JP2020532531A - 肺疾患に関連付けられる肺高血圧症の治療のための吸入用一酸化窒素の使用 - Google Patents

肺疾患に関連付けられる肺高血圧症の治療のための吸入用一酸化窒素の使用 Download PDF

Info

Publication number
JP2020532531A
JP2020532531A JP2020512411A JP2020512411A JP2020532531A JP 2020532531 A JP2020532531 A JP 2020532531A JP 2020512411 A JP2020512411 A JP 2020512411A JP 2020512411 A JP2020512411 A JP 2020512411A JP 2020532531 A JP2020532531 A JP 2020532531A
Authority
JP
Japan
Prior art keywords
ino
administered
patient
hour
ibw
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020512411A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020532531A5 (enExample
Inventor
クイン，デボラ
シャー，パラッグ
Original Assignee
ベレロフォン パルス テクノロジーズ エルエルシー
ベレロフォン パルス テクノロジーズ エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベレロフォン パルス テクノロジーズ エルエルシー, ベレロフォン パルス テクノロジーズ エルエルシー filed Critical ベレロフォン パルス テクノロジーズ エルエルシー
Publication of JP2020532531A publication Critical patent/JP2020532531A/ja
Publication of JP2020532531A5 publication Critical patent/JP2020532531A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1025—Respiratory system
    • A61M2210/1039—Lungs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system
    • A61M2210/125—Heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/30—Blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2020512411A 2017-08-30 2018-08-29 肺疾患に関連付けられる肺高血圧症の治療のための吸入用一酸化窒素の使用 Pending JP2020532531A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762552022P 2017-08-30 2017-08-30
US62/552,022 2017-08-30
US201762611325P 2017-12-28 2017-12-28
US62/611,325 2017-12-28
PCT/US2018/048526 WO2019046415A1 (en) 2017-08-30 2018-08-29 USE OF INHALED NITRIC OXIDE FOR THE TREATMENT OF PULMONARY HYPERTENSION ASSOCIATED WITH PULMONARY DISEASE

Publications (2)

Publication Number Publication Date
JP2020532531A true JP2020532531A (ja) 2020-11-12
JP2020532531A5 JP2020532531A5 (enExample) 2021-10-07

Family

ID=65526008

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2020512411A Pending JP2020532531A (ja) 2017-08-30 2018-08-29 肺疾患に関連付けられる肺高血圧症の治療のための吸入用一酸化窒素の使用
JP2020512022A Pending JP2020532521A (ja) 2017-08-30 2018-08-29 右室及び／又は左室機能の改善のための吸入用一酸化窒素の使用
JP2023080033A Pending JP2023100985A (ja) 2017-08-30 2023-05-15 右室及び／又は左室機能の改善のための吸入用一酸化窒素の使用
JP2024209997A Pending JP2025029093A (ja) 2017-08-30 2024-12-03 右室及び／又は左室機能の改善のための吸入用一酸化窒素の使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020512022A Pending JP2020532521A (ja) 2017-08-30 2018-08-29 右室及び／又は左室機能の改善のための吸入用一酸化窒素の使用
JP2023080033A Pending JP2023100985A (ja) 2017-08-30 2023-05-15 右室及び／又は左室機能の改善のための吸入用一酸化窒素の使用
JP2024209997A Pending JP2025029093A (ja) 2017-08-30 2024-12-03 右室及び／又は左室機能の改善のための吸入用一酸化窒素の使用

Country Status (14)

Country Link
US (2) US20200188319A1 (enExample)
EP (2) EP3675719A4 (enExample)
JP (4) JP2020532531A (enExample)
KR (1) KR20200083443A (enExample)
CN (3) CN120131593A (enExample)
AU (2) AU2018323547A1 (enExample)
BR (1) BR112020004205A2 (enExample)
CA (4) CA3266320A1 (enExample)
IL (2) IL272308A (enExample)
MX (2) MX2020002194A (enExample)
PH (1) PH12020500197A1 (enExample)
SG (1) SG11202000893QA (enExample)
TW (3) TW202416939A (enExample)
WO (2) WO2019046413A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
EP4095094A1 (en) 2017-02-27 2022-11-30 Third Pole, Inc. Systems and methods for ambulatory generation of nitric oxide
KR102354762B1 (ko) 2017-02-27 2022-01-25 써드 폴, 아이엔씨. 산화 질소 발생 시스템 및 방법
JP2022517788A (ja) * 2019-01-14 2022-03-10 ベレロフォン・セラピューティクス Ｐｄｅ－５阻害剤と吸入用一酸化窒素との併用薬物療法
CN114375284A (zh) 2019-05-15 2022-04-19 第三极股份有限公司 用于生成一氧化氮的系统和方法
JP2022533628A (ja) 2019-05-15 2022-07-25 サード ポール，インコーポレイテッド 一酸化窒素生成用電極
EP4069069A4 (en) 2020-01-11 2024-07-03 Third Pole, Inc. SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL
US12239460B2 (en) * 2020-05-06 2025-03-04 Janssen Pharmaceuticals, Inc. Controlling operation of drug administration devices using surgical hubs
WO2021243227A1 (en) * 2020-05-29 2021-12-02 Bellerophon Therapeutics Method for pulsatile delivery of a gaseous drug
EP4167920A4 (en) 2020-06-18 2024-06-12 Third Pole, Inc. Systems and methods for preventing and treating infections with nitric oxide
JP2024534608A (ja) 2021-09-23 2024-09-20 サード ポール，インコーポレイテッド 一酸化窒素を送達するシステム及び方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017100729A1 (en) * 2015-12-11 2017-06-15 Geno Llc Method and apparatus for administering gases including nitric oxide
WO2017139113A1 (en) * 2016-02-12 2017-08-17 Mallinckrodt Hospital Products IP Limited Use and monitoring of inhaled nitric oxide with left ventricular assist devices

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007333115B2 (en) * 2006-12-12 2013-01-10 Gilead Sciences, Inc. Composition for treating a pulmonary hypertension
WO2009048521A1 (en) * 2007-10-11 2009-04-16 Duke University Potentiating the effect of compound comprising nitric oxide
DK2247297T3 (en) * 2008-01-31 2019-03-11 Univ Vanderbilt THERAPEUTIC TREATMENT OF LUNG CONDITIONS
JP2011010865A (ja) * 2009-06-30 2011-01-20 Ikaria Holdings Inc 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法
US20120093948A1 (en) * 2009-11-20 2012-04-19 Fine David H Nitric Oxide Treatments
AU2011336358B2 (en) * 2010-12-03 2016-09-29 VERO Biotech LLC. Nitric oxide treatments
CA2874842C (en) * 2012-05-31 2021-01-26 Ino Therapeutics Llc Methods of administering nitric oxide to arterial or arterialized blood
HUE032029T2 (en) * 2012-12-04 2017-08-28 Ino Therapeutics Llc Cannula for minimizing dilution of dosing during nitric oxide delivery
US9795756B2 (en) * 2012-12-04 2017-10-24 Mallinckrodt Hospital Products IP Limited Cannula for minimizing dilution of dosing during nitric oxide delivery
US9381212B2 (en) * 2014-01-10 2016-07-05 Mallinckrodt Hospital Products IP Limited Methods of using inhaled nitric oxide gas for treatment of acute respiratory distress syndrome in children
WO2015148169A1 (en) * 2014-03-28 2015-10-01 Shape Medical Systems, Inc. Pattern recognition system for quantifying the likelihood of the contribution of multiple possible forms of chronic disease to patient reported dyspnea
US20170182088A1 (en) * 2015-12-28 2017-06-29 Geno Llc Method and apparatus for administering nitric oxide with supplemental drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017100729A1 (en) * 2015-12-11 2017-06-15 Geno Llc Method and apparatus for administering gases including nitric oxide
WO2017139113A1 (en) * 2016-02-12 2017-08-17 Mallinckrodt Hospital Products IP Limited Use and monitoring of inhaled nitric oxide with left ventricular assist devices

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"History of Changes for Study: NCT03267108, Clinical Study to Assess the Safety and Efficacy of Pulse", CLINICALTRIALS.GOV ARCHIVE [ONLINE], JPN6022021301, 27 August 2017 (2017-08-27), ISSN: 0004965398 *
B. HAJIAN ET AL.: ""PULSED INHALED NITRIC OXIDE HAS THE POTENTIAL TO IMPROVE EXERCISE TOLERANCE IN SEVERE COPD SUBJECTS", ATS 113TH INTERNATIONAL CONFERENCE POSTER [ONLINE], JPN6022021306, 23 May 2017 (2017-05-23), ISSN: 0005174625 *
B. HAJIAN ET AL.: ""UNRAVELLING THE MODE OF ACTION OF PULSED INHALED NITRIC OXIDE INSEVERE IPF USING FUNCTIONAL RESPIRA", ATS 113TH INTERNATIONAL CONFERENCE POSTER [ONLINE], JPN6022021311, 23 May 2017 (2017-05-23), ISSN: 0005174624 *
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, vol. 27, no. 3, JPN6022021303, 2013, pages 459 - 466, ISSN: 0005174627 *
THORAX, vol. 58, JPN6022021304, 2003, pages 289 - 293, ISSN: 0005174626 *

Also Published As

Publication number Publication date
JP2023100985A (ja) 2023-07-19
MX2025004666A (es) 2025-05-02
CA3266320A1 (en) 2025-05-31
TWI887195B (zh) 2025-06-21
BR112020004205A2 (pt) 2020-09-01
TW202416939A (zh) 2024-05-01
CN111315283A (zh) 2020-06-19
EP3675840A1 (en) 2020-07-08
EP3675840A4 (en) 2021-05-12
WO2019046413A1 (en) 2019-03-07
EP3675719A1 (en) 2020-07-08
TW201919590A (zh) 2019-06-01
AU2018323547A1 (en) 2020-02-13
TW201912151A (zh) 2019-04-01
CN120131593A (zh) 2025-06-13
US20200188319A1 (en) 2020-06-18
JP2025029093A (ja) 2025-03-05
KR20200083443A (ko) 2020-07-08
MX2020002194A (es) 2020-11-24
CA3073948A1 (en) 2019-03-07
JP2020532521A (ja) 2020-11-12
CA3266267A1 (en) 2025-04-28
PH12020500197A1 (en) 2020-10-19
WO2019046415A1 (en) 2019-03-07
US20200360647A1 (en) 2020-11-19
CN111372577A (zh) 2020-07-03
AU2018324004A1 (en) 2020-02-13
CA3073949A1 (en) 2019-03-07
SG11202000893QA (en) 2020-02-27
IL272308A (en) 2020-03-31
IL272314A (en) 2020-03-31
EP3675719A4 (en) 2021-07-14

Similar Documents

Publication Publication Date Title
JP2020532531A (ja) 肺疾患に関連付けられる肺高血圧症の治療のための吸入用一酸化窒素の使用
JP2021509108A (ja) 肺高血圧症の治療のための吸入用一酸化窒素及び酸素の使用
Srivastava et al. Influence on alternate nostril breathing on cardiorespiratory and autonomic functions in healthy young adults
JP2021509109A (ja) 肺高血圧症の治療のための吸入用一酸化窒素のパルス投与
JP2021533866A (ja) 重度の低酸素血症を改善するための吸入一酸化窒素（ｉＮＯ）の使用
JP2022516167A (ja) 肺に関連する状態を有する患者における活動レベルを改善するための一酸化窒素吸入療法（ｉＮＯ）の使用
HK40033353A (en) Use of inhaled nitric oxide for the treatment of pulmonary hypertension associated with lung disease
HK40033405A (en) Use of inhaled nitric oxide for the improvement of right and/or left ventricular function
HK40039218A (en) Use of inhaled nitric oxide and oxygen for the treatment of pulmonary hypertension

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210823

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210823

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220525

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220531

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220825

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20221026

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221130

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20230117

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230413

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20230616

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230718

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20231017