JP2020523365A5 - - Google Patents
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- JP2020523365A5 JP2020523365A5 JP2019568746A JP2019568746A JP2020523365A5 JP 2020523365 A5 JP2020523365 A5 JP 2020523365A5 JP 2019568746 A JP2019568746 A JP 2019568746A JP 2019568746 A JP2019568746 A JP 2019568746A JP 2020523365 A5 JP2020523365 A5 JP 2020523365A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- alkoxy
- carbonyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CCN1C(C)=NNC1* Chemical compound CCN1C(C)=NNC1* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762519226P | 2017-06-14 | 2017-06-14 | |
| US62/519,226 | 2017-06-14 | ||
| PCT/US2018/037412 WO2018232039A1 (en) | 2017-06-14 | 2018-06-13 | Methods for modifying rna splicing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020523365A JP2020523365A (ja) | 2020-08-06 |
| JP2020523365A5 true JP2020523365A5 (https=) | 2021-08-26 |
Family
ID=64659912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019568746A Pending JP2020523365A (ja) | 2017-06-14 | 2018-06-13 | Ｒｎａスプライシングを改変する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11608501B2 (https=) |
| EP (1) | EP3638318A4 (https=) |
| JP (1) | JP2020523365A (https=) |
| KR (1) | KR20200017476A (https=) |
| CN (1) | CN111372611A (https=) |
| AU (1) | AU2018284853A1 (https=) |
| BR (1) | BR112019026508A2 (https=) |
| CA (1) | CA3065547A1 (https=) |
| EA (1) | EA202090034A1 (https=) |
| IL (1) | IL271053A (https=) |
| WO (1) | WO2018232039A1 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10668171B2 (en) | 2015-05-30 | 2020-06-02 | Ptc Therapeutics, Inc. | Methods for modulating RNA splicing |
| JP2019535789A (ja) | 2016-11-28 | 2019-12-12 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを調節する方法 |
| JP2020523365A (ja) | 2017-06-14 | 2020-08-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを改変する方法 |
| JP7312749B2 (ja) | 2017-08-04 | 2023-07-21 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングをモジュレートする方法および組成物 |
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| KR102925387B1 (ko) * | 2019-02-04 | 2026-02-10 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| WO2020163382A1 (en) * | 2019-02-04 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| JP2022519637A (ja) * | 2019-02-04 | 2022-03-24 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| EP3920910A4 (en) * | 2019-02-04 | 2022-11-09 | Skyhawk Therapeutics, Inc. | METHODS AND COMPOSITIONS FOR MODULATION OF SPLICING |
| WO2020163406A1 (en) * | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| JP2022519311A (ja) * | 2019-02-05 | 2022-03-22 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| JP7551629B2 (ja) * | 2019-02-05 | 2024-09-17 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| WO2020163401A1 (en) * | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| WO2020163405A1 (en) * | 2019-02-05 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| JP7603595B2 (ja) * | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| JP7603594B2 (ja) * | 2019-02-06 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
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| US20220305003A1 (en) * | 2019-06-14 | 2022-09-29 | Children's Medical Research Institute | Methods of treating cancer with an inhibitor of znf827 |
| US11129829B2 (en) | 2019-06-17 | 2021-09-28 | Skyhawk Therapeutics, Inc. | Methods for modulating splicing |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| WO2021014428A1 (en) * | 2019-07-25 | 2021-01-28 | Novartis Ag | Regulatable expression systems |
| TW202131920A (zh) | 2019-11-01 | 2021-09-01 | 瑞士商諾華公司 | 剪接調節子用於減慢杭丁頓氏舞蹈症進展的治療之用途 |
| WO2021126779A1 (en) * | 2019-12-18 | 2021-06-24 | The Regents Of The University Of California | Inhibitors of lin28 and methods of use thereof |
| WO2021138678A1 (en) * | 2020-01-02 | 2021-07-08 | The General Hospital Corporation | Rna splicing modulation |
| WO2021174176A1 (en) | 2020-02-28 | 2021-09-02 | Remix Therapeutics Inc. | Pyridazine dervatives for modulating nucleic acid splicing |
| MX2022010681A (es) | 2020-02-28 | 2023-03-21 | Remix Therapeutics Inc | Compuestos y metodos para modular el empalme. |
| CN115485025A (zh) | 2020-02-28 | 2022-12-16 | 雷密克斯医疗公司 | 用于调节剪接的化合物和方法 |
| WO2021174174A1 (en) | 2020-02-28 | 2021-09-02 | Remix Therapeutics Inc. | Thiophenyl derivatives useful for modulating nucleic acid splicing |
| WO2021207530A1 (en) | 2020-04-08 | 2021-10-14 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| MX2022012678A (es) | 2020-04-08 | 2023-01-11 | Remix Therapeutics Inc | Compuestos y metodos para modular el corte y empalme. |
| CA3182912A1 (en) | 2020-05-13 | 2021-11-18 | Chdi Foundation, Inc. | Htt modulators for treating huntington's disease |
| CN116157135A (zh) * | 2020-06-03 | 2023-05-23 | 纽约市哥伦比亚大学理事会 | 使用基于crispr的碱基编辑器系统抑制谱系特异性抗原的组合物和方法 |
| MX2023000167A (es) | 2020-07-02 | 2023-05-03 | Remix Therapeutics Inc | Derivados de 5-[5-(piperidin-4-il)tieno[3,2-c]pirazol-2-il]indazol y compuestos relacionados como moduladores para el corte y empalme de ácidos nucleicos y para el tratamiento de enfermedades proliferativas. |
| TW202216710A (zh) | 2020-07-02 | 2022-05-01 | 美商雷密克斯醫療公司 | 調節剪接之化合物及方法 |
| US20240018522A1 (en) * | 2020-10-26 | 2024-01-18 | Remix Therapeutics Inc. | Oligonucleotides useful for modulation of splicing |
| EP4244362A1 (en) * | 2020-11-12 | 2023-09-20 | PTC Therapeutics, Inc. | Novel rna transcript |
| WO2022204471A1 (en) * | 2021-03-26 | 2022-09-29 | Ptc Therapeutics Inc. | Regulation of transgene expression using a small molecule inducible splicing switch |
| US20250333397A1 (en) | 2021-08-30 | 2025-10-30 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| US20240400584A1 (en) | 2021-08-30 | 2024-12-05 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| US20240368163A1 (en) | 2021-08-30 | 2024-11-07 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2023034812A1 (en) | 2021-08-30 | 2023-03-09 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| CA3230256A1 (en) | 2021-08-30 | 2023-03-09 | Dominic Reynolds | Compounds and methods for modulating splicing |
| TW202330552A (zh) | 2021-10-13 | 2023-08-01 | 美商雷密克斯醫療公司 | 調節剪接之化合物及方法 |
| IL312078A (en) | 2021-10-13 | 2024-06-01 | Remix Therapeutics Inc | Compounds and methods for modulating nucleic acid splicing |
| MX2024005933A (es) | 2021-11-17 | 2024-08-06 | Chdi Foundation Inc | Moduladores de htt pata tratar la enfermedad de huntington. |
| TW202346305A (zh) | 2022-01-05 | 2023-12-01 | 美商雷密克斯醫療公司 | 用於調節剪切之化合物及方法 |
| WO2023133229A2 (en) | 2022-01-05 | 2023-07-13 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
| WO2023133217A1 (en) | 2022-01-05 | 2023-07-13 | Remix Therapeutics Inc. | 2-(indazol-5-yl)-6-(piperidin-4-yl)-1,7-naphthyridine derivatives and related compounds as modulators for splicing nucleic acids and for the treatment of proliferative diseases |
| UY40374A (es) | 2022-08-03 | 2024-02-15 | Novartis Ag | Inhibidores de inflamasoma nlrp3 |
| CN121752556A (zh) * | 2023-06-16 | 2026-03-27 | 普莱克斯姆公司 | 降解swi/snf相关基质相关联肌动蛋白依赖性染色质调控因子a亚家族的化合物和药物组合物 |
| WO2025247338A1 (zh) * | 2024-05-30 | 2025-12-04 | 纽欧申医药(上海)有限公司 | 哒嗪环类化合物、其药物组合物及其应用 |
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| US10668171B2 (en) | 2015-05-30 | 2020-06-02 | Ptc Therapeutics, Inc. | Methods for modulating RNA splicing |
| JP2019535789A (ja) | 2016-11-28 | 2019-12-12 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを調節する方法 |
| JP2020523365A (ja) | 2017-06-14 | 2020-08-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを改変する方法 |
| JP7312749B2 (ja) | 2017-08-04 | 2023-07-21 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングをモジュレートする方法および組成物 |
| US20230152257A1 (en) | 2017-09-25 | 2023-05-18 | Skyhawk Therapeutics, Inc. | Methods and compositions for screening and identification of splicing |
-
2018
- 2018-06-13 JP JP2019568746A patent/JP2020523365A/ja active Pending
- 2018-06-13 KR KR1020207000911A patent/KR20200017476A/ko not_active Ceased
- 2018-06-13 WO PCT/US2018/037412 patent/WO2018232039A1/en not_active Ceased
- 2018-06-13 CN CN201880052678.0A patent/CN111372611A/zh active Pending
- 2018-06-13 US US16/622,223 patent/US11608501B2/en active Active
- 2018-06-13 EA EA202090034A patent/EA202090034A1/ru unknown
- 2018-06-13 AU AU2018284853A patent/AU2018284853A1/en not_active Abandoned
- 2018-06-13 EP EP18817883.4A patent/EP3638318A4/en not_active Withdrawn
- 2018-06-13 CA CA3065547A patent/CA3065547A1/en active Pending
- 2018-06-13 BR BR112019026508-2A patent/BR112019026508A2/pt not_active IP Right Cessation
-
2019
- 2019-11-29 IL IL271053A patent/IL271053A/en unknown
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