JP2020530453A5 - - Google Patents
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- JP2020530453A5 JP2020530453A5 JP2020506750A JP2020506750A JP2020530453A5 JP 2020530453 A5 JP2020530453 A5 JP 2020530453A5 JP 2020506750 A JP2020506750 A JP 2020506750A JP 2020506750 A JP2020506750 A JP 2020506750A JP 2020530453 A5 JP2020530453 A5 JP 2020530453A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- composition
- linker
- conjugate according
- albumin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 20
- 230000002519 immonomodulatory effect Effects 0.000 claims description 16
- 102000009027 Albumins Human genes 0.000 claims description 14
- 108010088751 Albumins Proteins 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 12
- 102000036639 antigens Human genes 0.000 claims description 12
- 108091007433 antigens Proteins 0.000 claims description 12
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 208000035473 Communicable disease Diseases 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 229960005486 vaccine Drugs 0.000 claims description 6
- 239000013604 expression vector Substances 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 238000003259 recombinant expression Methods 0.000 claims description 4
- 230000028993 immune response Effects 0.000 claims description 3
- 108020004414 DNA Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 238000009825 accumulation Methods 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000001165 lymph node Anatomy 0.000 claims description 2
- 210000004324 lymphatic system Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024039818A JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762543163P | 2017-08-09 | 2017-08-09 | |
| US62/543,163 | 2017-08-09 | ||
| PCT/US2018/046011 WO2019032827A1 (en) | 2017-08-09 | 2018-08-09 | PEPTIDE ALBUMIN BINDING CONJUGATES AND METHODS THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024039818A Division JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020530453A JP2020530453A (ja) | 2020-10-22 |
| JP2020530453A5 true JP2020530453A5 (enExample) | 2021-09-16 |
Family
ID=63371811
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020506750A Withdrawn JP2020530453A (ja) | 2017-08-09 | 2018-08-09 | アルブミン結合ペプチド結合体及びその方法 |
| JP2024039818A Pending JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024039818A Pending JP2024069465A (ja) | 2017-08-09 | 2024-03-14 | アルブミン結合ペプチド結合体及びその方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11077199B2 (enExample) |
| EP (1) | EP3665202A1 (enExample) |
| JP (2) | JP2020530453A (enExample) |
| CN (1) | CN111164104A (enExample) |
| WO (1) | WO2019032827A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11077199B2 (en) | 2017-08-09 | 2021-08-03 | Massachusetts Institute Of Technology | Albumin binding peptide conjugates and methods thereof |
| CN115590974A (zh) * | 2022-05-27 | 2023-01-13 | 苏州大学（Cn） | 功能化靶向制剂及其制备方法、应用 |
| CN115590947B (zh) * | 2022-05-27 | 2025-11-21 | 苏州大学 | 联合免疫用药物、温敏凝胶组合物、趋化因子颗粒及其应用 |
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| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| DE3374837D1 (en) | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| DE3687030T2 (de) | 1985-03-15 | 1993-03-11 | Eugene Stirchak | Stereoregulare polynukleotiden bindende polymere. |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| US5525491A (en) | 1991-02-27 | 1996-06-11 | Creative Biomolecules, Inc. | Serine-rich peptide linkers |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US5786571A (en) | 1997-05-09 | 1998-07-28 | Lexmark International, Inc. | Wrapped temperature sensing assembly |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US20040001827A1 (en) * | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| WO2001045746A2 (en) | 1999-12-24 | 2001-06-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20060228364A1 (en) * | 1999-12-24 | 2006-10-12 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| DE05733048T1 (de) | 2004-04-06 | 2007-05-10 | Affibody Ab | Serumalbuminbindende peptidkonjugate zur arzneimittelherstellung |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| BRPI0516577A (pt) * | 2004-10-05 | 2008-09-16 | Genentech Inc | agentes terapêuticos com toxicidade diminuìda |
| WO2007092023A1 (en) | 2006-02-11 | 2007-08-16 | Boston Biomedical Research Institute | Compositions and methods for binding or inactivating ghrelin |
| GB0621973D0 (en) | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
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| EP2238165B1 (en) | 2008-01-07 | 2017-07-05 | Government of the United States of America, as represented by the Secretary, Department of Health and Human Services | Anti-hiv domain antibodies and method of making and using same |
| US20100075897A1 (en) * | 2008-09-23 | 2010-03-25 | Jinan University | Method for sustainedly releasing bioactive peptides and application thereof |
| US20120134984A1 (en) | 2009-06-01 | 2012-05-31 | Olga Lubman | Molecules with extended half-lives and uses thereof |
| JP2013534520A (ja) * | 2010-06-08 | 2013-09-05 | ジェネンテック， インコーポレイテッド | システイン操作抗体及びコンジュゲート |
| CN110437321A (zh) | 2010-07-09 | 2019-11-12 | 阿菲博迪公司 | 多肽 |
| WO2012162068A2 (en) | 2011-05-21 | 2012-11-29 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use for extending serum half-life |
| JP2014525736A (ja) | 2011-06-23 | 2014-10-02 | アブリンクス エン．ヴェー． | ＩｇＥに対する免疫グロブリン単一可変ドメイン |
| CA2849705A1 (en) | 2011-09-23 | 2013-03-28 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Modified albumin-binding domains and uses thereof to improve pharmacokinetics |
| CA2849409A1 (en) | 2011-09-23 | 2013-03-28 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Anti-tumor necrosis factor-alpha agents and uses thereof |
| US20150133373A1 (en) | 2012-03-28 | 2015-05-14 | Amylin Pharmaceuticals, Llc | Transmucosal delivery of engineered polypeptides |
| ES2731524T3 (es) | 2012-04-05 | 2019-11-15 | Massachusetts Inst Technology | Composiciones inmunoestimuladoras y métodos de uso de las mismas |
| US9401875B2 (en) | 2012-06-01 | 2016-07-26 | Nippon Telegraph And Telephone Corporation | Packet transfer processing method and packet transfer processing device |
| EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
| US9300829B2 (en) | 2014-04-04 | 2016-03-29 | Canon Kabushiki Kaisha | Image reading apparatus and correction method thereof |
| EP2940128A1 (en) | 2014-04-30 | 2015-11-04 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Adenovirus comprising an albumin-binding moiety |
| CN106661125B (zh) | 2014-05-02 | 2021-10-01 | 动量制药公司 | 涉及工程化Fc构建体的组合物和方法 |
| CN113621050A (zh) | 2014-05-22 | 2021-11-09 | 皮里斯制药有限公司 | 新型特异性结合多肽及其用途 |
| WO2015193417A1 (en) | 2014-06-18 | 2015-12-23 | Prorec Bio Ab | Prolactin receptor antagonists for treatment of glioblastoma |
| WO2016025647A1 (en) | 2014-08-12 | 2016-02-18 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| TW201632181A (zh) | 2014-11-10 | 2016-09-16 | 德瑪製藥公司 | 二去水半乳糖醇及其類似物或衍生物與輻射共同對於治療肺之非小細胞癌、多形性膠質母細胞瘤及抑制癌幹細胞之增生的用途 |
| CN108135961A (zh) | 2015-06-12 | 2018-06-08 | 台湾基督长老教会马偕医疗财团法人马偕纪念医院 | 调控免疫反应的方法及多肽 |
| US11077199B2 (en) | 2017-08-09 | 2021-08-03 | Massachusetts Institute Of Technology | Albumin binding peptide conjugates and methods thereof |
-
2018
- 2018-08-09 US US16/059,523 patent/US11077199B2/en active Active
- 2018-08-09 JP JP2020506750A patent/JP2020530453A/ja not_active Withdrawn
- 2018-08-09 CN CN201880064127.6A patent/CN111164104A/zh active Pending
- 2018-08-09 EP EP18759824.8A patent/EP3665202A1/en active Pending
- 2018-08-09 WO PCT/US2018/046011 patent/WO2019032827A1/en not_active Ceased
-
2021
- 2021-07-09 US US17/371,367 patent/US11642416B2/en active Active
-
2023
- 2023-04-18 US US18/302,655 patent/US20230248840A1/en not_active Abandoned
-
2024
- 2024-03-14 JP JP2024039818A patent/JP2024069465A/ja active Pending
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