JP2021095381A - 口腔内粘膜被覆用抗炎症性液状組成物、およびこれを用いた口内炎の予防および/または治療用医薬組成物 - Google Patents
口腔内粘膜被覆用抗炎症性液状組成物、およびこれを用いた口内炎の予防および/または治療用医薬組成物 Download PDFInfo
- Publication number
- JP2021095381A JP2021095381A JP2019229561A JP2019229561A JP2021095381A JP 2021095381 A JP2021095381 A JP 2021095381A JP 2019229561 A JP2019229561 A JP 2019229561A JP 2019229561 A JP2019229561 A JP 2019229561A JP 2021095381 A JP2021095381 A JP 2021095381A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- composition
- rosin
- liquid composition
- oral mucosa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 107
- 239000007788 liquid Substances 0.000 title claims abstract description 39
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 32
- 210000004877 mucosa Anatomy 0.000 title claims abstract description 5
- 208000003265 stomatitis Diseases 0.000 title claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 4
- 230000000069 prophylactic effect Effects 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims abstract description 68
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims abstract description 68
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims abstract description 68
- 229920001800 Shellac Polymers 0.000 claims abstract description 34
- 210000000214 mouth Anatomy 0.000 claims abstract description 34
- 229940113147 shellac Drugs 0.000 claims abstract description 34
- 239000004208 shellac Substances 0.000 claims abstract description 34
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims abstract description 34
- 235000013874 shellac Nutrition 0.000 claims abstract description 34
- 239000002904 solvent Substances 0.000 claims abstract description 19
- 239000004859 Copal Substances 0.000 claims abstract description 18
- 241000782205 Guibourtia conjugata Species 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 83
- 239000011248 coating agent Substances 0.000 claims description 32
- 238000000576 coating method Methods 0.000 claims description 32
- 210000002200 mouth mucosa Anatomy 0.000 claims description 24
- 239000004615 ingredient Substances 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 6
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 235000011187 glycerol Nutrition 0.000 claims description 4
- 230000003020 moisturizing effect Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 235000018330 Macadamia integrifolia Nutrition 0.000 claims description 2
- 240000000912 Macadamia tetraphylla Species 0.000 claims description 2
- 235000003800 Macadamia tetraphylla Nutrition 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 239000000739 antihistaminic agent Substances 0.000 claims description 2
- 229940125715 antihistaminic agent Drugs 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- -1 jojoba oil Substances 0.000 claims description 2
- 229940119170 jojoba wax Drugs 0.000 claims description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 2
- 239000010466 nut oil Substances 0.000 claims description 2
- 239000004006 olive oil Substances 0.000 claims description 2
- 235000008390 olive oil Nutrition 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000010497 wheat germ oil Substances 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 abstract description 19
- 238000001035 drying Methods 0.000 abstract description 15
- 206010061218 Inflammation Diseases 0.000 abstract description 7
- 230000004054 inflammatory process Effects 0.000 abstract description 7
- 230000005713 exacerbation Effects 0.000 abstract description 3
- 239000010408 film Substances 0.000 description 40
- 239000000243 solution Substances 0.000 description 39
- 230000000052 comparative effect Effects 0.000 description 30
- 239000011347 resin Substances 0.000 description 18
- 229920005989 resin Polymers 0.000 description 18
- 230000007794 irritation Effects 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 206010052428 Wound Diseases 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 239000002324 mouth wash Substances 0.000 description 6
- 229940051866 mouthwash Drugs 0.000 description 6
- 210000003296 saliva Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 206010028034 Mouth ulceration Diseases 0.000 description 5
- 208000007117 Oral Ulcer Diseases 0.000 description 5
- 208000028169 periodontal disease Diseases 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 229960002117 triamcinolone acetonide Drugs 0.000 description 5
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000001856 Ethyl cellulose Substances 0.000 description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
- 229920001249 ethyl cellulose Polymers 0.000 description 4
- 235000019325 ethyl cellulose Nutrition 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 229920002689 polyvinyl acetate Polymers 0.000 description 4
- 239000011118 polyvinyl acetate Substances 0.000 description 4
- 229940124597 therapeutic agent Drugs 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 239000000020 Nitrocellulose Substances 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 3
- 235000015218 chewing gum Nutrition 0.000 description 3
- 229940112822 chewing gum Drugs 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 229920001220 nitrocellulos Polymers 0.000 description 3
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CQVWXNBVRLKXPE-UHFFFAOYSA-N 2-octyl cyanoacrylate Chemical compound CCCCCCC(C)OC(=O)C(=C)C#N CQVWXNBVRLKXPE-UHFFFAOYSA-N 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 241000016649 Copaifera officinalis Species 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- RSWGJHLUYNHPMX-ONCXSQPRSA-N abietic acid Chemical compound C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(O)=O RSWGJHLUYNHPMX-ONCXSQPRSA-N 0.000 description 2
- 239000003082 abrasive agent Substances 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229940042125 oral ointment Drugs 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- WKJGTOYAEQDNIA-IOOZKYRYSA-N (6r,7r)-7-[[(2r)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate Chemical compound O.C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 WKJGTOYAEQDNIA-IOOZKYRYSA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- 108010062580 Concanavalin A Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 208000034619 Gingival inflammation Diseases 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000003814 Interleukin-10 Human genes 0.000 description 1
- 108090000174 Interleukin-10 Proteins 0.000 description 1
- 102000013691 Interleukin-17 Human genes 0.000 description 1
- 108050003558 Interleukin-17 Proteins 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- FPVRUILUEYSIMD-RPRRAYFGSA-N [(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(OC(C)=O)[C@@]1(C)C[C@@H]2O FPVRUILUEYSIMD-RPRRAYFGSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229960003657 dexamethasone acetate Drugs 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 239000003966 growth inhibitor Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- RPQUGMLCZLGZTG-UHFFFAOYSA-N octyl cyanoacrylate Chemical compound CCCCCCCCOC(=O)C(=C)C#N RPQUGMLCZLGZTG-UHFFFAOYSA-N 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000011297 pine tar Substances 0.000 description 1
- 229940068124 pine tar Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000003009 skin protective agent Substances 0.000 description 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L93/00—Compositions of natural resins; Compositions of derivatives thereof
- C08L93/02—Shellac
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L93/00—Compositions of natural resins; Compositions of derivatives thereof
- C08L93/04—Rosin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Insects & Arthropods (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Animal Husbandry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
下記の手法により、実施例および比較例の液状組成物を調製した。各実施例および各比較例における各原料の配合量を下記の表1に示す。また、各実施例および各比較例における各構成成分の配合量を下記の表2に示す。なお、表1および表2に記載の実施例および比較例は、原則として樹脂の濃度が小さいものから順に配置されている。
ガムロジン(LAWTER ARGENTINA S.A.製)10.0重量%、ラックコート50EDS(50%セラックエタノール溶液)(日本シェラック工業株式会社製)80.0重量%、コパールHJ−01(30%コパールエタノール溶液)(株式会社岐阜セラック製造所製)3.3重量%、エタノール(99.5)今津1級(無水エタノール)(今津薬品工業株式会社製)6.7重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン8.0重量%、ラックコート50EDS 80.0重量%、コパールHJ−01 6.7重量%、エタノール(99.5)今津1級5.3重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン6.0重量%、ラックコート50EDS 80.0重量%、コパールHJ−01 13.3重量%、エタノール(99.5)今津1級0.7重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン10.0重量%、ラックコート50EDS 80.0重量%、エタノール(99.5)今津1級10.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン10.0重量%、ラックコート50EDS 70.0重量%、コパールHJ−01 16.7重量%、エタノール(99.5)今津1級3.3重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン10.0重量%、ラックコート50EDS 76.0重量%、コパールHJ−01 3.3重量%、エタノール(99.5)今津1級10.7重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン1.0重量%、ラックコート50EDS 80.0重量%、コパールHJ−01を40%エタノール溶液にまで濃縮した液15.0重量%、エタノール(99.5)今津1級4.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン3.0重量%、ラックコート50EDS 80.0重量%、コパールHJ−01を40%エタノール溶液にまで濃縮した液10.0重量%、エタノール(99.5)今津1級7.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン6.0重量%、ラックコート50EDS 80.0重量%、コパールHJ−01を40%エタノール溶液にまで濃縮した液2.5重量%、エタノール(99.5)今津1級11.5重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン33.3重量%、ラックコート50EDS 66.7重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン30.0重量%、ラックコート50EDS 60.0重量%、エタノール(99.5)今津1級10.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン10.0重量%、ラックコート50EDSを70%エタノール溶液にまで濃縮した液71.4重量%、エタノール(99.5)今津1級18.6重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン33.3重量%、コパールHJ−01 66.7重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン25.0重量%、ラックコート50EDS 50.0重量%、エタノール(99.5)今津1級25.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン10.0重量%、ラックコート50EDS 50.0重量%、コパールHJ−01 40.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン17.0重量%、ラックコート50EDS 80.0重量%、エタノール(99.5)今津1級3.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン8.0重量%、ラックコート50EDS 64.0重量%、コパールHJ−01 1.7重量%、エタノール(99.5)今津1級26.3重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン10.0重量%、ラックコート50EDS 60.0重量%、エタノール(99.5)今津1級30.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン10.0重量%、ラックコート50EDS 50.0重量%、エタノール(99.5)今津1級40.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン5.0重量%、ラックコート50EDS 30.0重量%、エタノール(99.5)今津1級65.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
ガムロジン50.0重量%、エタノール(99.5)今津1級50.0重量%を撹拌機にてよく混合溶解し、均一な溶液の組成物を得た。
上述した各実施例および各比較例において調製された液状組成物について、人体の口腔内の粘膜に対する刺激性、塗布された被膜の感触、塗布された被膜の速乾性および持続性について、5名の評価パネルを用いた官能試験を行った。
被験者5名に対して、口腔内粘膜である下唇裏側の唾液を拭き取った後に液状組成物を塗布したときの刺激の程度を下記の0〜2の3段階で評価して、5名の結果の平均値を算出した。また、平均値として1.5未満であれば実用上問題ないものと判断した。結果を下記の表3に示す:
刺激性:
ほとんど刺激を感じない=0
わずかに刺激を感じる=1
刺激を感じる=2。
被験者5名に対して、口腔内粘膜である下唇裏側の唾液を拭き取った後に液状組成物を塗布し、被膜が形成されるまで乾燥させた。その後、被膜表面の下や口腔内の感触、すなわち、被膜表面のつっぱり感やごわごわ感を下記の0〜2の3段階で評価して、5名の結果の平均値を算出した。また、平均値として1.5未満であれば実用上問題ないものと判断した。結果を下記の表3に示す:
ごわごわ感:
まったくごわごわしない=0
少しごわごわした感じがある=1
ごわごわして気になる=2。
被験者5名に対して、口腔内粘膜である下唇裏側の唾液を拭き取った後に液状組成物を塗布し、10秒後に被膜の乾燥度を指先でチェックした。さらに20秒後に改めて乾燥度を指先でチェックし、下記の0〜2の3段階で評価して、5名の結果の平均値を算出した。また、平均値として1.5未満であれば実用上問題ないものと判断した。結果を下記の表3に示す:
速乾性:
10秒以内で指先のべたべた感がなくなる=0
20秒以内で指先のべたべた感がなくなる=1
20秒を経過しても指先のべたべた感がなくならない=2。
被験者5名に対して、下唇裏側および上歯茎外側に液状組成物を塗布した。次いで、1時間ごとに被覆物が残留しているか否かを確認した。この際、1時間目のチェック後に水を飲むか軽くうがいをした。また、2時間目のチェック後に食事をした。さらに、3時間目以降は水および食事の摂取は自由とした。
Claims (9)
- ロジンおよびセラックと、
溶媒と、
を含有し、
前記ロジンの含有量が組成物の全量に対して1重量%以上15重量%以下であり、
前記セラックの含有量が組成物の全量に対して35重量%以上45重量%以下であり、
ロジン、セラックおよびコパールの合計含有量が組成物の全量に対して45重量%以上55重量%以下である、口腔内粘膜被覆用抗炎症性液状組成物。 - コパールをさらに含有する、請求項1に記載の口腔内粘膜被覆用抗炎症性液状組成物。
- 前記コパールの含有量が組成物の全量に対して0重量%を超えて10重量%以下である、請求項2に記載の口腔内粘膜被覆用抗炎症性液状組成物。
- 前記溶媒がエタノールを含む、請求項1〜3のいずれか1項に記載の口腔内粘膜被覆用抗炎症性液状組成物。
- 薬効成分および/または保湿成分を含む副成分をさらに含有する、請求項1〜4のいずれか1項に記載の口腔内粘膜被覆用抗炎症性液状組成物。
- 前記副成分の含有量が組成物の全量に対して1重量%以下である、請求項5に記載の口腔内粘膜被覆用抗炎症性液状組成物。
- 前記薬効成分が、抗炎症剤、抗ヒスタミン剤、消炎鎮痛剤、抗生物質、ビタミン剤、生薬および漢方製剤からなる群から選択される1種または2種以上を含む、請求項5または6に記載の口腔内粘膜被覆用抗炎症性液状組成物。
- 前記保湿成分が、グリセリン、小麦胚芽油、マカデミアナッツ油、オリーブ油、ホホバ油、ヒマシ油および植物抽出成分からなる群から選択される1種または2種以上を含む、請求項5〜7のいずれか1項に記載の口腔内粘膜被覆用抗炎症性液状組成物。
- 請求項1〜8のいずれか1項に記載の口腔内粘膜被覆用抗炎症性液状組成物からなる、口内炎の予防および/または治療用医薬組成物。
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019229561A JP6806388B1 (ja) | 2019-12-19 | 2019-12-19 | 口腔内粘膜被覆用抗炎症性液状組成物、およびこれを用いた口内炎の予防および/または治療用医薬組成物 |
TW109144809A TW202135847A (zh) | 2019-12-19 | 2020-12-17 | 口腔內黏膜被覆用抗炎性液狀組成物、及使用其之口內炎之預防及/或治療用醫藥組成物 |
US17/783,547 US20230017654A1 (en) | 2019-12-19 | 2020-12-18 | Anti-inflammatory liquid composition for covering oral mucosa and pharmaceutical composition for prevention and/or treatment of stomatitis using same |
PCT/JP2020/047388 WO2021125315A1 (ja) | 2019-12-19 | 2020-12-18 | 口腔内粘膜被覆用抗炎症性液状組成物、およびこれを用いた口内炎の予防および/または治療用医薬組成物 |
CN202080082826.0A CN114746082B (zh) | 2019-12-19 | 2020-12-18 | 口腔内黏膜涂覆用消炎性液态组合物、及采用该组合物的口腔炎预防和/或治疗用药物组合物 |
EP20902159.1A EP4079281A4 (en) | 2019-12-19 | 2020-12-18 | ANTI-INFLAMMATORY LIQUID COMPOSITION FOR COVERING THE BUCCAL MUCOSA, AND MEDICINAL COMPOSITION FOR THE PREVENTION AND/OR TREATMENT OF STOMATITIS USING THE SAME |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019229561A JP6806388B1 (ja) | 2019-12-19 | 2019-12-19 | 口腔内粘膜被覆用抗炎症性液状組成物、およびこれを用いた口内炎の予防および/または治療用医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP6806388B1 JP6806388B1 (ja) | 2021-01-06 |
JP2021095381A true JP2021095381A (ja) | 2021-06-24 |
Family
ID=73993008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019229561A Active JP6806388B1 (ja) | 2019-12-19 | 2019-12-19 | 口腔内粘膜被覆用抗炎症性液状組成物、およびこれを用いた口内炎の予防および/または治療用医薬組成物 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20230017654A1 (ja) |
EP (1) | EP4079281A4 (ja) |
JP (1) | JP6806388B1 (ja) |
CN (1) | CN114746082B (ja) |
TW (1) | TW202135847A (ja) |
WO (1) | WO2021125315A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7109827B1 (ja) | 2021-11-16 | 2022-08-01 | 株式会社ハニック・ホワイトラボ | 抗ウイルス剤 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0637386B2 (ja) * | 1985-12-13 | 1994-05-18 | ライオン株式会社 | 口腔用滞留型基剤 |
JPH0466523A (ja) | 1990-07-04 | 1992-03-02 | Kanebo Ltd | 歯周病菌の増殖抑制剤 |
AU2004268452B2 (en) * | 2003-08-27 | 2011-02-03 | Hanix Co., Ltd | Tooth Coating Composition |
US20050175552A1 (en) * | 2004-02-10 | 2005-08-11 | Hoic Diego A. | Tooth coating compositions and methods therefor |
GB0514943D0 (en) | 2005-07-20 | 2005-08-24 | Botan Ltd | Oral care compositions |
US20090142282A1 (en) * | 2007-12-04 | 2009-06-04 | Jonathan Lee Kendall | High-solids alcoholic solutions of rosin esters for varnish applications |
RU2367407C1 (ru) * | 2007-12-21 | 2009-09-20 | Закрытое акционерное общество "Опытно-экспериментальный завод "ВладМиВа" | Лак стоматологический |
AR071183A1 (es) * | 2008-04-04 | 2010-06-02 | Colgate Palmolive Co | Composicion oral que comprende un componente activo y un componente formador de pelicula adhesiva, metodo |
JP2011162470A (ja) * | 2010-02-09 | 2011-08-25 | Gc Corp | 歯牙用被覆材 |
KR101759525B1 (ko) * | 2016-12-01 | 2017-07-31 | (주)메디케이 | 치아 코팅제 및 조성물 |
-
2019
- 2019-12-19 JP JP2019229561A patent/JP6806388B1/ja active Active
-
2020
- 2020-12-17 TW TW109144809A patent/TW202135847A/zh unknown
- 2020-12-18 EP EP20902159.1A patent/EP4079281A4/en active Pending
- 2020-12-18 WO PCT/JP2020/047388 patent/WO2021125315A1/ja unknown
- 2020-12-18 US US17/783,547 patent/US20230017654A1/en active Pending
- 2020-12-18 CN CN202080082826.0A patent/CN114746082B/zh active Active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7109827B1 (ja) | 2021-11-16 | 2022-08-01 | 株式会社ハニック・ホワイトラボ | 抗ウイルス剤 |
WO2023089865A1 (ja) * | 2021-11-16 | 2023-05-25 | 株式会社ハニック・ホワイトラボ | 抗ウイルス剤 |
JP2023073719A (ja) * | 2021-11-16 | 2023-05-26 | 株式会社ハニック・ホワイトラボ | 抗ウイルス剤 |
Also Published As
Publication number | Publication date |
---|---|
WO2021125315A1 (ja) | 2021-06-24 |
US20230017654A1 (en) | 2023-01-19 |
EP4079281A1 (en) | 2022-10-26 |
TW202135847A (zh) | 2021-10-01 |
EP4079281A4 (en) | 2023-01-25 |
CN114746082A (zh) | 2022-07-12 |
JP6806388B1 (ja) | 2021-01-06 |
CN114746082B (zh) | 2024-03-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9161909B2 (en) | Adhesive compositions for the treatment of xerostomia | |
US4307075A (en) | Topical treatment of aphthous stomatitis | |
US4713243A (en) | Bioadhesive extruded film for intra-oral drug delivery and process | |
US8182843B2 (en) | Herbal compositions for the treatment of diseases of the oral cavity | |
US20090117059A1 (en) | Compositions and methods of use thereof, for the treatment of oral pain, comprising cloves or extracts thereof in combination with a steroid | |
EP2037941B1 (en) | Cobalamin compositions for treating or preventing mucositis | |
JPH059412B2 (ja) | ||
EP1814564B1 (en) | Transmucosal oral delivery device | |
US20090053309A1 (en) | Adhesive compositions for the treatment of xerostomia | |
TWI532504B (zh) | 用於口腔保健組成物之不含對羥基苯甲酸酯的防腐劑系統 | |
KR102182976B1 (ko) | 치아 또는 치아 주변 조직 부착용 패치 | |
JP6806388B1 (ja) | 口腔内粘膜被覆用抗炎症性液状組成物、およびこれを用いた口内炎の予防および/または治療用医薬組成物 | |
EP2954902B1 (fr) | Composition à base d'extrait de pépin de pamplemousse, d'extrait de feuille d'alchémille, d'extrait de stevia et de curcumine | |
EP3656370A1 (en) | Pharmaceutical composition and its use for the prevention and treatment of oral cavity pathologies | |
US20220023426A1 (en) | Oral mucosal carrier and protectant | |
KR102569590B1 (ko) | 필름형 치약 | |
KR102151313B1 (ko) | 구강 패치 | |
JPH0696518B2 (ja) | 口腔内製剤 | |
AU2021277766A1 (en) | Oral Composition Incorporating Denture Adhesive Gel |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191219 |
|
A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20191219 |
|
A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20200123 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200120 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200218 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200416 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20200630 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200914 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20200914 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20200924 |
|
C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20200929 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20201110 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20201127 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6806388 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |