JP2020537489A5 - - Google Patents

Info

Publication number

JP2020537489A5

JP2020537489A5 JP2020506917A JP2020506917A JP2020537489A5 JP 2020537489 A5 JP2020537489 A5 JP 2020537489A5 JP 2020506917 A JP2020506917 A JP 2020506917A JP 2020506917 A JP2020506917 A JP 2020506917A JP 2020537489 A5 JP2020537489 A5 JP 2020537489A5

Authority

JP

Japan

Prior art keywords

gfp

variant

domain

sensor molecule

sample

Prior art date

2018-08-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 21
• 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 21
• 239000005090 green fluorescent protein Substances 0.000 claims 21
• 102000040945 Transcription factor Human genes 0.000 claims 8
• 108091023040 Transcription factor Proteins 0.000 claims 8
• 230000035945 sensitivity Effects 0.000 claims 8
• 108060001084 Luciferase Proteins 0.000 claims 7
• 239000005089 Luciferase Substances 0.000 claims 7
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 6
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 6
• 150000001720 carbohydrates Chemical class 0.000 claims 6
• 235000014633 carbohydrates Nutrition 0.000 claims 6
• 239000000539 dimer Substances 0.000 claims 6
• 108010048367 enhanced green fluorescent protein Proteins 0.000 claims 6
• 108010021843 fluorescent protein 583 Proteins 0.000 claims 6
• 229960001375 lactose Drugs 0.000 claims 6
• 239000008101 lactose Substances 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 claims 5
• 229960000511 lactulose Drugs 0.000 claims 5
• PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 claims 5
• 102000004169 proteins and genes Human genes 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 102000034287 fluorescent proteins Human genes 0.000 claims 4
• 108091006047 fluorescent proteins Proteins 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 claims 3
• 101001023784 Heteractis crispa GFP-like non-fluorescent chromoprotein Proteins 0.000 claims 3
• 230000001580 bacterial effect Effects 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 108010054624 red fluorescent protein Proteins 0.000 claims 3
• 238000002165 resonance energy transfer Methods 0.000 claims 3
• 108010038196 saccharide-binding proteins Proteins 0.000 claims 3
• -1 t-HcRed Proteins 0.000 claims 3
• 239000011031 topaz Substances 0.000 claims 3
• 229910052853 topaz Inorganic materials 0.000 claims 3
• NNMALANKTSRILL-LXENMSTPSA-N 3-[(2z,5e)-2-[[3-(2-carboxyethyl)-5-[(z)-[(3e,4r)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl]-4-methyl-1h-pyrrol-2-yl]methylidene]-5-[(4-ethyl-3-methyl-5-oxopyrrol-2-yl)methylidene]-4-methylpyrrol-3-yl]propanoic acid Chemical compound O=C1C(CC)=C(C)C(\C=C\2C(=C(CCC(O)=O)C(=C/C3=C(C(C)=C(\C=C/4\C(\[C@@H](C)C(=O)N\4)=C\C)N3)CCC(O)=O)/N/2)C)=N1 NNMALANKTSRILL-LXENMSTPSA-N 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 235000013365 dairy product Nutrition 0.000 claims 2
• 108010000239 Aequorin Proteins 0.000 claims 1
• 241000059559 Agriotes sordidus Species 0.000 claims 1
• 108090000363 Bacterial Luciferases Proteins 0.000 claims 1
• 241000700108 Ctenophora <comb jellyfish phylum> Species 0.000 claims 1
• 108090000331 Firefly luciferases Proteins 0.000 claims 1
• 241000963438 Gaussia <copepod> Species 0.000 claims 1
• 241000131894 Lampyris noctiluca Species 0.000 claims 1
• 102000006830 Luminescent Proteins Human genes 0.000 claims 1
• 108010047357 Luminescent Proteins Proteins 0.000 claims 1
• 241000522587 Oplophorus gracilirostris Species 0.000 claims 1
• 102000007982 Phosphoproteins Human genes 0.000 claims 1
• 108010089430 Phosphoproteins Proteins 0.000 claims 1
• 108010052090 Renilla Luciferases Proteins 0.000 claims 1
• 241001136903 Rhagoletis pomonella Species 0.000 claims 1
• 150000002016 disaccharides Chemical class 0.000 claims 1
• 235000013336 milk Nutrition 0.000 claims 1
• 239000008267 milk Substances 0.000 claims 1
• 210000004080 milk Anatomy 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1