AU2018287519B2 - IL-1beta binding antibodies for use in treating cancer - Google Patents

IL-1beta binding antibodies for use in treating cancer Download PDF

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Publication number
AU2018287519B2
AU2018287519B2 AU2018287519A AU2018287519A AU2018287519B2 AU 2018287519 B2 AU2018287519 B2 AU 2018287519B2 AU 2018287519 A AU2018287519 A AU 2018287519A AU 2018287519 A AU2018287519 A AU 2018287519A AU 2018287519 B2 AU2018287519 B2 AU 2018287519B2
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Australia
Prior art keywords
cancer
canakinumab
functional fragment
patient
weeks
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AU2018287519A
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AU2018287519A1 (en
Inventor
Margaret DUGAN
Yi Yang Lau
Peter Libby
Monica LIGUEROS-SAYLAN
Patrice MATCHABA
Penelope OTTEWELL
Paul Ridker
Tom Thuren
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Novartis AG
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Novartis AG
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Priority to AU2021254559A priority Critical patent/AU2021254559A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001136—Cytokines
    • A61K39/00114—Interleukins [IL]
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2018287519A 2017-06-22 2018-05-03 IL-1beta binding antibodies for use in treating cancer Ceased AU2018287519B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021254559A AU2021254559A1 (en) 2017-06-22 2021-10-19 Il-1beta binding antibodies for use in treating cancer

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762523458P 2017-06-22 2017-06-22
US62/523,458 2017-06-22
US201762529515P 2017-07-07 2017-07-07
US62/529,515 2017-07-07
US201762550325P 2017-08-25 2017-08-25
US201762550307P 2017-08-25 2017-08-25
US62/550,325 2017-08-25
US62/550,307 2017-08-25
US201762596054P 2017-12-07 2017-12-07
US62/596,054 2017-12-07
US201862649631P 2018-03-29 2018-03-29
US62/649,631 2018-03-29
PCT/IB2018/053096 WO2018234879A1 (en) 2017-06-22 2018-05-03 USE OF IL-1β BINDING ANTIBODIES IN THE TREATMENT OF CANCER

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021254559A Division AU2021254559A1 (en) 2017-06-22 2021-10-19 Il-1beta binding antibodies for use in treating cancer

Publications (2)

Publication Number Publication Date
AU2018287519A1 AU2018287519A1 (en) 2019-11-07
AU2018287519B2 true AU2018287519B2 (en) 2021-07-22

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Family Applications (4)

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AU2018287519A Ceased AU2018287519B2 (en) 2017-06-22 2018-05-03 IL-1beta binding antibodies for use in treating cancer
AU2018288060A Ceased AU2018288060B2 (en) 2017-06-22 2018-06-22 IL-1beta binding antibodies for use in treating cancer
AU2021245184A Abandoned AU2021245184A1 (en) 2017-06-22 2021-10-07 Il-1beta binding antibodies for use in treating cancer
AU2021254559A Abandoned AU2021254559A1 (en) 2017-06-22 2021-10-19 Il-1beta binding antibodies for use in treating cancer

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AU2018288060A Ceased AU2018288060B2 (en) 2017-06-22 2018-06-22 IL-1beta binding antibodies for use in treating cancer
AU2021245184A Abandoned AU2021245184A1 (en) 2017-06-22 2021-10-07 Il-1beta binding antibodies for use in treating cancer
AU2021254559A Abandoned AU2021254559A1 (en) 2017-06-22 2021-10-19 Il-1beta binding antibodies for use in treating cancer

Country Status (18)

Country Link
US (3) US20190048072A1 (https=)
EP (1) EP3642234A1 (https=)
JP (4) JP2020524694A (https=)
KR (2) KR20200019865A (https=)
CN (1) CN110831967A (https=)
AU (4) AU2018287519B2 (https=)
BR (1) BR112019027558A2 (https=)
CA (2) CA3061874A1 (https=)
CL (1) CL2019003799A1 (https=)
CO (1) CO2019014433A2 (https=)
IL (1) IL271221A (https=)
JO (1) JOP20190292A1 (https=)
MX (1) MX2019015516A (https=)
PH (1) PH12019502857A1 (https=)
RU (1) RU2020102237A (https=)
SG (1) SG11201911283UA (https=)
TW (3) TW201904993A (https=)
WO (2) WO2018234879A1 (https=)

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LT2814843T (lt) 2012-02-13 2020-09-25 Agency For Science, Technology And Research ŽMOGAUS MONOKLONINIAI ANTIKŪNAI, NEUTRALIZUOJANTYS IL-1ß
CA3061874A1 (en) * 2017-06-22 2018-12-27 Novartis Ag Il-1beta binding antibodies for use in treating cancer
WO2019215484A1 (en) * 2018-05-09 2019-11-14 Novartis Ag Use of canakinumab
WO2020039401A1 (en) * 2018-08-24 2020-02-27 Novartis Ag Treatment comprising il-1βeta binding antibodies and combinations thereof
JP2022514087A (ja) * 2018-12-21 2022-02-09 ノバルティス アーゲー ＩＬ－１β結合抗体の使用
US11718673B2 (en) * 2019-04-01 2023-08-08 Immetas Therapeutics, Inc. Bispecific binding molecules that target the tumor microenvironment and an immune checkpoint protein
US20220249660A1 (en) * 2019-06-06 2022-08-11 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
AU2020310174A1 (en) * 2019-07-09 2022-02-03 Tavotek Biotherapeutics (Hong Kong) Limited Bispecific antibodies to TNF-alpha and IL-1beta and uses thereof
CA3175137A1 (en) * 2020-03-12 2021-09-16 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
RU2745814C1 (ru) * 2020-06-05 2021-04-01 Закрытое Акционерное Общество "Биокад" Водная фармацевтическая композиция левилимаба и ее применение
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