|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
GB2183661B
(en)
|
1985-03-30 |
1989-06-28 |
Marc Ballivet |
Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique
|
|
US6492107B1
(en)
|
1986-11-20 |
2002-12-10 |
Stuart Kauffman |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
|
DE3600905A1
(de)
|
1986-01-15 |
1987-07-16 |
Ant Nachrichtentech |
Verfahren zum dekodieren von binaersignalen sowie viterbi-dekoder und anwendungen
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US20040049014A1
(en)
|
1988-12-28 |
2004-03-11 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
IL162181A
(en)
|
1988-12-28 |
2006-04-10 |
Pdl Biopharma Inc |
A method of producing humanized immunoglubulin, and polynucleotides encoding the same
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
WO1990014443A1
(en)
|
1989-05-16 |
1990-11-29 |
Huse William D |
Co-expression of heteromeric receptors
|
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
|
GB8928874D0
(en)
*
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
JP3306063B2
(ja)
|
1990-08-24 |
2002-07-24 |
イグジス， インコーポレイテッド |
ランダムコドンを有するオリゴヌクレオチドを合成する方法
|
|
GB9019812D0
(en)
|
1990-09-11 |
1990-10-24 |
Scotgen Ltd |
Novel antibodies for treatment and prevention of infection in animals and man
|
|
EP0563296B1
(en)
|
1990-12-20 |
1999-03-17 |
Ixsys, Inc. |
Optimization of binding proteins
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
AU665025B2
(en)
|
1991-09-23 |
1995-12-14 |
Cambridge Antibody Technology Limited |
Production of chimeric antibodies - a combinatorial approach
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
EP1291360A1
(en)
|
1991-12-13 |
2003-03-12 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5777085A
(en)
|
1991-12-20 |
1998-07-07 |
Protein Design Labs, Inc. |
Humanized antibodies reactive with GPIIB/IIIA
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
EP0578515A3
(en)
|
1992-05-26 |
1995-05-10 |
Bristol Myers Squibb Co |
Humanized monoclonal antibodies.
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
GB9223377D0
(en)
|
1992-11-04 |
1992-12-23 |
Medarex Inc |
Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
|
|
US6210671B1
(en)
|
1992-12-01 |
2001-04-03 |
Protein Design Labs, Inc. |
Humanized antibodies reactive with L-selectin
|
|
AU6132994A
(en)
|
1993-02-02 |
1994-08-29 |
Scripps Research Institute, The |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
|
GB9325182D0
(en)
|
1993-12-08 |
1994-02-09 |
T Cell Sciences Inc |
Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions
|
|
US6331431B1
(en)
|
1995-11-28 |
2001-12-18 |
Ixsys, Inc. |
Vacuum device and method for isolating periplasmic fraction from cells
|
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
|
US5882644A
(en)
|
1996-03-22 |
1999-03-16 |
Protein Design Labs, Inc. |
Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
|
|
US5834597A
(en)
|
1996-05-20 |
1998-11-10 |
Protein Design Labs, Inc. |
Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
|
|
US6013256A
(en)
|
1996-09-24 |
2000-01-11 |
Protein Design Labs, Inc. |
Method of preventing acute rejection following solid organ transplantation
|
|
JPH10185925A
(ja)
|
1996-12-20 |
1998-07-14 |
Seibutsu Bunshi Kogaku Kenkyusho:Kk |
ダブル・ダイナミック・プログラミングによる構造アライメント方法
|
|
AU8691398A
(en)
|
1997-08-04 |
1999-02-22 |
Ixsys, Incorporated |
Methods for identifying ligand specific binding molecules
|
|
EP1028317A4
(en)
|
1997-10-02 |
2002-10-02 |
Akiko Itai |
METHOD FOR THE INTERFERENCE OF A THREE-DIMENSIONAL PROTEIN STRUCTURE
|
|
ES2375931T3
(es)
|
1997-12-05 |
2012-03-07 |
The Scripps Research Institute |
Humanización de anticuerpo murino.
|
|
JPH11232291A
(ja)
|
1998-02-16 |
1999-08-27 |
Seibutsu Bunshi Kogaku Kenkyusho:Kk |
蛋白質立体構造データベース検索方法
|
|
WO1999045959A1
(en)
|
1998-03-13 |
1999-09-16 |
Dana-Farber Cancer Institute, Inc. |
Humanized antibody and uses thereof
|
|
JP2002531466A
(ja)
|
1998-12-01 |
2002-09-24 |
プロテイン デザイン ラブス， インコーポレイテッド |
γ−インターフェロンに対するヒト化抗体
|
|
US6571638B2
(en)
|
2000-06-30 |
2003-06-03 |
Sawtek, Inc. |
Surface-acoustic-wave pressure sensor and associated methods
|
|
CA2443862A1
(en)
|
2001-04-17 |
2002-10-24 |
Peizhi Luo |
Structure-based construction of human antibody library
|
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
CN101962408A
(zh)
*
|
2002-07-12 |
2011-02-02 |
杰斐逊·富特 |
超人源化抗体
|
|
AU2003264009A1
(en)
|
2002-08-15 |
2004-03-03 |
Epitomics, Inc. |
Humanized rabbit antibodies
|
|
EP1660970A4
(en)
*
|
2003-08-01 |
2007-02-14 |
Dna Twopointo Inc |
SYSTEMS AND METHODS FOR BIOPOLYMER TECHNOLOGY
|
|
ITRM20030601A1
(it)
|
2003-12-24 |
2005-06-25 |
Lay Line Genomics Spa |
Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
|
|
JP4782700B2
(ja)
|
2004-01-20 |
2011-09-28 |
カロバイオス ファーマシューティカルズ インコーポレイティッド |
最低限必須な結合決定基を用いた抗体特異性の移入
|
|
CA2600929A1
(en)
*
|
2005-03-04 |
2006-09-14 |
Biogen Idec Ma Inc. |
Methods of humanizing immunoglobulin variable regions through rational modification of complementarity determining residues
|
|
US8343489B2
(en)
|
2006-03-21 |
2013-01-01 |
Weaver David T |
Methods for humanizing antibodies and humanized antibodies made thereby
|
|
KR20170036814A
(ko)
|
2007-05-21 |
2017-04-03 |
앨더바이오 홀딩스 엘엘씨 |
신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
|
|
US8460659B2
(en)
|
2008-10-31 |
2013-06-11 |
Janssen Biotech, Inc. |
Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases
|
|
WO2010065921A2
(en)
|
2008-12-05 |
2010-06-10 |
Lpath, Inc. |
Antibody design using anti-lipid antibody crystal structures
|
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
|
WO2014100542A1
(en)
*
|
2012-12-21 |
2014-06-26 |
Abbvie, Inc. |
High-throughput antibody humanization
|
|
ES2857553T3
(es)
|
2014-10-24 |
2021-09-29 |
Hoffmann La Roche |
Humanización de anticuerpos basada en ángulo interdominio VH-VL
|