JP2020535193A5 - - Google Patents
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- Publication number
- JP2020535193A5 JP2020535193A5 JP2020517938A JP2020517938A JP2020535193A5 JP 2020535193 A5 JP2020535193 A5 JP 2020535193A5 JP 2020517938 A JP2020517938 A JP 2020517938A JP 2020517938 A JP2020517938 A JP 2020517938A JP 2020535193 A5 JP2020535193 A5 JP 2020535193A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- linagliptin
- linagliptin intermediate
- reaction mass
- intermediate represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LTXREWYXXSTFRX-QGZVFWFLSA-N Linagliptin Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 LTXREWYXXSTFRX-QGZVFWFLSA-N 0.000 claims 11
- 239000000543 intermediate Substances 0.000 claims 11
- 229960002397 linagliptin Drugs 0.000 claims 11
- 239000013078 crystal Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 239000012296 anti-solvent Substances 0.000 claims 2
- GMSNIKWWOQHZGF-UHFFFAOYSA-N 3-methyl-9H-xanthine Chemical class O=C1NC(=O)N(C)C2=C1N=CN2 GMSNIKWWOQHZGF-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201741034292 | 2017-09-27 | ||
| IN201741034292 | 2017-09-27 | ||
| PCT/IB2018/057484 WO2019064214A1 (en) | 2017-09-27 | 2018-09-27 | INTERMEDIATE OF CRYSTALLINE LINAGLIPTIN AND PROCESS FOR THE PREPARATION OF LINAGLIPTIN |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020535193A JP2020535193A (ja) | 2020-12-03 |
| JP2020535193A5 true JP2020535193A5 (https=) | 2021-10-28 |
Family
ID=65903063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517938A Pending JP2020535193A (ja) | 2017-09-27 | 2018-09-27 | 結晶のリナグリプチン中間体およびリナグリプチンの調製のためのプロセス |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11040974B2 (https=) |
| JP (1) | JP2020535193A (https=) |
| KR (1) | KR20200092946A (https=) |
| CN (1) | CN111511743A (https=) |
| AU (1) | AU2018343236A1 (https=) |
| BR (1) | BR112020005964A2 (https=) |
| CA (1) | CA3076980A1 (https=) |
| MX (1) | MX2020004050A (https=) |
| RU (1) | RU2020114890A (https=) |
| WO (1) | WO2019064214A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110684026A (zh) * | 2019-10-24 | 2020-01-14 | 扬子江药业集团上海海尼药业有限公司 | 一种利格列汀的工业化制备方法 |
| CN110872292B (zh) * | 2019-11-30 | 2022-01-25 | 江苏君若药业有限公司 | 一条合成糖尿病药物利拉利汀的路线 |
| EP4349837A1 (en) | 2022-10-05 | 2024-04-10 | Zaklady Farmaceutyczne "Polpharma" S.A. | A pharmaceutical intermediate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| KR101452915B1 (ko) | 2006-05-04 | 2014-10-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 다형태 |
| IN2013MU02055A (https=) * | 2013-06-18 | 2015-07-03 | Cadila Healthcare Ltd | |
| WO2015011609A1 (en) * | 2013-07-23 | 2015-01-29 | Ranbaxy Laboratories Limited | Process for the preparation of linagliptin and an intermediate thereof |
-
2018
- 2018-09-27 AU AU2018343236A patent/AU2018343236A1/en not_active Abandoned
- 2018-09-27 WO PCT/IB2018/057484 patent/WO2019064214A1/en not_active Ceased
- 2018-09-27 CN CN201880076836.6A patent/CN111511743A/zh active Pending
- 2018-09-27 MX MX2020004050A patent/MX2020004050A/es unknown
- 2018-09-27 KR KR1020207012196A patent/KR20200092946A/ko not_active Ceased
- 2018-09-27 BR BR112020005964-1A patent/BR112020005964A2/pt not_active Application Discontinuation
- 2018-09-27 CA CA3076980A patent/CA3076980A1/en active Pending
- 2018-09-27 JP JP2020517938A patent/JP2020535193A/ja active Pending
- 2018-09-27 RU RU2020114890A patent/RU2020114890A/ru unknown
-
2020
- 2020-03-27 US US16/832,067 patent/US11040974B2/en active Active
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