JP2020536507A5 - - Google Patents
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- JP2020536507A5 JP2020536507A5 JP2020515692A JP2020515692A JP2020536507A5 JP 2020536507 A5 JP2020536507 A5 JP 2020536507A5 JP 2020515692 A JP2020515692 A JP 2020515692A JP 2020515692 A JP2020515692 A JP 2020515692A JP 2020536507 A5 JP2020536507 A5 JP 2020536507A5
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- JP
- Japan
- Prior art keywords
- seq
- nos
- amino acid
- acid sequence
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 127
- 102000025171 antigen binding proteins Human genes 0.000 claims description 106
- 108091000831 antigen binding proteins Proteins 0.000 claims description 106
- 102000003859 Claudin-6 Human genes 0.000 claims description 65
- 108090000229 Claudin-6 Proteins 0.000 claims description 65
- 210000004027 cell Anatomy 0.000 claims description 57
- 150000001413 amino acids Chemical class 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 24
- 108020001507 fusion proteins Proteins 0.000 claims description 21
- 102000037865 fusion proteins Human genes 0.000 claims description 21
- 206010028980 Neoplasm Diseases 0.000 claims description 20
- 201000011510 cancer Diseases 0.000 claims description 17
- 102000004106 Claudin-3 Human genes 0.000 claims description 15
- 108090000599 Claudin-3 Proteins 0.000 claims description 15
- 108090000601 Claudin-4 Proteins 0.000 claims description 15
- 102000004161 Claudin-4 Human genes 0.000 claims description 15
- 108050007295 Claudin-9 Proteins 0.000 claims description 15
- 102000018157 Claudin-9 Human genes 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 102000039446 nucleic acids Human genes 0.000 claims description 12
- 108020004707 nucleic acids Proteins 0.000 claims description 12
- 150000007523 nucleic acids Chemical class 0.000 claims description 12
- 239000013598 vector Substances 0.000 claims description 10
- 230000004614 tumor growth Effects 0.000 claims description 9
- 241000699670 Mus sp. Species 0.000 claims description 6
- 238000003556 assay Methods 0.000 claims description 6
- 239000006143 cell culture medium Substances 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 206010005003 Bladder cancer Diseases 0.000 claims description 4
- 206010014733 Endometrial cancer Diseases 0.000 claims description 4
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 230000000996 additive effect Effects 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 230000012010 growth Effects 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 230000005764 inhibitory process Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000523 sample Substances 0.000 claims description 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 4
- 230000006907 apoptotic process Effects 0.000 claims description 3
- 210000004881 tumor cell Anatomy 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 229920001817 Agar Polymers 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 230000002018 overexpression Effects 0.000 claims description 2
- 230000036039 immunity Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000027455 binding Effects 0.000 description 11
- 230000002611 ovarian Effects 0.000 description 7
- 230000003993 interaction Effects 0.000 description 6
- 238000012875 competitive assay Methods 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 210000005265 lung cell Anatomy 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 210000003443 bladder cell Anatomy 0.000 description 2
- 210000005168 endometrial cell Anatomy 0.000 description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 2
- 210000003494 hepatocyte Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 102100032306 Aurora kinase B Human genes 0.000 description 1
- 101000798306 Homo sapiens Aurora kinase B Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024099523A JP2024150445A (ja) | 2017-09-18 | 2024-06-20 | クローディン６抗体及びがんを治療するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560143P | 2017-09-18 | 2017-09-18 | |
| US62/560,143 | 2017-09-18 | ||
| PCT/US2018/051610 WO2019056023A2 (en) | 2017-09-18 | 2018-09-18 | ANTIBODIES AGAINST CLAUDIN 6 AND METHODS OF TREATING CANCER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024099523A Division JP2024150445A (ja) | 2017-09-18 | 2024-06-20 | クローディン６抗体及びがんを治療するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020536507A JP2020536507A (ja) | 2020-12-17 |
| JP2020536507A5 true JP2020536507A5 (https=) | 2021-10-28 |
| JP7599332B2 JP7599332B2 (ja) | 2024-12-13 |
Family
ID=65723110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515692A Active JP7599332B2 (ja) | 2017-09-18 | 2018-09-18 | クローディン６抗体及びがんを治療するための方法 |
| JP2024099523A Pending JP2024150445A (ja) | 2017-09-18 | 2024-06-20 | クローディン６抗体及びがんを治療するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024099523A Pending JP2024150445A (ja) | 2017-09-18 | 2024-06-20 | クローディン６抗体及びがんを治療するための方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20200291111A1 (https=) |
| EP (2) | EP3826667B1 (https=) |
| JP (2) | JP7599332B2 (https=) |
| KR (2) | KR102793719B1 (https=) |
| CN (2) | CN111565744B (https=) |
| AU (2) | AU2018334434B2 (https=) |
| BR (1) | BR112020005196A2 (https=) |
| CA (1) | CA3076207A1 (https=) |
| CZ (1) | CZ2021138A3 (https=) |
| DK (1) | DK3826667T3 (https=) |
| ES (1) | ES2986343T3 (https=) |
| FI (1) | FI3826667T3 (https=) |
| GB (1) | GB202103867D0 (https=) |
| HU (1) | HUE067603T2 (https=) |
| IL (2) | IL273196B2 (https=) |
| MX (2) | MX2020002921A (https=) |
| NO (1) | NO20210351A1 (https=) |
| PL (1) | PL3826667T3 (https=) |
| PT (1) | PT3826667T (https=) |
| SG (1) | SG11202002114RA (https=) |
| SI (1) | SI3826667T1 (https=) |
| WO (1) | WO2019056023A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO20210351A1 (en) * | 2017-09-18 | 2021-03-18 | Univ California | Claudin6 antibodies and methods of treating cancer |
| NZ762505A (en) | 2017-09-29 | 2026-03-27 | Daiichi Sankyo Co Ltd | Antibody-pyrrolobenzodiazepine derivative conjugate |
| KR102063341B1 (ko) * | 2018-12-31 | 2020-01-07 | 다이노나(주) | Icam-1에 특이적으로 결합하는 항체 및 그의 용도 |
| MA54955A (fr) | 2019-02-15 | 2021-12-22 | Integral Molecular Inc | Anticorps anti-claudine 6 et leurs utilisations |
| US20220177583A1 (en) * | 2019-03-20 | 2022-06-09 | The Regents Of The University Of California | Claudin-6 bispecific antibodies |
| DK3941946T3 (da) * | 2019-03-20 | 2025-03-24 | Univ California | Claudin-6-antistoffer og lægemiddelkonjugater |
| JP2023529557A (ja) | 2020-05-04 | 2023-07-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 抗ｅｎｐｐ１抗体の阻害 |
| CN112386687B (zh) * | 2020-12-09 | 2021-05-04 | 爱龄医美国际健康咨询服务(北京)有限公司 | 一种干细胞外泌体及其在药品和化妆品中的应用 |
| WO2023091512A2 (en) * | 2021-11-16 | 2023-05-25 | Allakos, Inc. | Antibodies to anti-siglec-9 and multispecific antibodies targeting siglec-7 and siglec-9 |
| EP4475852A4 (en) * | 2022-02-09 | 2026-05-06 | Sera Prognostics Inc | Shbg and ibp4 antibodies and methods using same |
| TW202430574A (zh) | 2022-11-30 | 2024-08-01 | 美商積分分子股份有限公司 | 針對密連蛋白６之抗體，包括其雙特異性格式 |
| IL324834A (en) | 2023-05-25 | 2026-01-01 | Univ California | Dosage of claudin-6 conjugates for cancer treatment |
| WO2025075127A1 (ja) * | 2023-10-04 | 2025-04-10 | 公立大学法人福島県立医科大学 | がんのバイオマーカー及び抗体治療 |
| TW202542202A (zh) * | 2024-01-04 | 2025-11-01 | 美商翰森生物有限責任公司 | 抗體、抗原結合片段及其醫療用途 |
| WO2025162270A1 (zh) * | 2024-02-01 | 2025-08-07 | 江苏恒瑞医药股份有限公司 | 抗cldn6抗体、其抗体-药物偶联物及其医药用途 |
| WO2026084392A1 (ko) * | 2024-10-14 | 2026-04-23 | 에이비엘바이오 주식회사 | 항-클라우딘6 항체 및 이의 용도 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| US4526988A (en) | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| EP0184365B1 (en) | 1984-12-04 | 1993-08-04 | Eli Lilly And Company | Improvements in the treatment of tumors in mammals |
| EP1053752A1 (en) | 1998-02-10 | 2000-11-22 | Yoshitomi Pharmaceutical Industries, Ltd. | Preparations with controlled release |
| AU756796B2 (en) | 1998-10-16 | 2003-01-23 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Combination therapy with VIP antagonist |
| GB2344287A (en) | 1998-12-03 | 2000-06-07 | Ferring Bv | Controlled release pharmaceutical formulation |
| WO2001058479A1 (en) | 2000-02-08 | 2001-08-16 | The Penn State Research Foundation | Immunotherapy using interleukin 13 receptor subunit alpha 2 |
| US7771951B2 (en) | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| AU2003279842A1 (en) | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
| CA2672581A1 (en) * | 2006-12-14 | 2008-06-19 | Forerunner Pharma Research Co., Ltd. | Anti-claudin 3 monoclonal antibody and treatment and diagnosis of cancer using the same |
| WO2008130158A1 (en) | 2007-04-19 | 2008-10-30 | Dong-A Pharmaceutical. Co., Ltd | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
| EP2241578B1 (en) * | 2008-01-11 | 2016-04-20 | The University of Tokyo | Anti-cldn6 antibody |
| EP2404936A1 (en) * | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| ES2989943T3 (es) * | 2011-05-13 | 2024-11-28 | Astellas Pharma Inc | Anticuerpos para el tratamiento de un cáncer que expresa la Claudina 6 |
| WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| RU2016122041A (ru) * | 2013-11-06 | 2017-12-11 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Новые анти-клаудин антитела и способы их применения |
| PT3514172T (pt) | 2014-04-01 | 2020-04-21 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Imunorrecetores específicos de claudina-6 e epítopos de células t |
| NO20210351A1 (en) * | 2017-09-18 | 2021-03-18 | Univ California | Claudin6 antibodies and methods of treating cancer |
-
2018
- 2018-09-18 NO NO20210351A patent/NO20210351A1/en not_active Application Discontinuation
- 2018-09-18 PT PT188572424T patent/PT3826667T/pt unknown
- 2018-09-18 HU HUE18857242A patent/HUE067603T2/hu unknown
- 2018-09-18 US US16/648,428 patent/US20200291111A1/en not_active Abandoned
- 2018-09-18 FI FIEP18857242.4T patent/FI3826667T3/fi active
- 2018-09-18 IL IL273196A patent/IL273196B2/en unknown
- 2018-09-18 ES ES18857242T patent/ES2986343T3/es active Active
- 2018-09-18 DK DK18857242.4T patent/DK3826667T3/da active
- 2018-09-18 BR BR112020005196-9A patent/BR112020005196A2/pt active Search and Examination
- 2018-09-18 CN CN201880073220.3A patent/CN111565744B/zh active Active
- 2018-09-18 KR KR1020207009742A patent/KR102793719B1/ko active Active
- 2018-09-18 IL IL313238A patent/IL313238A/en unknown
- 2018-09-18 SI SI201831128T patent/SI3826667T1/sl unknown
- 2018-09-18 WO PCT/US2018/051610 patent/WO2019056023A2/en not_active Ceased
- 2018-09-18 KR KR1020257011014A patent/KR20250050137A/ko active Pending
- 2018-09-18 CA CA3076207A patent/CA3076207A1/en active Pending
- 2018-09-18 EP EP18857242.4A patent/EP3826667B1/en active Active
- 2018-09-18 SG SG11202002114RA patent/SG11202002114RA/en unknown
- 2018-09-18 PL PL18857242.4T patent/PL3826667T3/pl unknown
- 2018-09-18 GB GBGB2103867.4A patent/GB202103867D0/en active Pending
- 2018-09-18 CN CN202410853420.8A patent/CN118667021A/zh active Pending
- 2018-09-18 JP JP2020515692A patent/JP7599332B2/ja active Active
- 2018-09-18 MX MX2020002921A patent/MX2020002921A/es unknown
- 2018-09-18 AU AU2018334434A patent/AU2018334434B2/en active Active
- 2018-09-18 EP EP24169481.9A patent/EP4435009A3/en active Pending
-
2020
- 2020-03-17 MX MX2025012685A patent/MX2025012685A/es unknown
-
2021
- 2021-03-19 CZ CZ2021138A patent/CZ2021138A3/cs unknown
-
2022
- 2022-04-13 US US17/719,609 patent/US20220372134A1/en not_active Abandoned
-
2023
- 2023-12-19 US US18/545,890 patent/US20240400674A1/en not_active Abandoned
-
2024
- 2024-06-20 JP JP2024099523A patent/JP2024150445A/ja active Pending
-
2025
- 2025-01-23 AU AU2025200467A patent/AU2025200467A1/en active Pending
- 2025-06-27 US US19/252,512 patent/US20250333501A1/en active Pending
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