JP2020525498A5 - - Google Patents

Info

Publication number

JP2020525498A5

JP2020525498A5 JP2019572377A JP2019572377A JP2020525498A5 JP 2020525498 A5 JP2020525498 A5 JP 2020525498A5 JP 2019572377 A JP2019572377 A JP 2019572377A JP 2019572377 A JP2019572377 A JP 2019572377A JP 2020525498 A5 JP2020525498 A5 JP 2020525498A5

Authority

JP

Japan

Prior art keywords

fusion protein

use according

per year

seq

fix

Prior art date

2018-06-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108020001507 fusion proteins Proteins 0.000 claims 21
• 102000037865 fusion proteins Human genes 0.000 claims 21
• 102100022641 Coagulation factor IX Human genes 0.000 claims 5
• 108010076282 Factor IX Proteins 0.000 claims 4
• 208000032843 Hemorrhage Diseases 0.000 claims 4
• 208000034158 bleeding Diseases 0.000 claims 4
• 231100000319 bleeding Toxicity 0.000 claims 4
• 230000000740 bleeding effect Effects 0.000 claims 4
• 229960004222 factor ix Drugs 0.000 claims 4
• 102000008100 Human Serum Albumin Human genes 0.000 claims 2
• 108091006905 Human Serum Albumin Proteins 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• 239000004365 Protease Substances 0.000 claims 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
• 108010000499 Thromboplastin Proteins 0.000 claims 2
• 102000002262 Thromboplastin Human genes 0.000 claims 2
• 230000015271 coagulation Effects 0.000 claims 2
• 238000005345 coagulation Methods 0.000 claims 2
• 230000036470 plasma concentration Effects 0.000 claims 2
• 230000002269 spontaneous effect Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 208000009429 hemophilia B Diseases 0.000 claims 1
• 229960000027 human factor ix Drugs 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1