JP2020533955A5 - - Google Patents
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- Publication number
- JP2020533955A5 JP2020533955A5 JP2020502655A JP2020502655A JP2020533955A5 JP 2020533955 A5 JP2020533955 A5 JP 2020533955A5 JP 2020502655 A JP2020502655 A JP 2020502655A JP 2020502655 A JP2020502655 A JP 2020502655A JP 2020533955 A5 JP2020533955 A5 JP 2020533955A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- binding fragment
- nos
- chimeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000012634 fragment Substances 0.000 claims 30
- 238000000034 method Methods 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 229940127121 immunoconjugate Drugs 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 2
- 102000001189 Cyclic Peptides Human genes 0.000 claims 2
- 108010069514 Cyclic Peptides Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 238000012879 PET imaging Methods 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023039300A JP2023086132A (ja) | 2017-07-18 | 2023-03-14 | アミロイドベータに対する抗体 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CA2017/050866 WO2018014126A1 (en) | 2016-07-18 | 2017-07-18 | Antibodies to amyloid beta |
| CAPCT/CA2017/050866 | 2017-07-18 | ||
| US15/808,842 | 2017-11-09 | ||
| US15/808,842 US20180125920A1 (en) | 2016-11-09 | 2017-11-09 | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| US201862622126P | 2018-01-25 | 2018-01-25 | |
| US62/622,126 | 2018-01-25 | ||
| PCT/CA2018/050875 WO2019014768A1 (en) | 2017-07-18 | 2018-07-18 | ANTI-BETA-AMYLOID ANTIBODY |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023039300A Division JP2023086132A (ja) | 2017-07-18 | 2023-03-14 | アミロイドベータに対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020533955A JP2020533955A (ja) | 2020-11-26 |
| JP2020533955A5 true JP2020533955A5 (https=) | 2021-08-26 |
| JP7330164B2 JP7330164B2 (ja) | 2023-08-21 |
Family
ID=65014947
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502655A Active JP7330164B2 (ja) | 2017-07-18 | 2018-07-18 | アミロイドベータに対する抗体 |
| JP2023039300A Pending JP2023086132A (ja) | 2017-07-18 | 2023-03-14 | アミロイドベータに対する抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023039300A Pending JP2023086132A (ja) | 2017-07-18 | 2023-03-14 | アミロイドベータに対する抗体 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP3574020B1 (https=) |
| JP (2) | JP7330164B2 (https=) |
| CA (1) | CA3070085A1 (https=) |
| ES (1) | ES2984844T3 (https=) |
| WO (1) | WO2019014768A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102776187B1 (ko) | 2015-11-09 | 2025-03-07 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 아밀로이드 베타에서의 n-말단 에피토프 및 이에 형태적으로-선택적인 항체 |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5837672A (en) | 1992-07-10 | 1998-11-17 | Athena Neurosciences, Inc. | Methods and compositions for the detection of soluble β-amyloid peptide |
| US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5735814A (en) | 1996-04-30 | 1998-04-07 | Medtronic, Inc. | Techniques of treating neurodegenerative disorders by brain infusion |
| NZ333334A (en) | 1997-04-17 | 2001-06-29 | Frank L Sorgi | Delivery system for gene therapy to the brain |
| US7012061B1 (en) | 1998-10-19 | 2006-03-14 | New York University | Method for increasing the permeability of the blood brain barrier |
| DE1257584T1 (de) | 2000-02-24 | 2003-05-28 | Lilly Co Eli | Humanisierte antikörper, die amyloid beta peptid demarkieren |
| CA2451998A1 (en) | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | Anti-a.beta. antibodies |
| AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| ATE468886T1 (de) | 2003-02-10 | 2010-06-15 | Applied Molecular Evolution | Abeta-bindende moleküle |
| CN1562050A (zh) | 2004-03-24 | 2005-01-12 | 中国海洋大学 | 褐藻酸寡糖在抗痴呆、抗糖尿病中的应用 |
| US7811563B2 (en) * | 2004-10-25 | 2010-10-12 | Northwestern University | Anti-addl antibodies and uses thereof |
| US20060129126A1 (en) | 2004-11-19 | 2006-06-15 | Kaplitt Michael G | Infusion device and method for infusing material into the brain of a patient |
| CA2589017A1 (en) * | 2004-12-15 | 2006-06-22 | Neuralab Limited | Amyloid beta antibodies for use in improving cognition |
| EP1838348B1 (en) | 2004-12-15 | 2013-06-26 | Janssen Alzheimer Immunotherapy | Humanized amyloid beta antibodies for use in improving cognition |
| CA2609980C (en) | 2005-05-27 | 2015-10-13 | Queen's University At Kingston | Treatment of protein folding disorders |
| MY155286A (en) | 2005-12-12 | 2015-09-30 | Hoffmann La Roche | Antibodies against amyloid beta 4 with glycosylated in the variable region |
| DK2121754T3 (en) | 2007-01-18 | 2015-02-23 | Lilly Co Eli | Pegylated amyloid BETA FAB |
| BRPI0818623A2 (pt) | 2007-10-05 | 2017-05-23 | Ac Immune Sa | composição farmacêutica, e, métodos para reduzir a carga da placa na camada de célula de gânglio retinal de um animal, para reduzir a quantidade de placas na camada de célula de gânglio retinal de um animal, para diminuir a quantidade total de amilóide-beta solúvel na camada de célula de gânglio retinal de um animal, para prevenir, tratar e/ou aliviar os efeitos de uma doença ocular associada com anormalidades patológicas/mudanças no tecido do sistema visual, para monitorar doença ocular residual mínima associada com anormalidades patológicas/mudanças nos tecidos do sistema visual, para predizer responsividade de um paciente, e para reter ou diminuir a pressão ocular nos olhos de um animal |
| DK2237803T3 (en) | 2007-12-28 | 2015-10-05 | Prothena Biosciences Ltd | Treatment and prophylaxis of amyloidosis |
| CN102123726A (zh) | 2008-06-12 | 2011-07-13 | 阿费里斯股份公司 | 用于治疗与帕金森氏病有关的症状的化合物 |
| AT506820B1 (de) | 2008-06-12 | 2011-07-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzine gegen alzheimer-krankheit |
| AU2011239966B2 (en) | 2010-04-16 | 2014-05-08 | Ac Immune S.A. | Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins |
| MX373318B (es) * | 2015-08-11 | 2020-05-21 | Novartis Ag | 5-bromo-2,6-di-(1h-pirazol-1-il) pirimidin-4-amina-para su uso en el tratamiento del cáncer. |
| EP3374381A4 (en) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | EPITOPES IN THE AMYLOID-BETA MEDIUM REGION AND CONFORMITY-SELECTIVE ANTIBODIES THEREOF |
| CN109476729A (zh) * | 2016-07-18 | 2019-03-15 | 英属哥伦比亚大学 | 淀粉样蛋白β的抗体 |
| US20180125920A1 (en) * | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
-
2018
- 2018-07-18 ES ES18835520T patent/ES2984844T3/es active Active
- 2018-07-18 EP EP18835520.0A patent/EP3574020B1/en active Active
- 2018-07-18 WO PCT/CA2018/050875 patent/WO2019014768A1/en not_active Ceased
- 2018-07-18 CA CA3070085A patent/CA3070085A1/en active Pending
- 2018-07-18 JP JP2020502655A patent/JP7330164B2/ja active Active
-
2023
- 2023-03-14 JP JP2023039300A patent/JP2023086132A/ja active Pending
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