JP2008522954A5 - - Google Patents

Info

Publication number

JP2008522954A5

JP2008522954A5 JP2007526128A JP2007526128A JP2008522954A5 JP 2008522954 A5 JP2008522954 A5 JP 2008522954A5 JP 2007526128 A JP2007526128 A JP 2007526128A JP 2007526128 A JP2007526128 A JP 2007526128A JP 2008522954 A5 JP2008522954 A5 JP 2008522954A5

Authority

JP

Japan

Prior art keywords

seq

peptide

isolated

sequence

amino acid

Prior art date

2005-08-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 53
• 150000001413 amino acids Chemical class 0.000 claims 8
• 125000003275 alpha amino acid group Chemical group 0.000 claims 7
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 150000008574 D-amino acids Chemical class 0.000 claims 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 claims 1
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 claims 1
• 108700006830 Drosophila Antp Proteins 0.000 claims 1
• 239000004471 Glycine Substances 0.000 claims 1
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
• 241000737052 Naso hexacanthus Species 0.000 claims 1
• 108010088535 Pep-1 peptide Proteins 0.000 claims 1
• 101710176384 Peptide 1 Proteins 0.000 claims 1
• 150000001408 amides Chemical class 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 230000000302 ischemic effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
• 108010011110 polyarginine Proteins 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 238000011191 terminal modification Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 230000026683 transduction Effects 0.000 claims 1
• 238000010361 transduction Methods 0.000 claims 1
• PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 claims 1
• 108010062760 transportan Proteins 0.000 claims 1