シールド エイエスエイ | アッセイシステム |
JP2007178328A (ja) * | 2005-12-28 | 2007-07-12 | Shimadzu Corp | 反応容器キット及び反応容器処理装置 |
WO2011040504A1 (ja) * | 2009-09-30 | 2011-04-07 | 凸版印刷株式会社 | 核酸分析装置 |
JP2014528577A (ja) * | 2011-09-30 | 2014-10-27 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | ユニット化された試薬ストリップ |
JP2014211437A (ja) * | 2013-04-05 | 2014-11-13 | 協和メデックス株式会社 | 試薬ボトル用キャップおよび試薬容器 |
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