JP2020529834A5 - - Google Patents
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- JP2020529834A5 JP2020529834A5 JP2019571593A JP2019571593A JP2020529834A5 JP 2020529834 A5 JP2020529834 A5 JP 2020529834A5 JP 2019571593 A JP2019571593 A JP 2019571593A JP 2019571593 A JP2019571593 A JP 2019571593A JP 2020529834 A5 JP2020529834 A5 JP 2020529834A5
- Authority
- JP
- Japan
- Prior art keywords
- modified human
- genetically modified
- cell
- interest
- exogenous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 12
- 108091008874 T cell receptors Proteins 0.000 claims 6
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 6
- 108020005067 RNA Splice Sites Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 101150087698 alpha gene Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 2
- 102100029452 T cell receptor alpha chain constant Human genes 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 108091033409 CRISPR Proteins 0.000 claims 1
- 238000010354 CRISPR gene editing Methods 0.000 claims 1
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 1
- 101000634853 Homo sapiens T cell receptor alpha chain constant Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022022074A JP2022078103A (ja) | 2017-06-30 | 2022-02-16 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2023133418A JP2023175699A (ja) | 2017-06-30 | 2023-08-18 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2025026102A JP2025102755A (ja) | 2017-06-30 | 2025-02-20 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2025172936A JP2026027250A (ja) | 2017-06-30 | 2025-10-14 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762527845P | 2017-06-30 | 2017-06-30 | |
| US62/527,845 | 2017-06-30 | ||
| US201762579473P | 2017-10-31 | 2017-10-31 | |
| US62/579,473 | 2017-10-31 | ||
| PCT/US2018/039740 WO2019005957A1 (en) | 2017-06-30 | 2018-06-27 | GENETICALLY MODIFIED T CELLS COMPRISING A MODIFIED INTRON IN THE ALPHA T CELL RECEPTOR GENE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022022074A Division JP2022078103A (ja) | 2017-06-30 | 2022-02-16 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020529834A JP2020529834A (ja) | 2020-10-15 |
| JP2020529834A5 true JP2020529834A5 (https=) | 2021-08-05 |
Family
ID=63103995
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571593A Pending JP2020529834A (ja) | 2017-06-30 | 2018-06-27 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2022022074A Pending JP2022078103A (ja) | 2017-06-30 | 2022-02-16 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2023133418A Withdrawn JP2023175699A (ja) | 2017-06-30 | 2023-08-18 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2025026102A Pending JP2025102755A (ja) | 2017-06-30 | 2025-02-20 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2025172936A Pending JP2026027250A (ja) | 2017-06-30 | 2025-10-14 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022022074A Pending JP2022078103A (ja) | 2017-06-30 | 2022-02-16 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2023133418A Withdrawn JP2023175699A (ja) | 2017-06-30 | 2023-08-18 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2025026102A Pending JP2025102755A (ja) | 2017-06-30 | 2025-02-20 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
| JP2025172936A Pending JP2026027250A (ja) | 2017-06-30 | 2025-10-14 | Ｔ細胞受容体アルファ遺伝子の改変されたイントロンを含む遺伝子改変ｔ細胞 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11053484B2 (https=) |
| EP (1) | EP3645038B1 (https=) |
| JP (5) | JP2020529834A (https=) |
| AU (2) | AU2018292526A1 (https=) |
| CA (1) | CA3068465A1 (https=) |
| WO (1) | WO2019005957A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3359660B1 (en) | 2015-10-05 | 2019-12-04 | Precision Biosciences, Inc. | Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene |
| JP6816133B2 (ja) | 2015-10-05 | 2021-01-20 | プレシジョン バイオサイエンシズ，インク． | 改変ヒトｔ細胞受容体アルファ定常領域遺伝子を含む遺伝子改変細胞 |
| EP3645038B1 (en) * | 2017-06-30 | 2026-02-18 | Precision Biosciences, Inc. | Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene |
| JP2020537515A (ja) | 2017-10-03 | 2020-12-24 | ジュノー セラピューティクス インコーポレイテッド | Ｈｐｖ特異的結合分子 |
| CA3094468A1 (en) * | 2018-04-05 | 2019-10-10 | Juno Therapeutics, Inc. | Methods of producing cells expressing a recombinant receptor and related compositions |
| US11786554B2 (en) | 2018-04-12 | 2023-10-17 | Precision Biosciences, Inc. | Optimized engineered nucleases having specificity for the human T cell receptor alpha constant region gene |
| SG11202110613SA (en) * | 2019-03-27 | 2021-10-28 | Res Inst Nationwide Childrens Hospital | Generation of chimeric antigen receptor (car)-primary nk cells for cancer immunotherapy using a combination of cas9/rnp and aav viruses |
| CN114026228A (zh) | 2019-05-07 | 2022-02-08 | 精密生物科学公司 | 用于识别序列的工程化大范围核酸酶的优化 |
| US20220411479A1 (en) * | 2019-10-30 | 2022-12-29 | Precision Biosciences, Inc. | Cd20 chimeric antigen receptors and methods of use for immunotherapy |
| EP4110356A4 (en) * | 2020-02-28 | 2024-03-27 | Wisconsin Alumni Research Foundation | NON-VIRAL GENERATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS OBTAINED BY GENE EDITING |
| GB202005184D0 (en) * | 2020-04-08 | 2020-05-20 | Autolus Ltd | Method |
| US20230183664A1 (en) | 2020-05-11 | 2023-06-15 | Precision Biosciences, Inc. | Self-limiting viral vectors encoding nucleases |
| EP4259159A4 (en) * | 2020-12-14 | 2025-04-09 | Emendobio Inc. | Biallelic knockout of trac |
| WO2023070002A2 (en) * | 2021-10-19 | 2023-04-27 | Precision Biosciences, Inc. | Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency |
| WO2023178292A1 (en) * | 2022-03-16 | 2023-09-21 | Regents Of The University Of Minnesota | Genetically engineered t cell for cell therapy |
| WO2025165787A1 (en) * | 2024-02-01 | 2025-08-07 | The Board Of Trustees Of The Leland Stanford Junior University | Touchless selection of gene modified cell therapies through trac intron knockins |
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| DE69534629D1 (de) | 1994-01-18 | 2005-12-29 | Scripps Research Inst | Derivate von zinkfingerproteinen und methoden |
| USRE39229E1 (en) | 1994-08-20 | 2006-08-08 | Gendaq Limited | Binding proteins for recognition of DNA |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
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| US6015832A (en) | 1997-12-31 | 2000-01-18 | The Regents Of The University Of Michigan | Methods of inactivating bacteria including bacterial spores |
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| JP6816133B2 (ja) | 2015-10-05 | 2021-01-20 | プレシジョン バイオサイエンシズ，インク． | 改変ヒトｔ細胞受容体アルファ定常領域遺伝子を含む遺伝子改変細胞 |
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| CA3009637A1 (en) | 2015-12-23 | 2017-06-29 | Precision Biosciences, Inc. | Engineered meganucleases with recognition sequences found in the human beta-2 microglobulin gene |
| JP2019509738A (ja) | 2016-03-11 | 2019-04-11 | ブルーバード バイオ， インコーポレイテッド | ゲノム編集された免疫エフェクター細胞 |
| EP4628587A3 (en) | 2016-04-15 | 2026-02-25 | Memorial Sloan Kettering Cancer Center | Transgenic t cell and chimeric antigen receptor t cell compositions and related methods |
| EP3645038B1 (en) | 2017-06-30 | 2026-02-18 | Precision Biosciences, Inc. | Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene |
| US11786554B2 (en) | 2018-04-12 | 2023-10-17 | Precision Biosciences, Inc. | Optimized engineered nucleases having specificity for the human T cell receptor alpha constant region gene |
-
2018
- 2018-06-27 EP EP18749901.7A patent/EP3645038B1/en active Active
- 2018-06-27 US US16/627,052 patent/US11053484B2/en active Active
- 2018-06-27 AU AU2018292526A patent/AU2018292526A1/en not_active Abandoned
- 2018-06-27 WO PCT/US2018/039740 patent/WO2019005957A1/en not_active Ceased
- 2018-06-27 CA CA3068465A patent/CA3068465A1/en active Pending
- 2018-06-27 JP JP2019571593A patent/JP2020529834A/ja active Pending
-
2021
- 2021-05-25 US US17/330,365 patent/US12448613B2/en active Active
-
2022
- 2022-02-16 JP JP2022022074A patent/JP2022078103A/ja active Pending
-
2023
- 2023-08-18 JP JP2023133418A patent/JP2023175699A/ja not_active Withdrawn
-
2025
- 2025-02-20 JP JP2025026102A patent/JP2025102755A/ja active Pending
- 2025-05-21 AU AU2025203753A patent/AU2025203753A1/en active Pending
- 2025-10-14 JP JP2025172936A patent/JP2026027250A/ja active Pending
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