JP2020527546A5 - - Google Patents

Info

Publication number

JP2020527546A5

JP2020527546A5 JP2019572724A JP2019572724A JP2020527546A5 JP 2020527546 A5 JP2020527546 A5 JP 2020527546A5 JP 2019572724 A JP2019572724 A JP 2019572724A JP 2019572724 A JP2019572724 A JP 2019572724A JP 2020527546 A5 JP2020527546 A5 JP 2020527546A5

Authority

JP

Japan

Prior art keywords

seq

peptide

amino acid

acid sequence

tlr7

Prior art date

2018-06-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 22
• 239000003795 chemical substances by application Substances 0.000 claims 11
• 239000003814 drug Substances 0.000 claims 11
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 9
• 235000001014 amino acid Nutrition 0.000 claims 9
• 150000001413 amino acids Chemical class 0.000 claims 9
• 229940079593 drug Drugs 0.000 claims 8
• 102100039390 Toll-like receptor 7 Human genes 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
• 101800002011 Amphipathic peptide Proteins 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 238000006664 bond formation reaction Methods 0.000 claims 2
• 102000045715 human TLR7 Human genes 0.000 claims 2
• 230000000737 periodic effect Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• QETLKNDKQOXZRP-XTGBIJOFSA-N 5alpha-cholest-8-en-3beta-ol Chemical compound C([C@@]12C)C[C@H](O)C[C@@H]1CCC1=C2CC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]21 QETLKNDKQOXZRP-XTGBIJOFSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 101100189913 Caenorhabditis elegans pept-1 gene Proteins 0.000 claims 1
• BHYOQNUELFTYRT-UHFFFAOYSA-N Cholesterol sulfate Natural products C1C=C2CC(OS(O)(=O)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 BHYOQNUELFTYRT-UHFFFAOYSA-N 0.000 claims 1
• 241000714259 Human T-lymphotropic virus 2 Species 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108010088535 Pep-1 peptide Proteins 0.000 claims 1
• 108010039918 Polylysine Proteins 0.000 claims 1
• 230000003042 antagnostic effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000010348 incorporation Methods 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 230000000813 microbial effect Effects 0.000 claims 1
• 230000008506 pathogenesis Effects 0.000 claims 1
• 239000008024 pharmaceutical diluent Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
• 108010011110 polyarginine Proteins 0.000 claims 1
• 229920000656 polylysine Polymers 0.000 claims 1
• PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 claims 1
• 108010062760 transportan Proteins 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1