TW201910515A - 以三維結構為主之人類化方法 - Google Patents

以三維結構為主之人類化方法 Download PDF

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Publication number
TW201910515A
TW201910515A TW107126267A TW107126267A TW201910515A TW 201910515 A TW201910515 A TW 201910515A TW 107126267 A TW107126267 A TW 107126267A TW 107126267 A TW107126267 A TW 107126267A TW 201910515 A TW201910515 A TW 201910515A
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TW
Taiwan
Prior art keywords
amino acid
score
human
acid residue
assigned
Prior art date
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TW107126267A
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English (en)
Chinese (zh)
Inventor
喬漢尼斯 奧爾
蓋 喬治絲
史蒂芬 克勞斯特曼
斯克佛 渥夫干
Original Assignee
瑞士商赫孚孟拉羅股份公司
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Application filed by 瑞士商赫孚孟拉羅股份公司 filed Critical 瑞士商赫孚孟拉羅股份公司
Publication of TW201910515A publication Critical patent/TW201910515A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW107126267A 2017-07-31 2018-07-30 以三維結構為主之人類化方法 TW201910515A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17183933 2017-07-31
??17183933.5 2017-07-31

Publications (1)

Publication Number Publication Date
TW201910515A true TW201910515A (zh) 2019-03-16

Family

ID=59649461

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107126267A TW201910515A (zh) 2017-07-31 2018-07-30 以三維結構為主之人類化方法

Country Status (6)

Country Link
US (1) US11680110B2 (https=)
EP (1) EP3625254B1 (https=)
JP (2) JP6889328B2 (https=)
CN (2) CN117050176A (https=)
TW (1) TW201910515A (https=)
WO (1) WO2019025299A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111613275B (zh) * 2020-05-26 2021-03-16 中国海洋大学 一种基于rmsd多特征的药物分子动力学结果分析方法
AR126009A1 (es) 2021-06-02 2023-08-30 Hoffmann La Roche Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam
CN118382639A (zh) 2021-08-06 2024-07-23 耶达研究发展公司 人源化抗体方法
CN116052760A (zh) * 2022-09-02 2023-05-02 北京中大唯信科技有限公司 基于三维结构的抗体人源化的方法
WO2025105282A1 (ja) * 2023-11-16 2025-05-22 国立大学法人熊本大学 抗体動的構造特性分析装置、抗体動的構造特性分析方法及びプログラム

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Also Published As

Publication number Publication date
JP2021151236A (ja) 2021-09-30
EP3625254C0 (en) 2023-12-13
CN110945023B (zh) 2023-08-18
JP6889328B2 (ja) 2021-06-18
US20200223945A1 (en) 2020-07-16
WO2019025299A1 (en) 2019-02-07
EP3625254B1 (en) 2023-12-13
JP2020530991A (ja) 2020-11-05
CN117050176A (zh) 2023-11-14
EP3625254A1 (en) 2020-03-25
CN110945023A (zh) 2020-03-31
JP7217772B2 (ja) 2023-02-03
US11680110B2 (en) 2023-06-20

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