JP2020530467A - 癌転移を処置するためにキナーゼを標的とする方法 - Google Patents

癌転移を処置するためにキナーゼを標的とする方法 Download PDF

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JP2020530467A
JP2020530467A JP2020507545A JP2020507545A JP2020530467A JP 2020530467 A JP2020530467 A JP 2020530467A JP 2020507545 A JP2020507545 A JP 2020507545A JP 2020507545 A JP2020507545 A JP 2020507545A JP 2020530467 A JP2020530467 A JP 2020530467A
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kinase inhibitor
cancer
kinase
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cdk5
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JP2020530467A5 (https=
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ディファ ユ
ディファ ユ
フランク ラウリー
フランク ラウリー
チャンユー ジャン
チャンユー ジャン
スニール アチャリヤ
スニール アチャリヤ
ピン リー
ピン リー
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University of Texas System
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University of Texas System
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JP2020507545A 2017-08-11 2018-08-10 癌転移を処置するためにキナーゼを標的とする方法 Pending JP2020530467A (ja)

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US201762544597P 2017-08-11 2017-08-11
US62/544,597 2017-08-11
PCT/US2018/046329 WO2019033041A1 (en) 2017-08-11 2018-08-10 TARGETING KINASES FOR THE TREATMENT OF CANCER METASTASES

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KR102141997B1 (ko) * 2017-11-22 2020-08-06 (주)인핸스드바이오 Pmvk를 유효성분으로 포함하는 방사선 저항성 암 진단용 또는 방사선 치료 예후 예측용 바이오마커 조성물
EP3781168A4 (en) * 2018-04-16 2022-10-05 The Regents of the University of California PAK4 INHIBITORS AND METHODS OF USE
US20220178924A1 (en) * 2019-03-03 2022-06-09 Purdue Research Foundation Systems and methods for identifying subtype, prognosis, and monitoring of breast cancer
US20220143028A1 (en) * 2019-03-28 2022-05-12 Cancer Research Technology Ltd Inhibitors of atypical protein kinase c and their use in treating hedgehog pathway-dependent cancers
TWI719446B (zh) * 2019-04-16 2021-02-21 中國醫藥大學 醫藥組合物及其用於製備抑制胃癌細胞增生藥物的用途
CN113143525A (zh) * 2021-05-10 2021-07-23 广东省人民医院 一种新型脑转移瘤动物模型的构建方法
KR102658209B1 (ko) * 2021-10-05 2024-04-18 재단법인 아산사회복지재단 Cdk 억제제 및 id2 활성화제를 포함하는 방광암의 예방 또는 치료용 약학 조성물
CN114410778B (zh) * 2021-12-29 2024-03-19 中南大学湘雅医院 Pf543在制备pd-l1/pd-1单抗肿瘤免疫治疗药物中的应用
WO2025031474A1 (en) * 2023-08-10 2025-02-13 Insilico Medicine Ip Limited Method and medicament for treating endometriosis
US11932594B1 (en) 2023-10-31 2024-03-19 King Faisal University 8-((2-hydroxy-5-methylphenyl)diazenyl)naphthalene-1,3-disulfonic acid as an antioxidant compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008528001A (ja) * 2005-01-25 2008-07-31 スカイ、ジェネティクス、インク 癌マーカーおよび検出方法
JP2013231048A (ja) * 1998-01-22 2013-11-14 Max-Planck-Ges Zur Foerderung Der Wissenschaften Ev Rtk−過剰機能−誘導障害、特に癌の治療のための阻害剤の使用
US20160008366A1 (en) * 2014-07-14 2016-01-14 Pharmacyclics Llc Btk inhibitors for the treatment of cns malignancies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2388590A1 (en) 2001-04-02 2011-11-23 Dana Farber Cancer Institute PD-1, a receptor for B7-4, and uses thereof
AU2003303082B2 (en) 2002-01-30 2009-07-02 Dana-Farber Cancer Institute, Inc. Compositions and methods related to TIM-3, a Th1-specific cell surface molecule
WO2007044571A2 (en) * 2005-10-06 2007-04-19 President And Fellows Of Harvard College Methods for identifying proteins essential for human cell proliferation and therapeutic agents that target them
EP1961825A1 (en) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Method for predicting the occurrence of metastasis in breast cancer patients
GB0706633D0 (en) * 2007-04-04 2007-05-16 Cyclacel Ltd Combination
US20100029748A1 (en) 2008-08-04 2010-02-04 Sloan-Kettering Institute For Cancer Research Metastasis Promoting Genes and Proteins
WO2013016434A1 (en) 2011-07-27 2013-01-31 The Board Institute, Inc. Compositions and methods of treating head and neck cancer
EP2829880A1 (en) * 2013-07-26 2015-01-28 Energeia Biosciences Method for identifying modulators of BCRP/ABCG2-mediated ATP release and use of said modulators for treating diseases
US10555931B2 (en) * 2014-05-28 2020-02-11 Piramal Enterprises Limited Pharmaceutical combination for the treatment of cancer
GB201414542D0 (en) * 2014-08-15 2014-10-01 Imp Innovations Ltd Novel therapy
CA2961894C (en) * 2014-09-19 2023-12-12 Memorial Sloan-Kettering Cancer Center Methods for treating brain metastatis using gap junction inhibitors
UY36660A (es) * 2015-04-30 2016-11-30 Bayer Pharma AG Combinaciones de inhibidores de irak4
JP2018135268A (ja) * 2015-06-05 2018-08-30 大日本住友製薬株式会社 新規ヘテロアリールアミノ−3−ピラゾール誘導体およびその薬理学上許容される塩

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013231048A (ja) * 1998-01-22 2013-11-14 Max-Planck-Ges Zur Foerderung Der Wissenschaften Ev Rtk−過剰機能−誘導障害、特に癌の治療のための阻害剤の使用
JP2008528001A (ja) * 2005-01-25 2008-07-31 スカイ、ジェネティクス、インク 癌マーカーおよび検出方法
US20160008366A1 (en) * 2014-07-14 2016-01-14 Pharmacyclics Llc Btk inhibitors for the treatment of cns malignancies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LOWERY,F.J.: "In Vivo Kinome Screen Reveals Non-canonical CDK-driven Metabolic Adaptation in Brain Metastasis.", THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER UTHEALTH GRADUATE SCHOOL OF BIOMEDICAL SCIENCES DI, JPN6022035153, 2016, pages 60 - 75, ISSN: 0005013825 *
STEM CELLS, vol. 35, JPN6022035152, June 2017 (2017-06-01), pages 1898 - 1912, ISSN: 0004856378 *

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