JP2020529194A5 - - Google Patents
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- Publication number
- JP2020529194A5 JP2020529194A5 JP2019571025A JP2019571025A JP2020529194A5 JP 2020529194 A5 JP2020529194 A5 JP 2020529194A5 JP 2019571025 A JP2019571025 A JP 2019571025A JP 2019571025 A JP2019571025 A JP 2019571025A JP 2020529194 A5 JP2020529194 A5 JP 2020529194A5
- Authority
- JP
- Japan
- Prior art keywords
- dna
- amount
- total
- subject
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008186 active pharmaceutical agent Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 23
- 238000011282 treatment Methods 0.000 claims 13
- 238000002054 transplantation Methods 0.000 claims 9
- 108700028369 Alleles Proteins 0.000 claims 8
- 238000012544 monitoring process Methods 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 238000011269 treatment regimen Methods 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- 238000012207 quantitative assay Methods 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000005070 sampling Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762522570P | 2017-06-20 | 2017-06-20 | |
| US62/522,570 | 2017-06-20 | ||
| US201762576631P | 2017-10-24 | 2017-10-24 | |
| US62/576,631 | 2017-10-24 | ||
| US201862653517P | 2018-04-05 | 2018-04-05 | |
| US201862653213P | 2018-04-05 | 2018-04-05 | |
| US62/653,517 | 2018-04-05 | ||
| US62/653,213 | 2018-04-05 | ||
| US201862655030P | 2018-04-09 | 2018-04-09 | |
| US62/655,030 | 2018-04-09 | ||
| PCT/US2018/038609 WO2018237081A1 (en) | 2017-06-20 | 2018-06-20 | PATIENT MONITOR TRANSPLANT WITH ACELLULAR DNA |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020529194A JP2020529194A (ja) | 2020-10-08 |
| JP2020529194A5 true JP2020529194A5 (enExample) | 2021-07-29 |
| JP7323462B2 JP7323462B2 (ja) | 2023-08-08 |
Family
ID=64737312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571025A Active JP7323462B2 (ja) | 2017-06-20 | 2018-06-20 | セルフリーｄｎａによる移植患者のモニタリング |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20210139983A1 (enExample) |
| EP (1) | EP3642356A4 (enExample) |
| JP (1) | JP7323462B2 (enExample) |
| CN (1) | CN110945144A (enExample) |
| AU (1) | AU2018288838A1 (enExample) |
| CA (1) | CA3067635A1 (enExample) |
| IL (1) | IL271459A (enExample) |
| WO (1) | WO2018237081A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10179937B2 (en) | 2014-04-21 | 2019-01-15 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| AU2011255641A1 (en) | 2010-05-18 | 2012-12-06 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| CA2821906C (en) | 2010-12-22 | 2020-08-25 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| DK3294906T3 (en) | 2015-05-11 | 2024-08-05 | Natera Inc | Methods for determining ploidy |
| WO2017181202A2 (en) | 2016-04-15 | 2017-10-19 | Natera, Inc. | Methods for lung cancer detection |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| US11773434B2 (en) | 2017-06-20 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| CA3085933A1 (en) | 2017-12-14 | 2019-06-20 | Tai Diagnostics, Inc. | Assessing graft suitability for transplantation |
| EP3781714B1 (en) | 2018-04-14 | 2026-01-07 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| WO2020172164A1 (en) * | 2019-02-19 | 2020-08-27 | Sequenom, Inc. | Compositions, methods, and systems to detect hematopoietic stem cell transplantation status |
| WO2020206269A1 (en) * | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| US12305235B2 (en) | 2019-06-06 | 2025-05-20 | Natera, Inc. | Methods for detecting immune cell DNA and monitoring immune system |
| WO2022015676A1 (en) * | 2020-07-13 | 2022-01-20 | The Medical College Of Wisconsin, Inc. | Methods for making treatment management decisions in transplant subjects and assessing transplant risks with threshold values |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2779750C (en) * | 2009-11-06 | 2019-03-19 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive diagnosis of graft rejection in organ transplant patients |
| JP5842811B2 (ja) * | 2010-03-24 | 2016-01-13 | 凸版印刷株式会社 | 競合プライマーによる標的塩基配列の検出方法 |
| US20130123120A1 (en) * | 2010-05-18 | 2013-05-16 | Natera, Inc. | Highly Multiplex PCR Methods and Compositions |
| AU2013249012B2 (en) * | 2012-04-19 | 2019-03-28 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free DNA |
| CN105102634A (zh) * | 2013-03-15 | 2015-11-25 | 伊穆科Gti诊治股份有限公司 | 使用尿的无细胞dna评价肾状态的方法和组合物 |
| LT3004388T (lt) * | 2013-05-29 | 2019-01-25 | Chronix Biomedical | Donoro ne ląstelinės dnr aptikimas ir jos kiekio nustatymas organo transplantanto recipientų apytakoje |
| US20160258010A1 (en) * | 2013-10-18 | 2016-09-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Allele specific pcr assay for detection of nucleotide variants |
| CN106536752B (zh) * | 2014-03-14 | 2021-08-06 | 凯尔迪克斯公司 | 用于在移植受体中监测免疫抑制疗法的方法 |
| MX2017013878A (es) * | 2015-04-30 | 2018-06-22 | Medical College Of Wisconsin Inc | Amplificación de discordancias optimizadas multiplicadas (moma) - reacción en cadena de polimerasa (pcr) en tiempo real, para evaluar el ácido desoxirribonucleico (adn) libre de celula. |
-
2018
- 2018-06-20 US US16/623,725 patent/US20210139983A1/en active Pending
- 2018-06-20 JP JP2019571025A patent/JP7323462B2/ja active Active
- 2018-06-20 CA CA3067635A patent/CA3067635A1/en active Pending
- 2018-06-20 AU AU2018288838A patent/AU2018288838A1/en not_active Abandoned
- 2018-06-20 WO PCT/US2018/038609 patent/WO2018237081A1/en not_active Ceased
- 2018-06-20 EP EP18821381.3A patent/EP3642356A4/en active Pending
- 2018-06-20 CN CN201880049158.4A patent/CN110945144A/zh active Pending
-
2019
- 2019-12-16 IL IL271459A patent/IL271459A/en unknown
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