CN110945144A - 利用无细胞dna的移植患者监测 - Google Patents

利用无细胞dna的移植患者监测 Download PDF

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Publication number
CN110945144A
CN110945144A CN201880049158.4A CN201880049158A CN110945144A CN 110945144 A CN110945144 A CN 110945144A CN 201880049158 A CN201880049158 A CN 201880049158A CN 110945144 A CN110945144 A CN 110945144A
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dna
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amount
total
sample
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CN201880049158.4A
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English (en)
Chinese (zh)
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青·富田·米切尔
迈克尔·米切尔
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Medical College of Wisconsin
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Medical College of Wisconsin
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201880049158.4A 2017-06-20 2018-06-20 利用无细胞dna的移植患者监测 Pending CN110945144A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762522570P 2017-06-20 2017-06-20
US62/522,570 2017-06-20
US201762576631P 2017-10-24 2017-10-24
US62/576,631 2017-10-24
US201862653517P 2018-04-05 2018-04-05
US201862653213P 2018-04-05 2018-04-05
US62/653,517 2018-04-05
US62/653,213 2018-04-05
US201862655030P 2018-04-09 2018-04-09
US62/655,030 2018-04-09
PCT/US2018/038609 WO2018237081A1 (en) 2017-06-20 2018-06-20 PATIENT MONITOR TRANSPLANT WITH ACELLULAR DNA

Publications (1)

Publication Number Publication Date
CN110945144A true CN110945144A (zh) 2020-03-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880049158.4A Pending CN110945144A (zh) 2017-06-20 2018-06-20 利用无细胞dna的移植患者监测

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US (1) US20210139983A1 (enExample)
EP (1) EP3642356A4 (enExample)
JP (1) JP7323462B2 (enExample)
CN (1) CN110945144A (enExample)
AU (1) AU2018288838A1 (enExample)
CA (1) CA3067635A1 (enExample)
IL (1) IL271459A (enExample)
WO (1) WO2018237081A1 (enExample)

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US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
AU2011255641A1 (en) 2010-05-18 2012-12-06 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
JP6659575B2 (ja) 2014-04-21 2020-03-04 ナテラ， インコーポレイテッド 変異の検出および染色体分節の倍数性
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
DK3294906T3 (en) 2015-05-11 2024-08-05 Natera Inc Methods for determining ploidy
CN109477138A (zh) 2016-04-15 2019-03-15 纳特拉公司 肺癌检测方法
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
EP3642353B1 (en) 2017-06-20 2025-03-05 The Medical College of Wisconsin, Inc. Assessing transplant complication risk with total cell-free dna
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
CN112236535A (zh) 2018-04-14 2021-01-15 纳特拉公司 用于借助于循环肿瘤dna的个人化检测的癌症检测和监测的方法
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
US20220093208A1 (en) * 2019-02-19 2022-03-24 Sequenom, Inc. Compositions, methods, and systems to detect hematopoietic stem cell transplantation status
WO2020206269A1 (en) * 2019-04-03 2020-10-08 The Medical College Of Wisconsin, Inc. Transplant patient monitoring with cell-free dna
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
EP3980559A1 (en) 2019-06-06 2022-04-13 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
WO2022015676A1 (en) * 2020-07-13 2022-01-20 The Medical College Of Wisconsin, Inc. Methods for making treatment management decisions in transplant subjects and assessing transplant risks with threshold values

Citations (3)

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US20160115541A1 (en) * 2013-05-29 2016-04-28 Chronix Biomedical Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients
WO2016176662A1 (en) * 2015-04-30 2016-11-03 Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna
US20170114411A1 (en) * 2012-04-19 2017-04-27 Medical College Of Wisconsin, Inc. Highly sensitive transplant rejection surveillance using targeted detection of donor specific cell free dna

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JP5842811B2 (ja) * 2010-03-24 2016-01-13 凸版印刷株式会社 競合プライマーによる標的塩基配列の検出方法
US20130123120A1 (en) * 2010-05-18 2013-05-16 Natera, Inc. Highly Multiplex PCR Methods and Compositions
JP2016512698A (ja) * 2013-03-15 2016-05-09 イムコア ジーティーアイ ダイアグノスティクス インコーポレイテッド 尿中セルフリーｄｎａを用いて腎状態を評価するための方法および組成物
US20160258010A1 (en) * 2013-10-18 2016-09-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Allele specific pcr assay for detection of nucleotide variants
DK3117012T3 (da) * 2014-03-14 2019-05-13 Caredx Inc Fremgangsmåder til overvågning af immunosuppressive terapier hos en transplantmodtager

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20170114411A1 (en) * 2012-04-19 2017-04-27 Medical College Of Wisconsin, Inc. Highly sensitive transplant rejection surveillance using targeted detection of donor specific cell free dna
US20160115541A1 (en) * 2013-05-29 2016-04-28 Chronix Biomedical Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients
WO2016176662A1 (en) * 2015-04-30 2016-11-03 Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna

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EP3642356A4 (en) 2021-03-17
WO2018237081A1 (en) 2018-12-27
CA3067635A1 (en) 2018-12-27
EP3642356A1 (en) 2020-04-29
JP2020529194A (ja) 2020-10-08
IL271459A (en) 2020-01-30
JP7323462B2 (ja) 2023-08-08
US20210139983A1 (en) 2021-05-13
AU2018288838A1 (en) 2020-01-16

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