JP2021193152A - 銅化合物、亜鉛化合物、及びl−メントールを含有する組成物 - Google Patents
銅化合物、亜鉛化合物、及びl−メントールを含有する組成物 Download PDFInfo
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- JP2021193152A JP2021193152A JP2021162530A JP2021162530A JP2021193152A JP 2021193152 A JP2021193152 A JP 2021193152A JP 2021162530 A JP2021162530 A JP 2021162530A JP 2021162530 A JP2021162530 A JP 2021162530A JP 2021193152 A JP2021193152 A JP 2021193152A
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- Prior art keywords
- zinc
- copper
- compound
- menthol
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 29
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 title claims abstract description 28
- 239000005749 Copper compound Substances 0.000 title claims abstract description 17
- 150000001880 copper compounds Chemical class 0.000 title claims abstract description 17
- 150000003752 zinc compounds Chemical class 0.000 title claims abstract description 17
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 title description 3
- 241000894006 Bacteria Species 0.000 claims abstract description 18
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 40
- 206010006326 Breath odour Diseases 0.000 claims description 24
- 208000028169 periodontal disease Diseases 0.000 claims description 24
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 20
- 229940108925 copper gluconate Drugs 0.000 claims description 20
- 239000011592 zinc chloride Substances 0.000 claims description 20
- 235000005074 zinc chloride Nutrition 0.000 claims description 20
- 208000032139 Halitosis Diseases 0.000 claims description 19
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 14
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 12
- 239000010949 copper Substances 0.000 claims description 12
- 229910052802 copper Inorganic materials 0.000 claims description 12
- 229940108928 copper Drugs 0.000 claims description 12
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 11
- 239000011701 zinc Substances 0.000 claims description 11
- 229910052725 zinc Inorganic materials 0.000 claims description 11
- 210000003296 saliva Anatomy 0.000 claims description 10
- 230000028327 secretion Effects 0.000 claims description 7
- 239000011787 zinc oxide Substances 0.000 claims description 7
- 235000014692 zinc oxide Nutrition 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 5
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 4
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 4
- 229930002875 chlorophyll Natural products 0.000 claims description 4
- 235000019804 chlorophyll Nutrition 0.000 claims description 4
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims description 4
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 4
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 4
- 239000011667 zinc carbonate Substances 0.000 claims description 4
- 235000004416 zinc carbonate Nutrition 0.000 claims description 4
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 4
- 239000011670 zinc gluconate Substances 0.000 claims description 4
- 235000011478 zinc gluconate Nutrition 0.000 claims description 4
- 229960000306 zinc gluconate Drugs 0.000 claims description 4
- 229940098697 zinc laurate Drugs 0.000 claims description 4
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 4
- 229960001763 zinc sulfate Drugs 0.000 claims description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 3
- 229940012185 zinc palmitate Drugs 0.000 claims description 3
- 229940043810 zinc pyrithione Drugs 0.000 claims description 3
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 claims description 3
- ZNVKGUVDRSSWHV-UHFFFAOYSA-L zinc;4-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=C(S([O-])(=O)=O)C=C1.OC1=CC=C(S([O-])(=O)=O)C=C1 ZNVKGUVDRSSWHV-UHFFFAOYSA-L 0.000 claims description 3
- GPYYEEJOMCKTPR-UHFFFAOYSA-L zinc;dodecanoate Chemical compound [Zn+2].CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O GPYYEEJOMCKTPR-UHFFFAOYSA-L 0.000 claims description 3
- GJAPSKMAVXDBIU-UHFFFAOYSA-L zinc;hexadecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O GJAPSKMAVXDBIU-UHFFFAOYSA-L 0.000 claims description 3
- 229960000355 copper sulfate Drugs 0.000 claims description 2
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 claims description 2
- 229940079841 sodium copper chlorophyllin Drugs 0.000 claims description 2
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 claims description 2
- 229940105125 zinc myristate Drugs 0.000 claims description 2
- GBFLQPIIIRJQLU-UHFFFAOYSA-L zinc;tetradecanoate Chemical compound [Zn+2].CCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCC([O-])=O GBFLQPIIIRJQLU-UHFFFAOYSA-L 0.000 claims description 2
- 201000001245 periodontitis Diseases 0.000 abstract 2
- 239000000243 solution Substances 0.000 description 18
- 238000012360 testing method Methods 0.000 description 17
- 239000000126 substance Substances 0.000 description 15
- 239000002609 medium Substances 0.000 description 11
- 210000000214 mouth Anatomy 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- 229940034610 toothpaste Drugs 0.000 description 7
- 239000000606 toothpaste Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- -1 copper fluorosilicate Chemical compound 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 235000002639 sodium chloride Nutrition 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 229940051866 mouthwash Drugs 0.000 description 4
- 239000007935 oral tablet Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 3
- 240000001624 Espostoa lanata Species 0.000 description 3
- 235000009161 Espostoa lanata Nutrition 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241001135221 Prevotella intermedia Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229940042125 oral ointment Drugs 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 2
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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- 241000589892 Treponema denticola Species 0.000 description 2
- JVOGSHDZLOJKKR-MXFMKSRJSA-I [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O Chemical compound [Na+].[Na+].[Na+].[Mg++].CCc1c(C)c2cc3[n-]c(c(C)c3C=C)c(C)c3nc(C[C@H]3CCC([O-])=O)c(CC([O-])=O)c3[n-]c(cc1n2)c(C)c3C([O-])=O JVOGSHDZLOJKKR-MXFMKSRJSA-I 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 2
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- 210000004027 cell Anatomy 0.000 description 2
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- YEOCHZFPBYUXMC-UHFFFAOYSA-L copper benzoate Chemical compound [Cu+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 YEOCHZFPBYUXMC-UHFFFAOYSA-L 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 231100000676 disease causative agent Toxicity 0.000 description 2
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- 229910017053 inorganic salt Inorganic materials 0.000 description 2
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- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
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- 238000002156 mixing Methods 0.000 description 2
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
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- SHVRRGGZMBWAJT-ODZAUARKSA-N (z)-but-2-enedioic acid;copper Chemical compound [Cu].OC(=O)\C=C/C(O)=O SHVRRGGZMBWAJT-ODZAUARKSA-N 0.000 description 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
Description
口臭の原因物質であるVSCは、唾液中のタンパクや脱落上皮細胞あるいは食物残渣に存在するシステインやメチオニンといった成分を基質として口腔内細菌が代謝を行う際に産生されるものであって、口臭を根本的に抑制するには、歯周病と同様に、口腔内細菌の殺菌又は増殖を抑制することが必要不可欠である。
(1)銅化合物、亜鉛化合物、及びL−メントールを含有する、口腔用組成物。
(2)銅化合物が、硫酸銅、グルコン酸銅、銅クロロフィリンナトリウム、及び銅クロロフィルからなる群より選ばれる1種又は2種以上である、(1)に記載の組成物。
(3)亜鉛化合物が、酸化亜鉛、炭酸亜鉛、塩化亜鉛、硫酸亜鉛、グルコン酸亜鉛、ウンデシレン酸亜鉛、低温焼成酸化亜鉛、パラフェノールスルホン酸亜鉛、パルミチン酸亜鉛、ピリチオン亜鉛、ミリスチン酸亜鉛、及びラウリン酸亜鉛からなる群より選ばれる1種又は2種以上である、(1)又は(2)に記載の組成物。
(4)銅化合物がグルコン酸銅であり、亜鉛化合物が塩化亜鉛である(1)に記載の組成物。
(5)口臭及び/又は歯周病の、予防又は改善に用いられる(1)乃至(4)のいずれか1に記載の組成物。
本発明において用いられる上記の「銅化合物」、「亜鉛化合物」及び「L−メントール」は、医薬部外品、食品又は化粧品原料として市販されており、容易に入手でき、また、公知の方法で製造することもできる。
(1)被験物質
グルコン酸銅(以下、GCu)及び塩化亜鉛(以下、ZnCl2)は和光純薬工業製、L−メントール(以下、Men)は鈴木薄荷製のものを使用した。
(2)試験菌株
本試験には、口臭及び歯周病の原因菌としてよく知られているPrevotella intermedia ATCC 25611を使用した。
(3)試験方法:菌液調製
Prevotella intermediaはアネロコロンビアウサギ血液寒天培地(日本ベクトン・ディッキンソン)で35℃、48〜72時間嫌気培養後、滅菌生理食塩液を用いて懸濁し、約3.0×108 CFU/mLの菌液を調製した。さらにGAM brothを用いて約107 CFU/mLとなるように菌液を調製した。
(4)試験方法:試験液調製
グルコン酸銅、塩化亜鉛、L−メントールの被験物質を各終濃度となるように培地にて調製し、この9.9 容に対してPrevotella intermediaの菌液を各0.1容添加して試験液を調製した。これを35℃、嫌気条件下で24時間培養を行った後、1mLあたりの生菌数(CFU/mL)を測定した。
(5)試験結果
各被験物質及び対照(菌液のみ)の生菌数測定結果を、それぞれ表1及び図1に示す。表1及び図1より、グルコン酸銅(GCu)、塩化亜鉛(ZnCl2)及びL−メントール(Men)を併用することで口臭及び歯周病の原因菌に対して優れた抗菌作用が飛躍的に発現するという意外な結果が得られた。
(1)被験物質
グルコン酸銅及び塩化亜鉛は和光純薬工業製、L−メントールは鈴木薄荷製のものを使用した。
(2)使用動物
Slc:Wistar雄ラット[日本エスエルシー(株)]6週齢を購入し、検疫・馴化を行った。
(3)試験方法
検疫・馴化期間(7日間)を終了したラットをウレタン(1g/kg)及びα−クロラロース(25mg/kg)を腹腔内投与し麻酔を行い、気道確保のために気管カニューレを実施し、投与液の胃内流入を防ぐため、食道を縫合糸で結紮した。
次に、グルコン酸銅4mg/mL及び塩化亜鉛10mg/mLの混合物を媒体(4%カルボキシメチルセルロースナトリウム水溶液:CMC水溶液と称す)を用いて調製した被験物質投与液をマイクロピペットで口腔内に100μL投与した。
同様にして、グルコン酸銅4mg/mL、塩化亜鉛10mg/mL、及びL−メントール10mg/mLの混合物を媒体(4%カルボキシメチルセルロースナトリウム水溶液:CMC水溶液と称す)を用いて調製した被験物質投与液を、マイクロピペットで口腔内に100μL投与した。
なお、対照として、媒体(4%CMC水溶液)を口腔内に、被験物質と同量(100μL)を投与した。
媒体又は被験物質投与10分後に、風袋重量測定済みの綿球を用いて、口腔内の媒体又は投与液を拭い取った。拭き取り後の重量から風袋と媒体又は被験物質投与液の重量を差し引いて、投与中の唾液分泌量を概算した。
口腔内の媒体又は投与液を拭い取った直後に、口腔内に風袋重量測定済みの綿球を入れた。いずれの群についても、10分ごとに綿球を交換し、交換後の重量との差し引きで唾液分泌量を測定した。測定は30分後まで実施した。
(4)試験結果
各被験物質及び対照(媒体)投与から30分間の総唾液分泌量の測定結果(いずれもn=6)を、それぞれ表2及び図2に示す。
表2及び図2より、グルコン酸銅、塩化亜鉛及びL−メントールを併用することで対照と比較して約400倍もの優れた唾液分泌促進作用が発現するという意外な結果が得られた。
表3の成分及び分量をとり、常法に従ってペースト状の歯磨剤を製造する。
表4の成分及び分量をとり、常法に従って洗口液を製造する。
表5の成分及び分量をとり、常法に従って口腔内用軟膏を製造する。
表6の成分及び分量をとり、日局製剤総則「トローチ剤」の項に準じてトローチ剤を製造する。
表7の成分及び分量をとり、日局製剤総則「口腔用錠剤」の項に準じて口腔内用錠剤を
製造する。
Claims (6)
- 銅化合物、亜鉛化合物、及びL−メントールを含有する、口臭及び/又は歯周病の原因菌の殺菌又は増殖抑制のための口腔用組成物。
- 銅化合物、亜鉛化合物、及びL−メントールを含有する、唾液分泌促進のための口腔用組成物。
- 銅化合物が、硫酸銅、グルコン酸銅、銅クロロフィリンナトリウム、及び銅クロロフィルからなる群より選ばれる1種又は2種以上である、請求項1又は2に記載の組成物。
- 亜鉛化合物が、酸化亜鉛、炭酸亜鉛、塩化亜鉛、硫酸亜鉛、グルコン酸亜鉛、ウンデシレン酸亜鉛、低温焼成酸化亜鉛、パラフェノールスルホン酸亜鉛、パルミチン酸亜鉛、ピリチオン亜鉛、ミリスチン酸亜鉛、及びラウリン酸亜鉛からなる群より選ばれる1種又は2種以上である、請求項1又は2に記載の組成物。
- 銅化合物がグルコン酸銅であり、亜鉛化合物が塩化亜鉛である請求項1から4の何れか一項に記載の組成物。
- 口臭及び/又は歯周病の、予防又は改善に用いられる請求項1から5のいずれか1項に記載の組成物。
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JP3661741B2 (ja) * | 1997-12-24 | 2005-06-22 | ライオン株式会社 | 口臭抑制用口腔用組成物 |
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