CN117050176A - 基于三维结构的人源化方法 - Google Patents

基于三维结构的人源化方法 Download PDF

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Publication number
CN117050176A
CN117050176A CN202310957514.5A CN202310957514A CN117050176A CN 117050176 A CN117050176 A CN 117050176A CN 202310957514 A CN202310957514 A CN 202310957514A CN 117050176 A CN117050176 A CN 117050176A
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CN
China
Prior art keywords
amino acid
human
variable domain
antibody
residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310957514.5A
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English (en)
Chinese (zh)
Inventor
J·奥尔
G·乔治斯
S·克洛斯特曼
W·舍费尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN117050176A publication Critical patent/CN117050176A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202310957514.5A 2017-07-31 2018-07-27 基于三维结构的人源化方法 Pending CN117050176A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17183933 2017-07-31
EP17183933.5 2017-07-31
CN201880048859.6A CN110945023B (zh) 2017-07-31 2018-07-27 基于三维结构的人源化方法
PCT/EP2018/070372 WO2019025299A1 (en) 2017-07-31 2018-07-27 METHOD OF HUMANIZATION BASED ON THREE DIMENSIONAL STRUCTURE

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880048859.6A Division CN110945023B (zh) 2017-07-31 2018-07-27 基于三维结构的人源化方法

Publications (1)

Publication Number Publication Date
CN117050176A true CN117050176A (zh) 2023-11-14

Family

ID=59649461

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202310957514.5A Pending CN117050176A (zh) 2017-07-31 2018-07-27 基于三维结构的人源化方法
CN201880048859.6A Active CN110945023B (zh) 2017-07-31 2018-07-27 基于三维结构的人源化方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201880048859.6A Active CN110945023B (zh) 2017-07-31 2018-07-27 基于三维结构的人源化方法

Country Status (6)

Country Link
US (1) US11680110B2 (https=)
EP (1) EP3625254B1 (https=)
JP (2) JP6889328B2 (https=)
CN (2) CN117050176A (https=)
TW (1) TW201910515A (https=)
WO (1) WO2019025299A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111613275B (zh) * 2020-05-26 2021-03-16 中国海洋大学 一种基于rmsd多特征的药物分子动力学结果分析方法
AR126009A1 (es) 2021-06-02 2023-08-30 Hoffmann La Roche Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam
CN118382639A (zh) 2021-08-06 2024-07-23 耶达研究发展公司 人源化抗体方法
CN116052760A (zh) * 2022-09-02 2023-05-02 北京中大唯信科技有限公司 基于三维结构的抗体人源化的方法
WO2025105282A1 (ja) * 2023-11-16 2025-05-22 国立大学法人熊本大学 抗体動的構造特性分析装置、抗体動的構造特性分析方法及びプログラム

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Also Published As

Publication number Publication date
JP2021151236A (ja) 2021-09-30
EP3625254C0 (en) 2023-12-13
TW201910515A (zh) 2019-03-16
CN110945023B (zh) 2023-08-18
JP6889328B2 (ja) 2021-06-18
US20200223945A1 (en) 2020-07-16
WO2019025299A1 (en) 2019-02-07
EP3625254B1 (en) 2023-12-13
JP2020530991A (ja) 2020-11-05
EP3625254A1 (en) 2020-03-25
CN110945023A (zh) 2020-03-31
JP7217772B2 (ja) 2023-02-03
US11680110B2 (en) 2023-06-20

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