JP2020530453A5 - - Google Patents
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- JP2020530453A5 JP2020530453A5 JP2020506750A JP2020506750A JP2020530453A5 JP 2020530453 A5 JP2020530453 A5 JP 2020530453A5 JP 2020506750 A JP2020506750 A JP 2020506750A JP 2020506750 A JP2020506750 A JP 2020506750A JP 2020530453 A5 JP2020530453 A5 JP 2020530453A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- composition
- linker
- conjugate according
- albumin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 20
- 230000002519 immonomodulatory effect Effects 0.000 claims description 16
- 102000009027 Albumins Human genes 0.000 claims description 14
- 108010088751 Albumins Proteins 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 12
- 102000036639 antigens Human genes 0.000 claims description 12
- 108091007433 antigens Proteins 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 208000035473 Communicable disease Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 229960005486 vaccine Drugs 0.000 claims description 6
- 239000013604 expression vector Substances 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 238000003259 recombinant expression Methods 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 3
- 108020004414 DNA Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 238000009825 accumulation Methods 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000001165 lymph node Anatomy 0.000 claims description 2
- 210000004324 lymphatic system Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024039818A JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762543163P | 2017-08-09 | 2017-08-09 | |
| US62/543,163 | 2017-08-09 | ||
| PCT/US2018/046011 WO2019032827A1 (en) | 2017-08-09 | 2018-08-09 | PEPTIDE ALBUMIN BINDING CONJUGATES AND METHODS THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024039818A Division JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020530453A JP2020530453A (ja) | 2020-10-22 |
| JP2020530453A5 true JP2020530453A5 (enExample) | 2021-09-16 |
Family
ID=63371811
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506750A Withdrawn JP2020530453A (ja) | 2017-08-09 | 2018-08-09 | アルブミン結合ペプチド結合体及びその方法 |
| JP2024039818A Pending JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024039818A Pending JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11077199B2 (enExample) |
| EP (1) | EP3665202A1 (enExample) |
| JP (2) | JP2020530453A (enExample) |
| CN (1) | CN111164104A (enExample) |
| WO (1) | WO2019032827A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111164104A (zh) | 2017-08-09 | 2020-05-15 | 麻省理工学院 | 白蛋白结合肽缀合物及其方法 |
| CN115590947B (zh) * | 2022-05-27 | 2025-11-21 | 苏州大学 | 联合免疫用药物、温敏凝胶组合物、趋化因子颗粒及其应用 |
| CN115590974A (zh) * | 2022-05-27 | 2023-01-13 | 苏州大学（Cn） | 功能化靶向制剂及其制备方法、应用 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| JP2528107B2 (ja) | 1985-03-15 | 1996-08-28 | サマ−トン，ジエ−ムス | ポリヌクレオチド測定試薬と方法 |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US5525491A (en) | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US5786571A (en) | 1997-05-09 | 1998-07-28 | Lexmark International, Inc. | Wrapped temperature sensing assembly |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| US20060228364A1 (en) * | 1999-12-24 | 2006-10-12 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| US7608681B2 (en) | 1999-12-24 | 2009-10-27 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US8642743B2 (en) * | 2004-04-06 | 2014-02-04 | Affibody Ab | Method for reducing the immune response to a biologically active protein |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| CA2583137A1 (en) * | 2004-10-05 | 2006-04-20 | Genentech, Inc. | Therapeutic agents with decreased toxicity |
| US8992928B2 (en) | 2006-02-11 | 2015-03-31 | Victor Raso | Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin |
| GB0621973D0 (en) | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
| DE08786222T1 (de) | 2007-07-31 | 2010-11-25 | Affibody Ab | Neue albuminbindende zusammensetzungen, verfahren und anwendungen |
| EP2238165B1 (en) | 2008-01-07 | 2017-07-05 | Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Anti-hiv domain antibodies and method of making and using same |
| US20100075897A1 (en) * | 2008-09-23 | 2010-03-25 | Jinan University | Method for sustainedly releasing bioactive peptides and application thereof |
| EP2437767B1 (en) | 2009-06-01 | 2015-07-08 | MedImmune, LLC | Molecules with extended half-lives and uses thereof |
| CA3220104A1 (en) * | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| BR112013000452A2 (pt) | 2010-07-09 | 2020-02-11 | Affibody Ab | Polipeptídeo de ligação de albumina, proteína de fusão ou conjugado, polinucleotídeo, método para produzir um polipeptídeo, composição, método para a preparação de uma composição, e, método para aumentar a solubilidade de um composto |
| US9376495B2 (en) | 2011-05-21 | 2016-06-28 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use in extending serum half-life |
| AU2012273928A1 (en) | 2011-06-23 | 2014-02-06 | Ablynx Nv | Immunoglobulin single variable domains directed against IgE |
| US20150044208A1 (en) | 2011-09-23 | 2015-02-12 | Technophage, Investigaçäo E Desenvolvimento Em Biotecnologia, Sa | Modified Albumin-Binding Domains and Uses Thereof to Improve Pharmacokinetics |
| AU2012310328A1 (en) | 2011-09-23 | 2014-04-10 | Technophage, Investigação E Desenvolvimento Em Biotecnologia, S.A. | Anti-Tumor Necrosis Factor-alpha agents and uses thereof |
| WO2013148966A1 (en) | 2012-03-28 | 2013-10-03 | Amylin Pharmaceuticals, Llc | Transmucosal delivery of engineered polypeptides |
| JP6375289B2 (ja) * | 2012-04-05 | 2018-08-15 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫刺激組成物およびその使用方法 |
| WO2013180295A1 (ja) | 2012-06-01 | 2013-12-05 | 日本電信電話株式会社 | パケット転送処理方法およびパケット転送処理装置 |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| US9300829B2 (en) | 2014-04-04 | 2016-03-29 | Canon Kabushiki Kaisha | Image reading apparatus and correction method thereof |
| EP2940128A1 (en) | 2014-04-30 | 2015-11-04 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Adenovirus comprising an albumin-binding moiety |
| SG10201913507SA (en) | 2014-05-02 | 2020-02-27 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| EP3145945B1 (en) | 2014-05-22 | 2020-07-15 | Pieris Pharmaceuticals GmbH | Novel specific-binding polypeptides and uses thereof |
| US20170128527A1 (en) | 2014-06-18 | 2017-05-11 | Prorec Bio Ab | Prolactin receptor antagonists for treatment of glioblastoma |
| WO2016025647A1 (en) * | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| CN115414480A (zh) | 2014-11-10 | 2022-12-02 | 德玛医药 | 结合放射用于治疗非小细胞肺癌和多形性胶质母细胞瘤的二去水卫矛醇 |
| RU2757489C2 (ru) | 2015-06-12 | 2021-10-18 | Маккэй Медикл Фаундэйшн Зе Пресбайтериэн Чёч Ин Тайвэнь Маккэй Мемориал Хоспитэл | Способы и антитела для модуляции иммунного ответа |
| CN111164104A (zh) | 2017-08-09 | 2020-05-15 | 麻省理工学院 | 白蛋白结合肽缀合物及其方法 |
-
2018
- 2018-08-09 CN CN201880064127.6A patent/CN111164104A/zh active Pending
- 2018-08-09 US US16/059,523 patent/US11077199B2/en active Active
- 2018-08-09 WO PCT/US2018/046011 patent/WO2019032827A1/en not_active Ceased
- 2018-08-09 EP EP18759824.8A patent/EP3665202A1/en active Pending
- 2018-08-09 JP JP2020506750A patent/JP2020530453A/ja not_active Withdrawn
-
2021
- 2021-07-09 US US17/371,367 patent/US11642416B2/en active Active
-
2023
- 2023-04-18 US US18/302,655 patent/US20230248840A1/en not_active Abandoned
-
2024
- 2024-03-14 JP JP2024039818A patent/JP2024069465A/ja active Pending
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