JP2020525417A5 - - Google Patents
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- Publication number
- JP2020525417A5 JP2020525417A5 JP2019569828A JP2019569828A JP2020525417A5 JP 2020525417 A5 JP2020525417 A5 JP 2020525417A5 JP 2019569828 A JP2019569828 A JP 2019569828A JP 2019569828 A JP2019569828 A JP 2019569828A JP 2020525417 A5 JP2020525417 A5 JP 2020525417A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- cycloalkyl
- group
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 125000005842 heteroatom Chemical group 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 15
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 229910052805 deuterium Inorganic materials 0.000 claims 10
- 150000004820 halides Chemical class 0.000 claims 10
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000017074 necrotic cell death Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 230000008718 systemic inflammatory response Effects 0.000 claims 1
- 0 C*1*=*C(C(*=I)=*C(N(C(*)(C(C)C(B2)(C)*)S)C(C)=O)=C2*)=I*1C Chemical compound C*1*=*C(C(*=I)=*C(N(C(*)(C(C)C(B2)(C)*)S)C(C)=O)=C2*)=I*1C 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710483983 | 2017-06-23 | ||
| CN201710483983.2 | 2017-06-23 | ||
| CN201810575869.7A CN109111464B (zh) | 2017-06-23 | 2018-06-06 | 一种具有细胞坏死抑制活性的杂环化合物 |
| CN201810575869.7 | 2018-06-06 | ||
| PCT/US2018/039180 WO2018237370A1 (en) | 2017-06-23 | 2018-06-23 | Heteroaryl compounds as inhibitors of necrosis, composition and method using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020525417A JP2020525417A (ja) | 2020-08-27 |
| JP2020525417A5 true JP2020525417A5 (https=) | 2021-07-26 |
| JP6950006B2 JP6950006B2 (ja) | 2021-10-13 |
Family
ID=64821922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019569828A Active JP6950006B2 (ja) | 2017-06-23 | 2018-06-23 | ネクローシス阻害剤であるヘテロアリール化合物、それを用いる組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11339177B2 (https=) |
| EP (1) | EP3642193B1 (https=) |
| JP (1) | JP6950006B2 (https=) |
| KR (1) | KR102367257B1 (https=) |
| CN (1) | CN109111464B (https=) |
| ES (1) | ES2916549T3 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202116771A (zh) * | 2019-07-17 | 2021-05-01 | 英屬開曼群島商百濟神州有限公司 | 作為ｈｐｋ１抑制劑之三環化合物及其用途 |
| CN115894489A (zh) * | 2021-09-22 | 2023-04-04 | 中国药科大学 | 一种受体相互作用蛋白激酶1的抑制剂及其制备方法、应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY155517A (en) * | 2008-03-31 | 2015-10-30 | C&C Res Lab | Heterocyclic derivatives |
| WO2010008847A2 (en) * | 2008-06-24 | 2010-01-21 | Takeda Pharmaceutical Company Limited | Pi3k/m tor inhibitors |
| US20110172217A1 (en) * | 2008-09-05 | 2011-07-14 | Shionogi & Co., Ltd. | Ring-fused morpholine derivative having pi3k-inhibiting activity |
| WO2010100144A1 (en) * | 2009-03-04 | 2010-09-10 | Merck Serono S.A. | Fused bicyclic compounds as inhibitors for pi3 kinase |
| US9295673B2 (en) * | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
| US20160256458A1 (en) * | 2013-11-18 | 2016-09-08 | Forma Therapeutics, Inc. | Benzopiperazine compositions as bet bromodomain inhibitors |
| CN106029076B (zh) * | 2013-11-18 | 2019-06-07 | 福马疗法公司 | 作为bet溴域抑制剂的苯并哌嗪组合物 |
| WO2018017435A1 (en) * | 2016-07-22 | 2018-01-25 | Accro Bioscience Inc. | Heteroaryl compounds as inhibitors of necrosis, composition and application thereof |
| CN107641118B (zh) | 2016-07-22 | 2020-11-06 | 爱科诺生物医药股份有限公司 | 具有细胞坏死抑制活性的化合物及其组合物和应用 |
| RU2019133646A (ru) * | 2017-03-30 | 2021-04-30 | Ф. Хоффманн-Ля Рош Аг | Изохинолины в качестве ингибиторов hpk1 |
-
2018
- 2018-06-06 CN CN201810575869.7A patent/CN109111464B/zh active Active
- 2018-06-23 JP JP2019569828A patent/JP6950006B2/ja active Active
- 2018-06-23 EP EP18819803.0A patent/EP3642193B1/en active Active
- 2018-06-23 US US16/625,703 patent/US11339177B2/en active Active
- 2018-06-23 KR KR1020197036806A patent/KR102367257B1/ko active Active
- 2018-06-23 ES ES18819803T patent/ES2916549T3/es active Active
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