JP2020536519A5 - - Google Patents
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- Publication number
- JP2020536519A5 JP2020536519A5 JP2020517799A JP2020517799A JP2020536519A5 JP 2020536519 A5 JP2020536519 A5 JP 2020536519A5 JP 2020517799 A JP2020517799 A JP 2020517799A JP 2020517799 A JP2020517799 A JP 2020517799A JP 2020536519 A5 JP2020536519 A5 JP 2020536519A5
- Authority
- JP
- Japan
- Prior art keywords
- promoter
- nucleotide sequence
- sequence encoding
- construct according
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims 19
- 239000002773 nucleotide Substances 0.000 claims 15
- 125000003729 nucleotide group Chemical group 0.000 claims 15
- 241000700605 Viruses Species 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 206010019280 Heart failures Diseases 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 102100025215 CCN family member 5 Human genes 0.000 claims 7
- 101000934220 Homo sapiens CCN family member 5 Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 230000002068 genetic effect Effects 0.000 claims 5
- 238000003259 recombinant expression Methods 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 241000700618 Vaccinia virus Species 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000007469 Actins Human genes 0.000 claims 1
- 108010085238 Actins Proteins 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims 1
- 101100232904 Homo sapiens IL2 gene Proteins 0.000 claims 1
- 101100232919 Homo sapiens IL4 gene Proteins 0.000 claims 1
- 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 claims 1
- 101150103227 IFN gene Proteins 0.000 claims 1
- 241000713666 Lentivirus Species 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 241001672814 Porcine teschovirus 1 Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 239000013601 cosmid vector Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 239000013600 plasmid vector Substances 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2017-0127442 | 2017-09-29 | ||
| KR20170127442 | 2017-09-29 | ||
| PCT/KR2018/011521 WO2019066548A2 (ko) | 2017-09-29 | 2018-09-28 | 심부전의 예방 또는 치료용 약학적 조성물 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536519A JP2020536519A (ja) | 2020-12-17 |
| JP2020536519A5 true JP2020536519A5 (enExample) | 2021-11-04 |
| JP7240749B2 JP7240749B2 (ja) | 2023-03-16 |
Family
ID=65902613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517799A Active JP7240749B2 (ja) | 2017-09-29 | 2018-09-28 | 心不全の予防または治療のための医薬組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12215362B2 (enExample) |
| EP (1) | EP3690054B1 (enExample) |
| JP (1) | JP7240749B2 (enExample) |
| KR (1) | KR102712841B1 (enExample) |
| CN (1) | CN111465697B (enExample) |
| WO (1) | WO2019066548A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2953301B2 (es) * | 2023-09-25 | 2024-06-03 | Univ Madrid Complutense | Péptido para el tratamiento de enfermedades cardiacas |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US20090239940A1 (en) | 1997-07-22 | 2009-09-24 | Del Monte Federica | Treating heart failure and ventricular arrhythmias |
| DK1027437T3 (da) * | 1997-10-29 | 2008-11-24 | Genentech Inc | Anvendelse af det WNT-1 inducerede udskilte polypeptid WISP-1 |
| EP1783228A1 (en) * | 2005-11-08 | 2007-05-09 | ETH Zürich | Recombinant expression of multiprotein complexes using polygenes |
| KR101187814B1 (ko) * | 2010-03-22 | 2012-10-08 | 광주과학기술원 | 심부전 예방 또는 치료용 약제학적 조성물 및 심부전 예방 또는 치료제의 스크리닝 방법 |
| US20180099029A9 (en) * | 2010-04-15 | 2018-04-12 | Mount Sinai School Of Medicine | Serca2 therapeutic compositions and methods of use |
| CN103648506A (zh) * | 2011-07-13 | 2014-03-19 | 西奈山伊坎医学院 | Serca2a的sumo化和心血管疾病 |
| ES2717175T3 (es) * | 2013-02-01 | 2019-06-19 | Selexis Sa | Expresión mejorada de transgenes y procesamiento |
| JP2017531652A (ja) * | 2014-10-06 | 2017-10-26 | アルスロジェン ビー．ブイ．Ａｒｔｈｒｏｇｅｎ Ｂ．Ｖ． | Ａａｖに基づく遺伝子治療 |
| MA43404A (fr) | 2015-11-11 | 2018-10-17 | Intrexon Corp | Compositions et procédés d'expression de multiples polypeptides biologiquement actifs à partir d'un seul vecteur pour le traitement d'affections et autres pathologies cardiaques |
| CN108778311A (zh) | 2015-11-13 | 2018-11-09 | 贝特基因 | 用于治疗心脏纤维化的药物组合物 |
| WO2019066556A1 (ko) * | 2017-09-29 | 2019-04-04 | (주)벳바젠 | 심장 부정맥의 예방 또는 치료용 약학적 조성물 |
-
2018
- 2018-09-28 JP JP2020517799A patent/JP7240749B2/ja active Active
- 2018-09-28 EP EP18861326.9A patent/EP3690054B1/en active Active
- 2018-09-28 CN CN201880077631.XA patent/CN111465697B/zh active Active
- 2018-09-28 US US16/651,779 patent/US12215362B2/en active Active
- 2018-09-28 WO PCT/KR2018/011521 patent/WO2019066548A2/ko not_active Ceased
- 2018-09-28 KR KR1020180115915A patent/KR102712841B1/ko active Active
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