JP2020530467A - 癌転移を処置するためにキナーゼを標的とする方法 - Google Patents
癌転移を処置するためにキナーゼを標的とする方法 Download PDFInfo
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- JP2020530467A JP2020530467A JP2020507545A JP2020507545A JP2020530467A JP 2020530467 A JP2020530467 A JP 2020530467A JP 2020507545 A JP2020507545 A JP 2020507545A JP 2020507545 A JP2020507545 A JP 2020507545A JP 2020530467 A JP2020530467 A JP 2020530467A
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022183795A JP7587860B2 (ja) | 2017-08-11 | 2022-11-17 | 癌転移を処置するためにキナーゼを標的とする方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762544597P | 2017-08-11 | 2017-08-11 | |
| US62/544,597 | 2017-08-11 | ||
| PCT/US2018/046329 WO2019033041A1 (en) | 2017-08-11 | 2018-08-10 | TARGETING KINASES FOR THE TREATMENT OF CANCER METASTASES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022183795A Division JP7587860B2 (ja) | 2017-08-11 | 2022-11-17 | 癌転移を処置するためにキナーゼを標的とする方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020530467A true JP2020530467A (ja) | 2020-10-22 |
| JP2020530467A5 JP2020530467A5 (enExample) | 2021-09-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2020507545A Pending JP2020530467A (ja) | 2017-08-11 | 2018-08-10 | 癌転移を処置するためにキナーゼを標的とする方法 |
| JP2022183795A Active JP7587860B2 (ja) | 2017-08-11 | 2022-11-17 | 癌転移を処置するためにキナーゼを標的とする方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2022183795A Active JP7587860B2 (ja) | 2017-08-11 | 2022-11-17 | 癌転移を処置するためにキナーゼを標的とする方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11406643B2 (enExample) |
| EP (2) | EP3665482A4 (enExample) |
| JP (2) | JP2020530467A (enExample) |
| CN (1) | CN111133315A (enExample) |
| AU (1) | AU2018314234B2 (enExample) |
| CA (1) | CA3072087A1 (enExample) |
| WO (1) | WO2019033041A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102141997B1 (ko) * | 2017-11-22 | 2020-08-06 | (주)인핸스드바이오 | Pmvk를 유효성분으로 포함하는 방사선 저항성 암 진단용 또는 방사선 치료 예후 예측용 바이오마커 조성물 |
| EP3781168A4 (en) * | 2018-04-16 | 2022-10-05 | The Regents of the University of California | PAK4 INHIBITORS AND METHODS OF USE |
| US20220178924A1 (en) * | 2019-03-03 | 2022-06-09 | Purdue Research Foundation | Systems and methods for identifying subtype, prognosis, and monitoring of breast cancer |
| KR20220002930A (ko) * | 2019-03-28 | 2022-01-07 | 캔써 리서치 테크놀로지 리미티드 | 비정형 단백질 키나제 c의 억제제 및 헷지호그 경로 의존성 암의 치료에서 이의 용도 |
| TWI719446B (zh) * | 2019-04-16 | 2021-02-21 | 中國醫藥大學 | 醫藥組合物及其用於製備抑制胃癌細胞增生藥物的用途 |
| CN113143525A (zh) * | 2021-05-10 | 2021-07-23 | 广东省人民医院 | 一种新型脑转移瘤动物模型的构建方法 |
| CN114410778B (zh) * | 2021-12-29 | 2024-03-19 | 中南大学湘雅医院 | Pf543在制备pd-l1/pd-1单抗肿瘤免疫治疗药物中的应用 |
| WO2025031474A1 (en) * | 2023-08-10 | 2025-02-13 | Insilico Medicine Ip Limited | Method and medicament for treating endometriosis |
| US11932594B1 (en) | 2023-10-31 | 2024-03-19 | King Faisal University | 8-((2-hydroxy-5-methylphenyl)diazenyl)naphthalene-1,3-disulfonic acid as an antioxidant compound |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528001A (ja) * | 2005-01-25 | 2008-07-31 | スカイ、ジェネティクス、インク | 癌マーカーおよび検出方法 |
| JP2013231048A (ja) * | 1998-01-22 | 2013-11-14 | Max-Planck-Ges Zur Foerderung Der Wissenschaften Ev | Rtk−過剰機能−誘導障害、特に癌の治療のための阻害剤の使用 |
| US20160008366A1 (en) * | 2014-07-14 | 2016-01-14 | Pharmacyclics Llc | Btk inhibitors for the treatment of cns malignancies |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2388590A1 (en) | 2001-04-02 | 2011-11-23 | Dana Farber Cancer Institute | PD-1, a receptor for B7-4, and uses thereof |
| AU2003303082B2 (en) | 2002-01-30 | 2009-07-02 | Dana-Farber Cancer Institute, Inc. | Compositions and methods related to TIM-3, a Th1-specific cell surface molecule |
| WO2007044571A2 (en) * | 2005-10-06 | 2007-04-19 | President And Fellows Of Harvard College | Methods for identifying proteins essential for human cell proliferation and therapeutic agents that target them |
| EP1961825A1 (en) | 2007-02-26 | 2008-08-27 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Method for predicting the occurrence of metastasis in breast cancer patients |
| GB0706633D0 (en) | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | Combination |
| US20100029748A1 (en) | 2008-08-04 | 2010-02-04 | Sloan-Kettering Institute For Cancer Research | Metastasis Promoting Genes and Proteins |
| MX365219B (es) | 2011-07-27 | 2019-05-27 | The Broad Inst Inc Star | Uso de una composición en un método para inhibir el crecimiento del carcinoma de células escamosas de cabeza y cuello (hnscc). |
| EP2829880A1 (en) * | 2013-07-26 | 2015-01-28 | Energeia Biosciences | Method for identifying modulators of BCRP/ABCG2-mediated ATP release and use of said modulators for treating diseases |
| ES2873959T3 (es) * | 2014-05-28 | 2021-11-04 | Piramal Entpr Ltd | Combinación farmacéutica que comprende un inhibidor de CDK y un inhibidor de tiorredoxina reductasa para el tratamiento del cáncer |
| GB201414542D0 (en) * | 2014-08-15 | 2014-10-01 | Imp Innovations Ltd | Novel therapy |
| AU2015317330B2 (en) * | 2014-09-19 | 2021-01-14 | Memorial Sloan-Kettering Cancer Center | Methods for treating brain metastasis |
| UY36660A (es) * | 2015-04-30 | 2016-11-30 | Bayer Pharma AG | Combinaciones de inhibidores de irak4 |
| JP2018135268A (ja) | 2015-06-05 | 2018-08-30 | 大日本住友製薬株式会社 | 新規ヘテロアリールアミノ−3−ピラゾール誘導体およびその薬理学上許容される塩 |
-
2018
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-
2022
- 2022-11-17 JP JP2022183795A patent/JP7587860B2/ja active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013231048A (ja) * | 1998-01-22 | 2013-11-14 | Max-Planck-Ges Zur Foerderung Der Wissenschaften Ev | Rtk−過剰機能−誘導障害、特に癌の治療のための阻害剤の使用 |
| JP2008528001A (ja) * | 2005-01-25 | 2008-07-31 | スカイ、ジェネティクス、インク | 癌マーカーおよび検出方法 |
| US20160008366A1 (en) * | 2014-07-14 | 2016-01-14 | Pharmacyclics Llc | Btk inhibitors for the treatment of cns malignancies |
Non-Patent Citations (2)
| Title |
|---|
| LOWERY,F.J.: "In Vivo Kinome Screen Reveals Non-canonical CDK-driven Metabolic Adaptation in Brain Metastasis.", THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER UTHEALTH GRADUATE SCHOOL OF BIOMEDICAL SCIENCES DI, JPN6022035153, 2016, pages 60 - 75, ISSN: 0005013825 * |
| STEM CELLS, vol. 35, JPN6022035152, June 2017 (2017-06-01), pages 1898 - 1912, ISSN: 0004856378 * |
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| CN111133315A (zh) | 2020-05-08 |
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| US20200197407A1 (en) | 2020-06-25 |
| EP3665482A1 (en) | 2020-06-17 |
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| JP7587860B2 (ja) | 2024-11-21 |
| EP3665482A4 (en) | 2021-06-30 |
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