AU2018292526A1 - Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene - Google Patents

Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene Download PDF

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Publication number
AU2018292526A1
AU2018292526A1 AU2018292526A AU2018292526A AU2018292526A1 AU 2018292526 A1 AU2018292526 A1 AU 2018292526A1 AU 2018292526 A AU2018292526 A AU 2018292526A AU 2018292526 A AU2018292526 A AU 2018292526A AU 2018292526 A1 AU2018292526 A1 AU 2018292526A1
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Prior art keywords
cell
sequence
seq
engineered meganuclease
nos
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Abandoned
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AU2018292526A
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Inventor
Clayton BEARD
Derek Jantz
James Jefferson Smith
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Precision Biosciences Inc
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Precision Biosciences Inc
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Publication of AU2018292526A1 publication Critical patent/AU2018292526A1/en
Priority to AU2025203753A priority Critical patent/AU2025203753A1/en
Abandoned legal-status Critical Current

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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2800/00—Nucleic acids vectors
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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AU2018292526A 2017-06-30 2018-06-27 Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene Abandoned AU2018292526A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025203753A AU2025203753A1 (en) 2017-06-30 2025-05-21 Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762527845P 2017-06-30 2017-06-30
US62/527,845 2017-06-30
US201762579473P 2017-10-31 2017-10-31
US62/579,473 2017-10-31
PCT/US2018/039740 WO2019005957A1 (en) 2017-06-30 2018-06-27 GENETICALLY MODIFIED T CELLS COMPRISING A MODIFIED INTRON IN THE ALPHA T CELL RECEPTOR GENE

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AU2025203753A Division AU2025203753A1 (en) 2017-06-30 2025-05-21 Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene

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AU2018292526A1 true AU2018292526A1 (en) 2020-01-16

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AU2025203753A Pending AU2025203753A1 (en) 2017-06-30 2025-05-21 Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene

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US (2) US11053484B2 (https=)
EP (1) EP3645038B1 (https=)
JP (5) JP2020529834A (https=)
AU (2) AU2018292526A1 (https=)
CA (1) CA3068465A1 (https=)
WO (1) WO2019005957A1 (https=)

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