DK3645034T5 - 21-dages doseringsregimen for fusionsproteiner omfatten-defaktor ix og human albumin til profylaktisk behandling af hæmofili og fremgangsmåder heraf - Google Patents
21-dages doseringsregimen for fusionsproteiner omfatten-defaktor ix og human albumin til profylaktisk behandling af hæmofili og fremgangsmåder heraf Download PDFInfo
- Publication number
- DK3645034T5 DK3645034T5 DK18736860.0T DK18736860T DK3645034T5 DK 3645034 T5 DK3645034 T5 DK 3645034T5 DK 18736860 T DK18736860 T DK 18736860T DK 3645034 T5 DK3645034 T5 DK 3645034T5
- Authority
- DK
- Denmark
- Prior art keywords
- defactor
- hemophilia
- prophylaxis
- methods
- fusion proteins
- Prior art date
Links
- 208000031220 Hemophilia Diseases 0.000 title 1
- 208000009292 Hemophilia A Diseases 0.000 title 1
- 102000008100 Human Serum Albumin Human genes 0.000 title 1
- 108091006905 Human Serum Albumin Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762526377P | 2017-06-29 | 2017-06-29 | |
| PCT/EP2018/067523 WO2019002532A1 (en) | 2017-06-29 | 2018-06-29 | 21-DAY FUSION PROTEIN DRAFTING COMPRISING IX FACTOR AND HUMAN ALBUMIN FOR THE PROPHYLACTIC TREATMENT OF HEMOPHILIA AND ASSOCIATED METHODS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3645034T3 DK3645034T3 (da) | 2023-11-20 |
| DK3645034T5 true DK3645034T5 (da) | 2024-08-26 |
Family
ID=62815032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18736860.0T DK3645034T5 (da) | 2017-06-29 | 2018-06-29 | 21-dages doseringsregimen for fusionsproteiner omfatten-defaktor ix og human albumin til profylaktisk behandling af hæmofili og fremgangsmåder heraf |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20200115436A1 (enExample) |
| EP (1) | EP3645034B1 (enExample) |
| JP (1) | JP2020525498A (enExample) |
| KR (1) | KR102597725B1 (enExample) |
| CN (1) | CN110799209A (enExample) |
| AU (1) | AU2018294517B2 (enExample) |
| CA (1) | CA3068360A1 (enExample) |
| DK (1) | DK3645034T5 (enExample) |
| ES (1) | ES2963665T3 (enExample) |
| IL (1) | IL271160B2 (enExample) |
| MX (1) | MX2019014651A (enExample) |
| PL (1) | PL3645034T3 (enExample) |
| RU (1) | RU2020103424A (enExample) |
| SG (1) | SG10202111032PA (enExample) |
| WO (1) | WO2019002532A1 (enExample) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001266557A1 (en) | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7939632B2 (en) | 2006-06-14 | 2011-05-10 | Csl Behring Gmbh | Proteolytically cleavable fusion proteins with high molar specific activity |
| CA2770609A1 (en) * | 2009-08-20 | 2011-02-24 | Csl Behring Gmbh | Albumin fused coagulation factors for non-intravenous administration in the therapy and prophylactic treatment of bleeding disorders |
| AU2011274414B2 (en) * | 2010-07-09 | 2016-10-06 | Bioverativ Therapeutics Inc. | Factor IX polypeptides and methods of use thereof |
| HK1213521A1 (zh) * | 2012-09-25 | 2016-07-08 | Bioverativ Therapeutics Inc. | Fix多肽的應用 |
| KR20160093735A (ko) * | 2013-12-23 | 2016-08-08 | 시에스엘 리미티드 | 혈우병의 예방학적 치료를 위한 인자 ｉｘ를 포함하는 융합 단백질 및 이의 방법 |
| SG11201608006QA (en) * | 2014-04-11 | 2016-10-28 | Csl Ltd | Half-life extended factor fviia protein for prevention and treatment of bleeding and dosing regimens therefor |
-
2018
- 2018-06-29 EP EP18736860.0A patent/EP3645034B1/en active Active
- 2018-06-29 ES ES18736860T patent/ES2963665T3/es active Active
- 2018-06-29 SG SG10202111032PA patent/SG10202111032PA/en unknown
- 2018-06-29 IL IL271160A patent/IL271160B2/en unknown
- 2018-06-29 RU RU2020103424A patent/RU2020103424A/ru unknown
- 2018-06-29 CA CA3068360A patent/CA3068360A1/en active Pending
- 2018-06-29 WO PCT/EP2018/067523 patent/WO2019002532A1/en not_active Ceased
- 2018-06-29 KR KR1020207002673A patent/KR102597725B1/ko active Active
- 2018-06-29 MX MX2019014651A patent/MX2019014651A/es unknown
- 2018-06-29 AU AU2018294517A patent/AU2018294517B2/en active Active
- 2018-06-29 PL PL18736860.0T patent/PL3645034T3/pl unknown
- 2018-06-29 CN CN201880042643.9A patent/CN110799209A/zh active Pending
- 2018-06-29 DK DK18736860.0T patent/DK3645034T5/da active
- 2018-06-29 JP JP2019572377A patent/JP2020525498A/ja active Pending
- 2018-06-29 US US16/626,153 patent/US20200115436A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018294517A1 (en) | 2020-01-30 |
| PL3645034T3 (pl) | 2024-09-02 |
| WO2019002532A1 (en) | 2019-01-03 |
| MX2019014651A (es) | 2020-02-07 |
| KR20200019749A (ko) | 2020-02-24 |
| CN110799209A (zh) | 2020-02-14 |
| IL271160B2 (en) | 2025-05-01 |
| IL271160A (en) | 2020-01-30 |
| US20200115436A1 (en) | 2020-04-16 |
| RU2020103424A (ru) | 2021-07-29 |
| DK3645034T3 (da) | 2023-11-20 |
| AU2018294517B2 (en) | 2024-09-26 |
| RU2020103424A3 (enExample) | 2021-11-12 |
| JP2020525498A (ja) | 2020-08-27 |
| EP3645034B1 (en) | 2023-08-30 |
| ES2963665T3 (es) | 2024-04-01 |
| IL271160B1 (en) | 2025-01-01 |
| CA3068360A1 (en) | 2019-01-03 |
| KR102597725B1 (ko) | 2023-11-06 |
| SG10202111032PA (en) | 2021-11-29 |
| EP3645034A1 (en) | 2020-05-06 |
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