JP2020535423A5 - - Google Patents
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- Publication number
- JP2020535423A5 JP2020535423A5 JP2020517797A JP2020517797A JP2020535423A5 JP 2020535423 A5 JP2020535423 A5 JP 2020535423A5 JP 2020517797 A JP2020517797 A JP 2020517797A JP 2020517797 A JP2020517797 A JP 2020517797A JP 2020535423 A5 JP2020535423 A5 JP 2020535423A5
- Authority
- JP
- Japan
- Prior art keywords
- fgf
- 2sdng
- compound
- subject
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000003977 fibroblast growth factor 18 Human genes 0.000 claims 26
- 108090000370 fibroblast growth factor 18 Proteins 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 23
- 238000000034 method Methods 0.000 claims 12
- 108010017322 catch-relaxing peptide (Mytilus) Proteins 0.000 claims 11
- 208000015100 cartilage disease Diseases 0.000 claims 7
- 210000001188 articular cartilage Anatomy 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 206010061762 Chondropathy Diseases 0.000 claims 4
- 206010007710 Cartilage injury Diseases 0.000 claims 3
- 206010017076 Fracture Diseases 0.000 claims 3
- 208000013201 Stress fracture Diseases 0.000 claims 3
- 239000000090 biomarker Substances 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 201000008482 osteoarthritis Diseases 0.000 claims 3
- 238000001356 surgical procedure Methods 0.000 claims 3
- 230000007717 exclusion Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17194169 | 2017-09-29 | ||
| EP17194169.3 | 2017-09-29 | ||
| EP18169317 | 2018-04-25 | ||
| EP18169317.7 | 2018-04-25 | ||
| PCT/EP2018/076391 WO2019063756A1 (en) | 2017-09-29 | 2018-09-28 | INFLAMMATORY BIOMARKERS FOR PREDICTING REACTIVITY TO FGF-18 COMPOUND |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535423A JP2020535423A (ja) | 2020-12-03 |
| JP2020535423A5 true JP2020535423A5 (https=) | 2021-11-04 |
| JP7418324B2 JP7418324B2 (ja) | 2024-01-19 |
Family
ID=63722379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517797A Active JP7418324B2 (ja) | 2017-09-29 | 2018-09-28 | Ｆｇｆ－１８化合物に対する反応性を予測する炎症バイオマーカー |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11467169B2 (https=) |
| EP (1) | EP3688468B1 (https=) |
| JP (1) | JP7418324B2 (https=) |
| CN (1) | CN111164429B (https=) |
| AU (1) | AU2018343980B2 (https=) |
| CA (1) | CA3075713A1 (https=) |
| DK (1) | DK3688468T3 (https=) |
| ES (1) | ES2918249T3 (https=) |
| HR (1) | HRP20220737T1 (https=) |
| HU (1) | HUE058848T2 (https=) |
| IL (1) | IL273574B2 (https=) |
| LT (1) | LT3688468T (https=) |
| PL (1) | PL3688468T3 (https=) |
| RS (1) | RS63292B1 (https=) |
| SI (1) | SI3688468T1 (https=) |
| WO (1) | WO2019063756A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016211950A1 (en) | 2015-01-29 | 2017-07-13 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| IL273613B2 (en) | 2017-09-29 | 2026-02-01 | Merck Patent Gmbh | Metabolic biomarkers for predicting response to FGF-18 compound |
| SI3688468T1 (sl) | 2017-09-29 | 2022-08-31 | Merck Patent Gmbh | Vnetni biomarkerji za predvidevanje odzivov na spojino FGF-18 |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2339002A1 (en) | 1996-10-16 | 2011-06-29 | ZymoGenetics, Inc. | Fibroblast growth factor homologs |
| ES2493840T3 (es) | 2002-10-07 | 2014-09-12 | Zymogenetics, Inc. | Procedimiento de administración de FGF-18 |
| AU2003287697A1 (en) | 2002-11-08 | 2004-06-03 | Barnes-Jewish Hospital | Uncoupled collagen synthesis and degradation assays |
| AU2005314438B2 (en) | 2004-12-10 | 2012-03-29 | Zymogenetics, Inc. | FGF18 production in prokaryotic hosts |
| US8224579B2 (en) | 2005-06-17 | 2012-07-17 | The Brigham And Women's Hospital, Inc. | Method of diagnosing osteoarthritis |
| HRP20120643T1 (hr) | 2006-08-25 | 2012-08-31 | Ares Trading S.A. | Liječenje poremećaja hrskavice sa fgf-18 |
| JP2009257842A (ja) | 2008-04-14 | 2009-11-05 | Ttc:Kk | 変形性関節症の検査方法及び診断用キット |
| JP5762282B2 (ja) | 2008-05-02 | 2015-08-12 | インタールーキン ジェネティクス， インコーポレイテッド | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
| US20090299769A1 (en) | 2008-05-29 | 2009-12-03 | Nordic Bioscience Imaging A/S | Prognostic osteoarthritis biomarkers |
| US20120115137A1 (en) | 2010-08-31 | 2012-05-10 | Kornman Kenneth S | Methods of Predicting Osteoarthritis |
| TWI527590B (zh) | 2011-06-17 | 2016-04-01 | 艾瑞斯貿易公司 | Ｆｇｆ－１８之凍乾調配物 |
| AU2013301607B2 (en) | 2012-08-06 | 2018-10-18 | Merck Patent Gmbh | Prognosis biomarkers in cartilage disorders |
| CN104736723B (zh) * | 2012-08-06 | 2017-10-31 | 默克专利有限公司 | 用于预测对fgf‑18化合物的响应性的遗传标记 |
| CA2931978A1 (en) * | 2013-12-02 | 2015-06-11 | Abbvie Inc. | Compositions and methods for treating osteoarthritis |
| KR102622290B1 (ko) | 2013-12-24 | 2024-01-05 | 아레스 트레이딩 에스.아. | 크실로글루칸 겔 중의 fgf-18 제형물 |
| ES2806026T3 (es) | 2013-12-24 | 2021-02-16 | Ares Trading Sa | Formulación de FGF-18 en hidrogeles de alginato/colágeno |
| HUE040350T2 (hu) * | 2014-02-20 | 2019-03-28 | Merck Patent Gmbh | FGF-18 vegyületadagoló étrend |
| MX2016010873A (es) | 2014-02-20 | 2016-11-17 | Merck Patent Gmbh | Factor de crecimiento de fibroblastos 18 en los procedimientos para el trasplante de injertos y para ingenieria de tejidos. |
| JP6510547B2 (ja) | 2014-02-20 | 2019-05-08 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｆｇｆ−１８を含むインプラント |
| AU2016211950A1 (en) | 2015-01-29 | 2017-07-13 | Ares Trading S.A. | Immunoassays for high positively charged proteins |
| MX380092B (es) | 2015-11-06 | 2025-03-11 | Samumed Llc | Tratamiento de la osteoartritis. |
| US9983214B2 (en) | 2016-04-15 | 2018-05-29 | Esm Technologies, Llc | Method for evaluating articular joint therapeutics |
| SI3688468T1 (sl) | 2017-09-29 | 2022-08-31 | Merck Patent Gmbh | Vnetni biomarkerji za predvidevanje odzivov na spojino FGF-18 |
| IL273613B2 (en) | 2017-09-29 | 2026-02-01 | Merck Patent Gmbh | Metabolic biomarkers for predicting response to FGF-18 compound |
| IL281333B2 (en) | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
-
2018
- 2018-09-28 SI SI201830693T patent/SI3688468T1/sl unknown
- 2018-09-28 WO PCT/EP2018/076391 patent/WO2019063756A1/en not_active Ceased
- 2018-09-28 US US16/650,878 patent/US11467169B2/en active Active
- 2018-09-28 LT LTEPPCT/EP2018/076391T patent/LT3688468T/lt unknown
- 2018-09-28 CN CN201880063173.4A patent/CN111164429B/zh active Active
- 2018-09-28 HU HUE18782012A patent/HUE058848T2/hu unknown
- 2018-09-28 AU AU2018343980A patent/AU2018343980B2/en active Active
- 2018-09-28 IL IL273574A patent/IL273574B2/en unknown
- 2018-09-28 ES ES18782012T patent/ES2918249T3/es active Active
- 2018-09-28 JP JP2020517797A patent/JP7418324B2/ja active Active
- 2018-09-28 CA CA3075713A patent/CA3075713A1/en active Pending
- 2018-09-28 EP EP18782012.1A patent/EP3688468B1/en active Active
- 2018-09-28 HR HRP20220737TT patent/HRP20220737T1/hr unknown
- 2018-09-28 RS RS20220541A patent/RS63292B1/sr unknown
- 2018-09-28 DK DK18782012.1T patent/DK3688468T3/da active
- 2018-09-28 PL PL18782012.1T patent/PL3688468T3/pl unknown
-
2022
- 2022-09-01 US US17/929,261 patent/US12332250B2/en active Active
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