JP2020534336A5 - - Google Patents
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- JP2020534336A5 JP2020534336A5 JP2020516814A JP2020516814A JP2020534336A5 JP 2020534336 A5 JP2020534336 A5 JP 2020534336A5 JP 2020516814 A JP2020516814 A JP 2020516814A JP 2020516814 A JP2020516814 A JP 2020516814A JP 2020534336 A5 JP2020534336 A5 JP 2020534336A5
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- 0 CC*CC1[C@@](C(C)*)C(C)C(CC(C)C)C1 Chemical compound CC*CC1[C@@](C(C)*)C(C)C(CC(C)C)C1 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710854520 | 2017-09-20 | ||
| CN201710854520.2 | 2017-09-20 | ||
| CN201711397888 | 2017-12-21 | ||
| CN201711397888.7 | 2017-12-21 | ||
| CN201810119324.5 | 2018-02-06 | ||
| CN201810119324 | 2018-02-06 | ||
| PCT/CN2018/106768 WO2019057123A1 (zh) | 2017-09-20 | 2018-09-20 | 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020534336A JP2020534336A (ja) | 2020-11-26 |
| JP2020534336A5 true JP2020534336A5 (enExample) | 2021-11-04 |
| JP7548814B2 JP7548814B2 (ja) | 2024-09-10 |
Family
ID=65810056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020516814A Active JP7548814B2 (ja) | 2017-09-20 | 2018-09-20 | Ido阻害剤および/またはido-hdac二重阻害剤としての多環式化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11266640B2 (enExample) |
| EP (1) | EP3686196B1 (enExample) |
| JP (1) | JP7548814B2 (enExample) |
| CN (1) | CN109843872B (enExample) |
| WO (1) | WO2019057123A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020001425A (es) | 2017-08-04 | 2020-08-06 | Skyhawk Therapeutics Inc | Metodos y composiciones para modular el empalme. |
| WO2019078968A2 (en) * | 2017-10-18 | 2019-04-25 | Angex Pharmaceutical, Inc. | CYCLIC COMPOUNDS AS IMMUNOMODULATORS |
| CN110156674A (zh) * | 2018-02-13 | 2019-08-23 | 中国科学院上海有机化学研究所 | 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物 |
| CN110357813A (zh) * | 2018-04-09 | 2019-10-22 | 信达生物制药(苏州)有限公司 | 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途 |
| CN118286225A (zh) | 2018-04-26 | 2024-07-05 | 辉瑞公司 | 作为细胞周期蛋白依赖性激酶抑制剂的2-氨基-吡啶或2-氨基-嘧啶衍生物 |
| TWI731420B (zh) | 2018-09-27 | 2021-06-21 | 大陸商深圳微芯生物科技股份有限公司 | 具有吲哚胺-2,3-雙加氧酶抑制活性的喹啉衍生物及其製備方法、藥物組合物、聯合用藥物與用途 |
| WO2020163248A1 (en) | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| KR102913697B1 (ko) | 2019-02-05 | 2026-01-15 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| WO2020163541A1 (en) | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| KR102925385B1 (ko) | 2019-02-06 | 2026-02-11 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| JP7603594B2 (ja) | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| CN111909107B (zh) * | 2019-05-10 | 2023-02-03 | 药康众拓(江苏)医药科技有限公司 | Ido/hdac双重抑制剂及其药物组合物和应用 |
| CN118286450A (zh) * | 2019-11-12 | 2024-07-05 | 纳米医疗有限公司 | 用于治疗癌症的含有ido拮抗剂前药的调配的和/或共同调配的脂质体组合物及其方法 |
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| ID23803A (id) * | 1997-08-15 | 2000-05-11 | Pfizer Prod Inc | Turunan-turunan 2-(4-aril atau heteroaril-piperazin-1-ilmetil)-1h-indola |
| MY145722A (en) * | 2000-04-27 | 2012-03-30 | Abbott Lab | Diazabicyclic central nervous system active agents |
| EP1177792A3 (en) * | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
| WO2003070244A1 (en) * | 2002-02-22 | 2003-08-28 | Abbott Laboratories | Antagonist of melanin concentrating hormone and their uses |
| AU2005219438B2 (en) * | 2004-03-03 | 2011-02-17 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US8415354B2 (en) * | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| CA2576971A1 (en) * | 2004-08-20 | 2006-03-02 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| GB0510204D0 (en) * | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| PE20091017A1 (es) * | 2007-10-31 | 2009-07-16 | Janssen Pharmaceutica Nv | Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno a4 hidrolasa |
| FR2924343A1 (fr) * | 2007-12-04 | 2009-06-05 | Palumed Sa | Nouvelles utilisations therapeutiques de molecules duales contenant un derive peroxydique. |
| FR2945533B1 (fr) * | 2009-05-12 | 2011-05-27 | Sanofi Aventis | Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
| WO2012164071A1 (en) * | 2011-06-02 | 2012-12-06 | Intervet International B.V. | Imidazole derivatives |
| JP6075736B2 (ja) * | 2011-12-21 | 2017-02-08 | ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. | ピロール−6員ヘテロアリール環誘導体、その合成法およびその医薬用途 |
| TW201446763A (zh) * | 2013-03-14 | 2014-12-16 | Abbvie Inc | 吡咯并[2,3-b]吡啶cdk9激酶抑制劑 |
| EP2968303B1 (en) * | 2013-03-14 | 2018-07-04 | The Trustees of Columbia University in the City of New York | Octahydrocyclopentapyrroles, their preparation and use |
| MX2015012899A (es) * | 2013-03-14 | 2016-06-02 | Abbvie Inc | Pirrolo [2,3-b] piridina como inhibidores de quinasa cdk9. |
| SG11201605417QA (en) * | 2014-02-03 | 2016-08-30 | Cadila Healthcare Ltd | Heterocyclic compounds |
| JP2017525753A (ja) | 2014-06-06 | 2017-09-07 | フレクサス・バイオサイエンシーズ・インコーポレイテッドFlexus Biosciences, Inc. | 免疫調節剤 |
| EA201790806A1 (ru) | 2014-11-05 | 2017-11-30 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
| AR102537A1 (es) * | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
| UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| WO2016115463A1 (en) * | 2015-01-15 | 2016-07-21 | Whitehead Institute For Biomedical Research | Inhibitors of phosphoglycerate dehydrogenase (phgdh) and uses thereof |
| US10001765B2 (en) | 2015-07-02 | 2018-06-19 | buildpulse, Inc. | Advanced identification and classification of sensors and other points in a building automation system |
| HUE057041T2 (hu) * | 2015-07-06 | 2022-04-28 | Alkermes Inc | Hiszton deacetiláz hetero-halogén gátlói |
| CN107001271B (zh) | 2015-08-07 | 2019-05-10 | 江苏恒瑞医药股份有限公司 | 羟基脒类衍生物、其制备方法及其在医药上的应用 |
| CN106478607B (zh) * | 2015-08-28 | 2019-05-24 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| EP3347097B1 (en) * | 2015-09-11 | 2021-02-24 | Sunshine Lake Pharma Co., Ltd. | Substituted aminopyrimidine derivatives as modulators of the kinases jak, flt3 and aurora |
| AU2016333855A1 (en) * | 2015-10-09 | 2018-04-26 | AbbVie S.à.r.l. | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and their use |
| WO2017097671A1 (de) * | 2015-12-10 | 2017-06-15 | Bayer Pharma Aktiengesellschaft | Substituierte perhydropyrrolo[3,4-c]pyrrol-derivate und ihre verwendung |
| US10076522B2 (en) | 2016-05-04 | 2018-09-18 | Motif BioSciences Inc. | Systems and methods for treating bacterial infection |
| US10544099B2 (en) | 2016-05-04 | 2020-01-28 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| WO2017192844A1 (en) | 2016-05-04 | 2017-11-09 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| CN106916164A (zh) * | 2017-03-06 | 2017-07-04 | 中国药科大学 | 噻唑并嘧啶酮类ido1抑制剂及其医药用途 |
| CN110540521A (zh) * | 2018-05-28 | 2019-12-06 | 北京诺诚健华医药科技有限公司 | 八氢戊搭烯类化合物、其制备方法及其在医药学上的应用 |
-
2018
- 2018-09-20 WO PCT/CN2018/106768 patent/WO2019057123A1/zh not_active Ceased
- 2018-09-20 US US16/649,455 patent/US11266640B2/en active Active
- 2018-09-20 EP EP18857966.8A patent/EP3686196B1/en active Active
- 2018-09-20 CN CN201880002070.7A patent/CN109843872B/zh active Active
- 2018-09-20 JP JP2020516814A patent/JP7548814B2/ja active Active
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