JP2020527564A5 - - Google Patents
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- JP2020527564A5 JP2020527564A5 JP2020502170A JP2020502170A JP2020527564A5 JP 2020527564 A5 JP2020527564 A5 JP 2020527564A5 JP 2020502170 A JP2020502170 A JP 2020502170A JP 2020502170 A JP2020502170 A JP 2020502170A JP 2020527564 A5 JP2020527564 A5 JP 2020527564A5
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- Prior art keywords
- amino acid
- stamp
- seq
- infection
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 104
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- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 claims description 40
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 claims description 40
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| AU2018304230A1 (en) | 2017-07-19 | 2020-02-06 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections |
| CN110283253B (zh) * | 2019-07-12 | 2020-04-10 | 东北农业大学 | 一种猪源衍生杂合抗菌肽mdp-2及其制备方法和应用 |
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| WO2021216845A1 (en) * | 2020-04-22 | 2021-10-28 | Dana-Farber Cancer Institute, Inc. | Antiviral structurally-stabilized ace2 helix 1 peptides and uses thereof |
| CN115884784A (zh) * | 2020-08-21 | 2023-03-31 | 北京微矿科技有限公司 | 抗微生物肽及其应用 |
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| JP2024539138A (ja) | 2021-10-22 | 2024-10-28 | イントゥーキュア エービー | 多価効果を持つペプチド |
| CN114395026B (zh) * | 2022-01-27 | 2023-11-21 | 福州大学 | 一种基于理性设计策略构建的广谱抗菌肽 |
| CN114432428B (zh) * | 2022-02-24 | 2024-07-23 | 西北农林科技大学 | PGLa提高细菌对抗生素的敏感性和延缓细菌耐药性产生的应用 |
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- 2018-07-18 JP JP2020502170A patent/JP7305614B2/ja active Active
- 2018-07-18 US US16/631,315 patent/US11325955B2/en active Active
- 2018-07-18 WO PCT/US2018/042640 patent/WO2019018499A2/en not_active Ceased
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2022
- 2022-09-26 JP JP2022152457A patent/JP2022177234A/ja active Pending
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