JP2021101744A5 - - Google Patents
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- JP2021101744A5 JP2021101744A5 JP2021069163A JP2021069163A JP2021101744A5 JP 2021101744 A5 JP2021101744 A5 JP 2021101744A5 JP 2021069163 A JP2021069163 A JP 2021069163A JP 2021069163 A JP2021069163 A JP 2021069163A JP 2021101744 A5 JP2021101744 A5 JP 2021101744A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- recombinant
- cell
- mreb
- mutant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 13
- 238000004519 manufacturing process Methods 0.000 claims 12
- 102100021238 Dynamin-2 Human genes 0.000 claims 10
- 101000817607 Homo sapiens Dynamin-2 Proteins 0.000 claims 10
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 7
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000001002 morphogenetic effect Effects 0.000 claims 3
- 239000013587 production medium Substances 0.000 claims 3
- 230000014616 translation Effects 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 claims 2
- 108010013639 Peptidoglycan Proteins 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000019552 anatomical structure morphogenesis Effects 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241001455617 Sula Species 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
- 230000000921 morphogenic effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019015716 | 2019-01-31 | ||
| JP2019015716 | 2019-01-31 | ||
| JP2019142388 | 2019-08-01 | ||
| JP2019142388 | 2019-08-01 | ||
| JP2020560429A JP6968468B2 (ja) | 2019-01-31 | 2020-01-30 | 組換えタンパク質の製造方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560429A Division JP6968468B2 (ja) | 2019-01-31 | 2020-01-30 | 組換えタンパク質の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021101744A JP2021101744A (ja) | 2021-07-15 |
| JP2021101744A5 true JP2021101744A5 (OSRAM) | 2023-01-19 |
| JP7526489B2 JP7526489B2 (ja) | 2024-08-01 |
Family
ID=71840352
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560429A Active JP6968468B2 (ja) | 2019-01-31 | 2020-01-30 | 組換えタンパク質の製造方法 |
| JP2021069163A Active JP7526489B2 (ja) | 2019-01-31 | 2021-04-15 | 組換えタンパク質の製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560429A Active JP6968468B2 (ja) | 2019-01-31 | 2020-01-30 | 組換えタンパク質の製造方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220033870A1 (OSRAM) |
| EP (1) | EP3919506A4 (OSRAM) |
| JP (2) | JP6968468B2 (OSRAM) |
| CN (1) | CN113439087A (OSRAM) |
| BR (1) | BR112021014805A2 (OSRAM) |
| CA (1) | CA3127177A1 (OSRAM) |
| SG (1) | SG11202107697UA (OSRAM) |
| WO (1) | WO2020158877A1 (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021020546A1 (ja) * | 2019-08-01 | 2021-02-04 | Ｓｐｉｂｅｒ株式会社 | 組換え細胞及び組換えタンパク質の製造方法 |
| EP4476356A1 (en) * | 2022-03-24 | 2024-12-18 | Richter Gedeon Nyrt. | Method for the manufacture of biopharmaceuticals |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58110600A (ja) | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
| JPS60221091A (ja) | 1983-12-21 | 1985-11-05 | Kyowa Hakko Kogyo Co Ltd | 新規プロモ−タ− |
| JP2564268B2 (ja) | 1985-08-28 | 1996-12-18 | 協和醗酵工業株式会社 | 融合抗原ポリペプチド |
| JP2545078B2 (ja) | 1987-04-06 | 1996-10-16 | 協和醗酵工業株式会社 | 核酸関連物質の製造法 |
| EP0326046A3 (en) | 1988-01-25 | 1990-06-13 | Takeda Chemical Industries, Ltd. | Production of human epidermal growth factor |
| JPH0322979A (ja) | 1989-06-19 | 1991-01-31 | Kyowa Hakko Kogyo Co Ltd | 新規プラスミノーゲン活性化因子 |
| JP3012026B2 (ja) | 1991-03-05 | 2000-02-21 | ヒゲタ醤油株式会社 | 高発現ベクター及び該高発現ベクター を保有する微生物並びに該微生物を 用いる有用物質の製造法 |
| JP3433807B2 (ja) | 1992-03-31 | 2003-08-04 | 鵜高 重三 | 新規アミノ酸配列及び該アミノ酸配列をコードするｄｎａを保有する発現ベクターを組み込んだバチルス・ブレビスを用いる有用物質の製造法 |
| JP2727391B2 (ja) | 1992-07-23 | 1998-03-11 | ヒゲタ醤油株式会社 | 高発現ベクター及び該高発現ベクターを保有する微生物並びに該微生物を用いる有用物質の製造法 |
| JP2771756B2 (ja) | 1993-04-09 | 1998-07-02 | 東洋エンジニアリング株式会社 | 組換え大腸菌の培養方法 |
| CA2360085A1 (en) * | 1999-01-27 | 2000-08-03 | Elitra Pharmaceuticals, Inc. | Genes identified as required for proliferation in escherichia coli |
| JP3753945B2 (ja) | 2001-02-14 | 2006-03-08 | ヒゲタ醤油株式会社 | 大腸菌とブレビバチルス属細菌間のプラスミドシャトルベクター |
| KR100689932B1 (ko) * | 2002-03-06 | 2007-03-12 | 도레이 가부시끼가이샤 | 유전자 재조합 누에를 이용한 생리 활성 단백질 생산법 |
| KR100499647B1 (ko) * | 2002-09-25 | 2005-07-05 | 한국과학기술원 | 박테리아에서의 외래단백질의 생산성을 증가시키는 방법 |
| US8232377B2 (en) * | 2006-05-16 | 2012-07-31 | National Institute Of Advanced Industrial Science And Technology | Method for high-level secretory production of protein |
| BRPI0701826B1 (pt) * | 2007-03-16 | 2021-02-17 | Embrapa - Empresa Brasileira De Pesquisa Agropecuária | proteínas da teia de aranha nephilengys cruentata, avicularia juruensis e parawixia bistriata isoladas da biodiversidade brasileira |
| DK3147369T3 (da) * | 2014-05-21 | 2025-09-08 | Spiber Inc | Fremgangsmåde til produktion af fibroinlignende protein |
| CN105331568B (zh) * | 2014-06-12 | 2019-01-04 | 清华大学 | 一种通过增大细菌体积而增加微生物胞内内含物积累量的方法 |
| CN109563531A (zh) * | 2016-08-02 | 2019-04-02 | 丝芭博株式会社 | 重组蛋白的生产方法 |
-
2020
- 2020-01-30 JP JP2020560429A patent/JP6968468B2/ja active Active
- 2020-01-30 US US17/426,610 patent/US20220033870A1/en active Pending
- 2020-01-30 EP EP20749538.3A patent/EP3919506A4/en active Pending
- 2020-01-30 WO PCT/JP2020/003487 patent/WO2020158877A1/ja not_active Ceased
- 2020-01-30 CN CN202080011556.4A patent/CN113439087A/zh active Pending
- 2020-01-30 CA CA3127177A patent/CA3127177A1/en active Pending
- 2020-01-30 SG SG11202107697UA patent/SG11202107697UA/en unknown
- 2020-01-30 BR BR112021014805A patent/BR112021014805A2/pt unknown
-
2021
- 2021-04-15 JP JP2021069163A patent/JP7526489B2/ja active Active
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