JP2020524698A5 - - Google Patents
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- JP2020524698A5 JP2020524698A5 JP2019571038A JP2019571038A JP2020524698A5 JP 2020524698 A5 JP2020524698 A5 JP 2020524698A5 JP 2019571038 A JP2019571038 A JP 2019571038A JP 2019571038 A JP2019571038 A JP 2019571038A JP 2020524698 A5 JP2020524698 A5 JP 2020524698A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- canakinumab
- use according
- functional fragment
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims description 54
- 229960001838 canakinumab Drugs 0.000 claims description 51
- 229940127089 cytotoxic agent Drugs 0.000 claims description 37
- 239000002246 antineoplastic agent Substances 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 32
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 31
- 229940124597 therapeutic agent Drugs 0.000 claims description 31
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 29
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 29
- 206010061218 Inflammation Diseases 0.000 claims description 26
- 230000004054 inflammatory process Effects 0.000 claims description 26
- 208000020816 lung neoplasm Diseases 0.000 claims description 25
- 206010028980 Neoplasm Diseases 0.000 claims description 23
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 22
- 201000005202 lung cancer Diseases 0.000 claims description 22
- 201000011510 cancer Diseases 0.000 claims description 18
- 102100032752 C-reactive protein Human genes 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 14
- 229960003301 nivolumab Drugs 0.000 claims description 9
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 7
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 7
- 102000004889 Interleukin-6 Human genes 0.000 claims description 6
- 108090001005 Interleukin-6 Proteins 0.000 claims description 6
- 239000012271 PD-L1 inhibitor Substances 0.000 claims description 6
- 229940100601 interleukin-6 Drugs 0.000 claims description 6
- 229940121656 pd-l1 inhibitor Drugs 0.000 claims description 6
- 229960002621 pembrolizumab Drugs 0.000 claims description 6
- 229960003852 atezolizumab Drugs 0.000 claims description 5
- 229950002916 avelumab Drugs 0.000 claims description 5
- 229950009791 durvalumab Drugs 0.000 claims description 5
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- 238000011518 platinum-based chemotherapy Methods 0.000 claims description 3
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 2
- 229960003668 docetaxel Drugs 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims description 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 55
- 239000012270 PD-1 inhibitor Substances 0.000 claims 2
- 239000012668 PD-1-inhibitor Substances 0.000 claims 2
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940071643 prefilled syringe Drugs 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 12
- 208000006265 Renal cell carcinoma Diseases 0.000 description 11
- 206010009944 Colon cancer Diseases 0.000 description 6
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 description 6
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 6
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 4
- 208000026310 Breast neoplasm Diseases 0.000 description 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 206010005003 Bladder cancer Diseases 0.000 description 3
- 208000034578 Multiple myelomas Diseases 0.000 description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 description 3
- 206010060862 Prostate cancer Diseases 0.000 description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 3
- 229960000397 bevacizumab Drugs 0.000 description 3
- 201000004101 esophageal cancer Diseases 0.000 description 3
- 206010017758 gastric cancer Diseases 0.000 description 3
- 229960005386 ipilimumab Drugs 0.000 description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 3
- 201000001441 melanoma Diseases 0.000 description 3
- 201000002528 pancreatic cancer Diseases 0.000 description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 description 3
- 201000011549 stomach cancer Diseases 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 201000005112 urinary bladder cancer Diseases 0.000 description 3
- YXTKHLHCVFUPPT-YYFJYKOTSA-N (2s)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid;(1r,2r)-1,2-dimethanidylcyclohexane;5-fluoro-1h-pyrimidine-2,4-dione;oxalic acid;platinum(2+) Chemical compound [Pt+2].OC(=O)C(O)=O.[CH2-][C@@H]1CCCC[C@H]1[CH2-].FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 YXTKHLHCVFUPPT-YYFJYKOTSA-N 0.000 description 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 description 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 2
- 229940045513 CTLA4 antagonist Drugs 0.000 description 2
- 229930012538 Paclitaxel Natural products 0.000 description 2
- 229940123237 Taxane Drugs 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000002254 cytotoxic agent Substances 0.000 description 2
- 231100000599 cytotoxic agent Toxicity 0.000 description 2
- JYEFSHLLTQIXIO-SMNQTINBSA-N folfiri regimen Chemical compound FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 JYEFSHLLTQIXIO-SMNQTINBSA-N 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 229960001592 paclitaxel Drugs 0.000 description 2
- 229960002633 ramucirumab Drugs 0.000 description 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
- 239000002525 vasculotropin inhibitor Substances 0.000 description 2
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 description 1
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 239000002176 L01XE26 - Cabozantinib Substances 0.000 description 1
- 229940121849 Mitotic inhibitor Drugs 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 108010081667 aflibercept Proteins 0.000 description 1
- 201000009036 biliary tract cancer Diseases 0.000 description 1
- 208000020790 biliary tract neoplasm Diseases 0.000 description 1
- 229960001292 cabozantinib Drugs 0.000 description 1
- ONIQOQHATWINJY-UHFFFAOYSA-N cabozantinib Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 ONIQOQHATWINJY-UHFFFAOYSA-N 0.000 description 1
- 229960004117 capecitabine Drugs 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229960005167 everolimus Drugs 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229960002760 ziv-aflibercept Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023014125A JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762523458P | 2017-06-22 | 2017-06-22 | |
| US62/523,458 | 2017-06-22 | ||
| US201762529515P | 2017-07-07 | 2017-07-07 | |
| US62/529,515 | 2017-07-07 | ||
| US201762550325P | 2017-08-25 | 2017-08-25 | |
| US201762550307P | 2017-08-25 | 2017-08-25 | |
| US62/550,325 | 2017-08-25 | ||
| US62/550,307 | 2017-08-25 | ||
| US201762596054P | 2017-12-07 | 2017-12-07 | |
| US62/596,054 | 2017-12-07 | ||
| US201862649631P | 2018-03-29 | 2018-03-29 | |
| US62/649,631 | 2018-03-29 | ||
| TW107115136 | 2018-05-03 | ||
| PCT/IB2018/053096 WO2018234879A1 (en) | 2017-06-22 | 2018-05-03 | USE OF IL-1β BINDING ANTIBODIES IN THE TREATMENT OF CANCER |
| US15/970,542 | 2018-05-03 | ||
| IBPCT/IB2018/053096 | 2018-05-03 | ||
| TW107115136A TW201904993A (zh) | 2017-06-22 | 2018-05-03 | IL-1β 結合抗體之用途 |
| US15/970,542 US20190048072A1 (en) | 2017-06-22 | 2018-05-03 | USE OF IL-1beta BINDING ANTIBODIES |
| PCT/IB2018/054637 WO2018235056A1 (en) | 2017-06-22 | 2018-06-22 | IL-1BETA BINDING ANTIBODIES FOR USE IN THE TREATMENT OF CANCER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023014125A Division JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020524698A JP2020524698A (ja) | 2020-08-20 |
| JP2020524698A5 true JP2020524698A5 (https=) | 2021-08-05 |
Family
ID=62530267
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570897A Withdrawn JP2020524694A (ja) | 2017-06-22 | 2018-05-03 | がんの処置における使用のためのＩＬ−１β結合性抗体 |
| JP2019571038A Withdrawn JP2020524698A (ja) | 2017-06-22 | 2018-06-22 | がんの処置における使用のためのＩＬ−１β結合性抗体 |
| JP2022146790A Pending JP2022181214A (ja) | 2017-06-22 | 2022-09-15 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
| JP2023014125A Withdrawn JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570897A Withdrawn JP2020524694A (ja) | 2017-06-22 | 2018-05-03 | がんの処置における使用のためのＩＬ−１β結合性抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022146790A Pending JP2022181214A (ja) | 2017-06-22 | 2022-09-15 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
| JP2023014125A Withdrawn JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20190048072A1 (https=) |
| EP (1) | EP3642234A1 (https=) |
| JP (4) | JP2020524694A (https=) |
| KR (2) | KR20200019865A (https=) |
| CN (1) | CN110831967A (https=) |
| AU (4) | AU2018287519B2 (https=) |
| BR (1) | BR112019027558A2 (https=) |
| CA (2) | CA3061874A1 (https=) |
| CL (1) | CL2019003799A1 (https=) |
| CO (1) | CO2019014433A2 (https=) |
| IL (1) | IL271221A (https=) |
| JO (1) | JOP20190292A1 (https=) |
| MX (1) | MX2019015516A (https=) |
| PH (1) | PH12019502857A1 (https=) |
| RU (1) | RU2020102237A (https=) |
| SG (1) | SG11201911283UA (https=) |
| TW (3) | TW201904993A (https=) |
| WO (2) | WO2018234879A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2814843T (lt) | 2012-02-13 | 2020-09-25 | Agency For Science, Technology And Research | ŽMOGAUS MONOKLONINIAI ANTIKŪNAI, NEUTRALIZUOJANTYS IL-1ß |
| CA3061874A1 (en) * | 2017-06-22 | 2018-12-27 | Novartis Ag | Il-1beta binding antibodies for use in treating cancer |
| WO2019215484A1 (en) * | 2018-05-09 | 2019-11-14 | Novartis Ag | Use of canakinumab |
| WO2020039401A1 (en) * | 2018-08-24 | 2020-02-27 | Novartis Ag | Treatment comprising il-1βeta binding antibodies and combinations thereof |
| JP2022514087A (ja) * | 2018-12-21 | 2022-02-09 | ノバルティス アーゲー | ＩＬ－１β結合抗体の使用 |
| US11718673B2 (en) * | 2019-04-01 | 2023-08-08 | Immetas Therapeutics, Inc. | Bispecific binding molecules that target the tumor microenvironment and an immune checkpoint protein |
| US20220249660A1 (en) * | 2019-06-06 | 2022-08-11 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| AU2020310174A1 (en) * | 2019-07-09 | 2022-02-03 | Tavotek Biotherapeutics (Hong Kong) Limited | Bispecific antibodies to TNF-alpha and IL-1beta and uses thereof |
| CA3175137A1 (en) * | 2020-03-12 | 2021-09-16 | Toray Industries, Inc. | Medicament for treatment and/or prevention of cancer |
| RU2745814C1 (ru) * | 2020-06-05 | 2021-04-01 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция левилимаба и ее применение |
| EP3970727A1 (en) * | 2020-09-16 | 2022-03-23 | Johann Wolfgang Goethe-Universität Frankfurt | Means for reducing radiotherapy resistance and adverse effects |
| KR20230113306A (ko) * | 2020-10-30 | 2023-07-28 | 고쿠리츠켄큐카이하츠호진 고쿠리츠쥰칸키뵤 겐큐센터 | 주산기 심근증 치료제 |
| WO2022167916A1 (en) * | 2021-02-03 | 2022-08-11 | Novartis Ag | Use of il-1b binding antibodies for treating neuroinflammatory disorders |
| WO2023038619A1 (en) * | 2021-09-08 | 2023-03-16 | Board Of Regents, The University Of Texas System | USE OF IL-1β BINDING ANTIBODIES |
| CN115125303B (zh) * | 2022-06-07 | 2023-02-24 | 北京大学第一医院 | 阿帕替尼药敏标记物及其相关试剂的应用 |
| CN116139268A (zh) * | 2023-03-13 | 2023-05-23 | 上海交通大学医学院附属仁济医院 | 靶向IL-1β的抗体在制备治疗去势抵抗型前列腺癌中的用途 |
| CN116688130A (zh) * | 2023-06-08 | 2023-09-05 | 桂林医学院附属医院 | 靶向IL-1β/IL-1R1通路的拮抗剂在抑制肝癌肺转移前微环境或肺转移的药物中的应用 |
| MX2025015070A (es) * | 2023-06-13 | 2026-02-03 | Merck Sharp & Dohme Llc | Metodos de uso de peptidos ciclicos para atrapar interleucina-1 beta |
| WO2025235276A1 (en) * | 2024-05-06 | 2025-11-13 | Icahn School Of Medicine At Mount Sinai | Combination of il-1 receptor inhibitors, anti pd-1, and il-4 inhibitors in the treatment of cancer |
| WO2025242806A1 (en) | 2024-05-23 | 2025-11-27 | Universität Duisburg-Essen | A METHOD FOR PREDICTING THE RESPONSE OF A PATIENT WITH DLBCL TO ANTI-IL-1ß THERAPY |
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| DK1234031T3 (en) | 1999-11-30 | 2017-07-03 | Mayo Foundation | B7-H1, AN UNKNOWN IMMUNE REGULATORY MOLECULE |
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-
2018
- 2018-05-03 CA CA3061874A patent/CA3061874A1/en active Pending
- 2018-05-03 US US15/970,542 patent/US20190048072A1/en not_active Abandoned
- 2018-05-03 JP JP2019570897A patent/JP2020524694A/ja not_active Withdrawn
- 2018-05-03 AU AU2018287519A patent/AU2018287519B2/en not_active Ceased
- 2018-05-03 KR KR1020197035726A patent/KR20200019865A/ko not_active Ceased
- 2018-05-03 WO PCT/IB2018/053096 patent/WO2018234879A1/en not_active Ceased
- 2018-05-03 TW TW107115136A patent/TW201904993A/zh unknown
- 2018-06-22 TW TW107121619A patent/TW201904995A/zh unknown
- 2018-06-22 TW TW112108903A patent/TW202400641A/zh unknown
- 2018-06-22 RU RU2020102237A patent/RU2020102237A/ru unknown
- 2018-06-22 MX MX2019015516A patent/MX2019015516A/es unknown
- 2018-06-22 JP JP2019571038A patent/JP2020524698A/ja not_active Withdrawn
- 2018-06-22 CN CN201880041546.8A patent/CN110831967A/zh active Pending
- 2018-06-22 BR BR112019027558-4A patent/BR112019027558A2/pt not_active Application Discontinuation
- 2018-06-22 SG SG11201911283UA patent/SG11201911283UA/en unknown
- 2018-06-22 AU AU2018288060A patent/AU2018288060B2/en not_active Ceased
- 2018-06-22 KR KR1020207001676A patent/KR20200021086A/ko not_active Ceased
- 2018-06-22 CA CA3066045A patent/CA3066045A1/en active Pending
- 2018-06-22 US US16/624,130 patent/US20230220063A1/en not_active Abandoned
- 2018-06-22 WO PCT/IB2018/054637 patent/WO2018235056A1/en not_active Ceased
- 2018-06-22 EP EP18749503.1A patent/EP3642234A1/en not_active Withdrawn
- 2018-06-22 PH PH1/2019/502857A patent/PH12019502857A1/en unknown
- 2018-12-22 JO JOP/2019/0292A patent/JOP20190292A1/ar unknown
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2019
- 2019-12-05 IL IL271221A patent/IL271221A/en unknown
- 2019-12-19 CO CONC2019/0014433A patent/CO2019014433A2/es unknown
- 2019-12-20 CL CL2019003799A patent/CL2019003799A1/es unknown
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2021
- 2021-10-07 AU AU2021245184A patent/AU2021245184A1/en not_active Abandoned
- 2021-10-19 AU AU2021254559A patent/AU2021254559A1/en not_active Abandoned
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2022
- 2022-01-10 US US17/572,228 patent/US20220389090A1/en not_active Abandoned
- 2022-09-15 JP JP2022146790A patent/JP2022181214A/ja active Pending
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