JP2020530496A - タンパク質アルギニンメチルトランスフェラーゼ５（ｐｒｍｔ５）の選択的阻害剤 - Google Patents

タンパク質アルギニンメチルトランスフェラーゼ５（ｐｒｍｔ５）の選択的阻害剤 Download PDF

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Publication number
JP2020530496A
JP2020530496A JP2020530436A JP2020530436A JP2020530496A JP 2020530496 A JP2020530496 A JP 2020530496A JP 2020530436 A JP2020530436 A JP 2020530436A JP 2020530436 A JP2020530436 A JP 2020530436A JP 2020530496 A JP2020530496 A JP 2020530496A
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methyl
arca
alkyl
amino
compound
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JP2020530496A5 (enExample
Inventor
ルエンゴ フアン
ルエンゴ フアン
リン ホン
リン ホン
シェティ ルーパー
シェティ ルーパー
ホーキンズ マイケル
ホーキンズ マイケル
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プレリュード セラピューティクス，インコーポレイティド
プレリュード セラピューティクス，インコーポレイティド
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Publication of JP2020530496A publication Critical patent/JP2020530496A/ja
Publication of JP2020530496A5 publication Critical patent/JP2020530496A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2020530436A 2017-08-09 2018-08-09 タンパク質アルギニンメチルトランスフェラーゼ５（ｐｒｍｔ５）の選択的阻害剤 Ceased JP2020530496A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762543141P 2017-08-09 2017-08-09
US62/543,141 2017-08-09
US201862630581P 2018-02-14 2018-02-14
US62/630,581 2018-02-14
US201862664442P 2018-04-30 2018-04-30
US62/664,442 2018-04-30
PCT/US2018/046057 WO2019032859A1 (en) 2017-08-09 2018-08-09 SELECTIVE INHIBITORS OF THE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)

Publications (2)

Publication Number Publication Date
JP2020530496A true JP2020530496A (ja) 2020-10-22
JP2020530496A5 JP2020530496A5 (enExample) 2021-09-16

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JP2020530436A Ceased JP2020530496A (ja) 2017-08-09 2018-08-09 タンパク質アルギニンメチルトランスフェラーゼ５（ｐｒｍｔ５）の選択的阻害剤

Country Status (18)

Country Link
US (4) US10570140B2 (enExample)
EP (2) EP3665179B1 (enExample)
JP (1) JP2020530496A (enExample)
KR (1) KR20200036922A (enExample)
CN (1) CN111527099B (enExample)
AU (1) AU2018313910B2 (enExample)
BR (1) BR112020002736A2 (enExample)
CA (1) CA3072439A1 (enExample)
DK (1) DK3665179T3 (enExample)
ES (1) ES2885180T3 (enExample)
IL (1) IL272519B (enExample)
MA (1) MA49840A (enExample)
MX (1) MX2020001598A (enExample)
PL (1) PL3665179T3 (enExample)
PT (1) PT3665179T (enExample)
UA (1) UA126481C2 (enExample)
WO (1) WO2019032859A1 (enExample)
ZA (1) ZA202000773B (enExample)

Cited By (1)

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JP2022521491A (ja) * 2019-02-13 2022-04-08 プレリュード・セラピューティクス・インコーポレイテッド タンパク質アルギニンメチルトランスフェラーゼ５（ｐｒｍｔ５）の選択的阻害剤

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US10711007B2 (en) 2018-03-14 2020-07-14 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
PL3765461T3 (pl) * 2018-03-14 2024-03-04 Prelude Therapeutics, Incorporated Selektywne inhibitory białkowej metylotranserazy argininy 5 (prmt5)
US11077101B1 (en) 2018-07-18 2021-08-03 Tango Therapeutics, Inc. Compounds and methods of use
EP3833669A4 (en) * 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
EP3833355A4 (en) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. PRMT5 INHIBITORS
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EP3946352A4 (en) * 2019-04-05 2022-12-28 Prelude Therapeutics, Incorporated SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5
US20220152072A1 (en) * 2019-04-05 2022-05-19 Prelude Therapeutics, Incorporated Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)
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MX2022003340A (es) 2019-09-18 2022-06-14 Prelude Therapeutics Inc Inhibidores selectivos de la proteina arginina metiltransferasa 5 (prmt5).
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CN114599361B (zh) * 2019-10-22 2024-07-09 印度鲁宾有限公司 Prmt5抑制剂的药物组合物
US12403137B2 (en) 2019-10-28 2025-09-02 Tango Therapeutics, Inc. Compounds and methods of use
AU2021319201A1 (en) 2020-07-31 2023-02-16 Tango Therapeutics, Inc. Piperidin-1-yl-n-pyridin-3-yl-2-oxoacetamide derivatives useful for the treatment of mtap-deficient and/or mta-accumulating cancers
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WO2022125735A1 (en) 2020-12-10 2022-06-16 Prelude Therapeutics Incorporated Processes for making prmt5 inhibitors
AR124369A1 (es) * 2020-12-16 2023-03-22 Amgen Inc Inhibidores de prmt5 novedosos
IL316942A (en) 2020-12-18 2025-01-01 Prelude Therapeutics Inc CDK inhibitors and their use as drugs
WO2023001133A1 (zh) * 2021-07-20 2023-01-26 上海齐鲁制药研究中心有限公司 Prmt5抑制剂
US20230181589A1 (en) * 2021-12-03 2023-06-15 The Trustees Of Indiana University Prmt5 inhibitors for ocular therapy
US11939340B2 (en) 2022-01-21 2024-03-26 Prelude Therapeutics Incorporated CDK inhibitors and their use as pharmaceuticals
US20230257394A1 (en) 2022-02-03 2023-08-17 Prelude Therapeutics, Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
US20240018136A1 (en) 2022-03-09 2024-01-18 Prelude Therapeutics, Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
AU2022448546A1 (en) 2022-03-23 2024-10-17 Prelude Therapeutics, Incorporated Polymorphic compounds and uses thereof
CN116655638B (zh) * 2022-05-12 2024-01-26 上海齐鲁制药研究中心有限公司 氘代prmt5抑制剂
WO2024077216A1 (en) 2022-10-06 2024-04-11 Prelude Therapeutics Incorporated Cdk inhibitors and their use as pharmaceuticals
US20240352029A1 (en) 2023-04-14 2024-10-24 Prelude Therapeutics Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
CN116554194A (zh) * 2023-05-23 2023-08-08 江苏八巨药业有限公司 一种卡培他滨中间体的合成方法
WO2025064402A1 (en) * 2023-09-22 2025-03-27 St. Jude Children's Research Hospital, Inc. Method for treating sickle cell disease by targeting senescent cells

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Publication number Priority date Publication date Assignee Title
JP2022521491A (ja) * 2019-02-13 2022-04-08 プレリュード・セラピューティクス・インコーポレイテッド タンパク質アルギニンメチルトランスフェラーゼ５（ｐｒｍｔ５）の選択的阻害剤

Also Published As

Publication number Publication date
AU2018313910A1 (en) 2020-03-05
ZA202000773B (en) 2022-07-27
US20200148692A1 (en) 2020-05-14
CN111527099A (zh) 2020-08-11
WO2019032859A1 (en) 2019-02-14
PT3665179T (pt) 2021-09-10
US20220153747A1 (en) 2022-05-19
EP3665179B1 (en) 2021-06-09
CA3072439A1 (en) 2019-02-14
CN111527099B (zh) 2024-03-22
PL3665179T3 (pl) 2021-11-29
KR20200036922A (ko) 2020-04-07
US10570140B2 (en) 2020-02-25
US20200361946A1 (en) 2020-11-19
IL272519B (en) 2022-05-01
IL272519A (en) 2020-03-31
AU2018313910B2 (en) 2022-12-08
BR112020002736A2 (pt) 2020-07-28
DK3665179T3 (da) 2021-08-16
MA49840A (fr) 2020-06-17
ES2885180T3 (es) 2021-12-13
US11208416B2 (en) 2021-12-28
MX2020001598A (es) 2020-10-28
EP3665179A1 (en) 2020-06-17
UA126481C2 (uk) 2022-10-12
EP3939986A1 (en) 2022-01-19
US20190048014A1 (en) 2019-02-14
US11078205B2 (en) 2021-08-03

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