JP2020511547A5 - - Google Patents
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- Publication number
- JP2020511547A5 JP2020511547A5 JP2020501418A JP2020501418A JP2020511547A5 JP 2020511547 A5 JP2020511547 A5 JP 2020511547A5 JP 2020501418 A JP2020501418 A JP 2020501418A JP 2020501418 A JP2020501418 A JP 2020501418A JP 2020511547 A5 JP2020511547 A5 JP 2020511547A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- optionally substituted
- fluorine atoms
- membered ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762474686P | 2017-03-22 | 2017-03-22 | |
| US62/474,686 | 2017-03-22 | ||
| PCT/US2018/023455 WO2018175512A1 (en) | 2017-03-22 | 2018-03-21 | Bruton's tyrosine kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511547A JP2020511547A (ja) | 2020-04-16 |
| JP2020511547A5 true JP2020511547A5 (https=) | 2021-04-30 |
| JP7219902B2 JP7219902B2 (ja) | 2023-02-09 |
Family
ID=63585694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020501418A Active JP7219902B2 (ja) | 2017-03-22 | 2018-03-21 | ブルトン型チロシンキナーゼ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11554118B2 (https=) |
| EP (1) | EP3601264A4 (https=) |
| JP (1) | JP7219902B2 (https=) |
| KR (1) | KR102627756B1 (https=) |
| CN (1) | CN110494433B (https=) |
| AU (1) | AU2018237123B2 (https=) |
| CA (1) | CA3055602A1 (https=) |
| EA (1) | EA201992147A1 (https=) |
| IL (1) | IL269152B2 (https=) |
| MX (1) | MX2019011116A (https=) |
| WO (1) | WO2018175512A1 (https=) |
| ZA (1) | ZA201906887B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018175512A1 (en) * | 2017-03-22 | 2018-09-27 | Suzhou Baijibugong Pharmaceutical Technology Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| CN113365631B (zh) * | 2019-01-18 | 2024-08-30 | 杭州邦顺制药有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
| EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
| AU2020276334B2 (en) | 2019-05-10 | 2022-12-22 | Henan Zhiwei Biomedicine Co., Ltd. | Substituted 1-amino-1H-imidazole-5-carboxamide as Bruton's Tyrosine Kinase inhibitors |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN111471048B (zh) * | 2020-04-30 | 2021-06-15 | 成都海博为药业有限公司 | 一种具有含氮桥环、螺环或并环结构的化合物及其用途 |
| CN115073468B (zh) * | 2021-03-15 | 2023-12-22 | 药雅科技(上海)有限公司 | 咪唑并吡嗪类btk抑制剂的制备及用途 |
| CN116348453B (zh) * | 2021-04-25 | 2025-07-04 | 烨辉医药科技(上海)有限公司 | 杂芳族甲酰胺化合物及其用途 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003290333A1 (en) * | 2002-12-24 | 2004-07-22 | Biofocus Plc | Compound libraries of imidazo(1,5-a)pyridin-3-yl derivatives and related heterobicycles for targetting compounds capable of binding to g-protein coupled receptors |
| AU2004268918A1 (en) * | 2003-09-03 | 2005-03-10 | Galapagos Nv | Imidazo(1,5-a)pyridine or imidazo(1,5-a)piperidine derivatives and their use for the preparation of medicament against 5-HT2A receptor-related disorders |
| WO2008022060A2 (en) * | 2006-08-14 | 2008-02-21 | Novartis Ag | Imidazo-pyridine derivatives for modulating protein kinase activity |
| DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
| SG10202107066WA (en) | 2007-03-28 | 2021-07-29 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| ES2396613T3 (es) | 2008-05-19 | 2013-02-22 | OSI Pharmaceuticals, LLC | Imidazopirazinas e imidazotriazinas sustituidas |
| JP5764145B2 (ja) * | 2010-02-08 | 2015-08-12 | メルク・シャープ・エンド・ドーム・ベー・フェー | ８−メチル−１−フェニル−イミダゾル［１，５−ａ］ピラジン化合物 |
| EP2691392A1 (en) | 2011-03-31 | 2014-02-05 | EMBLEM Technology Transfer GmbH | Imidazo [1,2-a]pyridine compounds for use in therapy |
| GB2486038B (en) * | 2011-06-28 | 2013-09-25 | Andrew Levine | Speech-to-text conversion |
| EP2548877A1 (en) * | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
| CA2841887A1 (en) | 2011-07-19 | 2013-01-24 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk - inhibitors |
| EP3689878B1 (en) | 2011-07-19 | 2021-10-06 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk-inhibitors |
| FR2985185B1 (fr) * | 2012-01-04 | 2013-12-27 | Sanofi Sa | Utilisation en therapeutique de derives d'imidazopyridine |
| CN104080789B (zh) * | 2012-01-31 | 2016-05-11 | 南京奥昭生物科技有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| WO2014113942A1 (en) * | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Btk inhibitors |
| US20140206681A1 (en) | 2013-01-23 | 2014-07-24 | Ronald M. Kim | Btk inhibitors |
| JP2016533385A (ja) * | 2013-08-22 | 2016-10-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | アルキニルアルコール及び使用方法 |
| WO2015057992A1 (en) * | 2013-10-16 | 2015-04-23 | Izumi Raquel | Btk inhibitors for hematopoietic mobilization |
| WO2015157955A1 (en) * | 2014-04-17 | 2015-10-22 | Abbvie Inc. | Heterocyclic btk inhibit ors |
| CN105017256A (zh) | 2014-04-29 | 2015-11-04 | 浙江导明医药科技有限公司 | 多氟化合物作为布鲁顿酪氨酸激酶抑制剂 |
| WO2016106623A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Benzamide imidazopyrazine btk inhibitors |
| WO2016106652A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
| WO2016106626A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Imidazopyrazine analogs with 3-tertiary carbon substitutions as btk inhibitors |
| MA41614A (fr) * | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| WO2016210165A1 (en) | 2015-06-24 | 2016-12-29 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| WO2017033113A1 (en) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Therapeutic combinations of a mek inhibitor and a btk inhibitor |
| CN106478633A (zh) * | 2015-08-27 | 2017-03-08 | 正大天晴药业集团股份有限公司 | 一类布鲁顿酪氨酸激酶抑制剂 |
| US20170071962A1 (en) * | 2015-09-11 | 2017-03-16 | Acerta Pharma B.V. | Therapeutic Combinations of a Proteasome Inhibitor and a BTK Inhibitor |
| US20170035881A1 (en) | 2015-10-19 | 2017-02-09 | Acerta Pharma B.V. | Therapeutic Combinations of an IRAK4 Inhibitor and a BTK Inhibitor |
| US10736893B2 (en) | 2015-11-06 | 2020-08-11 | Acerta Pharma B.V. | Imidazopyrazine inhibitors of Bruton's tyrosine kinase |
| CN109071455B (zh) | 2016-03-11 | 2022-08-02 | 嘉兴和剂药业有限公司 | 用于调节布鲁顿酪氨酸激酶的化合物及方法 |
| US10640512B2 (en) * | 2016-06-30 | 2020-05-05 | Hangzhou Sanyintai Pharmaceutical Technology Co., Ltd. | Imidazopyrazinamine phenyl derivative and use thereof |
| WO2018033091A1 (zh) * | 2016-08-17 | 2018-02-22 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制酪氨酸激酶活性的稠合双环类化合物 |
| WO2018175512A1 (en) * | 2017-03-22 | 2018-09-27 | Suzhou Baijibugong Pharmaceutical Technology Co. Ltd. | Bruton's tyrosine kinase inhibitors |
-
2018
- 2018-03-21 WO PCT/US2018/023455 patent/WO2018175512A1/en not_active Ceased
- 2018-03-21 CN CN201880020300.2A patent/CN110494433B/zh active Active
- 2018-03-21 CA CA3055602A patent/CA3055602A1/en active Pending
- 2018-03-21 JP JP2020501418A patent/JP7219902B2/ja active Active
- 2018-03-21 AU AU2018237123A patent/AU2018237123B2/en active Active
- 2018-03-21 IL IL269152A patent/IL269152B2/en unknown
- 2018-03-21 EA EA201992147A patent/EA201992147A1/ru unknown
- 2018-03-21 US US16/496,426 patent/US11554118B2/en active Active
- 2018-03-21 MX MX2019011116A patent/MX2019011116A/es unknown
- 2018-03-21 EP EP18770944.9A patent/EP3601264A4/en not_active Withdrawn
- 2018-03-21 KR KR1020197031084A patent/KR102627756B1/ko active Active
-
2019
- 2019-05-22 US US16/420,148 patent/US10933063B2/en active Active
- 2019-10-18 ZA ZA2019/06887A patent/ZA201906887B/en unknown
-
2021
- 2021-01-01 US US17/140,025 patent/US11974999B2/en active Active
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