JP2020524698A5 - - Google Patents
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- JP2020524698A5 JP2020524698A5 JP2019571038A JP2019571038A JP2020524698A5 JP 2020524698 A5 JP2020524698 A5 JP 2020524698A5 JP 2019571038 A JP2019571038 A JP 2019571038A JP 2019571038 A JP2019571038 A JP 2019571038A JP 2020524698 A5 JP2020524698 A5 JP 2020524698A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- canakinumab
- use according
- functional fragment
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000012634 fragment Substances 0.000 claims description 54
- 229960001838 canakinumab Drugs 0.000 claims description 51
- 229940127089 cytotoxic agent Drugs 0.000 claims description 37
- 239000002246 antineoplastic agent Substances 0.000 claims description 35
- 239000003814 drug Substances 0.000 claims description 32
- 108010074051 C-Reactive Protein Proteins 0.000 claims description 31
- 229940124597 therapeutic agent Drugs 0.000 claims description 31
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 29
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 29
- 206010061218 Inflammation Diseases 0.000 claims description 26
- 230000004054 inflammatory process Effects 0.000 claims description 26
- 208000020816 lung neoplasm Diseases 0.000 claims description 25
- 206010028980 Neoplasm Diseases 0.000 claims description 23
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 22
- 201000005202 lung cancer Diseases 0.000 claims description 22
- 201000011510 cancer Diseases 0.000 claims description 18
- 102100032752 C-reactive protein Human genes 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 14
- 229960003301 nivolumab Drugs 0.000 claims description 9
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 7
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 7
- 102000004889 Interleukin-6 Human genes 0.000 claims description 6
- 108090001005 Interleukin-6 Proteins 0.000 claims description 6
- 239000012271 PD-L1 inhibitor Substances 0.000 claims description 6
- 229940100601 interleukin-6 Drugs 0.000 claims description 6
- 229940121656 pd-l1 inhibitor Drugs 0.000 claims description 6
- 229960002621 pembrolizumab Drugs 0.000 claims description 6
- 229960003852 atezolizumab Drugs 0.000 claims description 5
- 229950002916 avelumab Drugs 0.000 claims description 5
- 229950009791 durvalumab Drugs 0.000 claims description 5
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- 238000011518 platinum-based chemotherapy Methods 0.000 claims description 3
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 2
- 229960003668 docetaxel Drugs 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims description 2
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 55
- 239000012270 PD-1 inhibitor Substances 0.000 claims 2
- 239000012668 PD-1-inhibitor Substances 0.000 claims 2
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940071643 prefilled syringe Drugs 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 12
- 208000006265 Renal cell carcinoma Diseases 0.000 description 11
- 206010009944 Colon cancer Diseases 0.000 description 6
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 description 6
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 6
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 6
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 4
- 206010006187 Breast cancer Diseases 0.000 description 4
- 208000026310 Breast neoplasm Diseases 0.000 description 4
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 206010005003 Bladder cancer Diseases 0.000 description 3
- 208000034578 Multiple myelomas Diseases 0.000 description 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 3
- 206010035226 Plasma cell myeloma Diseases 0.000 description 3
- 206010060862 Prostate cancer Diseases 0.000 description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 3
- 229960000397 bevacizumab Drugs 0.000 description 3
- 201000004101 esophageal cancer Diseases 0.000 description 3
- 206010017758 gastric cancer Diseases 0.000 description 3
- 229960005386 ipilimumab Drugs 0.000 description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 3
- 201000001441 melanoma Diseases 0.000 description 3
- 201000002528 pancreatic cancer Diseases 0.000 description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 description 3
- 201000011549 stomach cancer Diseases 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 201000005112 urinary bladder cancer Diseases 0.000 description 3
- YXTKHLHCVFUPPT-YYFJYKOTSA-N (2s)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid;(1r,2r)-1,2-dimethanidylcyclohexane;5-fluoro-1h-pyrimidine-2,4-dione;oxalic acid;platinum(2+) Chemical compound [Pt+2].OC(=O)C(O)=O.[CH2-][C@@H]1CCCC[C@H]1[CH2-].FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 YXTKHLHCVFUPPT-YYFJYKOTSA-N 0.000 description 2
- 102000008203 CTLA-4 Antigen Human genes 0.000 description 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 2
- 229940045513 CTLA4 antagonist Drugs 0.000 description 2
- 229930012538 Paclitaxel Natural products 0.000 description 2
- 229940123237 Taxane Drugs 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000002254 cytotoxic agent Substances 0.000 description 2
- 231100000599 cytotoxic agent Toxicity 0.000 description 2
- JYEFSHLLTQIXIO-SMNQTINBSA-N folfiri regimen Chemical compound FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 JYEFSHLLTQIXIO-SMNQTINBSA-N 0.000 description 2
- 208000032839 leukemia Diseases 0.000 description 2
- 229960001592 paclitaxel Drugs 0.000 description 2
- 229960002633 ramucirumab Drugs 0.000 description 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
- 239000002525 vasculotropin inhibitor Substances 0.000 description 2
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 description 1
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 206010014733 Endometrial cancer Diseases 0.000 description 1
- 206010014759 Endometrial neoplasm Diseases 0.000 description 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 239000002176 L01XE26 - Cabozantinib Substances 0.000 description 1
- 229940121849 Mitotic inhibitor Drugs 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 108010081667 aflibercept Proteins 0.000 description 1
- 201000009036 biliary tract cancer Diseases 0.000 description 1
- 208000020790 biliary tract neoplasm Diseases 0.000 description 1
- 229960001292 cabozantinib Drugs 0.000 description 1
- ONIQOQHATWINJY-UHFFFAOYSA-N cabozantinib Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1)=CC=C1NC(=O)C1(C(=O)NC=2C=CC(F)=CC=2)CC1 ONIQOQHATWINJY-UHFFFAOYSA-N 0.000 description 1
- 229960004117 capecitabine Drugs 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229960005167 everolimus Drugs 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960004768 irinotecan Drugs 0.000 description 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229960002760 ziv-aflibercept Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023014125A JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762523458P | 2017-06-22 | 2017-06-22 | |
| US62/523,458 | 2017-06-22 | ||
| US201762529515P | 2017-07-07 | 2017-07-07 | |
| US62/529,515 | 2017-07-07 | ||
| US201762550325P | 2017-08-25 | 2017-08-25 | |
| US201762550307P | 2017-08-25 | 2017-08-25 | |
| US62/550,307 | 2017-08-25 | ||
| US62/550,325 | 2017-08-25 | ||
| US201762596054P | 2017-12-07 | 2017-12-07 | |
| US62/596,054 | 2017-12-07 | ||
| US201862649631P | 2018-03-29 | 2018-03-29 | |
| US62/649,631 | 2018-03-29 | ||
| TW107115136 | 2018-05-03 | ||
| PCT/IB2018/053096 WO2018234879A1 (en) | 2017-06-22 | 2018-05-03 | USE OF IL-1β BINDING ANTIBODIES IN THE TREATMENT OF CANCER |
| IBPCT/IB2018/053096 | 2018-05-03 | ||
| US15/970,542 | 2018-05-03 | ||
| US15/970,542 US20190048072A1 (en) | 2017-06-22 | 2018-05-03 | USE OF IL-1beta BINDING ANTIBODIES |
| TW107115136A TW201904993A (zh) | 2017-06-22 | 2018-05-03 | IL-1β 結合抗體之用途 |
| PCT/IB2018/054637 WO2018235056A1 (en) | 2017-06-22 | 2018-06-22 | Il-1beta binding antibodies for use in treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023014125A Division JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020524698A JP2020524698A (ja) | 2020-08-20 |
| JP2020524698A5 true JP2020524698A5 (https=) | 2021-08-05 |
Family
ID=62530267
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570897A Withdrawn JP2020524694A (ja) | 2017-06-22 | 2018-05-03 | がんの処置における使用のためのＩＬ−１β結合性抗体 |
| JP2019571038A Withdrawn JP2020524698A (ja) | 2017-06-22 | 2018-06-22 | がんの処置における使用のためのＩＬ−１β結合性抗体 |
| JP2022146790A Pending JP2022181214A (ja) | 2017-06-22 | 2022-09-15 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
| JP2023014125A Withdrawn JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019570897A Withdrawn JP2020524694A (ja) | 2017-06-22 | 2018-05-03 | がんの処置における使用のためのＩＬ−１β結合性抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022146790A Pending JP2022181214A (ja) | 2017-06-22 | 2022-09-15 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
| JP2023014125A Withdrawn JP2023071657A (ja) | 2017-06-22 | 2023-02-01 | がんの処置における使用のためのＩＬ－１β結合性抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20190048072A1 (https=) |
| EP (1) | EP3642234A1 (https=) |
| JP (4) | JP2020524694A (https=) |
| KR (2) | KR20200019865A (https=) |
| CN (1) | CN110831967A (https=) |
| AU (4) | AU2018287519B2 (https=) |
| BR (1) | BR112019027558A2 (https=) |
| CA (2) | CA3061874A1 (https=) |
| CL (1) | CL2019003799A1 (https=) |
| CO (1) | CO2019014433A2 (https=) |
| IL (1) | IL271221A (https=) |
| JO (1) | JOP20190292A1 (https=) |
| MX (1) | MX2019015516A (https=) |
| PH (1) | PH12019502857A1 (https=) |
| RU (1) | RU2020102237A (https=) |
| SG (1) | SG11201911283UA (https=) |
| TW (3) | TW201904993A (https=) |
| WO (1) | WO2018234879A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20200964T1 (hr) | 2012-02-13 | 2020-10-30 | Agency For Science, Technology And Research | IL-ß NEUTRALIZIRAJUĆA LJUDSKA MONOKLONSKA PROTUTIJELA |
| JP2020524694A (ja) * | 2017-06-22 | 2020-08-20 | ノバルティス アーゲー | がんの処置における使用のためのＩＬ−１β結合性抗体 |
| TW201946652A (zh) * | 2018-05-09 | 2019-12-16 | 瑞士商諾華公司 | 康納單抗(canakinumab)之用途 |
| CN113227138A (zh) * | 2018-12-21 | 2021-08-06 | 诺华股份有限公司 | IL-1β结合抗体的用途 |
| CN114127107B (zh) * | 2019-04-01 | 2024-11-01 | Immetas治疗股份有限公司 | 靶向肿瘤微环境和免疫检查点蛋白的双特异性结合分子 |
| US20220249660A1 (en) * | 2019-06-06 | 2022-08-11 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| KR20220032076A (ko) * | 2019-07-09 | 2022-03-15 | 타보텍 바이오테라퓨틱스 (홍콩) 리미티드 | Tnf-알파 및 il-1베타에 대한 이중특이적 항체 및 이의 용도 |
| KR20220152318A (ko) * | 2020-03-12 | 2022-11-15 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방을 위한 의약품 |
| RU2745814C1 (ru) * | 2020-06-05 | 2021-04-01 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция левилимаба и ее применение |
| EP3970727A1 (en) * | 2020-09-16 | 2022-03-23 | Johann Wolfgang Goethe-Universität Frankfurt | Means for reducing radiotherapy resistance and adverse effects |
| WO2022091375A1 (ja) * | 2020-10-30 | 2022-05-05 | 国立研究開発法人国立循環器病研究センター | 周産期心筋症治療剤 |
| WO2022167916A1 (en) * | 2021-02-03 | 2022-08-11 | Novartis Ag | Use of il-1b binding antibodies for treating neuroinflammatory disorders |
| WO2023038619A1 (en) * | 2021-09-08 | 2023-03-16 | Board Of Regents, The University Of Texas System | USE OF IL-1β BINDING ANTIBODIES |
| CN115125303B (zh) * | 2022-06-07 | 2023-02-24 | 北京大学第一医院 | 阿帕替尼药敏标记物及其相关试剂的应用 |
| CN116139268A (zh) * | 2023-03-13 | 2023-05-23 | 上海交通大学医学院附属仁济医院 | 靶向IL-1β的抗体在制备治疗去势抵抗型前列腺癌中的用途 |
| CN116688130A (zh) * | 2023-06-08 | 2023-09-05 | 桂林医学院附属医院 | 靶向IL-1β/IL-1R1通路的拮抗剂在抑制肝癌肺转移前微环境或肺转移的药物中的应用 |
| MX2025015070A (es) * | 2023-06-13 | 2026-02-03 | Merck Sharp & Dohme Llc | Metodos de uso de peptidos ciclicos para atrapar interleucina-1 beta |
| WO2025235276A1 (en) * | 2024-05-06 | 2025-11-13 | Icahn School Of Medicine At Mount Sinai | Combination of il-1 receptor inhibitors, anti pd-1, and il-4 inhibitors in the treatment of cancer |
| WO2025242806A1 (en) | 2024-05-23 | 2025-11-27 | Universität Duisburg-Essen | A METHOD FOR PREDICTING THE RESPONSE OF A PATIENT WITH DLBCL TO ANTI-IL-1ß THERAPY |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU784634B2 (en) | 1999-11-30 | 2006-05-18 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
| GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| ES2350687T3 (es) | 2002-07-03 | 2011-01-26 | Ono Pharmaceutical Co., Ltd. | Composiciones de inmunopotenciación. |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| AU2006230099B2 (en) | 2005-03-25 | 2012-04-19 | Gitr, Inc. | GITR binding molecules and uses therefor |
| DK1899378T3 (da) | 2005-06-21 | 2010-02-01 | Xoma Technology Ltd | IL-1 beta-bindende antistoffer og fragmenter deraf |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| EP1901091B1 (en) | 2005-07-04 | 2013-08-21 | Nikon Vision Co., Ltd. | Distance measuring apparatus |
| EP2366787B1 (en) | 2006-01-13 | 2019-12-11 | The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services | Codon optimized IL-15 and IL-15R-Alpha genes for expression in mammalian cells |
| ES2398076T3 (es) | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| US9244059B2 (en) | 2007-04-30 | 2016-01-26 | Immutep Parc Club Orsay | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| DK2160401T3 (da) | 2007-05-11 | 2014-10-20 | Altor Bioscience Corp | Fusionsmolekyler og il-15-varianter |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| US20090258020A1 (en) * | 2008-01-07 | 2009-10-15 | Patrys Limited | Antibody designated barb3, barb3 related antibodies, and methods of making and using same |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| WO2010098788A2 (en) | 2008-08-25 | 2010-09-02 | Amplimmune, Inc. | Pd-i antagonists and methods for treating infectious disease |
| US8927697B2 (en) | 2008-09-12 | 2015-01-06 | Isis Innovation Limited | PD-1 specific antibodies and uses thereof |
| KR101814408B1 (ko) | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도 |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| EP2473531A4 (en) | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | Anti-gitr antibodies |
| NZ628923A (en) | 2009-11-24 | 2016-02-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| CN102892786B (zh) | 2010-03-11 | 2016-03-16 | Ucb医药有限公司 | Pd-1抗体 |
| WO2011155607A1 (ja) | 2010-06-11 | 2011-12-15 | 協和発酵キリン株式会社 | 抗ｔｉｍ－３抗体 |
| JP2013532153A (ja) | 2010-06-18 | 2013-08-15 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 慢性免疫病に対する免疫治療のためのｔｉｍ−３およびｐｄ−１に対する二重特異性抗体 |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| KR20140043724A (ko) | 2011-03-03 | 2014-04-10 | 아펙시젠, 인코포레이티드 | 항-il-6 수용체 항체 및 사용 방법 |
| WO2012121679A1 (en) * | 2011-03-09 | 2012-09-13 | Agency For Science, Technology And Research | Method of modulating phenotype of a renal cell cancer-associated monocyte or macrophage |
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | Ｂ7-ｈ1 및 ｐｄ-1과 결합하는 항체 및 다른 분자들 |
| EP2537933A1 (en) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | An IL-15 and IL-15Ralpha sushi domain based immunocytokines |
| US8841418B2 (en) | 2011-07-01 | 2014-09-23 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to TIM3 |
| HRP20201595T1 (hr) | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| HRP20200964T1 (hr) * | 2012-02-13 | 2020-10-30 | Agency For Science, Technology And Research | IL-ß NEUTRALIZIRAJUĆA LJUDSKA MONOKLONSKA PROTUTIJELA |
| HK1204557A1 (en) | 2012-05-31 | 2015-11-27 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind pd-l1 |
| JO3300B1 (ar) | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| JP6403166B2 (ja) | 2012-08-03 | 2018-10-10 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 単一抗原抗ｐｄ−ｌ１およびｐｄ−ｌ２二重結合抗体およびその使用方法 |
| CA2886433C (en) | 2012-10-04 | 2022-01-04 | Dana-Farber Cancer Institute, Inc. | Human monoclonal anti-pd-l1 antibodies and methods of use |
| NZ630790A (en) | 2012-10-24 | 2016-11-25 | Admune Therapeutics Llc | Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes |
| AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
| EA037554B1 (ru) | 2013-03-15 | 2021-04-13 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Анти-lag-3 связывающие белки |
| JP6742903B2 (ja) | 2013-05-02 | 2020-08-19 | アナプティスバイオ インコーポレイティッド | プログラム死−１（ｐｄ−１）に対する抗体 |
| US9676853B2 (en) | 2013-05-31 | 2017-06-13 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-1 |
| WO2014209804A1 (en) | 2013-06-24 | 2014-12-31 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
| AR097306A1 (es) | 2013-08-20 | 2016-03-02 | Merck Sharp & Dohme | Modulación de la inmunidad tumoral |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| EA034666B1 (ru) | 2013-09-13 | 2020-03-04 | Бейджин Свитзерланд Гмбх | Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела |
| WO2015061668A1 (en) | 2013-10-25 | 2015-04-30 | Dana-Farber Cancer Institute, Inc. | Anti-pd-l1 monoclonal antibodies and fragments thereof |
| WO2015081158A1 (en) | 2013-11-26 | 2015-06-04 | Bristol-Myers Squibb Company | Method of treating hiv by disrupting pd-1/pd-l1 signaling |
| WO2015083120A1 (en) * | 2013-12-04 | 2015-06-11 | Novartis Ag | USE OF IL-1β BINDING ANTIBODIES |
| MY184154A (en) | 2013-12-12 | 2021-03-23 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| SI3094351T1 (sl) | 2014-01-15 | 2022-05-31 | Kadmon Corporation, Llc | Imunomodulatorna sredstva |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| SG10201900002QA (en) | 2014-01-24 | 2019-02-27 | Dana Farber Cancer Institue Inc | Antibody molecules to pd-1 and uses thereof |
| EP3099716A1 (en) | 2014-01-28 | 2016-12-07 | Bristol-Myers Squibb Company | Anti-lag-3 antibodies to treat hematological malignancies |
| EP3099717B1 (en) | 2014-01-31 | 2019-03-27 | Novartis AG | Antibody molecules to tim-3 and uses thereof |
| US20150259420A1 (en) | 2014-03-14 | 2015-09-17 | Novartis Ag | Antibody molecules to lag-3 and uses thereof |
| SG10201912986PA (en) | 2014-05-28 | 2020-02-27 | Agenus Inc | Anti-gitr antibodies and methods of use thereof |
| EP3149042B1 (en) | 2014-05-29 | 2019-08-28 | Spring Bioscience Corporation | Pd-l1 antibodies and uses thereof |
| PT3151921T (pt) | 2014-06-06 | 2019-11-21 | Bristol Myers Squibb Co | Anticorpos contra recetor do fator de necrose tumoral induzido por glicocorticoide e utilizações dos mesmos |
| WO2015195163A1 (en) | 2014-06-20 | 2015-12-23 | R-Pharm Overseas, Inc. | Pd-l1 antagonist fully human antibody |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| TWI726608B (zh) | 2014-07-03 | 2021-05-01 | 英屬開曼群島商百濟神州有限公司 | 抗pd-l1抗體及其作為治療及診斷之用途 |
| JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
| JP2017531427A (ja) | 2014-10-03 | 2017-10-26 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）抗体およびその使用法 |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| TWI716362B (zh) | 2014-10-14 | 2021-01-21 | 瑞士商諾華公司 | 針對ｐｄ－ｌ１之抗體分子及其用途 |
| PT3215532T (pt) | 2014-11-06 | 2019-12-18 | Hoffmann La Roche | Anticorpos anti-tim3 e métodos de utilização |
| TWI595006B (zh) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗ｐｄ－１抗體類和使用彼等之方法 |
| US20160200815A1 (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
| CA2978892A1 (en) | 2015-03-06 | 2016-09-15 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind tim3 |
| EA201792184A1 (ru) | 2015-04-01 | 2018-04-30 | Анаптисбайо, Инк. | Антитела, направленные против т-клеточного иммуноглобулина и белка муцина 3 (tim-3) |
| JP6941565B2 (ja) * | 2015-05-12 | 2021-09-29 | ドレクセル ユニバーシティ | がん転移を処置または防止するのに有用な化合物および組成物、ならびにこれらの使用法 |
| CA2988115A1 (en) | 2015-06-03 | 2016-12-08 | Bristol-Myers Squibb Company | Anti-gitr antibodies for cancer diagnostics |
| AU2016297249B2 (en) | 2015-07-23 | 2020-11-12 | Inhibrx Biosciences, Inc. | Multivalent and multispecific GITR-binding fusion proteins |
| US20180222982A1 (en) * | 2015-07-29 | 2018-08-09 | Novartis Ag | Combination therapies comprising antibody molecules to pd-1 |
| CA2994346A1 (en) | 2015-08-12 | 2017-02-16 | Medimmune Limited | Gitrl fusion proteins and uses thereof |
| JP2020524694A (ja) * | 2017-06-22 | 2020-08-20 | ノバルティス アーゲー | がんの処置における使用のためのＩＬ−１β結合性抗体 |
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2018
- 2018-05-03 JP JP2019570897A patent/JP2020524694A/ja not_active Withdrawn
- 2018-05-03 CA CA3061874A patent/CA3061874A1/en active Pending
- 2018-05-03 TW TW107115136A patent/TW201904993A/zh unknown
- 2018-05-03 AU AU2018287519A patent/AU2018287519B2/en not_active Ceased
- 2018-05-03 KR KR1020197035726A patent/KR20200019865A/ko not_active Ceased
- 2018-05-03 US US15/970,542 patent/US20190048072A1/en not_active Abandoned
- 2018-05-03 WO PCT/IB2018/053096 patent/WO2018234879A1/en not_active Ceased
- 2018-06-22 MX MX2019015516A patent/MX2019015516A/es unknown
- 2018-06-22 TW TW112108903A patent/TW202400641A/zh unknown
- 2018-06-22 PH PH1/2019/502857A patent/PH12019502857A1/en unknown
- 2018-06-22 TW TW107121619A patent/TW201904995A/zh unknown
- 2018-06-22 KR KR1020207001676A patent/KR20200021086A/ko not_active Ceased
- 2018-06-22 AU AU2018288060A patent/AU2018288060B2/en not_active Ceased
- 2018-06-22 EP EP18749503.1A patent/EP3642234A1/en not_active Withdrawn
- 2018-06-22 JP JP2019571038A patent/JP2020524698A/ja not_active Withdrawn
- 2018-06-22 RU RU2020102237A patent/RU2020102237A/ru unknown
- 2018-06-22 SG SG11201911283UA patent/SG11201911283UA/en unknown
- 2018-06-22 BR BR112019027558-4A patent/BR112019027558A2/pt not_active Application Discontinuation
- 2018-06-22 CA CA3066045A patent/CA3066045A1/en active Pending
- 2018-06-22 US US16/624,130 patent/US20230220063A1/en not_active Abandoned
- 2018-06-22 CN CN201880041546.8A patent/CN110831967A/zh active Pending
- 2018-12-22 JO JOP/2019/0292A patent/JOP20190292A1/ar unknown
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2019
- 2019-12-05 IL IL271221A patent/IL271221A/en unknown
- 2019-12-19 CO CONC2019/0014433A patent/CO2019014433A2/es unknown
- 2019-12-20 CL CL2019003799A patent/CL2019003799A1/es unknown
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2021
- 2021-10-07 AU AU2021245184A patent/AU2021245184A1/en not_active Abandoned
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2022
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