CN111527099B - 蛋白质精氨酸甲基转移酶5(prmt5)的选择性抑制剂 - Google Patents

蛋白质精氨酸甲基转移酶5(prmt5)的选择性抑制剂 Download PDF

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CN111527099B
CN111527099B CN201880065979.7A CN201880065979A CN111527099B CN 111527099 B CN111527099 B CN 111527099B CN 201880065979 A CN201880065979 A CN 201880065979A CN 111527099 B CN111527099 B CN 111527099B
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alkyl
methyl
compound
substituted
amino
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CN111527099A (zh
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胡安·卢恩戈
林虹
鲁帕·谢蒂
迈克尔·霍金斯
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Pruder Therapeutics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201880065979.7A 2017-08-09 2018-08-09 蛋白质精氨酸甲基转移酶5(prmt5)的选择性抑制剂 Expired - Fee Related CN111527099B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762543141P 2017-08-09 2017-08-09
US62/543,141 2017-08-09
US201862630581P 2018-02-14 2018-02-14
US62/630,581 2018-02-14
US201862664442P 2018-04-30 2018-04-30
US62/664,442 2018-04-30
PCT/US2018/046057 WO2019032859A1 (en) 2017-08-09 2018-08-09 SELECTIVE INHIBITORS OF THE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)

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CN111527099A CN111527099A (zh) 2020-08-11
CN111527099B true CN111527099B (zh) 2024-03-22

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US (4) US10570140B2 (enExample)
EP (2) EP3939986A1 (enExample)
JP (1) JP2020530496A (enExample)
KR (1) KR20200036922A (enExample)
CN (1) CN111527099B (enExample)
AU (1) AU2018313910B2 (enExample)
BR (1) BR112020002736A2 (enExample)
CA (1) CA3072439A1 (enExample)
DK (1) DK3665179T3 (enExample)
ES (1) ES2885180T3 (enExample)
IL (1) IL272519B (enExample)
MA (1) MA49840A (enExample)
MX (1) MX2020001598A (enExample)
PL (1) PL3665179T3 (enExample)
PT (1) PT3665179T (enExample)
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WO (1) WO2019032859A1 (enExample)
ZA (1) ZA202000773B (enExample)

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EP4031555A1 (en) 2019-09-18 2022-07-27 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
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US20220251088A1 (en) * 2020-12-10 2022-08-11 Prelude Therapeutics, Incorporated Processes for Making PRMT5 Inhibitors
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CA3205652A1 (en) 2020-12-18 2022-06-23 Prelude Therapeutics Incorporated Cdk inhibitors and their use as pharmaceuticals
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US20230181589A1 (en) * 2021-12-03 2023-06-15 The Trustees Of Indiana University Prmt5 inhibitors for ocular therapy
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CN116655638B (zh) * 2022-05-12 2024-01-26 上海齐鲁制药研究中心有限公司 氘代prmt5抑制剂
WO2024077216A1 (en) 2022-10-06 2024-04-11 Prelude Therapeutics Incorporated Cdk inhibitors and their use as pharmaceuticals
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CA3072439A1 (en) 2019-02-14
UA126481C2 (uk) 2022-10-12
PL3665179T3 (pl) 2021-11-29
AU2018313910B2 (en) 2022-12-08
KR20200036922A (ko) 2020-04-07
ZA202000773B (en) 2022-07-27
CN111527099A (zh) 2020-08-11
US10570140B2 (en) 2020-02-25
US11078205B2 (en) 2021-08-03
PT3665179T (pt) 2021-09-10
IL272519B (en) 2022-05-01
BR112020002736A2 (pt) 2020-07-28
ES2885180T3 (es) 2021-12-13
MX2020001598A (es) 2020-10-28
AU2018313910A1 (en) 2020-03-05
EP3939986A1 (en) 2022-01-19
IL272519A (en) 2020-03-31
US20200148692A1 (en) 2020-05-14
DK3665179T3 (da) 2021-08-16
EP3665179A1 (en) 2020-06-17
US20220153747A1 (en) 2022-05-19
US11208416B2 (en) 2021-12-28
WO2019032859A1 (en) 2019-02-14
MA49840A (fr) 2020-06-17
EP3665179B1 (en) 2021-06-09
JP2020530496A (ja) 2020-10-22
US20190048014A1 (en) 2019-02-14
US20200361946A1 (en) 2020-11-19

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