JP2020534299A5 - - Google Patents

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JP2020534299A5
JP2020534299A5 JP2020515978A JP2020515978A JP2020534299A5 JP 2020534299 A5 JP2020534299 A5 JP 2020534299A5 JP 2020515978 A JP2020515978 A JP 2020515978A JP 2020515978 A JP2020515978 A JP 2020515978A JP 2020534299 A5 JP2020534299 A5 JP 2020534299A5
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Japan
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approximately
neuroprotective composition
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triterpene
acid
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JP2020515978A
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JP7370966B2 (ja
JP2020534299A (ja
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Priority claimed from PCT/US2018/049358 external-priority patent/WO2019055245A1/en
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JP2020515978A 2017-09-14 2018-09-04 神経学的状態を治療するための方法および改善された神経保護組成物 Active JP7370966B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762558631P 2017-09-14 2017-09-14
US62/558,631 2017-09-14
PCT/US2018/049358 WO2019055245A1 (en) 2017-09-14 2018-10-02 IMPROVED METHOD AND COMPOSITION FOR THE TREATMENT OF TRITERPENE SENSITIVE CONDITIONS, DISEASES OR DISORDERS

Publications (3)

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JP2020534299A JP2020534299A (ja) 2020-11-26
JP2020534299A5 true JP2020534299A5 (enExample) 2021-10-14
JP7370966B2 JP7370966B2 (ja) 2023-10-30

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JP2020515978A Active JP7370966B2 (ja) 2017-09-14 2018-09-04 神経学的状態を治療するための方法および改善された神経保護組成物

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US (2) US10722482B2 (enExample)
EP (1) EP3681477A4 (enExample)
JP (1) JP7370966B2 (enExample)
KR (1) KR20200083969A (enExample)
CN (1) CN111417384A (enExample)
AU (1) AU2018334467B2 (enExample)
CA (1) CA3075023A1 (enExample)
IL (1) IL273161A (enExample)
MX (1) MX2020002884A (enExample)
RU (1) RU2758376C2 (enExample)
WO (2) WO2019055245A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702567B2 (en) 2016-09-14 2020-07-07 Phoenix Biotechnology, Inc. Method and compositions for treating viral infection
US10729735B1 (en) 2016-09-14 2020-08-04 Phoenix Biotechnology, Inc. Method and compostitions for treating coronavirus infection
US10596186B2 (en) 2016-09-14 2020-03-24 Phoenix Biotechnology, Inc. Method and compositions for treating viral infections
US11331291B2 (en) * 2017-09-14 2022-05-17 Phoenix Biotechnology, Inc. Method of and improved composition for treating triterpene-responsive conditions, diseases or disorders
CN111417384A (zh) * 2017-09-14 2020-07-14 菲尼克斯生物技术公司 用于治疗神经系统病况的方法和改进的神经保护性组合物
US11806359B2 (en) 2020-03-31 2023-11-07 Phoenix Biotechnology, Inc. Method and compositions for treating Coronavirus infection
WO2021202547A1 (en) * 2020-04-01 2021-10-07 Triterpenoid Therapeutics, Inc. Methods and compositions for treating and preventing viral infection
CN111888367A (zh) * 2020-07-31 2020-11-06 兰州大学 一种萜类化合物在制备增强蛋白酶体活性药物中的应用
US12357641B2 (en) * 2022-10-13 2025-07-15 Hong Kong Baptist University Identification of oleanolic acid and plant extract for glucose-6-phosphate dehydrogenase-related disorders including Bag3opathy

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US922078A (en) 1909-03-01 1909-05-18 Charles Burwell Benson Tongue-depressor.
DK166650B1 (da) 1991-03-15 1993-06-28 Aarhus Oliefabrik As Fedtbaser samt anvendelse af disse i kosmetiske og farmaceutiske emulsionsprodukter
US5977174A (en) 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US5985936A (en) 1997-12-18 1999-11-16 Forbes Medi-Tech, Inc. Method of preventing and delaying onset of Alzheimer's disease and composition therefor
DK1079824T3 (da) 1998-05-19 2011-11-21 Res Dev Foundation Triterpen-sammensætninger og fremgangsmåder til anvendelse deraf
ES2308979T3 (es) 1999-04-27 2008-12-16 Forbes Medi-Tech Inc. Procedimiento para la preparacion de una composicion de fitosteroles.
CN1129613C (zh) 1999-12-24 2003-12-03 中国科学院上海药物研究所 夹竹桃花多糖及其制备方法和应用
US20020077350A1 (en) 2000-08-01 2002-06-20 Ashni Naturaceuticals, Inc. Compositions exhibiting synergistic inhibition of the expression and/or activity of clyclooxygenase-2
US6629835B2 (en) * 2000-08-01 2003-10-07 Metaproteomics, Llc Combinations of diterpene triepoxide lactones and ditepene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2
CA2418479C (en) 2000-08-18 2007-12-18 The Board Of Trustees Of The University Of Illinois Prodrugs of betulinic acid derivatives for the treatment of cancer
DE60204078T2 (de) 2001-04-09 2006-01-26 Loders Croklaan B.V. Konzentrat von Triterpenen
EP1476031A1 (en) 2001-05-11 2004-11-17 University of Ottawa Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods
WO2003099011A1 (en) 2002-05-28 2003-12-04 Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Cardiac glycosides to treat cystic fibrosis and other il-8 dependent disorders
KR100751071B1 (ko) * 2003-10-10 2007-08-21 에스케이케미칼주식회사 뇌기능 개선 효과를 갖는 트리테르펜계 화합물
DE602004014974D1 (de) * 2003-12-19 2008-08-21 Lipid Nutrition Bv Verwendung von zusammensetzungen mit oleansäure und ursolsäure zur herstellung eines medikaments zur behandlung von überempfindlichkeit und hyperreaktivität
EP1730163A4 (en) 2004-03-17 2009-12-30 Panacos Pharmaceuticals Inc Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid
US7118508B2 (en) 2004-07-28 2006-10-10 General Motors Corporation Planetary transmissions having three interconnected gear members and clutched input members
US20060135443A1 (en) 2004-10-18 2006-06-22 Bionaut Pharmaceuticals, Inc. Use of Na*/K*-ATPase inhibitors and antagonists thereof
US8022055B2 (en) 2005-02-09 2011-09-20 Dabur Pharma Limited Betulinic acid derivatives
CA2603124A1 (en) 2005-03-29 2006-10-05 Regents Of The University Of Minnesota Selective oxidation of triterpenes employing tempo
US20060252733A1 (en) 2005-04-07 2006-11-09 Novelix Pharmaceuticals, Inc. Betulin, betulin derivatives, betulinic acid and betulinic acid derivatives as novel therapeutics in the treatment of disease of lipid and/or glucose metabolism
WO2006133314A2 (en) 2005-06-08 2006-12-14 Regents Of The University Of Minnesota Synthesis of betulonic and betulinic aldehydes
KR101254938B1 (ko) 2005-06-10 2013-04-16 포라가세이고오교오가부시끼가이샤 신규 트리테르펜산 유도체 및 이를 포함하는 피부 외용제
US7402325B2 (en) 2005-07-28 2008-07-22 Phoenix Biotechnology, Inc. Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
ZA200805703B (en) 2005-12-16 2009-10-28 Panacos Pharmaceuticals Inc Preparation of pharmaceutical salts of 3-0-(3',3'-dimethyl-succinyl) betulinic acid
EP1803461A1 (en) 2005-12-27 2007-07-04 Heinz-Herbert Fiebig Therapeutic use of an extract from the leaves of Nerium oleander
GB0604535D0 (en) 2006-03-07 2006-04-12 Sndv Sprl Betulonic acid derivatives
DE102006020582A1 (de) * 2006-05-03 2007-11-15 Gesellschaft zur Förderung der Krebstherapie e.V. Verfahren zur Herstellung einer triterpensäurehaltigen wässrigen Lösung, triterpensäurehaltige wässrige Lösung und deren Verwendung
WO2008063318A2 (en) 2006-10-12 2008-05-29 The Texas A & M University System And Safe Et Al Betulinic acid, derivatives and analogs thereof and uses therefor
WO2008057420A2 (en) 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
WO2008091532A1 (en) 2007-01-19 2008-07-31 Panacos Pharmaceuticals, Inc. Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof
US8987212B2 (en) 2007-08-07 2015-03-24 Muhammed Majeed Oleanoyl peptide composition and method of treating skin aging
RU2508114C2 (ru) 2007-11-13 2014-02-27 Феникс Байотекнолоджи Инк. Способ определения вероятности терапевтического ответа на противораковую химиотерапию сердечным гликозидом
ES2326065B1 (es) 2008-03-28 2010-07-08 Consejo Superior De Investigaciones Cientificas (Csic) Utilizacion de un triterpeno pentaciclico para la preparacion de una composicion farmaceutica destinada al tratamiento de la esclerosis multiple.
EP2279197B1 (en) 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
RS58392B1 (sr) 2008-04-18 2019-04-30 Reata Pharmaceuticals Inc Antioksidantni modulatori inflamacije: derivati oleanoličke kiseline sa amino i drugim modifikacijama na c-17
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
HUE033288T2 (en) 2008-04-18 2017-11-28 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: C-17 homologated oleic acid derivatives
WO2010028487A1 (en) 2008-09-10 2010-03-18 Université Du Québec À Chicoutimi Bidesmosidic betulin and betulinic acid derivatives and uses thereof as antitumor agents
WO2010053817A1 (en) 2008-11-04 2010-05-14 Trustees Of Dartmouth College Betulinic acid derivatives and methods of use thereof
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
TW201104501A (en) 2009-07-24 2011-02-01 Asustek Comp Inc Device and method for inputting Chinese character
CN101704872B (zh) 2009-11-23 2012-06-27 张南 23-羟基白桦酸衍生物、其制备方法及应用
US8685469B2 (en) 2009-11-30 2014-04-01 University Of Kwazulu-Natal In vitro anti-sickling activity of betulinic acid, oleanolic acid and their derivatives
US9011937B2 (en) * 2010-11-22 2015-04-21 Phoenix Biotechnology, Inc. Method of treating neurological conditions with extract of Nerium species or Thevetia species
RU2582223C2 (ru) 2010-01-11 2016-04-20 Феникс Байотекнолоджи, Инк. Способ лечения неврологических состояний сердечными гликозидами
TWI386415B (zh) 2010-02-02 2013-02-21 Univ Kaohsiung Medical 熊果酸衍生物及其醫藥組合物
KR20170049623A (ko) * 2010-11-22 2017-05-10 피닉스 바이오테크놀러지 인코포레이티드. 네리움 종 또는 테베티아 종의 추출물로 신경학적 병태를 치료하는 방법
TWI410431B (zh) 2010-12-22 2013-10-01 Ind Tech Res Inst 齊敦果酸衍生物在製備預防或治療c型肝炎之藥物的用途
US20140221328A1 (en) 2011-01-10 2014-08-07 Bandi Parthasaradhi Reddy Pharmaceutically acceptable salts of novel betulinic acid derivatives
HRP20151212T1 (hr) 2011-01-31 2015-12-04 Bristol-Myers Squibb Company C-28 AMINI C-3 MODIFICIRANIH DERIVATA BETULINSKE KISELINE KAO INHIBITORI SAZRIJEVANJA HIV-a P
CN102558280B (zh) 2011-11-18 2014-09-17 温州大学 一种30-卤代桦木酸的生产方法
US8987502B2 (en) 2011-12-01 2015-03-24 Hangzhou Bensheng Pharmaceutical Co., Ltd. Oleanolic acid amidate derivatives, preparation methods and uses thereof
DK2786757T3 (da) 2011-12-01 2017-11-20 Hangzhou Bensheng Pharmaceutical Co Ltd 2-substitueret oleanolsyre-derivat, fremgangsmåde til fremstilling af samme, og anvendelse deraf
US20150119373A1 (en) 2012-04-24 2015-04-30 Hetero Research Foundation Novel betulinic acid derivatives as hiv inhibitors
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
KR101889528B1 (ko) 2012-08-14 2018-08-17 넥스올리고(주) 신규한 우르솔릭산 유도체 및 이의 제조 방법
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
LT2892911T (lt) 2012-09-10 2017-11-10 Reata Pharmaceuticals, Inc. Oleanolinės rūgšties c17 heteroarilo dariniai ir jų panaudojimo būdas
TWI630212B (zh) 2012-09-10 2018-07-21 瑞塔醫藥有限責任公司 丁香油素(oleanolic acid)之c17-烷二基與烯二基衍生物及其使用方法
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
BR112015019590A2 (pt) 2013-02-25 2017-07-18 Bristol Myers Squibb Co derivados de ácido betulínico modificado com c-3 alquila e alquenila úteis no tratamento de hiv
EP2813221A1 (en) * 2013-06-13 2014-12-17 Natac Biotech, S.L. Combination of pentacyclic triterpenes and hydroxytyrosol and derivatives thereof
WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
US9920090B2 (en) 2014-06-19 2018-03-20 VIIV Healthcare UK (No.5) Limited Betulinic acid derivatives with HIV maturation inhibitory activity
EP3512524B1 (en) * 2016-09-14 2021-04-07 Phoenix Biotechnology, Inc. Method and compositions for treating viral infection
CN111417384A (zh) * 2017-09-14 2020-07-14 菲尼克斯生物技术公司 用于治疗神经系统病况的方法和改进的神经保护性组合物

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